dinitrochlorobenzene and Verruca studies

Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.

Research Excerpts

Excerpt	Relevance	Reference
"In a purely clinical, unbiased study, 50 patients with verrucae plana were treated with dinitrochlorobenzene for 1-24 weeks, keeping half the lesions as controls."	7.68	Dinitrochlorobenzene treatment of verrucae plana. ( Patel, RM; Shah, KC; Umrigar, DD, 1991)
"Fifty-nine patients with verrucae (45 with verrucae plana and 14 with verrucae vulgaris) were treated with dinitrochlorobenzene (DNCB) as a topical application on the normal uninvolved skin of the shoulder for sensitization and challenge."	7.67	Therapeutic effect of dinitrochlorobenzene (DNCB) on verruca plana and verruca vulgaris. ( Cho, CK; Chun, SI; Kim, JG; Lee, S, 1984)
"A joint clinical study was conducted to test the effectiveness of topical dinitrochlorobenzene ointment in the treatment of warts."	7.66	Dinitrochlorobenzene immunotherapy of human warts. ( Sanders, BB; Smith, KW, 1981)
"A study using daily topical applications of dinitrochlorobenzene on recalcitrant verrucae vulgares demonstrated this to be of practical value."	7.66	Immunotherapy of verrucae vulgares with dinitrochlorobenzene. ( Buckner, D; Price, NM, 1978)
"Cimetidine is an H2-receptor antagonist which is mainly used to treat gastrointestinal diseases."	5.29	The effect of cimetidine on verruca plana juvenilis: clinical trials in six patients. ( Choi, YS; Hann, SK; Park, YK, 1993)
" Dinitrochlorobenzene, squaric acid dibutyl ester and diphencyprone are most commonly employed in the therapy of alopecia areata and viral warts."	4.81	The therapeutic use of topical contact sensitizers in benign dermatoses. ( Buckley, DA; Du Vivier, AW, 2001)
" Obligate contact sensitizers such as diphencyprone or dinitrochlorobenzene have been used against viral and autoimmune diseases."	3.72	[Topical immunomodulators in dermatology]. ( Hengge, UR; Meykadeh, N, 2003)
" In this report, we describe an HIV-infected man with persistent, severe cutaneous hand warts that did not respond to multiple therapies, including liquid nitrogen cryotherapy, topical dinitrochlorobenzene, topical podophyllin, and intralesional interferon-alfa injections."	3.70	Resolution of recalcitrant hand warts in an HIV-infected patient treated with potent antiretroviral therapy. ( Colven, R; Spach, DH, 1999)
"In a purely clinical, unbiased study, 50 patients with verrucae plana were treated with dinitrochlorobenzene for 1-24 weeks, keeping half the lesions as controls."	3.68	Dinitrochlorobenzene treatment of verrucae plana. ( Patel, RM; Shah, KC; Umrigar, DD, 1991)
"Fifty-nine patients with verrucae (45 with verrucae plana and 14 with verrucae vulgaris) were treated with dinitrochlorobenzene (DNCB) as a topical application on the normal uninvolved skin of the shoulder for sensitization and challenge."	3.67	Therapeutic effect of dinitrochlorobenzene (DNCB) on verruca plana and verruca vulgaris. ( Cho, CK; Chun, SI; Kim, JG; Lee, S, 1984)
"A patient who for 26 years had common warts, which were resistant to various treatment modalities, was treated with a single intralesional injection of interferon-gamma after dinitrochlorobenzene immunotherapy, because immunologic studies indicated she had failed to respond to prior treatment modalities as a result of a functional impairment of her cellular immune response."	3.67	Interferon-gamma as adjuvant therapy for resistant warts. ( Hayakawa, J; Nagashima, M; Shiohara, T, 1989)
