dinoprost and Food-Hypersensitivity

Topics: Administration, Oral; Adult; Allergens; Child; Dinoprost; Food Hypersensitivity; Humans; Leukotriene E4; Milk Hypersensitivity

Topics: Digestive System; Dinoprost; Dinoprostone; Food Hypersensitivity; Humans; Immunologic Techniques; Mast Cells; Prostaglandins E; Prostaglandins F

Six allergic patients and six normal controls were studied serologically before and after provocative challenge with allergic substances. The patients showed impaired modulation of the immune system prior to challenge. The challenge blood changes in patients with adverse clinical responses were consistent with type 1 and/or type 3 immune responses. Normal controls showed no abnormal laboratory or clinical changes. The data support the hypothesis that an abnormal immune reaction develops in allergic patients who sustain an adverse clinical response to ingestion of foods or inhalation of chemicals to which they are sensitive.

Topics: Adult; Aged; Complement System Proteins; Dinoprost; Female; Food Hypersensitivity; Histamine Release; Humans; Immunoglobulins; Immunologic Techniques; Male; Middle Aged; Neurotransmitter Agents; Prostaglandins F; Respiratory Hypersensitivity

Prostaglandins appear to have cytoprotective effects in the upper bowel and are released in increased amounts in patients with abnormal peristalsis and diarrhea. Drugs which interfere with prostaglandin (PG) synthesis often prevent the symptoms of food intolerance and have been reported as improving food-related symptoms in the irritable bowel syndrome.

Topics: Adult; Asthma; Dinoprost; Dinoprostone; Eczema; Female; Food Hypersensitivity; Humans; Intestinal Mucosa; Prostaglandins; Prostaglandins E; Prostaglandins F; Urticaria

Six out of eight patients with a history of aspirin-provoked urticaria/angioedema responded with adverse reactions, including urticaria and bronchospasm, to provoking doses of oral aspirin from 30-515 mg. The other two patients did not react to 1.2 g of aspirin on three occasions. Five of the six patients who had reacted became desensitized after their initial aspirin reaction, tolerating 650 mg on the second day. They then took 650 mg day-1 of aspirin for three weeks, during which time the ingestion of foods which had previously caused a variety of moderate or severe reactions caused no symptoms. The resting plasma PGF2 alpha in ten 'aspirin-sensitive' urticaria patients (24.89 +/- 2.79 pg m-1) was significantly higher than the levels in ten normal subjects (6.75 +/- 1.1 pg ml-1) (P less than 0.01). In the patient group the lowest levels of PGF2 alpha were found in the two patients who subsequently did not experience a positive reaction after aspirin provocation. The PGF2 alpha/PGE2 ratio in 'aspirin-sensitive' urticaria patients (1.83 +/- 0.026) was significantly higher than that in normal subjects (0.63 +/- 0.14) (P less than 0.01).

Topics: Adolescent; Adult; Aspirin; Dinoprost; Dinoprostone; Drug Hypersensitivity; Female; Food Hypersensitivity; Humans; Male; Middle Aged; Prostaglandins E; Prostaglandins F; Urticaria