dinoprost and Eye-Burns

BN 52 021, a specific antagonist of PAF receptors, was tested in the early-phase treatment of chemically burned eyes in 30 rabbits. The local application of BN 52 021 eyedrops-1% (water-soluble preparation, 5 times daily, in comparison with the other eye as a control) led to a visible anti-inflammatory effect (microscopically and macroscopically) of the chemically burned anterior eye segment. There was only a moderate increase of the concentration of PGF2 alpha after the chemical burn. The use of specific PAF antagonists seems to have a real chance for treatment of inflammatory reactions of the anterior eye segment. A combination with other mediator antagonists should be tested in further experiments.

Topics: Animals; Burns, Chemical; Conjunctiva; Cornea; Dinoprost; Diterpenes; Eye Burns; Ginkgolides; Lactones; Ophthalmic Solutions; Plant Extracts; Rabbits; Radioimmunoassay; Wound Healing