diosgenin has been researched along with Disease Models, Animal in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.30) | 18.7374 |
| 1990's | 1 (1.30) | 18.2507 |
| 2000's | 5 (6.49) | 29.6817 |
| 2010's | 44 (57.14) | 24.3611 |
| 2020's | 26 (33.77) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, W; Ji, C; Niu, H; Wei, Z; Wen, L; Xia, Q; Xin, G; Zheng, H | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Lu, Z; Peng, JY; Wang, J; Yao, Y | 1 |
| Azuma, K; Gao, X; Liu, X; Saido, TC; Saito, T; Wang, KY; Wang, X; Zhang, JH; Zhou, Q | 1 |
| Baev, DS; Borisov, SA; Mironov, ME; Rybalova, TV; Shults, EE; Tolstikova, TG | 1 |
| Antony, J; Dhanabal, S; Ponnusankar, S; Som, S | 1 |
| Li, H; Li, S; Liu, J; Nie, B; Pang, B; Qu, S; Xu, J; Yang, M; Zhang, K | 1 |
| Qi, Y; Shang, Q; Shang, W; Zeng, J; Zhu, L | 1 |
| Fan, L; Li, J; Liu, B; Ni, R; Song, Y; Wang, A; Wang, H; Zhang, L | 1 |
| Jo, HJ; Kim, YH; Park, CK; Rahman, MM | 1 |
| Alexandrova, A; Andreeva, M; Atanasova, D; Georgieva, A; Kanzova, H; Petrov, L; Philipov, S; Pramatarov, G; Stoilova, O; Tsvetanova, E | 1 |
| Tohda, C; Yang, X | 1 |
| Huang, C; Le, K; Sun, Y; Wu, S; Xie, M; Xu, M; Zhao, M | 1 |
| Cai, B; Chun, C; Guan, Y; Jia, Y; Li, J; Liao, A; Liu, G; Wang, Z; Xu, D; Zhang, Y | 1 |
| Jiang, W; Lei, L; Li, Q; Ni, Y; Wan, Z; Wei, J | 1 |
| Chu, Y; Guo, Y; Leng, J; Li, J; Li, X; Liu, C; Tian, H; Wang, Y; Zhang, L; Zhang, S | 1 |
| Baluchnejadmojarad, T; Khanizadeh, AM; Mohamadi-Zarch, SM; Nourabadi, D; Roghani, M | 1 |
| Huang, G; Li, S; Tang, X; Zhang, T | 1 |
| Choi, SS; de Guzman, ACV; Purevdulam, B; Razzak, MA | 1 |
| Han, X; Peng, JY; Qi, Y; Song, S; Sun, C; Xu, L; Xu, Y; Yang, Y; Yin, L; Zhao, Y; Zhu, M | 1 |
| Li, R; Lu, H; Ma, C; Shi, J; Sun, F; Yang, X; Yu, L; Yu, Y; Zhang, F; Zhang, S | 1 |
| Liu, T; Qin, L; Sun, B; Wu, L; Wu, Y; Zhang, C; Zhong, F | 1 |
| Chang, CJ; Huang, CH; Lu, SY; Pan, CL; Tsai, GJ; Tsai, WC | 1 |
| He, C; Kong, C; Li, R; Lu, Q; Lyu, D | 1 |
| Ahn, KS; Alahmadi, TA; Alharbi, SA; Chinnathambi, A; Hui, KM; Kumar, AP; Lee, JH; Ong, TH; Rajendran, P; Sethi, G; Shanmugam, MK; Sikka, S; Siveen, KS; Vali, S; Wang, L; Yang, MH | 1 |
| Cai, J; Cao, Y; Dong, X; Fan, P; Liu, J; Liu, X; Zhang, N; Zhu, K | 1 |
| Huang, BY; Mai, CT; Wang, CL; Wang, QM; Wang, TT; Wu, MM; Zhang, XJ | 1 |
| Song, HG; Sun, N; Wang, PF; Zhao, WX | 1 |
| Cao, L; He, C; Liu, W; Lu, F; Pu, Y; Yin, D; Yu, Z; Zhao, C; Zhu, M | 1 |
| Han, X; Liu, K; Ma, X; Peng, J; Qi, Y; Qiao, Y; Tang, Z; Tao, X; Xu, L; Xu, Y; Yin, L | 1 |
| Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y | 1 |
