dinoprost and Abortion--Missed

Prostaglandin F2a was used for termination of pregnancy in two groups of patients. The first included eighteen patients with either missed abortion or intrauterine fetal death, and were treated by intrauterine-extraamniotic infusion of 20 mg prostaglandin F2a. The treatment was successful in 14 patients (mean induction-abortion interval 6.7 hours). Four patients, where the above method failed to induce labor, were given intravenously prostaglandin F2a or oxytocin simultaneously or separately; the expulsion time ranged from 12 to 48 hours. The second group included twelve patients who underwent a therapeutic abortion following either a diagnosis of fetal congenital abnormality or because of a maternal indication. The therapeutic abortion was performed using prostaglandin F2a (25-40 mg) via amniocentesis. The treatment was successful in all patients (mean induction-delivery interval 10.6 hours).

Topics: Abortion, Missed; Abortion, Therapeutic; Amniotic Fluid; Dinoprost; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Fetal Death; Humans; Labor, Induced; Oxytocin; Pregnancy; Pregnancy Trimester, Second; Retrospective Studies; Time Factors

Prostaglandin F2-alpha was administered by the intravenous, extra-amniotic and intramuscular routes in three comparable groups of patients with missed abortion, during a randomized study. Out of 45 patients (15 in each group), nine patients (60%) of the intravenous group aborted within a mean time of 16.2 hours, whereas 14 patients (93.4%) of the extra-amniotic group and 12 patients (80%) of the intramuscular group aborted in averaged times of 8.2 and 10.6 hours, respectively. The percentage of complete abortions was highest in the intravenous group 88.8%, followed by the intramuscular group (50%), and the extra-amniotic group (35.7%). Side effects of nausea, vomiting, diarrhoea and shivering were observed in all groups studied, but were marginally higher in the intravenous group.

Topics: Abortion, Missed; Adult; Amnion; Dinoprost; Female; Humans; Infusions, Intravenous; Injections; Injections, Intramuscular; Pregnancy; Prostaglandins F; Uterine Contraction

Prostaglandins (PG) are currently the drugs of choice to terminate pathological 2nd trimester pregnancies. 6 different dose schedules of were are tested in 100 women with missed abortion, hydatidiform mole, and fetal malformations: extraamniotic PGF2 alpha, intravenous PGE2, intravenous sulprostone (2 schedules), and intramuscular sulprostone (2 schedules). All tested regimens were effective. Induction-to-abortion times and incidence of side effects were different. Extraamniotic PGF2 alpha and intramuscular sulprostone appear to be the most practicable regimens.

Topics: Abortion, Missed; Congenital Abnormalities; Dinoprost; Dinoprostone; Female; Humans; Hydatidiform Mole; Infant, Newborn; Injections, Intramuscular; Injections, Intravenous; Labor, Induced; Pregnancy; Pregnancy Trimester, Second; Prostaglandins; Prostaglandins E; Prostaglandins E, Synthetic; Prostaglandins F

Extra-amniotic infusion of prostaglandin F2 alpha (PGF2 alpha) and intravenous (IV) oxytocin in increasing doses were compared in a retrospective study to establish the efficacy of the two methods for termination of pregnancies with second trimester missed abortion. Sixty women with this complication underwent pregnancy termination, 28 by extra-amniotic infusion of PGF2 alpha and oxytocin augmentation, if necessary, and 32 by IV oxytocin in increasing doses. All patients in the PGF2 alpha group aborted within 24 hours from onset of infusion and seven of them needed oxytocin augmentation. There were nine failures in the oxytocin group and the other 23 aborted within 17 hours. The mean (plus or minus standard error of the mean) induction-abortion interval was significantly less in the oxytocin group (6.9 +/- 3.4 hours) than in the PGF2 alpha group (12.6 +/- 5.7 hours) p < 0.001. Eight patients in the group had mild side effects, such as nausea, flushes or transient hypotension. Uterine hypertonus was observed in two women receiving PGF2 alpha and treated by temporary interruption of the infusion. In the oxytocin group, one patient had coagulation disturbances and one, hemorrhage. We conclude that extra-amniotic PGF2 alpha infusion is more effective than IV oxytocin in increasing doses, for termination of second trimester missed abortion, but takes effect more slowly. We can assume that further use of IV oxytocin immediately after termination of the PGF2 alpha administration can shorten the induction-abortion interval.

