diphenhydramine has been researched along with Acathisia, Drug-Induced in 17 studies
Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.
antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients who presented to our emergency department with a primary or secondary chief complaint of nausea were randomized to one of the following 4 groups: (1) metoclopramide 10 mg+diphenhydramine 25 mg; (2) metoclopramide 10 mg+placebo; (3) metoclopramide 20 mg+diphenhydramine 25 mg; (4) metoclopramide 20 mg+placebo." | 9.14 | A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. ( Bender, B; Bijur, P; Davitt, M; Esses, D; Friedman, BW; Gallagher, EJ; Paternoster, J; Solorzano, C, 2009) |
| "Physostigmine was superior to lorazepam in controlling antimuscarinic delirium and agitation after bolus dosing, and control of delirium after a 4-h infusion." | 5.41 | A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome. ( Baker, K; Heard, K; Janis, GC; Leonard, J; Mistry, RD; Ng, P; Wang, GS, 2021) |
| " Patients who presented to our emergency department with a primary or secondary chief complaint of nausea were randomized to one of the following 4 groups: (1) metoclopramide 10 mg+diphenhydramine 25 mg; (2) metoclopramide 10 mg+placebo; (3) metoclopramide 20 mg+diphenhydramine 25 mg; (4) metoclopramide 20 mg+placebo." | 5.14 | A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. ( Bender, B; Bijur, P; Davitt, M; Esses, D; Friedman, BW; Gallagher, EJ; Paternoster, J; Solorzano, C, 2009) |
| "The utility of intravenous prochlorperazine as an antiemetic agent and abortive therapy for headache may be limited by the frequent occurrence of akathisia, the distressing effects of which have been shown to disrupt patient care." | 5.09 | Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial. ( Drotts, DL; Vinson, DR, 2001) |
| "Metoclopramide was administered as a 2-minute bolus infusion." | 2.77 | A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. ( Aydin, B; Erdur, B; Ergin, A; Kabay, B; Ozen, M; Parlak, I; Tura, P, 2012) |
| "When compared at 2 and 24 hours, aggressive (20 mg dosed up to four times) IV metoclopramide and 6 mg of subcutaneous sumatriptan relieved migraine headache pain comparably." | 2.71 | A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. ( Bijur, PE; Corbo, J; Esses, D; Friedman, BW; Gallagher, EJ; Lipton, RB; Solorzano, C, 2005) |
| "Pediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents." | 2.66 | Intravenous Migraine Treatment in Children and Adolescents. ( Hershey, AD; Kabbouche, M; Maconochie, I; Murphy, B; Qaiser, S; Werner, K, 2020) |
| " Extrapyramidal side effects like tardive dyskinesia are known to develop with chronic use of metoclopramide, while acute akathisia is a lesser known side effect following IV administration." | 1.37 | Case of acute akathisia from intravenous metoclopramide. ( Lim, BL; Qiu, LM, 2011) |
| "Akathisia is a common but frequently unrecognized complication of antipsychotic medication." | 1.27 | Akathisia: the syndrome of motor restlessness. ( Friedman, JH; Wagner, RL, 1987) |
| " Before studying the efficacy of MCP as an antiemetic in children, we first had to establish the safe dose range." | 1.27 | Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. ( Allen, JC; Gralla, R; Kellick, M; Reilly, L; Young, C, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Werner, K | 1 |
| Qaiser, S | 1 |
| Kabbouche, M | 1 |
| Murphy, B | 1 |
| Maconochie, I | 1 |
| Hershey, AD | 1 |
| Wang, GS | 1 |
| Baker, K | 1 |
| Ng, P | 1 |
| Janis, GC | 1 |
| Leonard, J | 1 |
| Mistry, RD | 1 |
| Heard, K | 1 |
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Friedman, BW | 2 |
| Bender, B | 1 |
| Davitt, M | 1 |
| Solorzano, C | 2 |
| Paternoster, J | 1 |
| Esses, D | 2 |
| Bijur, P | 1 |
| Gallagher, EJ | 2 |
| Kostic, MA | 1 |
| Gutierrez, FJ | 1 |
| Rieg, TS | 1 |
| Moore, TS | 1 |
| Gendron, RT | 1 |
| Erdur, B | 2 |
| Tura, P | 1 |
| Aydin, B | 1 |
| Ozen, M | 1 |
| Ergin, A | 2 |
| Parlak, I | 2 |
| Kabay, B | 1 |
| Trottier, ED | 1 |
| Bailey, B | 1 |