| Deng, ZK; Wu, J; Zhao, YM | 1 |
| Huang, W; Niu, H; Shen, Y; Shi, N; Wei, Z; Wen, L; Xia, Q; Xing, Z; Xiong, Q; Zeng, Z; Zhang, R | 1 |
| Gong, WL; Shakya, S; Wu, JW; Xu, FJ; Yu, FL; Zhu, H | 1 |
| Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S | 1 |
| Chen, D; Huang, Z; Jiang, Z; Li, B; Li, Q; Wu, S; Xu, P | 1 |
| Liu, M; Lu, J; Sun, H; Wang, S; Zhang, T | 1 |
| Cheng, J; Hao, Q; Sun, C; Xue, Y; Zhang, J; Zou, Q | 1 |
| Baluchnejadmojarad, T; Khosravi, Z; Roghani, M; Sedaghat, R | 1 |
| Huang, T; Sun, L; Wei, Q; Xiao, X; Zhang, Z; Zhu, T | 1 |
| Cao, YJ; Hou, L; Li, XS; Liu, B; Qi, Y; Sun, YM; Wan, CP; Wen, WB; Wu, J; Xu, Y; Zhang, Y; Zheng, X | 1 |
| Wu, Y; Yang, L; Yuan, Y | 1 |
| Han, X; Peng, J; Qi, Y; Xu, L; Xu, T; Xu, Y; Yin, L; Zheng, L | 1 |
| Cai, H; Gao, L; Wang, FR; Wang, Z; Yu, CX; Zhang, FX; Zhang, HQ; Zhang, J; Zhao, JJ | 1 |
| Goto, Y; Lee, YA; Nemere, I; Tohda, C | 1 |
| Feng, J; Jiang, H; Ma, SL; Su, D; Zhao, PJ | 1 |
| Amstislavskaya, TG; Chen, JH; Ding, SJ; Ho, YJ; Hung, YT; Kao, PF; Lan, HH; Liao, JM; Tikhonova, MA | 1 |
| Fu, X; Ju, D; Li, Y; Liu, H; Liu, M; Pan, J; Song, C; Wang, S; Xiang, L; Xiao, GG; Zhang, Z | 1 |
| Cayabyab, FS; He, PP; Li, L; Liu, D; Lv, YC; Ouyang, XP; Tan, YL; Tang, CK; Tang, YY; Xie, W; Yang, J; Yao, F; Zhang, M; Zheng, XL | 1 |
| Bi, GB; Chen, L; Liu, Y; Nie, TH; Niu, F; Tian, G; Xu, CY; Ye, L; Zhao, S | 1 |
| Amstislavskaya, TG; Chen, JH; Ho, YJ; Hsu, CY; Huang, CW; Hung, CS; Kao, PF; Kolosova, NG; Tikhonova, MA; Ting, CH; Tseng, GT | 1 |
| Hai, C; Liu, J; Liu, Y; Long, Z; Sun, Q; Wang, L; Wang, X; Zhang, X | 1 |
| An, G; Feng, G; Guo, Y; Liang, X; Song, H; Wang, M; Xing, E; Zhao, X | 1 |
| Moura, ML; Pereira de Oliveira, A; Rolim, HM | 1 |
| Hori, M; Huang, CH; Jan, TR; Lin, YC; Wang, CC | 1 |
| Du, B; Li, B; Liu, X; Tan, Y; Wu, Y; Xiao, J; Zhang, G | 1 |
| Junchao, Y; Libin, J; Liying, X; Lu, Z; Ruilin, C; Wei, Z; Yuan, W; Yuanhong, Z; Zhen, W | 1 |
| Haratake, A; Matsunaga, K; Nagata-Akaho, N; Setoguchi, S; Takata, J; Watase, D | 1 |
| Huang, CH; Jan, TR; Ku, CY | 1 |
| Greeson, J; Lecanu, L; McCourty, A; Papadopoulos, V; Rammouz, G; Sidahmed, EK | 1 |
| Gong, G; Huang, W; Li, D; Qin, Y; Wu, X; Yang, X; Zhao, Y; Zhou, S | 1 |
| Goto, T; Hirai, S; Hoshino, S; Kawada, T; Lee, JY; Mizoguchi, N; Nakano, Y; Narukami, T; Shono, J; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T | 1 |
| Gong, G; Huang, W; Qin, Y | 1 |
| Gao, W; Huang, L; Liu, C; Liu, Z; Man, S; Yan, L; Zhang, Y | 1 |
| Mabuchi, R; Miyoshi, N; Nagasawa, T; Ohshima, H; Tanaka, T; Wakabayashi, K; Yasui, Y | 1 |
