dinoprost and Esophageal-Neoplasms

Increased fruit and vegetable consumption is associated with decreased risk of a number of cancers of epithelial origin, including esophageal cancer. Dietary administration of lyophilized black raspberries (LBRs) has significantly inhibited chemically induced oral, esophageal, and colon carcinogenesis in animal models. Likewise, berry extracts added to cell cultures significantly inhibited cancer-associated processes. Positive results in preclinical studies have supported further investigation of berries and berry extracts in high-risk human cohorts, including patients with existing premalignancy or patients at risk for cancer recurrence. We are currently conducting a 6-mo chemopreventive pilot study administering 32 or 45 g (female and male, respectively) of LBRs to patients with Barrett's esophagus (BE), a premalignant esophageal condition in which the normal stratified squamous epithelium changes to a metaplastic columnar-lined epithelium. BE's importance lies in the fact that it confers a 30- to 40-fold increased risk for the development of esophageal adenocarcinoma, a rapidly increasing and extremely deadly malignancy. This is a report on interim findings from 10 patients. To date, the results support that daily consumption of LBRs promotes reductions in the urinary excretion of two markers of oxidative stress, 8-epi-prostaglandin F2alpha (8-Iso-PGF2) and, to a lesser more-variable extent, 8-hydroxy-2'-deoxyguanosine (8-OHdG), among patients with BE.

Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Deoxyguanosine; Dinoprost; Esophageal Neoplasms; Female; Food Preservation; Freeze Drying; Fruit; Gastroesophageal Reflux; Humans; Male; Middle Aged; Oxidative Stress; Phytotherapy; Pilot Projects; Precancerous Conditions; Rosaceae

In a clinical study the intraoperative changes in prostaglandin levels and their possible influence on venous admixture during one-lung anesthesia are investigated in 9 patients undergoing abdomino-thoracic resection of a carcinoma of the oesophagus. During one-lung anesthesia PaO2 decreased and Qsp/Qt increased significantly. In 7 of the 9 patients prostaglandin E2 in the arterial blood was significantly above normal level during two-lung- and one-lung ventilation, prostaglandin F2 alpha was below normal values in all patients during two-lung- and one-lung ventilation. The clear prevalence of vasodilating prostaglandin E2 may have reduced the effectiveness of hypoxic pulmonary vasoconstriction during one-lung ventilation.

Topics: Anesthesia; Blood Pressure; Dinoprost; Dinoprostone; Esophageal Neoplasms; Heart; Humans; Hypoxia; Male; Middle Aged; Prostaglandins; Prostaglandins E; Prostaglandins F; Pulmonary Circulation; Respiration; Vasoconstriction