diospyrin and Disease-Models--Animal

diospyrin has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for diospyrin and Disease-Models--Animal

Article	Year
Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Derivatisation of diospyrin, a bisnaphthoquinonoid isolated from Diospyros montana Roxb., led to the modification of its inhibitory activity, in vitro, towards a murine tumour model, Ehrlich ascites carcinoma (EAC), and two human cancer cell lines, viz., malignant skin melanoma (A375) and epidermoid laryngeal carcinoma (Hep2). Among the novel derivatives, an epoxide exhibited the maximum antiproliferative activity (IC(50) values in the range of 0.03-0.21 microM) and a comparatively lower toxicity (IC(50) approximately 98 microM) in normal human peripheral blood mononuclear cells (PBMC). This compound might provide a novel 'lead' for the development of clinically effective antiproliferative agents against cancer. Topics: Animals; Antineoplastic Agents; Cell Proliferation; Diospyros; Disease Models, Animal; Humans; Inhibitory Concentration 50; Leukocytes, Mononuclear; Mice; Naphthoquinones; Plant Bark; Tumor Cells, Cultured	2007

Article

Year

Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid.

Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11

Derivatisation of diospyrin, a bisnaphthoquinonoid isolated from Diospyros montana Roxb., led to the modification of its inhibitory activity, in vitro, towards a murine tumour model, Ehrlich ascites carcinoma (EAC), and two human cancer cell lines, viz., malignant skin melanoma (A375) and epidermoid laryngeal carcinoma (Hep2). Among the novel derivatives, an epoxide exhibited the maximum antiproliferative activity (IC(50) values in the range of 0.03-0.21 microM) and a comparatively lower toxicity (IC(50) approximately 98 microM) in normal human peripheral blood mononuclear cells (PBMC). This compound might provide a novel 'lead' for the development of clinically effective antiproliferative agents against cancer.

Topics: Animals; Antineoplastic Agents; Cell Proliferation; Diospyros; Disease Models, Animal; Humans; Inhibitory Concentration 50; Leukocytes, Mononuclear; Mice; Naphthoquinones; Plant Bark; Tumor Cells, Cultured

2007