dinoprost has been researched along with Pleurisy* in 3 studies
3 other study(ies) available for dinoprost and Pleurisy
| Article | Year |
|---|---|
Prostaglandin F2alpha produced by inducible cyclooxygenase may contribute to the resolution of inflammation.
Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2alpha concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F2alpha produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction. Topics: Analysis of Variance; Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Inflammation; Nitrobenzenes; Pleurisy; Prostaglandins F, Synthetic; Rats; Rats, Wistar; Receptors, Prostaglandin; Sulfonamides | 2005 |
Prostanoid release by macrophages at a distance from an inflammatory site.
During the development of an acute inflammatory reaction induced in the rat pleural cavity by dextran, calcium pyrophosphate, saline or phosphate buffered saline, macrophages present at a distant site (peritoneal cavity) display an increased capacity to release prostanoids: prostaglandins, prostacyclin and thromboxane. Enhanced levels of 6-keto-PGF1 alpha were observed both in peritoneal lavages (experiments in vivo) and in macrophage supernatants after 24-h culture (experiments in vitro). TXB2 levels were mainly increased in peritoneal lavages and PGE2 in culture supernatants. In vivo, levels of prostanoids in the peritoneal cavity reached a maximum 24 h after the induction of pleurisy whatever the injected substance. In vitro, amounts of arachidonic acid metabolites were highest in supernatants of cultured peritoneal macrophages harvested 72 h after the pleural injection of dextran or CaPP. These results show that the regulation of macrophage functions is closely related to prostanoid production, especially the release of PGE2 and PGI2. Topics: Animals; Dinoprost; Dinoprostone; Macrophages; Male; Peritoneal Cavity; Pleurisy; Prostaglandins; Prostaglandins F; Rats; Rats, Inbred Strains; Thromboxane B2; Time Factors | 1989 |
[Observation on the changes of prostaglandin E and F2 alpha contents of the plasma and pleural effusion in patients with bronchial asthma, chronic cor pulmonale and pleurisy].
Topics: Adult; Aged; Asthma; Dinoprost; Female; Humans; Male; Middle Aged; Pleural Effusion; Pleurisy; Prostaglandins; Prostaglandins E; Prostaglandins F; Pulmonary Heart Disease | 1983 |