| Chang, SP; Chiang, SS; Pan, TM | 1 |
| Kuboyama, T; Nemere, I; Tohda, C; Umezaki, M; Urano, T | 1 |
| Mohammadi, M; Rashidi, B; Salimeh, A | 1 |
| Balasubramanian, MP; Jagadeesan, J; Nandakumar, N; Rengarajan, T | 1 |
| Chen, L; Gao, M; Kou, J; Sun, Q; Yu, B; Yu, H | 1 |
| Fan, MJ; Hsieh, WT; Liu, FC; Pan, CH; Sheu, MJ; Tsai, CH; Wu, CH | 1 |
| Du, Q; Li, B; Liu, Z; Wang, A; Wang, F; Wang, Y; Wang, Z | 1 |
| Chen, Y; Kadota, S; Kouda, K; Le Tran, Q; Miyahara, T; Tezuka, Y; Yin, J | 1 |
| Patlolla, JM; Raju, J; Rao, CV; Swamy, MV | 1 |
| Amigo, L; González, S; Mendoza, H; Miquel, JF; Nervi, F; Rigotti, A; Zanlungo, S | 1 |
| Chai, H; Cordell, GA; Farnsworth, NR; Hollingshead, MG; Kardono, LB; Kinghorn, AD; Lantvit, D; Lee, IS; Mayo, JG; Mi, Q; Ngassapa, O; Peraza-Sánchez, S; Pezzuto, JM; Reyes-Lim, E; Riswan, S; Zhao, W | 1 |
| Squibb, RE; Squibb, RL | 1 |
2 review(s) available for diosgenin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances.
Topics: Animals; Biological Availability; Cognition; Diosgenin; Disease Models, Animal; Humans; Molecular Structure; Nervous System Diseases; Neuroprotective Agents; Plants, Medicinal | 2020 |
Cardioprotector Activity of an Esteroidal Saponin: A Scientific and Technological Prospection.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Cardiotonic Agents; Diosgenin; Disease Models, Animal; Dyslipidemias; Humans; Hypertension; Mice; Patents as Topic; Rats; Saponins | 2017 |
75 other study(ies) available for diosgenin and Disease Models, Animal
| Article | Year |
|---|---|
Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo.
Topics: Administration, Oral; Animals; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Structure-Activity Relationship; Thrombosis | 2016 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Dioscin ameliorates diabetes cognitive dysfunction via adjusting P2X7R/NLRP3 signal.
Topics: Animals; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Diosgenin; Disease Models, Animal; Inflammasomes; Interleukin-1beta; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Receptors, Purinergic P2X7; Signal Transduction | 2021 |
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; beta Catenin; Body Weight; Brain; Cytokines; Diosgenin; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Models, Biological; NF-kappa B; Sex Characteristics; Signal Transduction; Synapses | 2021 |
Synthesis of Anti-Inflammatory Spirostene-Pyrazole Conjugates by a Consecutive Multicomponent Reaction of Diosgenin with Oxalyl Chloride, Arylalkynes and Hydrazines or Hydrazones.
