dinoprost and Duodenitis

To study role of E2 and F2alpha prostaglandins in development of erosive-ulcerative lesions of gastrointestinal tract.. were examined patients with mucosal erosive-ulcerative and inflammatory lesions of gastrointestinal tract, as well as patients with osteoarthritis who received selective and non selective NSAIDs. Determination of E2 and F2alpha endogenous PG group was investigated with help of immunefuoration method with help of R&D Systems, Inc. Control group was 15 healthy patients.. in presented work you can find that there is relationship between degree of reduction of PG level and severity of gastrointestinal mucosal lesion area. The lowest values of PGE2 and PG F2alpha observed in patients with gastric ulcer disease, especially during exacerbation. Patients with low PG synthesis in body increases likelihood of gastropathy as to reception of non-selective COX inhibitors, and at receiving selective COX-2 inhibitors.

Topics: Case-Control Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Duodenitis; Gastric Mucosa; Gastritis; Humans; Intestinal Mucosa; Osteoarthritis; Peptic Ulcer

In patients with functional disorders of the stomach and chronic gastroduodenitis, the content of cellular bioregulaters (prostaglandins) in the blood and gastric mucosa was abnormal. The revealed alterations may give rise to a reduction of mucosal resistance because of cytoprotection weakening and derangement of the control over gastric secretion. The data obtained make great contributions to our concepts of the pathogenesis of gastroduodenal pathology and children and provide evidence for new approaches to its prevention and treatment.

Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Dinoprost; Dinoprostone; Duodenitis; Gastric Acid; Gastric Mucosa; Gastritis; Gastroenteritis; Humans