diosgenin has been researched along with Alloxan Diabetes in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 18 (58.06) | 24.3611 |
| 2020's | 8 (25.81) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, BN; Hong, HN; Kang, TH; Kim, DH; Kim, TW; Le, HT; Lim, CW; Park, KH | 1 |
| Banerjee, D; Dubey, SK; Katiyar, C; Krishna, KV; Narwaria, A; Taliyan, R; Tandon, N; Wadhwa, G; Yadav, SS | 1 |
| Jayaraman, S; Kumar, PK; Pari, L; Piramanayagam, S; Prasad, M; Rajagopal, P; Veeraraghavan, VP | 1 |
| Claridge, TDW; Drijfhout, FP; Etuk, IC; Li, WW; Okokon, JE; Thomas, PS | 1 |
| Dong, H; Fang, K; Gao, Y; Gong, J; Hu, M; Nie, K; Su, H; Tang, Y; Wang, H; Wang, Z; Wu, Q | 1 |
| Han, X; Jin, Y; Liu, KX; Peng, JY; Qi, Y; Xu, LN; Xu, YW; Yin, LH; Zhao, YY | 1 |
| Chu, Y; Guo, Y; Leng, J; Li, J; Li, X; Liu, C; Tian, H; Wang, Y; Zhang, L; Zhang, S | 1 |
| Afshin-Majd, S; Baluchnejadmojarad, T; Kiasalari, Z; Mahmoudi, N; Naderi, G; Rahmani, T; Roghani, M; Sanaierad, A | 1 |
| Cegieła, U; Folwarczna, J; Janas, A; Kisiel-Nawrot, E; Kocik, S; Londzin, P; Trawczyński, M | 1 |
| Dong, Y; Guo, C; Liu, Y; Xie, G; Zhu, H | 1 |
| Baluchnejadmojarad, T; Khosravi, Z; Roghani, M; Sedaghat, R | 1 |
| Huang, T; Sun, L; Wei, Q; Xiao, X; Zhang, Z; Zhu, T | 1 |
| Chen, Q; Du, D; Guo, X; He, S; He, Y; Huang, B; Huang, W; Wang, Y; Xin, G; Xing, Z; Zhang, R; Zhao, H | 1 |
| Atmaja, K; Sali, VK; Sangeetha, MK; ShriShri Mal, N; Vasanthi, HR | 1 |
| Fujita, S; Iemitsu, M; Sato, K | 1 |
| Kalailingam, P; Kaliaperumal, R; Kannaian, B; Tamilmani, E | 1 |
| Deepa, MA; Ponmurugan, P; Saravanan, G; Senthilkumar, B | 1 |
| Jayachandra Reddy, N; Kannan, M; Kumar, R; Sudha Rani, S; Tharaheswari, M; Varshney, KC | 1 |
| Asok, A; Chopade, BA; Derle, A; Dhavale, DD; Ghosh, S; Kumbhar, N; Markad, P; More, P; Patil, AB; Ramanamurthy, B; Shaikh, ML; Shinde, VS | 1 |
| Begum, MS; Meriga, B; Mohan, K; Naidu, PB; Ponmurugan, P; RavindarNaik, R; Saravanan, G | 1 |
| Hao, S; Li, D; Liu, K; Wang, T; Xu, R; Zhu, Z | 1 |
| Baluchnejadmojarad, T; Roghani, M; Roghani-Dehkordi, F | 1 |
| Gu, W; Lin, P; Lu, JM; Wang, YF; Yan, HL; Yu, J | 1 |
| Kaikini, AA; Kanchan, DM; Peshattiwar, VV; Sathaye, S; Somani, GS | 1 |
| Baluchnejadmojarad, T; Kiasalari, Z; Mahmoudi, N; Rahmani, T; Roghani, M | 1 |
| Mohamed Jalaludeen, A; Monisha, P; Pari, L | 1 |
| Asemota, HN; McAnuff, MA; Morrison, EY; Omoruyi, FO | 1 |
| Asemota, HN; McAnuff-Harding, MA; Omoruyi, FO | 2 |
| Fukunaga, T; Kato, A; Miura, T | 1 |
| Baccou, JC; Loubatieères-Mariani, MM; Ribes, G; Sauvaire, Y | 1 |
31 other study(ies) available for diosgenin and Alloxan Diabetes
| Article | Year |
|---|---|
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Diosgenin; Molecular Structure; Molecular Weight; Polyethylene Glycols | 2012 |
A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats.
