dinoprost and Urinary-Incontinence

Topics: Adult; Dinoprost; Female; Humans; Middle Aged; Urinary Bladder, Neurogenic; Urinary Incontinence

Topics: Adult; Dinoprost; Female; Humans; Middle Aged; Urinary Bladder, Neurogenic; Urinary Incontinence

To study the role of prostaglandin production by detrusor muscle in women with idiopathic primary detrusor instability, biopsies of detrusor muscle were obtained from 20 women. Nine women had detrusor instability, and 11 women had stable bladders. Prostaglandin F2 alpha and the stable metabolites of prostacyclin and thromboxane A2, namely, 6-keto-prostaglandin F1 alpha and thromboxane B2, respectively, were measured after in vitro incubations of detrusor muscle for 3 hours. A significant reduction in the production of 6-keto-prostaglandin1 alpha in women with detrusor instability was noted. There were no differences in the production of prostaglandin F2 alpha and thromboxane B2, between women with stable and unstable bladders. These results suggest for the first time that women with idiopathic primary detrusor instability may have a deficient production of prostacyclin.

Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Dinoprost; Epoprostenol; Female; Humans; Middle Aged; Muscles; Thromboxane B2; Urinary Bladder Diseases; Urinary Incontinence

In a urodynamic study, the effect of carbachol, distigmine and prostaglandin-F2 alpha on neuropathic detrusor areflexia and on the non-contracting detrusor as well as the effect of scopolamine, emepronium bromide and flavoxate on the idiopathic unstable bladder and neuropathic detrusor hyperreflexia were examined. Carbachol and distigmine do not have any effect on detrusor contractility but reduce the bladder capacity by decreasing the detrusor compliance. The instillation therapy by prostaglandin-F2 alpha provokes detrusor contractions in some cases of non-contracting detrusor. Emepronium bromide and flavoxate therapy of the idiopathic unstable bladder and neuropathic detrusor hyperreflexia showed improvement of the subjective symptoms, but not of the urodynamic findings. The oral therapy of scopolamine has no effect on overactive detrusor function. Treatment of the idiopathic unstable bladder by prolonged detrusor distension with the aid of peridural anaesthesia showed satisfactory results in more than 50%.

Topics: Adult; Aged; Carbachol; Dinoprost; Female; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Prostaglandins F; Reflex; Urinary Bladder Diseases; Urinary Incontinence; Urodynamics