dinoprost and Schistosomiasis

dinoprost has been researched along with Schistosomiasis* in 2 studies

Other Studies

2 other study(ies) available for dinoprost and Schistosomiasis

Article	Year
Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression. The American journal of pathology, 1984, Volume: 114, Issue:2 The ability of arachidonic acid (AA) metabolites to regulate I-region-associated (Ia) antigen expression on macrophages from schistosome-egg-induced pulmonary granulomas was examined. The prostaglandin (PG) analog 15-S-15-CH3-PGE1 (M-PGE1) and PGF2 alpha were found to modulate the kinetics of Ia expression when administered in vivo. Methyl-PGE1 significantly suppressed Ia antigen expression by hypersensitivity granuloma macrophages, while PGF2 alpha appeared to potentiate the expression. Lymphokine-induced Ia antigen expression by cultured granuloma macrophages was likewise dramatically inhibited by M-PGE1. Further analysis using systemically administered inhibitors of AA metabolism demonstrated that the cyclooxygenase inhibitor indomethacin caused augmentation of Ia expression. In contrast, lipoxygenase inhibitors significantly reduced both Ia expression and granuloma size. The role of AA metabolites in modulating chronic inflammation is discussed. Topics: Alprostadil; Animals; Arachidonic Acids; Cells, Cultured; Dinoprost; Female; Granuloma; Histocompatibility Antigens Class II; Hypersensitivity; Kinetics; Lung Diseases, Parasitic; Lymphokines; Macrophages; Mice; Mice, Inbred CBA; Prostaglandins E, Synthetic; Prostaglandins F; Schistosoma mansoni; Schistosomiasis	1984
Plasma prostaglandin activities in some immuno-inflammatory diseases. General pharmacology, 1984, Volume: 15, Issue:1 In the present study the relationship between plasma prostaglandins (PGs) level and the immuno-inflammatory reactions, known to accompany bronchial asthma and/or schistosomiasis infection, was investigated. It was found that plasma PGF2 alpha increased significantly above the control values in 30 asthmatics, 30 schistosomal and 30 asthmatic schistosomal patients. Plasma PGE increased also together with that of PGF2 alpha which is considered to be useful for the protection of the patient against the injurious effects of the infection, due to the known opposing actions of PGE to those of PGF2 alpha. Topics: Adolescent; Adult; Aged; Asthma; Dinoprost; Humans; Middle Aged; Prostaglandins; Prostaglandins E; Prostaglandins F; Schistosomiasis	1984

Article

Year

Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression.

The American journal of pathology, 1984, Volume: 114, Issue:2

The ability of arachidonic acid (AA) metabolites to regulate I-region-associated (Ia) antigen expression on macrophages from schistosome-egg-induced pulmonary granulomas was examined. The prostaglandin (PG) analog 15-S-15-CH3-PGE1 (M-PGE1) and PGF2 alpha were found to modulate the kinetics of Ia expression when administered in vivo. Methyl-PGE1 significantly suppressed Ia antigen expression by hypersensitivity granuloma macrophages, while PGF2 alpha appeared to potentiate the expression. Lymphokine-induced Ia antigen expression by cultured granuloma macrophages was likewise dramatically inhibited by M-PGE1. Further analysis using systemically administered inhibitors of AA metabolism demonstrated that the cyclooxygenase inhibitor indomethacin caused augmentation of Ia expression. In contrast, lipoxygenase inhibitors significantly reduced both Ia expression and granuloma size. The role of AA metabolites in modulating chronic inflammation is discussed.

Topics: Alprostadil; Animals; Arachidonic Acids; Cells, Cultured; Dinoprost; Female; Granuloma; Histocompatibility Antigens Class II; Hypersensitivity; Kinetics; Lung Diseases, Parasitic; Lymphokines; Macrophages; Mice; Mice, Inbred CBA; Prostaglandins E, Synthetic; Prostaglandins F; Schistosoma mansoni; Schistosomiasis

1984

Plasma prostaglandin activities in some immuno-inflammatory diseases.

General pharmacology, 1984, Volume: 15, Issue:1

In the present study the relationship between plasma prostaglandins (PGs) level and the immuno-inflammatory reactions, known to accompany bronchial asthma and/or schistosomiasis infection, was investigated. It was found that plasma PGF2 alpha increased significantly above the control values in 30 asthmatics, 30 schistosomal and 30 asthmatic schistosomal patients. Plasma PGE increased also together with that of PGF2 alpha which is considered to be useful for the protection of the patient against the injurious effects of the infection, due to the known opposing actions of PGE to those of PGF2 alpha.

Topics: Adolescent; Adult; Aged; Asthma; Dinoprost; Humans; Middle Aged; Prostaglandins; Prostaglandins E; Prostaglandins F; Schistosomiasis

1984