dinoprost and Convalescence

Topics: Acute Disease; Adolescent; Adult; Convalescence; Dinoprost; Dinoprostone; Drug Evaluation; Foodborne Diseases; Humans; Middle Aged; Phenylbutazone; Radioimmunoassay; Salmonella Food Poisoning; Vitamin E

The dynamics of the level of prostaglandins E and F was studied in 45 patients with bacterial intestinal infections. It was established that during the acute period of the disease their content showed a significant increase. Inclusion of the indomethacin (a prostaglandin inhibitor) in the complex pathogenetic treatment of intestinal infections promotes early disappearance of pathological symptoms of the disease.

Topics: Acute Disease; Bacterial Infections; Child, Preschool; Convalescence; Dinoprost; Drug Evaluation; Humans; Indomethacin; Infant; Intestinal Diseases; Prostaglandins E

Topics: Adult; Aged; Anti-Bacterial Agents; Chloral Hydrate; Convalescence; Dinoprost; Drug Therapy, Combination; Erysipelas; Female; Humans; Male; Middle Aged; Prostaglandins F; Recurrence; Thiazoles

We studied prostaglandins and kallikrein urinary excretion in 14 children with acute poststreptococcal glomerulonephritis within 48 hours of hospital admission (period A), and again, 4-6 weeks later, when they were clinically recovered (period B). Seventeen apparently healthy children were studied as controls. The results (mean +/- SEM) indicate that PGE2 urinary excretion (ng/kg/day) was diminished during both periods of study (control group = 2.06 +/- 0.43, patients = period A 0.91 +/- 0.28 [P less than 0.02], period B 0.92 +/- 0.21 [P less than 0.02]). PGF2 alpha urinary excretion (ng/kg/day) was also suppressed during period A, but not during period B when large individual variability existed (control group = 7.10 +/- 1.07, patients period A 3.56 +/- 0.66 [P less than 0.001], period B 10.51 +/- 5.01 [NS]). Kallikrein urinary excretion (EU/kg/day) was also depressed during the acute phase and remained low during convalescence (control group = 0.492 +/- 0.1, patients period A 0.143 +/- 0.044 [P less than 0.001], period B 0.265 +/- 0.093 [P less than 0.02]). There was no difference in PGE/PGF ratio between controls and patients in the periods of study (control 0.328 +/- 0.055, period A 0.395 +/- 0.144, period B 0.384 +/- 0.128). Urine volume (ml/day) was lower in period A (582 +/- 75.8) but comparable in period B (1020 +/- 140.2) and control children (1210 +/- 80.2). No correlation could be found between the urinary excretion of PGE2, PGF2 alpha and kallikrein with any of the following parameters: urinary or serum sodium and potassium, serum or urinary osmolality, Cosm, urine flow, plasma renin activity, plasma or urinary aldosterone, hypertension or fluid retention.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Acute Disease; Adolescent; Age Factors; Child; Child, Preschool; Convalescence; Dinoprost; Dinoprostone; Female; Glomerulonephritis; Humans; Kallikreins; Male; Prostaglandins E; Prostaglandins F