"A joint clinical study was conducted to test the effectiveness of topical dinitrochlorobenzene ointment in the treatment of warts."	3.66	Dinitrochlorobenzene immunotherapy of human warts. ( Sanders, BB; Smith, KW, 1981)
"Twenty-one patients suffering from multiple common warts were treated by topically-applied dinitrochlorobenzene (DNCB)."	3.66	[Treatment of common warts with topically applied DNCB (author's transl)]. ( Czarnecki, N; Hintner, H, 1979)
"A study using daily topical applications of dinitrochlorobenzene on recalcitrant verrucae vulgares demonstrated this to be of practical value."	3.66	Immunotherapy of verrucae vulgares with dinitrochlorobenzene. ( Buckner, D; Price, NM, 1978)
"Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troublesome, chronic condition."	2.48	Topical treatments for cutaneous warts. ( Abbott, R; Bennett, C; Gibbs, S; Holland, R; Kwok, CS, 2012)
"Treatment-resistant warts are a common and frustrating problem for patients, parents, and providers alike."	2.45	Immunotherapy for childhood warts. ( Burkhart, CN; Dasher, DA; Morrell, DS, 2009)
"Viral warts are common and usually harmless but very troublesome."	2.43	Topical treatments for cutaneous warts. ( Gibbs, S; Harvey, I, 2006)
"Cimetidine is an H2-receptor antagonist which is mainly used to treat gastrointestinal diseases."	1.29	The effect of cimetidine on verruca plana juvenilis: clinical trials in six patients. ( Choi, YS; Hann, SK; Park, YK, 1993)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (63.64)	18.7374
1990's	5 (11.36)	18.2507
2000's	9 (20.45)	29.6817
2010's	2 (4.55)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Cho, SI	1
Shin, S	1
Lee, W	1
Jo, G	1
Kim, S	1
Mun, JH	1
Dasher, DA	1
Burkhart, CN	1
Morrell, DS	1
Kwok, CS	1
Gibbs, S	5
Bennett, C	1
Holland, R	1
Abbott, R	1
Meykadeh, N	1
Hengge, UR	1
Harvey, I	3
Sterling, JC	2
Stark, R	2
Goihman-Yahr, M	3
Monroe, JR	1
Johansson, E	1
Förström, L	1
Dunagin, WG	2
Millikan, LE	1
Grayson, RJ	1
Ratner, SW	1
Shaps, RS	1
Heid, E	1
Grosshans, E	1
Laplanche, G	1
Caussade, P	1
Lee, S	1
Cho, CK	1
Kim, JG	1
Chun, SI	1
Bos, RP	1
Brouns, RM	1
Theuws, JL	1
Henderson, PT	1
Lahti, A	1
Hannuksela, M	1
Sanders, BB	2
Smith, KW	1
Eriksen, K	2
Claudy, AL	1
Roche, H	1
Gogue, Y	1
Choi, YS	1
Hann, SK	1
Park, YK	1
Stone, OJ	1
Spach, DH	1
Colven, R	1
Buckley, DA	2
du Vivier, AW	2
Russo, L	1
Russo, A	1
Russo, V	1
Fernandez, J	2
Boatswain, A	1
Convit, J	2
Omar de Carli, H	1
Cortegozo, AC	1
Restbergs, V	1
Nater, JP	1
Baar, AJ	1
Bleumink, E	1
Haneke, E	1
Gutschmidt, E	1
Czarnecki, N	1
Hintner, H	1
Buckner, D	1
Price, NM	1
Bekhor, PS	1
Entwisle, BR	1
McKenzie, IF	1
Coskey, RJ	1
Stretcher, GS	1
Goihman Yahr, M	1
Shah, KC	1
Patel, RM	1
Umrigar, DD	1
McCarthy, DJ	1
Shiohara, T	1
Hayakawa, J	1
Nagashima, M	1
Bender, ME	1
Intrator, F	1
de Oliveira Borges, AR	1
Assunção Filho, CT	1
Sudo, L	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparative Evaluation of Carbon Dioxide Laser and Cryotherapy by Dermoscopy in Treatment of Viral Wart[NCT03166137]		60 participants (Anticipated)	Interventional	2017-08-01	Not yet recruiting
Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts, A Randomized Clinical Trial[NCT03158168]	Phase 3	70 participants (Anticipated)	Interventional	2018-03-01	Recruiting
Randomized Double Blind Study Comparing Liquid Nitrogen Cryotherapy With Nd:YAG in the Treatment of Verruca Vulgaris[NCT01609530]		31 participants (Actual)	Interventional	2012-01-31	Terminated (stopped due to Unable to accrue the projected number of patients required.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Immunotherapy for childhood warts. Pediatric annals, 2009, Volume: 38, Issue:7 Topics: Adjuvants, Immunologic; Aminoquinolines; Antigens; Child; Child, Preschool; Cimetidine; Cyclobutanes	2009