Topics: Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Chlorides; Combinatorial Chemistry Techniques; Diosgenin; Disease Models, Animal; Edema; Hydrazines; Hydrazones; Mice; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Oxalates; Pyrazoles | 2021 |
Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1-42) induced neurotoxicity in animal model of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Diosgenin; Disease Models, Animal; Hippocampus; Maze Learning; Nerve Growth Factor; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar | 2022 |
Dioscin promotes autophagy by regulating the AMPK-mTOR pathway in ulcerative colitis.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Colitis, Ulcerative; Colon; Dextran Sulfate; Diosgenin; Disease Models, Animal; Mice; TOR Serine-Threonine Kinases | 2022 |
Dioscin exhibits protective effects on in vivo and in vitro asthma models via suppressing TGF-β1/Smad2/3 and AKT pathways.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Collagen; Diosgenin; Disease Models, Animal; Humans; Hyperplasia; Immunoglobulin E; Immunoglobulin G; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Proto-Oncogene Proteins c-akt; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2022 |
Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia.
Topics: Anemia, Aplastic; Animals; Apoptosis; Bone Marrow; Diosgenin; Disease Models, Animal; Mice | 2022 |
Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain.
Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Diosgenin; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Mice; Neuralgia; TRPV Cation Channels | 2022 |
Effect of Chitosan-Diosgenin Combination on Wound Healing.
Topics: Animals; Antioxidants; Chitosan; Diosgenin; Disease Models, Animal; Ethanol; Glutathione; Mice; Wound Healing | 2023 |
Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer's disease model mice.
Topics: Alzheimer Disease; Animals; Axons; Diosgenin; Disease Models, Animal; Hippocampus; Mice; Mice, Transgenic; Osteonectin | 2023 |
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line; Cell Proliferation; Cytokines; Diosgenin; Disease Models, Animal; Female; Human Umbilical Vein Endothelial Cells; Humans; Imiquimod; Keratinocytes; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Receptors, Interleukin | 2020 |
Polyphyllin I attenuates pressure over-load induced cardiac hypertrophy via inhibition of Wnt/β-catenin signaling pathway.
Topics: Angiotensin II; Animals; Cardiomegaly; Diosgenin; Disease Models, Animal; Echocardiography; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Rats; Wnt Signaling Pathway | 2020 |
Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-Fat; Diosgenin; Disease Models, Animal; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Streptozocin | 2020 |
Protective effect of diosgenin on LPS/D-Gal-induced acute liver failure in C57BL/6 mice.
Topics: Animals; Diosgenin; Disease Models, Animal; Inflammation; Lipopolysaccharides; Liver Failure, Acute; Mice; Mice, Inbred C57BL | 2020 |
Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-κB/IkB-α and Bax/Caspase-1 signaling pathways.
Topics: Animals; bcl-2-Associated X Protein; Biomarkers; Caspase 1; Colitis; Colon; Cytoprotection; Diosgenin; Disease Models, Animal; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Anti-Parkinson's Disease Function of Dioscin-Zein-Carboxymethyl Cellulose Nanocomplex in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Carboxymethylcellulose Sodium; Diosgenin; Disease Models, Animal; Parkinson Disease; Zein | 2020 |
Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Diosgenin; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Vascular Remodeling | 2021 |
Diosgenin alleviates hypercholesterolemia via SRB1/CES-1/CYP7A1/FXR pathway in high-fat diet-fed rats.
Topics: Animals; Anticholesteremic Agents; Biomarkers; Carboxylic Ester Hydrolases; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Diet, High-Fat; Diosgenin; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Male; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Scavenger Receptors, Class B; Signal Transduction; Simvastatin | 2021 |
Transcriptome analysis of the effect of diosgenin on autoimmune thyroiditis in a rat model.
Topics: Animals; Calgranulin B; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diosgenin; Disease Models, Animal; Humans; Iodide Peroxidase; Male; Rats; Receptors, Thyrotropin; Thyroglobulin; Thyroiditis, Autoimmune; Thyrotropin; Thyroxine; Transcriptome; Triiodothyronine | 2021 |
Anti-Allergic Diarrhea Effect of Diosgenin Occurs via Improving Gut Dysbiosis in a Murine Model of Food Allergy.
Topics: Animals; Anti-Allergic Agents; Caco-2 Cells; Diosgenin; Disease Models, Animal; Dysbiosis; Food Hypersensitivity; Gastrointestinal Microbiome; Humans; Mice | 2021 |
Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases.
Topics: Animals; Diosgenin; Disease Models, Animal; Heart Diseases; Humans; Male; Mice; Neovascularization, Physiologic; RNA, Long Noncoding | 2021 |
Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-κB/STAT3 signaling cascades.
