dinoprost and Creutzfeldt-Jakob-Syndrome

dinoprost has been researched along with Creutzfeldt-Jakob-Syndrome* in 2 studies

Other Studies

2 other study(ies) available for dinoprost and Creutzfeldt-Jakob-Syndrome

Article	Year
Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease. Neurology, 2002, Jan-08, Volume: 58, Issue:1 The concentration of the cyclooxygenase product prostaglandin E(2) was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD. Topics: Adult; Creutzfeldt-Jakob Syndrome; Dinoprost; Dinoprostone; Humans; Middle Aged	2002
Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies. Journal of neuropathology and experimental neurology, 2000, Volume: 59, Issue:10 The levels of 2 arachidonic acid metabolites formed either by enzymatic activity of cyclooxygenase, i.e. prostaglandin E2 (PGE2), or by free radical-catalyzed peroxidation, i.e. F2-isoprostane 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha), were measured in the CSF of subjects with sporadic and familial Creutzfeldt-Jakob disease (CJD) and in brain homogenates of scrapie-infected mice. The CSF levels of both metabolites were increased in sporadic CJD (n = 52) and familial CJD (n = 10) patients when compared with a group of patients with noninflammatory disorders. Similarly, PGE2 and 8-epi-PGF2alpha levels were higher in brain homogenates obtained from C57BL/6J mice infected with the ME7 scrapie strain than in brain homogenates from control animals. As PGE2 is 1 of the most abundant prostaglandins released during inflammation and 8-epi-PGF2alpha is a quantitative marker of lipid peroxidation, our results provide in vivo biochemical evidence for the occurrence of inflammation and oxidative stress in human and experimental transmissible spongiform encephalopathies (TSEs), a concept so far based mainly on histopathological and in vitro evidence. Interestingly, in sporadic CJD patients, high CSF levels of PGE2, but not 8-epi-PGF2alpha, correlated with short survival time, suggesting that the inflammatory response correlates with the clinical duration of disease. Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Creutzfeldt-Jakob Syndrome; Cyclooxygenase 2; Dinoprost; Dinoprostone; F2-Isoprostanes; Female; Humans; Isoenzymes; Lipid Peroxidation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Middle Aged; Prostaglandin-Endoperoxide Synthases; Scrapie; Survival Analysis	2000

Article

Year

Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease.

Neurology, 2002, Jan-08, Volume: 58, Issue:1

The concentration of the cyclooxygenase product prostaglandin E(2) was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD.

Topics: Adult; Creutzfeldt-Jakob Syndrome; Dinoprost; Dinoprostone; Humans; Middle Aged

2002

Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies.

Journal of neuropathology and experimental neurology, 2000, Volume: 59, Issue:10

The levels of 2 arachidonic acid metabolites formed either by enzymatic activity of cyclooxygenase, i.e. prostaglandin E2 (PGE2), or by free radical-catalyzed peroxidation, i.e. F2-isoprostane 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha), were measured in the CSF of subjects with sporadic and familial Creutzfeldt-Jakob disease (CJD) and in brain homogenates of scrapie-infected mice. The CSF levels of both metabolites were increased in sporadic CJD (n = 52) and familial CJD (n = 10) patients when compared with a group of patients with noninflammatory disorders. Similarly, PGE2 and 8-epi-PGF2alpha levels were higher in brain homogenates obtained from C57BL/6J mice infected with the ME7 scrapie strain than in brain homogenates from control animals. As PGE2 is 1 of the most abundant prostaglandins released during inflammation and 8-epi-PGF2alpha is a quantitative marker of lipid peroxidation, our results provide in vivo biochemical evidence for the occurrence of inflammation and oxidative stress in human and experimental transmissible spongiform encephalopathies (TSEs), a concept so far based mainly on histopathological and in vitro evidence. Interestingly, in sporadic CJD patients, high CSF levels of PGE2, but not 8-epi-PGF2alpha, correlated with short survival time, suggesting that the inflammatory response correlates with the clinical duration of disease.

Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Creutzfeldt-Jakob Syndrome; Cyclooxygenase 2; Dinoprost; Dinoprostone; F2-Isoprostanes; Female; Humans; Isoenzymes; Lipid Peroxidation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Middle Aged; Prostaglandin-Endoperoxide Synthases; Scrapie; Survival Analysis

2000