Topical treatments for cutaneous warts. The Cochrane database of systematic reviews, 2012, Sep-12, Issue:9 Topics: Administration, Topical; Adult; Bleomycin; Child; Cryotherapy; Dermatologic Agents; Dinitrochloroben	2012
Local treatments for cutaneous warts. The Cochrane database of systematic reviews, 2003, Issue:3 Topics: Administration, Topical; Bleomycin; Cryotherapy; Dinitrochlorobenzene; Fluorouracil; Humans; Interfe	2003
Topical treatments for cutaneous warts. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Administration, Topical; Bleomycin; Cryotherapy; Dermatologic Agents; Dinitrochlorobenzene; Fluorour	2006
Topical treatments for cutaneous warts. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Administration, Topical; Bleomycin; Cryotherapy; Dermatologic Agents; Dinitrochlorobenzene; Fluorour	2006
Topical treatments for cutaneous warts. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Administration, Topical; Bleomycin; Cryotherapy; Dermatologic Agents; Dinitrochlorobenzene; Fluorour	2006
Topical treatments for cutaneous warts. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Administration, Topical; Bleomycin; Cryotherapy; Dermatologic Agents; Dinitrochlorobenzene; Fluorour	2006
[Dinitrochlorobenzene. Therapeutic use]. Annales de dermatologie et de venereologie, 1984, Volume: 111, Issue:9 Topics: Alopecia Areata; Carcinoma, Basal Cell; Dermatitis, Contact; Dinitrochlorobenzene; Humans; Hypersens	1984
Topical immunotherapy in dermatology. International journal of clinical practice, 1999, Volume: 53, Issue:2 Topics: Administration, Topical; Allergens; Alopecia Areata; Cyclobutanes; Cyclopropanes; Decision Making; D	1999
Local treatments for cutaneous warts. The Cochrane database of systematic reviews, 2001, Issue:2 Topics: Administration, Topical; Bleomycin; Cryotherapy; Dinitrochlorobenzene; Fluorouracil; Humans; Interfe	2001
The therapeutic use of topical contact sensitizers in benign dermatoses. The British journal of dermatology, 2001, Volume: 145, Issue:3 Topics: Allergens; Alopecia Areata; Cyclopropanes; Dinitrochlorobenzene; Female; Humans; Immunotherapy; Irri	2001
What's new about warts. Cutis, 1976, Volume: 18, Issue:4 Topics: Antibodies, Viral; Cantharidin; Child; Condylomata Acuminata; Dinitrochlorobenzene; Glutaral; Humans	1976

Article	Year
Combined immunotherapy of recalcitrant warts. International journal of dermatology, 2006, Volume: 45, Issue:5 Topics: Administration, Cutaneous; Aminoquinolines; Dinitrochlorobenzene; Drug Administration Schedule; Drug	2006
Unilateral dinitrochlorobenzene immunopathy of recalcitrant warts. Lancet (London, England), 1978, Feb-25, Volume: 1, Issue:8061 Topics: Administration, Topical; Adolescent; Adult; Child; Dinitrochlorobenzene; Female; Humans; Hypersensit	1978
[Immunotherapy of warts. Is it an experimental model for cancer immunotherapy?]. Medicina cutanea ibero-latino-americana, 1977, Volume: 5, Issue:6 Topics: Clinical Trials as Topic; Dinitrochlorobenzene; Drug Evaluation; Female; Humans; Hypersensitivity, D	1977

dinitrochlorobenzene and Verruca

Research Excerpts

Research

Studies (44)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Judicial precedents associated with periungual warts in South Korea. International journal of dermatology, 2019, Volume: 58, Issue:2 Topics: Administration, Topical; Adolescent; Bleomycin; Child; Dermatology; Dinitrochlorobenzene; Female; Hu	2019