Topics: Administration, Oral; Animals; Cell Line, Tumor; Computer Simulation; Diosgenin; Disease Models, Animal; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Transgenic; NF-kappa B; Prostatic Neoplasms; Proteomics; Signal Transduction; STAT3 Transcription Factor | 2021 |
Dioscin prevents DSS-induced colitis in mice with enhancing intestinal barrier function and reducing colon inflammation.
Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Diosgenin; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Male; Mice | 2021 |
Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization.
Topics: Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Diosgenin; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; PPAR gamma; RAW 264.7 Cells | 2021 |
Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury.
Topics: Animals; Constriction; Diosgenin; Disease Models, Animal; Hyperalgesia; Interleukin-12; Interleukin-1beta; Male; Neuralgia; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pentobarbital; Phosphorylation; Rats; Rats, Sprague-Dawley; Solanum; Spinal Cord; Tumor Necrosis Factor-alpha; Up-Regulation | 2017 |
Therapeutic effects of diosgenin in experimental autoimmune encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Encephalomyelitis, Autoimmune, Experimental; Female; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Microglia; Statistics, Nonparametric; Treatment Outcome | 2017 |
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Topics: Animals; Diosgenin; Disease Models, Animal; Fibrosis; Fructose; Inflammation; Kidney; Lipid Metabolism; Male; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2018 |
Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Topics: Adenine; Animals; Biomarkers; Creatinine; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Transport Proteins, Facilitative; HCT116 Cells; Humans; Hyperuricemia; Intestinal Elimination; Intestinal Mucosa; Intestines; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Renal Elimination; Spirostans; Time Factors; Uric Acid; Uricosuric Agents | 2018 |
Neuroprotective action and mechanistic evaluation of protodioscin against rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain; Cell Line, Tumor; Cognition; Dihydroxyphenylalanine; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Humans; Male; Maze Learning; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinsonian Disorders; Rats, Wistar; Saponins | 2018 |
Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3Kγ/Akt inhibition.
Topics: Acute Disease; Animals; Class Ib Phosphatidylinositol 3-Kinase; Diosgenin; Disease Models, Animal; Lung Injury; Male; Mice; Mice, Inbred BALB C; Mitochondria; Pancreatitis; Phosphoinositide-3 Kinase Inhibitors; Protective Agents; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar | 2018 |
Influence of Nutritional Status on the Absorption of Polyphyllin I, an Anticancer Candidate from Paris polyphylla in Rats.
Topics: Administration, Oral; Animal Nutritional Physiological Phenomena; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Diosgenin; Disease Models, Animal; Intestinal Absorption; Intestine, Small; Liliaceae; Liver; Male; Models, Biological; Nutritional Status; Permeability; Protein-Energy Malnutrition; Rats, Sprague-Dawley; Rhizome; Tight Junctions | 2018 |
Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspase 3; Corpus Striatum; Diosgenin; Disease Models, Animal; Down-Regulation; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Mice; Pilocarpine; Proto-Oncogene Proteins c-bcl-2; Saponins; Up-Regulation | 2018 |
Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting the TLR/NF-κB Pathway.
Topics: Animals; Antiparkinson Agents; Brain; Cell Line, Transformed; Cells, Cultured; Diosgenin; Disease Models, Animal; Forelimb; Lipopolysaccharides; Male; Mice; Neuroglia; NF-kappa B; Nitric Oxide Synthase Type II; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Toll-Like Receptor 2 | 2018 |
Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model.
Topics: Animals; Apoptosis; beta Catenin; Cartilage, Articular; Diosgenin; Disease Models, Animal; Extracellular Matrix; Inflammation; Iodoacetates; Male; Osteoarthritis; Oxidative Stress; PPAR gamma; Protective Agents; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2018 |
The Protective Effects of Preconditioning With Dioscin on Myocardial Ischemia/Reperfusion-Induced Ventricular Arrhythmias by Increasing Connexin 43 Expression in Rats.
