dinoprost has been researched along with Abortion--Habitual* in 4 studies
4 other study(ies) available for dinoprost and Abortion--Habitual
Article | Year |
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Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion.
Experimental evidence indicates that cyclooxygenase-2 (COX-2) plays a critical role in blastocyst implantation; however, little is known of the role of COX-2 in unexplained recurrent spontaneous abortion (URSA).. We evaluated the expression level and potential signaling pathway of COX-2 in 30 cases of URSA who were excluded the abnormality of chromosomes, anatomy, endocrine, infectious, autoimmune diseases and in 30 normal pregnancies.. The mRNA and the protein expression level of COX-2 in the URSA group (-0.238 +/- 0.848, 0.368 +/- 0.089, respectively) were significantly lower than that in the control group (1.943 +/- 3.845, 1.046 +/- 0.108, respectively) (both, P < 0.01). The expression of prostaglandins PGF(2a), PGD(2), PGE(2), and PGI(2), in the URSA group ((2326.0 +/- 295.6) pg/ml, (2164.0 +/- 240.5) pg/ml, (238.7 +/- 26.4) pg/ml, (2337.0 +/- 263.0) pg/ml, respectively) were significantly lower than that in the control group ((3450.0 +/- 421.7) pg/ml, (3174.0 +/- 415.6) pg/ml, (323.5 +/- 43.8) pg/ml, (3623.0 +/- 460.4) pg/ml, respectively) (P < 0.05). The mRNA expression level of PPARbeta and RXRalpha (0.859 +/- 0.653, -0.172 +/- 0.752, respectively) in URSA group was significantly lower than that in the control group (1.554 +/- 1.735, 0.777 +/- 2.482, respectively) (both P< 0.05). The mRNA and protein expression levels of vascular endothelial growth factor-A (VEGF-A) in the URSA group (2.010 +/- 1.522, 0.35 +/- 0.46) was significantly lower than that in the control group (4.569 +/- 2.430, 0.750 +/- 0.350) (both P < 0.05).. COX-2 and the COX-2-derived PGI(2) signaling pathway possibly play an important role in successful embryo implantation, and their decreased expression may result in URSA. The decreased expression may influence the expression of VEGF-A which interferes with placental angiogenesis causing failure of embryo implantation, leading to spontaneous abortion. Topics: Abortion, Habitual; Adult; Blotting, Western; Cyclooxygenase 2; Dinoprost; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Female; Humans; Polymerase Chain Reaction; Pregnancy; Prostaglandin D2; Signal Transduction; Vascular Endothelial Growth Factor A | 2010 |
[Contents of prostaglandins E2 and F2alpha and cAMP in the endometrium of women with habitual abortion during late pregnancy terms].
Measurements of prostaglandins E2 and F2 alpha in the endometrium of 35 women of a reproductive age, suffering from habitual abortions in late pregnancy terms, have shown elevation of these prostaglandin levels in the secretory phase as against the reference group and their normal values during the proliferative phase. It is possible, that disordered prostaglandin synthesis in the endometrium, manifesting in pregnancy, is one of the causes of habitual abortions. cAMP levels were somewhat decreased in the secretory phase in this patient population; this permits a hypothesis on disorders in the adenylate cyclase system. Topics: Abortion, Habitual; Adenylyl Cyclases; Adult; Cyclic AMP; Dinoprost; Dinoprostone; Endometrium; Female; Humans; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third | 1991 |
A study of the serum factor "X" in women with pathological pregnancy and during delivery.
Topics: Abortion, Habitual; Animals; Dinoprost; Female; Humans; In Vitro Techniques; Muscle, Smooth; Obstetric Labor Complications; Pre-Eclampsia; Pregnancy; Prostaglandins F; Rats; Uterine Contraction | 1983 |
Notes on the mechanism of action of the serum factor from women with toxicoses of early and late pregnancy and habitual abortions.
Topics: Abortion, Habitual; Animals; Dinoprost; Female; Guinea Pigs; Humans; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Pre-Eclampsia; Pregnancy; Prostaglandins F; Rats | 1982 |