[Topical immunomodulators in dermatology]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2003, Volume: 54, Issue:7 Topics: Adjuvants, Immunologic; Administration, Topical; Adult; Aged; Aged, 80 and over; Aminoquinolines; As	2003
Persistent warts in an adolescent with severe atopy. JAAPA : official journal of the American Academy of Physician Assistants, 2006, Volume: 19, Issue:7 Topics: Administration, Topical; Adolescent; Chronic Disease; Dermatology; Dinitrochlorobenzene; Female; Fin	2006
Dinitrochlorbenzene (DNCB) treatment of viral warts. A 5-year follow-up study. Acta dermato-venereologica, 1984, Volume: 64, Issue:6 Topics: Adolescent; Adult; Aged; Dinitrochlorobenzene; Female; Follow-Up Studies; Humans; Immunity, Cellular	1984
Dinitrochlorobenzene immunotherapy for verrucae resistant to standard treatment modalities. Journal of the American Academy of Dermatology, 1982, Volume: 6, Issue:1 Topics: Adolescent; Adult; Aged; Dinitrochlorobenzene; Drug Eruptions; Female; Humans; Immunization; Immunot	1982
Topical DNCB therapy for recalcitrant Verruca plantaris. Journal of the American Podiatry Association, 1982, Volume: 72, Issue:11 Topics: Adjuvants, Immunologic; Adult; Dinitrochlorobenzene; Female; Foot Dermatoses; Humans; Keratoderma, P	1982
Therapeutic effect of dinitrochlorobenzene (DNCB) on verruca plana and verruca vulgaris. International journal of dermatology, 1984, Volume: 23, Issue:9 Topics: Administration, Topical; Dermatitis, Contact; Dinitrochlorobenzene; Humans; Nitrobenzenes; Pigmentat	1984
Use of dinitrochlorobenzene (DNCB) in therapy of warts. Journal of the American Academy of Dermatology, 1984, Volume: 10, Issue:6 Topics: Animals; Dinitrochlorobenzene; Humans; Mice; Nitrobenzenes; Rats; Warts	1984
[DNCB, a hazardous medication]. Nederlands tijdschrift voor geneeskunde, 1980, May-17, Volume: 124, Issue:20 Topics: Alopecia; Dinitrochlorobenzene; Humans; Mutagens; Mutation; Nitrobenzenes; Salmonella typhimurium; W	1980
Topical immunotherapy with tuberculin jelly for common warts. Archives of dermatological research, 1982, Volume: 273, Issue:1-2 Topics: Administration, Topical; Adult; Dinitrochlorobenzene; Humans; Immunotherapy; Skin Diseases; Tubercul	1982
Dinitrochlorobenzene immunotherapy of human warts. Cutis, 1981, Volume: 27, Issue:4 Topics: Administration, Topical; Adolescent; Adult; Child; Dinitrochlorobenzene; Female; Humans; Immunity, C	1981
Wart regression. Journal of the American Academy of Dermatology, 1981, Volume: 5, Issue:5 Topics: Dinitrochlorobenzene; Humans; Remission, Spontaneous; Warts	1981
Treatment of the common wart by induced allergic inflammation. Dermatologica, 1980, Volume: 160, Issue:3 Topics: Adolescent; Adult; Aged; Dinitrochlorobenzene; Female; Humans; Male; Middle Aged; Nitrobenzenes; War	1980
[Immunotherapy of multiple recurring warts. Reassessment of the use of dinitrochlorobenzene (author's transl)]. Annales de dermatologie et de venereologie, 1980, Volume: 107, Issue:6 Topics: Adolescent; Adult; Child; Dinitrochlorobenzene; Hand Dermatoses; Humans; Hypersensitivity, Delayed;	1980
The effect of cimetidine on verruca plana juvenilis: clinical trials in six patients. The Journal of dermatology, 1993, Volume: 20, Issue:8 Topics: Administration, Oral; Adult; Cimetidine; Dinitrochlorobenzene; Drug Evaluation; Drug Tolerance; Fema	1993
Inducing viral immunity without a vaccine--possible use with human immunodeficiency virus. Medical hypotheses, 1993, Volume: 40, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Dermatitis, Contact; Dermatitis, Toxicodendron; Dinitrochloroben	1993
