dinoprost and Sexual-Dysfunction--Physiological

To observe the effect of Uighur medicine gu-jing-mai-si-ha tablet (GJMSHT) for treatment of premature ejaculation (PE) and to explore part of its mechanism.. The condition of patients was scored by related questionnaire, and the intravaginal ejaculation latency time (IELT) was observed before and after GJMSHT treatment, with the blood levels of nitric oxide (NO) and prostaglandin F2alpha (PGF2alpha) detected in PE patients as well. The results were compared with those in the control group.. After treatment, the scores of PE and IELT, as well as the levels of NO and PGF2alpha, all increased significantly compared to those before treatment in the treated group (P<0.01), while in the control group, all the parameters were insignificantly changed (P>0.05). Therefore, the difference of these parameters between the two groups after treatment all showed statistical significance (P<0.01).. GJMSHT could treat PE effectively, its mechanism is possibly by strengthening the coordination of the related smooth muscles through increasing the blood levels of NO and PGF2alpha, and the endurance of patients to the cavitary effect of prostatico-urethral pressure, thus postponing the arrival of urgent ejaculatory feeling.

Topics: Adult; Dinoprost; Drugs, Chinese Herbal; Ejaculation; Female; Humans; Male; Nitric Oxide; Sexual Dysfunction, Physiological; Tablets

Clinical investigations were carried out of a total of 1675 cows to elucidate the reason for anaphrodisia. The functional activity of the ovaries was determined by the use of cytovaginal smears stained after Chamov. Animals with anaphrodisia on the base of ovarian hypofunction were treated with hormonal preparations of gonadotropic action, while those with persisting periodic corpora lutea--with prostanglandin or the yellow bodies were manually removed. it was found that anaphrodisia in cows was more largely due to ovarian hypofunction (78.5 per cent), and to a lower extent--to persisting yellow bodies (21.5 per cent). In the case of ovarian hypofunction very good results were obtained with the use of gravohormone and prolan, and in the case of persisting corpora lutea--with the use of prostaglandine F2 alpha. The manual removal was associated with low conception rate and higher index of insemination. The cytovaginal smears could be used as an adjunct for the indirect determination of the functional activity of the ovaries.

Topics: Animals; Cattle; Cattle Diseases; Chorionic Gonadotropin; Cloprostenol; Dinoprost; Drug Combinations; Female; Fertility Agents; Gonadotropins, Equine; Male; Ovarian Function Tests; Ovary; Prostaglandins F; Sexual Dysfunction, Physiological