Topics: Animals; Arrhythmias, Cardiac; Biomarkers; Connexin 43; Creatine Kinase, MB Form; Diosgenin; Disease Models, Animal; Heart Rate; Male; Myocardial Reperfusion Injury; Phosphorylation; Protective Agents; Rats, Sprague-Dawley; Tachycardia, Ventricular; Troponin I; Up-Regulation; Ventricular Fibrillation; Ventricular Premature Complexes | 2019 |
Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation.
Topics: Animals; Apoptosis; Cytokines; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diosgenin; Disease Models, Animal; Humans; Inflammation; Inflammation Mediators; Male; Malondialdehyde; Oxidative Stress; Rats; Sperm Count; Spermatozoa; Testis; Testosterone | 2019 |
Dioscin Attenuates Myocardial Damages in Diabetic Rats maybe by Regulating NO-sGC-cGMP-PKG Pathway.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diosgenin; Disease Models, Animal; Fibrosis; Guanylate Cyclase; Nitric Oxide; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Dioscin, a Steroidal Saponin Isolated from Dioscorea nipponica, Attenuates Collagen-Induced Arthritis by Inhibiting Th17 Cell Response.
Topics: Animals; Arthritis; Cell Differentiation; Cells, Cultured; Collagen; Cytokines; Dioscorea; Diosgenin; Disease Models, Animal; Female; Male; Mice, Inbred BALB C; Mice, Inbred DBA; Phytotherapy; Th17 Cells | 2019 |
[Polyphyllin I alleviates myocardial ischemia/reperfusion injury via nuclear factor-ΚB signal pathway].
Topics: Animals; Apoptosis; Diosgenin; Disease Models, Animal; Myocardial Ischemia; Myocardial Reperfusion Injury; NF-kappa B; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Protective effects of dioscin against alcohol-induced liver injury.
Topics: Animals; Cytochrome P-450 CYP2E1; Diosgenin; Disease Models, Animal; Ethanol; Fatty Acids; Fatty Liver, Alcoholic; Liver; Liver Diseases, Alcoholic; Male; Mice, Inbred C57BL; Protective Agents; Rats; Rats, Wistar; Toxicity Tests, Acute; Toxicity Tests, Chronic | 2014 |
Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease.
Topics: Animals; Cell Proliferation; Diosgenin; Disease Models, Animal; Female; Goiter; Graves Disease; HEK293 Cells; Humans; Mice; Mice, Inbred BALB C; Random Allocation; Thyroid Gland | 2014 |
Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D₃-MARRS.
Topics: Alzheimer Disease; Animals; Axons; Cells, Cultured; Cerebral Cortex; Cognition; Diosgenin; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neurons; Nootropic Agents; Protein Disulfide-Isomerases | 2013 |
Paris saponin I induces apoptosis via increasing the Bax/Bcl-2 ratio and caspase-3 expression in gefitinib-resistant non-small cell lung cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Diosgenin; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glucose; Humans; Lung Neoplasms; Male; Mice; Proto-Oncogene Proteins c-bcl-2; Saponins; Xenograft Model Antitumor Assays | 2014 |
Effects of chronic treatment with diosgenin on bone loss in a D-galactose-induced aging rat model.
Topics: Aging; Animals; Dioscorea; Diosgenin; Disease Models, Animal; Femur; Galactose; Osteoporosis; Oxidative Stress; Rats; Rats, Wistar | 2014 |
High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio.
Topics: Animals; Body Weight; Bone Density; Bone Density Conservation Agents; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Estradiol; Estrogen Replacement Therapy; Female; Gene Expression Regulation; Humans; Organ Size; Osteoporosis, Postmenopausal; Osteoprotegerin; Ovariectomy; RANK Ligand; Rats; Rats, Wistar; Tibia; Uterus | 2014 |
Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; Cell Line; Cholesterol; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Foam Cells; Gene Expression Regulation; Humans; Hypolipidemic Agents; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Transfection | 2015 |
Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats.
Topics: Animals; Bone Density; Diosgenin; Disease Models, Animal; Female; Osteoporosis; Rats; Rats, Sprague-Dawley; Tretinoin | 2016 |
Improving Bone Microarchitecture in Aging with Diosgenin Treatment: A Study in Senescence-Accelerated OXYS Rats.