Topics: Alkaloids; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diosgenin; Female; Isoleucine; Limit of Detection; Linear Models; Plant Extracts; Rats; Rats, Wistar; Reproducibility of Results; Trigonella | 2022 |
Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach.
Topics: ADAM17 Protein; Animals; Aorta; Cytokines; Diabetes Mellitus, Experimental; Diosgenin; Endoplasmic Reticulum Stress; Hyperglycemia; Hypertension; Inflammation; Lipids; Male; Molecular Docking Simulation; Oxidative Stress; Rats; Streptozocin; Tumor Necrosis Factor-alpha | 2022 |
In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diosgenin; Hyperglycemia; Hypoglycemic Agents; Hypolipidemic Agents; Plant Extracts; Rats; Solanum | 2022 |
Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6.
Topics: Animals; Benzoates; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diosgenin; Mice; Podocytes; Sirtuins; Sulfur Compounds | 2022 |
Effect and possible mechanisms of dioscin on ameliorating metabolic glycolipid metabolic disorder in type-2-diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Diosgenin; Gene Expression Regulation; Gluconeogenesis; Glycolipids; Hep G2 Cells; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Lipogenesis; Liver; Male; Mice, Inbred C57BL; MicroRNAs; Rats, Wistar; STAT3 Transcription Factor | 2020 |
Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-Fat; Diosgenin; Disease Models, Animal; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Streptozocin | 2020 |
Diosgenin Attenuates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats: Underlying Mechanisms.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diosgenin; Hippocampus; Inflammation; Learning; Neuroprotective Agents; Oxidative Stress; Rats | 2021 |
Effects of diosgenin on the skeletal system in rats with experimental type 1 diabetes.
Topics: Animals; Biomarkers; Bone Density Conservation Agents; Bone Remodeling; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diosgenin; Female; Femur; Osteoporosis; Rats, Wistar; Streptozocin | 2020 |
Ameliorative effects of protodioscin on experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Blood Glucose; Blood Urea Nitrogen; Carboxymethylcellulose Sodium; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, High-Fat; Diosgenin; Fatty Acids, Nonesterified; Kidney; Male; Metformin; Phospholipids; Proteinuria; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha | 2018 |
Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation.
Topics: Animals; Apoptosis; Cytokines; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diosgenin; Disease Models, Animal; Humans; Inflammation; Inflammation Mediators; Male; Malondialdehyde; Oxidative Stress; Rats; Sperm Count; Spermatozoa; Testis; Testosterone | 2019 |
Dioscin Attenuates Myocardial Damages in Diabetic Rats maybe by Regulating NO-sGC-cGMP-PKG Pathway.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diosgenin; Disease Models, Animal; Fibrosis; Guanylate Cyclase; Nitric Oxide; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Synthesis of diosgenin-ibuprofen derivatives and their activities against insulin-dependent diabetes mellitus.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diosgenin; Hypoglycemic Agents; Ibuprofen; Lipopolysaccharides; Mice; Mice, Inbred NOD; Molecular Structure | 2013 |
PPAR's and Diosgenin a chemico biological insight in NIDDM.
Topics: 3T3-L1 Cells; Administration, Oral; Animals; Binding Sites; Cell Differentiation; Diabetes Mellitus, Experimental; Diet, High-Fat; Diosgenin; Glutathione Peroxidase; Insulin; Lipid Peroxidation; Male; Mice; Molecular Docking Simulation; Peroxisome Proliferator-Activated Receptors; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2013 |
Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats.
Topics: Animals; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dioscorea; Diosgenin; Enzyme-Linked Immunosorbent Assay; Glucose Transporter Type 4; Hyperglycemia; Immunoblotting; Isoenzymes; Male; Muscle, Skeletal; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction | 2014 |
Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats.
Topics: Animals; Blood Glucose; Cardiovascular Diseases; Costus; Diabetes Mellitus, Experimental; Diosgenin; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Pancreas; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Streptozocin | 2014 |
Modulatory effects of diosgenin on attenuating the key enzymes activities of carbohydrate metabolism and glycogen content in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diosgenin; Dose-Response Relationship, Drug; Glycogen; Insulin; Kidney; Male; Muscle, Skeletal; Rats; Rats, Wistar; Streptozocin; Trigonella | 2014 |
Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats.
