diphenhydramine has been researched along with Acute Liver Injury, Drug-Induced in 13 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 7.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| "There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia." | 3.79 | Acetaminophen/diphenhydramine overdose in profound hypothermia. ( Rollstin, AD; Seifert, SA, 2013) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 1 |
| Trauner, M | 1 |
| van Staden, CJ | 1 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 1 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Serper, M | 1 |
| Wolf, MS | 1 |
| Parikh, NA | 1 |
| Tillman, H | 1 |
| Lee, WM | 1 |
| Ganger, DR | 1 |
| Rabaglio, M | 1 |
| Ruepp, B | 1 |
| Rollstin, AD | 1 |
| Seifert, SA | 1 |
| Kosmidis, PA | 1 |
| Kalofonos, HP | 1 |
| Christodoulou, C | 1 |
| Syrigos, K | 1 |
| Makatsoris, T | 1 |
| Skarlos, D | 1 |
| Bakogiannis, C | 1 |
| Nicolaides, C | 1 |
| Bafaloukos, D | 1 |
| Bamias, A | 1 |
| Samantas, E | 1 |
| Xiros, N | 1 |
| Boukovinas, I | 1 |
| Fountzilas, G | 1 |
| Dimopoulos, MA | 1 |
| McDonough, J | 1 |
| Knight, ME | 1 |
| Roberts, RJ | 1 |
| Herdemerten, S | 1 |
| Tackmann, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Trial to Study Acute Liver Failure in Adults[NCT00518440] | 3,488 participants (Actual) | Observational | 1998-01-31 | Completed | |||
| A Phase III Trial Evaluating The Role Of Exemestane Plus GnRH Analogue As Adjuvant Therapy For Premenopausal Women With Endocrine Responsive Breast Cancer[NCT00066703] | Phase 3 | 2,672 participants (Actual) | Interventional | 2003-11-03 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Estimated percentage of patients alive and disease-free at 5 years from randomization, where breast cancer-free interval is defined as the time from randomization to the invasive breast cancer recurrence at local, regional, or distant site, or invasive contralateral breast cancer; or censored at date of last follow up. (NCT00066703)
Timeframe: 5-year estimate reported at a median follow-up of 72 months
| Intervention | percentage of participants (Number) |
|---|---|
| T+OFS | 88.8 |
| E+OFS | 92.8 |
Estimated percentage of patients alive and disease-free at 5 years from randomization, where disease-free survival is defined as the time from randomization to the first appearance of one of the following: invasive breast cancer recurrence at local, regional, or distant site, invasive contralateral breast cancer, second (non-breast) invasive cancer, or death without cancer event; or censored at date of last follow up. (NCT00066703)
Timeframe: 5-year estimate reported at a median follow-up of 72 months
| Intervention | percentage of participants (Number) |
|---|---|
| T+OFS | 87.3 |
| E+OFS | 91.1 |
Estimated percentage of patients alive and disease-free at 5 years from randomization, where distant recurrence-free interval is defined as the time from randomization to breast cancer recurrence at a distant site; or censored at date of last follow-up (NCT00066703)
Timeframe: 5-year estimates reported at a median follow-up of 72 months
| Intervention | percentage of participants (Number) |
|---|---|
| T+OFS | 92.0 |
| E+OFS | 93.8 |
Estimated percentage of patients alive at 8 years from randomization, where overall survival is defined as the time from randomization to death from any cause; or censored at date last known alive. (NCT00066703)
Timeframe: 8-year estimates, reported at a median follow-up of 9 years
| Intervention | percentage of participants (Number) |
|---|---|
| T+OFS | 93.3 |
| E+OFS | 93.4 |
2 reviews available for diphenhydramine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Phenothiazine and butyrophenone intoxication in children.
Topics: Absorption; Adolescent; Basal Ganglia Diseases; Benztropine; Butyrophenones; Cardiovascular System; | 1986 |
1 trial available for diphenhydramine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcino | 2008 |
10 other studies available for diphenhydramine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products: Results From the Acute Liver Failure Study Group.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Chemical and Drug Induced Liver Injury; Databases, Factual | 2016 |
Death due to liver failure during endocrine therapy for premenopausal breast cancer.
Topics: Adult; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chem | 2010 |
Acetaminophen/diphenhydramine overdose in profound hypothermia.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2013 |
Emergency! Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv | 1998 |
[Bilateral leg nerve paralysis following mandrax intoxication].
Topics: Adult; Chemical and Drug Induced Liver Injury; Diphenhydramine; Electromyography; Hemorrhagic Disord | 1973 |