dinoprost and Colonic-Diseases

In a study of 54 patients with a variety of lesions, prostaglandin F2 alpha pharmacoangiography produced vasoconstrictive effects in both neoplastic and inflammatory lesions of the colon. These effects occurred only at the affected sites and their immediate vicinity. Vasoconstriction seemed to correlate directly with the vascularity of the lesion, rather than with pathogenesis. Less marked vasoconstriction was seen in renal lesions. No vasoconstrictive effects were recognized in liver, soft tissue, or bone tumors. Thus prostaglandin F2 alpha acts as a vasodilator in normal human colonic vessels, while it acts as a vasoconstrictor in colonic lesions. The potential use of prostaglandin F2 alpha in the control of bleeding colonic lesions is also discussed.

Topics: Adult; Aged; Angiography; Colon; Colonic Diseases; Colonic Neoplasms; Dinoprost; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Prostaglandins F; Regional Blood Flow; Vasoconstriction