Topics: Abortion, Missed; Adult; Dinoprost; Female; Humans; Infusions, Intravenous; Oxytocin; Pregnancy; Pregnancy Trimester, Second; Retrospective Studies

Topics: Abortion, Induced; Abortion, Missed; Dinoprost; Female; Humans; Pregnancy; Pregnancy Trimester, Second

Topics: Abortion, Missed; Dinoprost; Female; Fetal Death; Humans; Labor, Induced; Pregnancy; Prostaglandins F

Topics: Abortifacient Agents; Abortion, Missed; Adolescent; Adult; Dinoprost; Female; Humans; Pregnancy; Prostaglandins F

Topics: Abortion, Induced; Abortion, Missed; Adult; Amnion; Dinoprost; Female; Fetal Death; Humans; Injections; Labor, Induced; Pregnancy; Pregnancy Trimester, Third; Prostaglandins F

A combined method consisting of extraamniotic infusion of normal saline with prostaglandin F2 alpha was used in 20 patients for termination of midtrimester missed abortion. All 20 patients aborted within 12 h. The mean infusion abortion interval was 7.34 h. Side effects were observed only in 5 patients (25%), a low percentage when compared with other prostaglandin methods. The possibility of adjusting or stopping the infusion permitted the rapid control of side effects and the intensity of uterine contractions. According to the results obtained in this series, the proposed method seems to be more suitable than other procedures reported for termination of midtrimester missed abortion.

Topics: Abortion, Induced; Abortion, Missed; Adult; Cervix Uteri; Dinoprost; Female; Humans; Pregnancy; Prostaglandins F

Topics: Abortion, Missed; Abortion, Therapeutic; Adult; Dinoprost; Female; Fetal Death; Humans; Labor, Induced; Oxytocin; Pregnancy; Prostaglandins F

Abortifacient effects of 16,16-dimethyl-trans delta 2-PGE1 methyl ester (ONO-802) were studied clinically. The uterine contractile effect of the agent was compared with those of PGF2 alpha and oxytocin (OXY) in the unanesthetized rabbit. 1. Intermittent intravaginal administration of ONO-802 was applied to 32 cases of legal abortion, 15 of missed abortion and 17 of hydatid mole. Eighty eight, 100 and 81 per cent of these patients resulted in abortion, respectively, with fewer side effects than those of natural PGs. 2. In the five groups of non- or pseudo-pregnant rabbits and those in their 7-9, 14-16 and 19-28 days in pregnancy, uterine contractile effects of these agents were assessed by both the contractile patterns and area of contractile curves of initial 5 minutes. The results are as follows: 1) In the non-pregnant rabbits, all of these agents revealed marked uterine contractile effect. 2) ONO-802 induced uterine contraction characterized by its wedge-shaped curves continued considerably longer than that induced by others. 3) ONO-802 revealed much stronger effect on uterine contraction in 7-9 day-of-pregnant rabbits. 4) Fourteen-16-day-of-pregnant rabbits were least influenced by the three agents as regards their uterine contraction in accordance with the highest progesterone levels in their sera among the three groups of pregnant rabbits.

Topics: Abortion, Missed; Abortion, Therapeutic; Alprostadil; Animals; Dinoprost; Female; Humans; Oxytocin; Pregnancy; Prostaglandins E, Synthetic; Prostaglandins F; Rabbits; Uterine Contraction; Uterine Hemorrhage

Pellets of prostaglandin F2alpha (PGF2alpha), introduced intracervically, were used to induce delivery in 12 cases of prolonged pregnancy, 13 cases of retained dead fetus, 10 cases of missed abortion, 4 cases of therapeutic abortion, and 1 case of hydatidiform mole. In the 12 cases of prolonged pregnancy there were 4 failures due to obstetrical complications, or a success rate of 66.67%. In the 10 cases of missed abortion there were 5 failures, in the 4 cases of therapeutic abortion there were 2 failures, in the 13 cases of retained dead fetus there were 3 failures and 4 partial successes, and the 1 cases on hydatidiform mole was also only a partial success. The 4 groups had a success rate of 64.3% and a failure rate of 35.7%. Electronic monitoring of fetal conditions is absolutely necessary when using PGs for induction of delivery. The article reviews the literature on the subject.

Topics: Abortion, Missed; Abortion, Therapeutic; Cervix Uteri; Dinoprost; Drug Implants; Female; Humans; Labor, Induced; Pregnancy; Prostaglandins F