diospyros has been researched along with Diabetes-Mellitus* in 2 studies
2 other study(ies) available for diospyros and Diabetes-Mellitus
| Article | Year |
|---|---|
Multimodal approaches of the hydroalcoholic extract of Diospyros peregrina fruits in diabetic therapy.
The matured fruits of Diospyros peregrina possess significant antidiabetic activity. The present investigation was undertaken to evaluate the target of action of the hydroalcoholic extract of D. peregrina fruit in diabetic pathophysiology. The extract was tested in vitro for inhibition of glucose absorption by α-amylase inhibition assay, glucose uptake study by isolated rat hemidiaphragm method and free radical scavenging activity by DPPH method. The extract exhibited significant α-amylase inhibition (IC₅₀ 136.5 µg mL⁻¹), peripheral glucose utilisation and radical scavenging (IC₅₀ 167.5 µg mL⁻¹) activity. From the results, it may be concluded that the hydroalcoholic extract of D. peregrina fruit can counteract diabetes by multiple mechanisms, namely inhibition of carbohydrate absorption, improving peripheral glucose utilisation and antioxidant defence. Topics: alpha-Amylases; Animals; Biphenyl Compounds; Blood Glucose; Diabetes Mellitus; Diospyros; Free Radical Scavengers; Fruit; Glucose; Hypoglycemic Agents; Picrates; Plant Extracts; Rats | 2011 |
Inhibitory activities of proanthocyanidins from persimmon against oxidative stress and digestive enzymes related to diabetes.
The present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins of persimmon peel as antioxidants and therapeutic agents for diabetes. Both polymers and oligomers showed the scavenging effect of 2,2-diphenyl-l-picrylhydrazyl, with IC50 values of 4.35 and 2.41 microg/mL, respectively, and they also showed a protective activity against protein oxidation induced by 2,2'-azobis (2-amidinopropane) dihydrochloride. In particular, oligomers exerted a stronger activity against free radicals than polymers. In addition, to investigate their protective potential against diabetes-related pathological conditions, their inhibitory activities on digestive enzymes and advanced glycation endproduct (AGE) formation were evaluated. Polymers showed a strong inhibitory activity against alpha-amylase, while oligomers had a relatively weak effect. This suggests that the inhibition of alpha-amylase activity would probably depend on the degree of polymerization. On the other hand, against alpha-glucosidase activity and AGE formation, oligomers exerted a stronger protective effect than polymers. The present study suggests that polymers and oligomers from proanthocyanidins of persimmon peel could play a role as antidiabetic agents with antioxidative effects. Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems. Topics: alpha-Amylases; alpha-Glucosidases; Antioxidants; Diabetes Mellitus; Diospyros; Free Radical Scavengers; Glycation End Products, Advanced; Oxidation-Reduction; Oxidative Stress; Plant Extracts; Proanthocyanidins; Serum Albumin, Bovine; Time Factors | 2007 |