Topics: Aging; Animals; Dioscorea; Diosgenin; Disease Models, Animal; Drug Evaluation, Preclinical; Femur; Male; Osteoporosis; Phytotherapy; Plant Extracts; Rats; Rats, Wistar | 2015 |
Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Adiposity; Animals; Biomarkers; Blood Glucose; Diet, High-Fat; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Receptor beta; Insulin; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; PPAR gamma; Reactive Oxygen Species; Retinoid X Receptor alpha; Signal Transduction; Time Factors | 2015 |
Therapeutic effect of dioscin on collagen-induced arthritis through reduction of Th1/Th2.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen Type II; Dioscorea; Diosgenin; Disease Models, Animal; Diterpenes; Epoxy Compounds; GATA3 Transcription Factor; Humans; Male; Mice; Mice, Inbred DBA; Phenanthrenes; STAT Transcription Factors; Synovial Membrane; Th1 Cells; Th1-Th2 Balance; Th2 Cells | 2016 |
Oral administration with diosgenin enhances the induction of intestinal T helper 1-like regulatory T cells in a murine model of food allergy.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Diosgenin; Disease Models, Animal; Food Hypersensitivity; Forkhead Transcription Factors; Humans; Interferon-gamma; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Receptors, CCR5; Receptors, CXCR3; T-Box Domain Proteins; T-Lymphocytes, Regulatory; Th1 Cells | 2017 |
Dioscin augments HSV-tk-mediated suicide gene therapy for melanoma by promoting connexin-based intercellular communication.
Topics: Animals; Antiviral Agents; Bystander Effect; Cell Communication; Cell Survival; Connexin 26; Connexin 43; Connexins; Diosgenin; Disease Models, Animal; Drug Synergism; Ganciclovir; Genes, Transgenic, Suicide; Genetic Therapy; Melanoma, Experimental; Mice; Mutation; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured | 2017 |
Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor α.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Asthmatic Agents; Asthma; Dexamethasone; Dioscorea; Diosgenin; Disease Models, Animal; Dual Specificity Phosphatase 1; Epithelial Cells; Female; Gene Expression Regulation; Glucocorticoids; HSP70 Heat-Shock Proteins; Humans; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Plant Extracts; Primary Cell Culture; Receptors, Glucocorticoid; Respiratory Mucosa; Secretory Leukocyte Peptidase Inhibitor; Transcription Factors; Tumor Necrosis Factor-alpha | 2017 |
Effect of orally ingested diosgenin into diet on skin collagen content in a low collagen skin mouse model and its mechanism of action.
Topics: Administration, Oral; Animals; Cell Differentiation; Cells, Cultured; Collagen; Diet; Diosgenin; Disease Models, Animal; Eating; Feeding Behavior; Fibroblasts; Male; Mice; Mice, Hairless; Proto-Oncogene Proteins c-fos; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin; Tubulin | 2017 |
Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy.
Topics: Allergens; Animals; Diosgenin; Disease Models, Animal; Food Hypersensitivity; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C | 2009 |
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Astrocytes; Caproates; Cognition Disorders; Diosgenin; Disease Models, Animal; Gliosis; Hippocampus; Male; Maze Learning; Memory Disorders; Nerve Degeneration; Neuroprotective Agents; Phosphorylation; Plaque, Amyloid; Prosencephalon; Rats; Rats, Long-Evans; Spirostans; tau Proteins | 2010 |
Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Cholesterol; Cholesterol, LDL; Diosgenin; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Hyperlipidemias; Lipase; Lipoprotein Lipase; Membrane Potential, Mitochondrial; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Reactive Oxygen Species; Superoxide Dismutase; Triglycerides | 2010 |
Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; Diosgenin; Disease Models, Animal; Glucose; Inflammation; Insulin Resistance; Male; Mice; Mice, Obese; Obesity; Phytotherapy; Plant Extracts; RNA, Messenger; Saponins; Trigonella | 2010 |
Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo.
Topics: Animals; Anticoagulants; Blood Coagulation Tests; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Hematologic Tests; Hemostasis; Ligation; Male; Mice; Mice, Inbred Strains; Models, Animal; Phytotherapy; Plant Extracts; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Vena Cava, Inferior; Venous Thrombosis | 2011 |
Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cisplatin; Diosgenin; Disease Models, Animal; Female; Lung Neoplasms; Male; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred Strains; Neoplasm Metastasis; Saponins; Wound Healing | 2011 |
Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Dioscorea; Diosgenin; Disease Models, Animal; Gene Expression Profiling; Male; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis.
