Compounds > diosgenin
Page last updated: 2024-08-26

diosgenin and Acute Liver Injury, Drug-Induced

diosgenin has been researched along with Acute Liver Injury, Drug-Induced in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's8 (80.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Li, N; Liu, L; Wang, Y; Yue, X; Zhang, Y1
Han, X; Li, H; Liu, K; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zheng, L1
Gao, Y; Liang, QD; Ma, ZC; Tan, HL; Tang, XL; Wang, YG; Xiao, CR; Zhang, YX; Zhao, YH1
Han, X; Hu, C; Peng, J; Qi, Y; Tao, X; Wang, C; Xu, L; Xu, Y; Yao, H; Yin, L; Zhao, Y1
Han, X; Peng, J; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L; Zhang, W; Zheng, L1
Lu, B; Peng, J; Xu, L; Yin, L1
Cong, X; Li, H; Lu, B; Peng, J; Xu, L; Xu, Y; Yin, L1
Cong, X; Peng, J; Xu, L; Yin, L; Zhao, X; Zheng, L1
Jaeschke, H; McGill, MR; Williams, CD1
Meagher, LP; Miles, CO; Smith, BL; Wilkins, AL1

Other Studies

10 other study(ies) available for diosgenin and Acute Liver Injury, Drug-Induced

ArticleYear
3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs.
    Toxicology, 2022, 01-30, Volume: 466

    Topics: Acetaminophen; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Chemical and Drug Induced Liver Injury; Composite Resins; Cytochrome P-450 Enzyme System; Diosgenin; Drug Evaluation, Preclinical; Glucose; Hep G2 Cells; Humans; Pharmaceutical Preparations; Tissue Scaffolds

2022
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Diosgenin; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thioacetamide

2018
[Preliminary study on hepatotoxicity induced by dioscin and its possible mechanism].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:14

    Topics: Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Diosgenin; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; RNA, Messenger

2015
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
    International immunopharmacology, 2016, Volume: 36

    Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cytokines; Dioscorea; Diosgenin; Hep G2 Cells; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4

2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
    Environmental toxicology and pharmacology, 2016, Volume: 45

    Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Dimethylnitrosamine; Dioscorea; Diosgenin; Interferon-Stimulated Gene Factor 3, gamma Subunit; Male; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Toll-Like Receptor 4

2016
Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CClâ‚„-induced liver damage in mice.
    Planta medica, 2011, Volume: 77, Issue:5

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computational Biology; Diosgenin; Endoplasmic Reticulum Chaperone BiP; Liver; Male; Mice; Necrosis; Protective Agents; Protein Interaction Mapping; Proteomics; Silymarin

2011
Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice.
    Environmental toxicology and pharmacology, 2012, Volume: 34, Issue:2

    Topics: Animals; Carbon Tetrachloride; Caspase 3; Caspase 8; Chemical and Drug Induced Liver Injury; Diosgenin; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Protective Agents; Superoxide Dismutase

2012
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
    Toxicology letters, 2012, Oct-02, Volume: 214, Issue:1

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Biological Products; Chemical and Drug Induced Liver Injury; Comet Assay; Diosgenin; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Male; Mice; Mitochondria; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2012
Caveats of using acetaminophen hepatotoxicity models for natural product testing.
    Toxicology letters, 2012, Nov-23, Volume: 215, Issue:1

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diosgenin; Humans; Male

2012
Ovine metabolism of diosgenin coated on cellulose in relation to hepatogenous photosensitization of ruminants.
    Veterinary and human toxicology, 2003, Volume: 45, Issue:1

    Topics: Administration, Oral; Animals; Cellulose; Chemical and Drug Induced Liver Injury; Diosgenin; Gas Chromatography-Mass Spectrometry; Intestinal Mucosa; Liver Diseases; Panicum; Plant Poisoning; Rumen; Sheep; Sheep Diseases

2003