| Lucas, N | 1 |
| Lortie, A | 1 |
| Qiu, LM | 1 |
| Lim, BL | 1 |
| Vinson, DR | 3 |
| Corbo, J | 1 |
| Lipton, RB | 1 |
| Bijur, PE | 1 |
| Baden, EY | 1 |
| Prodany, K | 1 |
| Wiener, SW | 1 |
| Hoffman, RS | 1 |
| Parlak, M | 1 |
| Ayrik, C | 1 |
| Tomruk, O | 1 |
| Turkcuer, I | 1 |
| Ergin, N | 1 |
| Jacobs, MB | 1 |
| Drotts, DL | 1 |
| Friedman, JH | 1 |
| Wagner, RL | 1 |
| Allen, JC | 1 |
| Gralla, R | 1 |
| Reilly, L | 1 |
| Kellick, M | 1 |
| Young, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| A Randomized Double Blinded Study Comparing Use of Prochlorperazine Versus Prochlorperazine and Ketorolac in the Treatment of Pediatric Migraine in the Emergency Department[NCT01534806] | Phase 4 | 0 participants (Actual) | Interventional | 2012-01-31 | Withdrawn (stopped due to Drug is backordered;) | ||
| Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326] | 300 participants (Anticipated) | Interventional | 2012-03-01 | Completed | |||
| A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872] | Phase 4 | 500 participants (Actual) | Interventional | 2017-09-05 | Terminated (stopped due to no longer recruiting or studying) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
2 reviews available for diphenhydramine and Acathisia, Drug-Induced
| Article | Year |
|---|---|
Intravenous Migraine Treatment in Children and Adolescents.
Topics: Administration, Intravenous; Adolescent; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Inflammat | 2020 |
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
9 trials available for diphenhydramine and Acathisia, Drug-Induced
| Article | Year |
|---|---|
A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome.
Topics: Adolescent; Akathisia, Drug-Induced; Anti-Anxiety Agents; Delirium; Diphenhydramine; Double-Blind Me | 2021 |
A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients.
Topics: Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Dopamine Antagonists; Double-Bli | 2009 |
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Double-Blind Method; Female; Humans; H | 2012 |
Prochlorperazine in children with migraine: a look at its effectiveness and rate of akathisia.
Topics: Adolescent; Akathisia, Drug-Induced; Child; Diphenhydramine; Dopamine Antagonists; Drug Therapy, Com | 2012 |
Diphenhydramine in the treatment of akathisia induced by prochlorperazine.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antiparkinson Agents; Cohort Studies; Diphenhydramine; D | 2004 |
A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines.
Topics: Adult; Akathisia, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dizziness; | 2005 |
Midazolam vs. diphenhydramine for the treatment of metoclopramide-induced akathisia: a randomized controlled trial.
Topics: Adult; Akathisia, Drug-Induced; Analysis of Variance; Diphenhydramine; Dose-Response Relationship, D | 2007 |
Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antiemetics; Conscious Sedation; Diphenhydramine; Double | 2001 |
6 other studies available for diphenhydramine and Acathisia, Drug-Induced
| Article | Year |
|---|---|
Case of acute akathisia from intravenous metoclopramide.
Topics: Abdominal Pain; Adult; Akathisia, Drug-Induced; Diphenhydramine; Emergency Service, Hospital; Female | 2011 |
Diphenhydramine in the treatment of akathesia induced by prochlorperazine.
Topics: Akathisia, Drug-Induced; Antiparkinson Agents; Antipsychotic Agents; Diphenhydramine; Emergency Serv | 2005 |
Diltiazem and akathisia.
Topics: Akathisia, Drug-Induced; Angina Pectoris; Benzazepines; Diltiazem; Diphenhydramine; Humans; Male; Mi | 1983 |
Akathisia: problematic but preventable.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Confidence Intervals; Diphenhydramine; Dopamine Antagon | 2002 |
Akathisia: the syndrome of motor restlessness.
Topics: Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Diphenhydramine; Haloperidol; Humans; Ma | 1987 |
Metoclopramide: dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antineoplastic Agents; Basal Ganglia Diseases; Child; Di | 1985 |