Topics: Adipose Tissue; Alkaloids; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Diosgenin; Endoplasmic Reticulum Stress; Insulin; Interleukin-6; Leptin; Male; Molecular Docking Simulation; Oxidative Stress; Pancreas; PPAR gamma; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2014 |
Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against α-amylase and α-glucosidase.
Topics: alpha-Amylases; alpha-Glucosidases; Animals; Catalytic Domain; Circular Dichroism; Diabetes Mellitus, Experimental; Dioscorea; Diosgenin; Enzyme Inhibitors; Intestines; Kinetics; Mice; Molecular Docking Simulation; Plant Extracts; Protein Binding; Spectrometry, Fluorescence; Sus scrofa | 2014 |
Diosgenin reorganises hyperglycaemia and distorted tissue lipid profile in high-fat diet-streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Dietary Fats; Diosgenin; Dyslipidemias; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Lipids; Male; Phytotherapy; Plant Extracts; Rats, Wistar; Trigonella; Weight Gain | 2015 |
Attenuation of Streptozotocin-Induced Lipid Profile Anomalies in the Heart, Brain, and mRNA Expression of HMG-CoA Reductase by Diosgenin in Rats.
Topics: Animals; Blood Glucose; Brain; Cholesterol; Diabetes Mellitus, Experimental; Diosgenin; Fatty Acids; Heart; Hydroxymethylglutaryl CoA Reductases; Insulin; Lipid Metabolism; Male; Myocardium; Rats; Rats, Wistar; RNA, Messenger; Triglycerides | 2015 |
Diosgenin Mitigates Streptozotocin Diabetes-induced Vascular Dysfunction of the Rat Aorta: The Involved Mechanisms.
Topics: Animals; Aorta; Diabetes Mellitus, Experimental; Diosgenin; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypoglycemic Agents; Male; Organ Culture Techniques; Rats; Rats, Wistar; Vasodilation | 2015 |
Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diosgenin; Dose-Response Relationship, Drug; Gene Expression; Glucose Transporter Type 4; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Lipids; Liver; Male; Muscle, Skeletal; Phosphoenolpyruvate Carboxykinase (ATP); Polygonatum; PPAR gamma; Rats; Saponins; Signal Transduction; Streptozocin | 2016 |
Renoprotective effect of diosgenin in streptozotocin induced diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diosgenin; Glutathione; Hypoglycemic Agents; Kidney; Lipid Peroxidation; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Streptozocin; Superoxide Dismutase | 2016 |
Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diosgenin; Ganglia, Spinal; Inflammation; Male; Malondialdehyde; Neuralgia; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Sciatic Nerve; Streptozocin; Superoxide Dismutase | 2017 |
Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats.
Topics: Animals; Antioxidants; Aorta; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diosgenin; Drinking; Glucose Tolerance Test; Glutathione; Glycated Hemoglobin; Insulin; Lipid Peroxidation; Male; Oxidative Stress; Rats | 2012 |
Changes in some liver enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides) or commercial diosgenin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diosgenin; Follow-Up Studies; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Liver; Male; Plant Extracts; Protein Kinases; Pyruvate Kinase; Rats; Rats, Wistar; Sapogenins | 2005 |
Intestinal disaccharidases and some renal enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides).
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diet; Dioscorea; Diosgenin; Disaccharidases; Intestine, Small; Kidney; Plant Extracts; Rats; Rats, Wistar | 2006 |
Intestinal lipids and minerals in streptozotocin-induced diabetic rats fed bitter yam (Dioscorea polygonoides) sapogenin extract.
Topics: Animals; Body Weight; Cholesterol, HDL; Diabetes Mellitus, Experimental; Dioscorea; Diosgenin; Feces; Intestinal Mucosa; Intestines; Lipid Metabolism; Male; Minerals; Plant Extracts; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Streptozocin | 2006 |
Effects of steroidal glycosides on blood glucose in normal and diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diosgenin; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Saponins; Spirostans | 1995 |
Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek.
Topics: Alloxan; Animals; Cholesterol; Chromatography, Gas; Chromatography, Thin Layer; Diabetes Mellitus, Experimental; Diosgenin; Dogs; Feces; Gas Chromatography-Mass Spectrometry; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins; Spirostans; Trigonella | 1991 |