dinoprost and Diabetic-Ketoacidosis

Diabetes is a common metabolic state during ageing, and one in five elderly individuals suffers from diabetes. However, few studies have been performed in elderly diabetic patients, and large randomized clinical trials in this population are rare. The purpose of this study was to investigate changes in serum leptin levels in elderly patients with diabetic ketoacidosis (DKA) before and after treatment and assess its relationship with oxidative stress parameters.. Serum leptin levels, plasma superoxide dismutase (SOD) activity, plasma malondialdehyde (MDA) levels, plasma total antioxidant capacity (TAC) and plasma 8-iso-prostaglandin F. Plasma SOD activity, TAC and serum leptins before treatment were significantly lower in elderly patients with DKA compared with the control group (P < 0.05), whereas plasma MDA and 8-iso-PGF. Serum leptin levels in the elderly patients with DKA were significantly reduced after treatment, which was associated with oxidative stress.

Topics: Aged, 80 and over; Biomarkers; Blood Glucose; Body Mass Index; Diabetic Ketoacidosis; Dinoprost; Female; Glycated Hemoglobin; Humans; Leptin; Male; Malondialdehyde; Oxidative Stress; Superoxide Dismutase; Waist Circumference