Topics: Animals; Bone Density; Dioscorea; Diosgenin; Disease Models, Animal; Female; Fermentation; Flavins; Glycine max; Heterocyclic Compounds, 3-Ring; Isoflavones; Lovastatin; Monascus; Osteoporosis; Ovariectomy; Phytoestrogens; Plant Roots; Rats; Rats, Sprague-Dawley | 2011 |
Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Axons; Cerebellar Cortex; Diosgenin; Disease Models, Animal; Female; Gene Knockdown Techniques; Male; Memory Disorders; Mice; Molecular Docking Simulation; Neurons; Plaque, Amyloid; Presynaptic Terminals; Protein Conformation; Protein Disulfide-Isomerases; Protein Kinase Inhibitors | 2012 |
Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Diosgenin; Disease Models, Animal; Free Radicals; Glutathione; Isoproterenol; Lipid Peroxidation; Male; Myocardial Infarction; Myocardium; Physical Conditioning, Animal; Rats; Rats, Wistar | 2013 |
Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma.
Topics: Animals; Antioxidants; Diosgenin; Disease Models, Animal; Down-Regulation; Female; Lipid Peroxidation; Liver; Mammary Neoplasms, Animal; Methylnitrosourea; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Saponins; Treatment Outcome; Trigonella | 2012 |
Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cell Line; Cell Movement; Dioscorea; Diosgenin; Disease Models, Animal; Down-Regulation; Humans; Lipopolysaccharides; Lung; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Monocytes; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Transcription Factor RelA | 2013 |
Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Anticholesteremic Agents; Aorta; Atherosclerosis; Cardiovascular Agents; Cholesterol, Dietary; Diet; Dioscorea; Diosgenin; Disease Models, Animal; Fatty Liver; Food Handling; Functional Food; Hypercholesterolemia; Liver; Male; Nanoparticles; Particle Size; Plant Preparations; Plant Tubers; Rabbits | 2013 |
Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice.
Topics: 14-3-3 Proteins; Blotting, Western; Brain Ischemia; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavanones; Flavonoids; Gene Expression; Glycosides; Hippocampus; Maze Learning; Memory Disorders; Oligonucleotide Array Sequence Analysis; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine 3-Monooxygenase | 2004 |
In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.
Topics: Animals; Bone Density; Dioscorea; Diosgenin; Disease Models, Animal; Female; Mice; Mice, Inbred Strains; Osteoporosis; Ovariectomy; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Saponins | 2004 |
Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.
Topics: Animals; Apoptosis; Azoxymethane; Cell Division; Colonic Neoplasms; Diosgenin; Disease Models, Animal; History, Early Modern 1451-1600; HT29 Cells; Humans; Intestinal Mucosa; Male; Plant Extracts; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Reference Values; Saponins; Sensitivity and Specificity; Trigonella; Tumor Cells, Cultured | 2004 |
Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile; Bile Acids and Salts; Cell Fractionation; Cell Membrane; Cholesterol; Diosgenin; Disease Models, Animal; L-Lactate Dehydrogenase; Lipids; Liver; Male; Phospholipids; Rats; Rats, Sprague-Dawley; Sphingomyelins; Taurocholic Acid | 1999 |
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
Topics: Animals; Biological Factors; Colonic Neoplasms; Diosgenin; Disease Models, Animal; Diterpenes; Drug Screening Assays, Antitumor; Female; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Inhibitory Concentration 50; KB Cells; Leukemia P388; Male; Melanoma; Mice; Molecular Structure; Naphthoquinones; Ovarian Neoplasms; Paclitaxel; Polymers; Prostatic Neoplasms; Triterpenes; Tumor Cells, Cultured | 2002 |
Effect of food toxicants on voluntary wheel running in rats.
Topics: Animals; Cadmium; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Food Deprivation; Glycosides; Iron; Iron Deficiencies; Liver; Male; Motor Activity; Rats; Sapogenins; Testis | 1979 |