diospyros has been researched along with Neuroblastoma* in 2 studies
2 other study(ies) available for diospyros and Neuroblastoma
| Article | Year |
|---|---|
Deastringent Peel Extracts of Persimmon (
The peel of astringent persimmon ( Topics: Animals; Antioxidants; Cell Line; Cell Survival; Diospyros; Flavonoids; Fruit; Galactosides; Gallic Acid; Glucosides; Humans; Kaempferols; Monosaccharides; Neuroblastoma; Oxidative Stress; Phenols; Pheochromocytoma; Plant Extracts; Protective Agents; Quercetin; Rats | 2018 |
Flavonoids from the leaves of Diospyros kaki reduce hydrogen peroxide-induced injury of NG108-15 cells.
Flavonoids from the leaves of Diospyros kaki L (FLDK-P70) are main therapeutic components of NaoXingQing, which is a novel and patented Traditional Chinese Medicine drug used for the treatment of syndrome of apoplexy for years in China. The present study investigated the effects of FLDK-P70 on hydrogen peroxide (H2O2)-induced apoptosis-like damage of NG108-15 cells. Pretreatment of cells with FLDK-P70 alleviated H2O2-induced cell injury and apoptosis by upregulating Bcl-2 expression and improving redox imbalance as indicated by the alleviation of the decline in the intracellular endogenous antioxidants: glutathione and glutathione peroxidase as well as catalase, with the decrease of the leak of lactate dehydrogenase and the reduction of the accumulation of malondialdehyde. These results indicate that FLDK-P70 may be potentially used in the prevention and treatment of ischemia/reperfusion injury and other neurodegenerative disease. Upregulating bcl-2 and improving cellular redox state by FLDK-P70 may play critical roles in attenuating oxidative injury. Topics: Antioxidants; Apoptosis; Cell Survival; Diospyros; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Humans; Hydrogen Peroxide; Medicine, Chinese Traditional; Neuroblastoma; Oxidation-Reduction; Oxidative Stress; Plant Leaves; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Up-Regulation | 2005 |