Resolution of recalcitrant hand warts in an HIV-infected patient treated with potent antiretroviral therapy. Journal of the American Academy of Dermatology, 1999, Volume: 40, Issue:5 Pt 2 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Cryosurgery; Dinitr	1999
Topical immunotherapy with contact sensitizers for viral warts. The British journal of dermatology, 2002, Volume: 146, Issue:4 Topics: Dinitrochlorobenzene; Humans; Immunotherapy; Irritants; Randomized Controlled Trials as Topic; Warts	2002
Letter: Immunotherapy of warts. Lancet (London, England), 1975, Apr-19, Volume: 1, Issue:7912 Topics: Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Immunity, Maternally-Acquired; Immunotherap	1975
[Treatment of verruca vulgaris with induced allergic inflammation]. Ugeskrift for laeger, 1979, Apr-02, Volume: 141, Issue:14 Topics: Adolescent; Adult; Aged; Dermatitis, Contact; Dinitrochlorobenzene; Evaluation Studies as Topic; Fem	1979
[The treatment of common warts with 2,4-dinitrochlorobenzene (DNCB)]. Nederlands tijdschrift voor geneeskunde, 1979, Mar-14, Volume: 123, Issue:15 Topics: Administration, Topical; Adult; Aged; Chronic Disease; Dinitrochlorobenzene; Female; Foot Diseases;	1979
Premature multiple Bowen's disease in poikiloderma congenitale with warty hyperkeratoses. Dermatologica, 1979, Volume: 158, Issue:5 Topics: Administration, Topical; Adolescent; Bowen's Disease; Carcinoma, Squamous Cell; Dinitrochlorobenzene	1979
[Treatment of common warts with topically applied DNCB (author's transl)]. Wiener klinische Wochenschrift, 1979, Dec-21, Volume: 91, Issue:24 Topics: Administration, Topical; Adolescent; Adrenal Cortex Hormones; Adult; Child; Coxsackievirus Infection	1979
Immunotherapy of verrucae vulgares with dinitrochlorobenzene. The British journal of dermatology, 1978, Volume: 98, Issue:4 Topics: Adolescent; Adult; Dermatitis, Contact; Dinitrochlorobenzene; Female; Humans; Immunity, Cellular; Im	1978
Topical DNCB therapy for resistant warts. The Australasian journal of dermatology, 1978, Volume: 19, Issue:1 Topics: Adolescent; Adult; Dermatitis, Contact; Dinitrochlorobenzene; Humans; Middle Aged; Nitrobenzenes; Wa	1978
Warts. Diagnosis and treatment. JAMA, 1976, Jun-28, Volume: 235, Issue:26 Topics: Cryosurgery; Curettage; Dinitrochlorobenzene; Fluorouracil; Humans; Tretinoin; Warts	1976
[Immunotherapy of disseminated common warts with dinitrochlorobenzene]. Medicina cutanea ibero-latino-americana, 1976, Volume: 4, Issue:3 Topics: Dinitrochlorobenzene; Drug Evaluation; Humans; Immunotherapy; Nitrobenzenes; Warts	1976
Dinitrochlorobenzene treatment of verrucae plana. The Journal of dermatology, 1991, Volume: 18, Issue:11 Topics: Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Dinitrochlorobenzene; Female; Humans;	1991
Therapeutic considerations in the treatment of pedal verrucae. Clinics in podiatric medicine and surgery, 1986, Volume: 3, Issue:3 Topics: Adrenal Cortex Hormones; Bleomycin; Caustics; Cryosurgery; Dinitrochlorobenzene; Electrosurgery; Flu	1986
Interferon-gamma as adjuvant therapy for resistant warts. Journal of the American Academy of Dermatology, 1989, Volume: 21, Issue:2 Pt 2 Topics: Biopsy; Combined Modality Therapy; Dinitrochlorobenzene; Female; Humans; Immune Tolerance; Interfero	1989
Concepts of wart regression. Archives of dermatology, 1986, Volume: 122, Issue:6 Topics: Dinitrochlorobenzene; Humans; Immunity, Cellular; Immunotherapy; Macrophages; Papillomaviridae; Remi	1986
[Treatment of verruca with DNCB]. Medicina cutanea ibero-latino-americana, 1985, Volume: 13, Issue:5 Topics: Administration, Topical; Adolescent; Adult; Child; Child, Preschool; Dinitrochlorobenzene; Drug Eval	1985