dinoprost and Urination-Disorders

Topics: Alprostadil; Animals; Dinoprost; Dinoprostone; Female; Humans; Male; Muscle Contraction; Prostaglandins; Prostaglandins E; Prostaglandins F; Ureter; Urethra; Urinary Bladder; Urinary Tract Physiological Phenomena; Urination Disorders

To assess the efficacy of prostaglandins in enhancing bladder function after vaginal hysterectomy.. Prospective randomised study of women who underwent vaginal hysterectomy between November 1989 and August 1990.. Sackler School of Medicine Tel Aviv University Medical Center, Department of Obstetrics and Gynaecology 'B'.. 24 women who underwent vaginal hysterectomy and anterior and posterior colporrhaphy for prolapse.. Administration of prostaglandin F2 alpha 5 mg intravesically or E2 3 mg intravaginally versus 100 ml saline intravesically (control) daily, starting on the first postoperative day, until adequate spontaneous voiding was established.. Women receiving PGE2 resumed spontaneous bladder functions earlier, required significantly fewer days catheterisation and had significantly less febrile morbidity compared to women in the control group or PGE2 group.. Prostaglandins PGE2 intravaginally are beneficial in enhancing functions after vaginal hysterectomy [corrected].

Topics: Adult; Aged; Dinoprost; Dinoprostone; Female; Humans; Hysterectomy, Vaginal; Middle Aged; Pessaries; Prospective Studies; Urinary Bladder; Urination Disorders

Fifty women underwent vaginal hysterectomy with or without anterior and posterior colporrhaphy. After the operations the women were allocated randomly to one of three groups. One group (17 patients) received daily vaginal suppositories of 10 mg of prostaglandin E2. The second group (15) received a daily intravesical solution of 50 micrograms of prostaglandin F2 alpha dissolved in 100 mL of normal saline. The third group (18) received a daily instillation of 100 mL of saline and served as the control group. The postvoiding residual urinary volume was checked daily through a suprapubic catheter, which was removed once the residual volume was less than 50 mL. The prostaglandin did not shorten the time required for postoperative bladder drainage. The rates of febrile morbidity and hospital stay were the same in all three groups. Since most of the women in the study voided spontaneously within three days, the "sit and wait" approach seems reasonable in such patients, and prophylactic treatment to enhance bladder function after vaginal operations does not seem justified.

Topics: Administration, Intravesical; Aged; Dinoprost; Dinoprostone; Female; Humans; Hysterectomy, Vaginal; Length of Stay; Middle Aged; Pessaries; Postoperative Complications; Prospective Studies; Urinary Catheterization; Urination Disorders; Urodynamics

Prostaglandin F2 alpha 10 mg was administered intravesically in a double-blind placebo-controlled study to promote micturition in cases of urinary retention after operative treatment of urinary stress incontinence in women. Fifteen of 18 patients (83%) succeeded in voiding after treatment with prostaglandin F2 alpha, but the placebo was ineffective in all 18 patients (P less than 0.001). Although the effect of prostaglandin F2 alpha on bladder muscle contraction was short-lived, it seemed to enhance the restoration of bladder motor function with no serious side effects, and thus to be clinically useful in the treatment of post-operative urinary retention.

Topics: Administration, Intravesical; Adult; Aged; Clinical Trials as Topic; Dinoprost; Double-Blind Method; Female; Humans; Middle Aged; Postoperative Complications; Prostaglandins F; Random Allocation; Urinary Incontinence, Stress; Urination Disorders

The delay in spontaneous micturition after pelvic surgical procedures is a significant complication. This study was performed to establish the validity of intravesical instillation of prostaglandin F2 alpha in the prevention of urinary retention after vaginal surgery. For this purpose 102 patients were randomly and alternatively allocated to receive either 16 mg of prostaglandin F2 alpha diluted in 40 mL of saline or saline only given intravesically. Similar numbers of patients with vaginal hysterectomy (27 versus 31), vaginal repair (12 versus 11), and repair with Kelly urethral plication (12 versus 9) were included in the study and control group, respectively. The frequency of urinary retention in the women treated with prostaglandin F2 alpha was decreased significantly as compared with those treated with saline alone (P less than .02). But this was true for women undergoing vaginal hysterectomy only. There was also a significantly shorter hospitalization of women receiving prostaglandin F2 alpha (P less than .05) and there were no side effects.

Topics: Bacteriuria; Dinoprost; Female; Humans; Hysterectomy; Hysterectomy, Vaginal; Male; Muscle Contraction; Postoperative Complications; Prostaglandins F; Urethra; Urinary Bladder; Urination Disorders; Vagina

Topics: Adult; Dinoprost; Female; Humans; Prostaglandins F; Urination Disorders