dinoprost and Pregnancy--Prolonged

Postpartum atony remains the most common cause life-threatening haemorrhage in obstetrics. In a case of postpartum atony unresponsive to medical treatment after Caesarean section haemorrhage was controlled and satisfactory uterine tonus was achieved by inverted sutures of the uterine fundus. Imminent hysterectomy could thus be avoided.

Topics: Adult; Cesarean Section; Combined Modality Therapy; Dinoprost; Ergonovine; Female; Humans; Oxytocin; Postpartum Hemorrhage; Pregnancy; Pregnancy, Prolonged; Sutures; Uterine Inertia

The authors analyzed results of 295 labors induced with endocervical application of dinoprostin (152 term- and 143 postterm labors) in relation to 242 (125 term- and 117 postterm-) spontaneous labors. Delayed labor increases the occurrence of meconial amniotic fluid (21.96%:9.03% p < 0.01), and pathological and prepathological CTG records (23.85%: 11.97% p < 0.005). In addition, children show lower Apgar score (p < 0.001), and among them there are more hypertrophic (6.54%:2.53% p < 0.05), postterm (6.92%:0.0% p < 0.005), and dysmature children (11.92%:3.12% p < 0.01) when compared to children born between the days 274 and 287 of the gestational age. Perinatal morbidity of children born after 287 gestational days in rather high-32.31%. Induction of labor with endocervical application of prostine shortens the duration of the labor (p < 0.001). Large numbers of labors are finished with vacuum extraction-3.73% (3.29% of term- and 4.19% of postterm labors) and cesarear section-12.88% (10.53% of term- and 15.38% of postterm labors) usually due to dystocia of the uterus and hypoxion of the neonate. Labor trauma is the most usual trauma among perinatal problems of new born infants delivered by the induction with prostaglandins and high perinatal morbidity rate is due not only to the induction method but also to the incorrect assessment of the gestational age.

Topics: Adolescent; Adult; Dinoprost; Female; Humans; Infant, Newborn; Labor, Induced; Pregnancy; Pregnancy Outcome; Pregnancy, Prolonged

In 20 women, the umbilical artery flow velocity waveform (FVW) was recorded immediately before and 30-40 min after administering vaginal or extraamniotic prostaglandin E2 to ripen the cervix. Maternal plasma concentrations of prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) metabolites (bicyclo-PGEM and PGFM, respectively) were measured at the time of the Doppler recordings. The administration of prostaglandin E2 was associated with a significant rise in maternal plasma PGFM and bicyclo-PGEM concentrations, but there was no change in the umbilical artery FVW Pulsatility index (PI). These results suggest that cervical ripening with local prostaglandin E2 has no effect on the umbilical artery FVW.

Topics: Administration, Intravaginal; Blood Flow Velocity; Cervix Uteri; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Pregnancy; Pregnancy, Prolonged; Pulsatile Flow; Ultrasonography; Umbilical Arteries

Using a self-made double-balloon-catheter the instillation of 2.5 mg Prostaglandin F2 alpha into the extraovular chorio-decidual space was down 46 times in 42 late pregnant women. The indication was the unripe cervix uteri in case of urgent parturition. This method is more effective than the pericervical and endocervical application, respectively. Under continuous supervision using external CTG there were neither complications in fetus nor in the mother.

Topics: Catheterization; Dinoprost; Female; Gels; Humans; Labor, Induced; Pregnancy; Pregnancy, Prolonged; Uterine Cervical Incompetence

Topics: Adolescent; Adult; Dinoprost; Female; Fetal Membranes, Premature Rupture; Humans; Infusions, Parenteral; Labor, Induced; Labor, Obstetric; Pregnancy; Pregnancy, Prolonged; Prostaglandins F; Stimulation, Chemical; Time Factors

Topics: Aminopeptidases; Cystinyl Aminopeptidase; Dinoprost; Female; Humans; Labor, Obstetric; Oxytocin; Pregnancy; Pregnancy, Prolonged; Prostaglandins F; Uterus