dinitrochlorobenzene has been researched along with Psoriasis in 24 studies
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quantitative techniques of sensitization to 2,4-dinitrochlorobenzene (DNCB) was used to determine in psoriasis the intensity and frequency of allergic reactions to DNCB following primary challenge with 2,000 microgram allergen and secondary challenge with decreasing doses of DNCB." | 7.65 | Immunological studies in psoriasis. The quantitative evaluation of cell-mediated immunity in patients with psoriasis by experimental sensitization to 2,4-dinitrochlorobenzene. ( Haftek, M; Obalek, S; Sliński, W, 1977) |
| "Cell mediated immune reactivity was studied in eighty-five psoriasis patients and twenty-five healthy controls by an improved (quantitative) method for measuring contact hypersensitivity to 2,4 dinitrochlorobenzene (DNCB)." | 3.66 | Impaired contact hypersensitivity in untreated psoriasis and the effects of photochemotherapy and dithranol/UV-B. ( Friedmann, PS; Moss, C; Shuster, S, 1981) |
| "Quantitative techniques of sensitization to 2,4-dinitrochlorobenzene (DNCB) was used to determine in psoriasis the intensity and frequency of allergic reactions to DNCB following primary challenge with 2,000 microgram allergen and secondary challenge with decreasing doses of DNCB." | 3.65 | Immunological studies in psoriasis. The quantitative evaluation of cell-mediated immunity in patients with psoriasis by experimental sensitization to 2,4-dinitrochlorobenzene. ( Haftek, M; Obalek, S; Sliński, W, 1977) |
| "Dinitrochlorobenzene (DNCB) has been used widely to assess cell-mediated immunity in man." | 1.27 | Quantitation of sensitization and responsiveness to dinitrochlorobenzene in normal subjects. ( Friedmann, PS; Moss, C; Shuster, S; Simpson, JM, 1983) |
| " We have developed quantitative techniques to explore the dose-response relationships of both afferent and efferent limbs of the response, and used this method to examine changes in reactivity to DNCB after exposure to UV radiation and in people with contact allergies." | 1.27 | Quantitation of sensitization and responsiveness to dinitrochlorobenzene in normal subjects. ( Friedmann, PS; Moss, C; Shuster, S; Simpson, JM, 1983) |
| " Responses to epicutaneous challenge with a series of concentrations of DNCB were measured as volumes calculated from diameter and thickness and the various groups were compared by the differences in the log dose-response curves." | 1.26 | Impaired contact hypersensitivity in untreated psoriasis and the effects of photochemotherapy and dithranol/UV-B. ( Friedmann, PS; Moss, C; Shuster, S, 1981) |
| "Patients with untreated psoriasis were less responsive than healthy controls; responses were less still in patients treated with dithranol/UV-B/tar and they were least of all in patients treated with photochemotherapy with 8-methoxypsoralen and UV-A (PUVA), particularly in those who pigmented least." | 1.26 | Impaired contact hypersensitivity in untreated psoriasis and the effects of photochemotherapy and dithranol/UV-B. ( Friedmann, PS; Moss, C; Shuster, S, 1981) |
| "The in vitro results in the ankylosing spondylitis, psoriatic arthritis and Reiter's disease patients suggest some abnormality in the T-cell population in sero-negative arthritis." | 1.25 | Cell-mediated immunity in the rheumatoid diseases. I. Skin testing and mitogenic responses in sero-negative arthritides. ( Dick, WC; Froebel, K; MacSween, RN; Sturrock, RD, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (91.67) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| von Bonin, A | 1 |
| Rausch, A | 1 |
| Mengel, A | 1 |
| Hitchcock, M | 1 |
| Krüger, M | 1 |
| von Ahsen, O | 1 |
| Merz, C | 1 |
| Röse, L | 1 |
| Stock, C | 1 |
| Martin, SF | 1 |
| Leder, G | 1 |
| Döcke, WD | 1 |
| Asadullah, K | 1 |
| Zügel, U | 1 |
| DEPAOLI, M | 1 |
| Strauss, GH | 2 |
| Bridges, BA | 1 |
| Greaves, M | 1 |
| Hall-Smith, P | 1 |
| Price, M | 1 |
| Vella-Briffa, D | 1 |
| Friedmann, PS | 5 |
| Moss, C | 5 |
| Shuster, S | 3 |
| Simpson, JM | 2 |
| Lubach, D | 1 |
| Marghescu, S | 1 |
| Bialasiewicz, AA | 1 |
| Fulton, RA | 1 |
| Souteyrand, P | 1 |
| Thivolet, J | 1 |
| Naik, SM | 1 |
| Cannon, G | 1 |
| Burbach, GJ | 1 |
| Singh, SR | 1 |
| Swerlick, RA | 1 |
| Wilcox, JN | 1 |
| Ansel, JC | 1 |
| Caughman, SW | 1 |
| Obalek, S | 1 |
| Haftek, M | 3 |
| Sliński, W | 1 |
| Vosmík, F | 2 |
| Hausner, P | 2 |
| Votava, L | 1 |
| Fucíková, T | 1 |
| Pekárek, J | 1 |
| Krueger, GG | 1 |
| Hill, HR | 1 |
| Jederberg, WW | 1 |
| Gliński, W | 2 |
| Obałek, S | 2 |
| Leshaw, S | 1 |
| Simon, RS | 1 |
| Bear, RL | 1 |
| Froebel, K | 1 |
| Sturrock, RD | 1 |
| Dick, WC | 1 |
| MacSween, RN | 1 |
| Heid, E | 1 |
| Bigel, P | 1 |
| Reuter, G | 1 |
| Fourssereau, J | 1 |
| Basset, A | 2 |
| Sandner-Roth, S | 1 |
| Foussereau, J | 1 |
| Bleumink, E | 1 |
| Nater, JP | 1 |
| White, SI | 2 |
| Parker, S | 1 |
| Matthews, JN | 1 |
| Prokhorenko, VI | 1 |
| Shapranova, IM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Photochemotherapy of Acute Graft-versus-host Disease (aGVHD) of the Skin - is Graft-versus-leukemia Preserved in Patients Transplanted for Acute Leukemia?[NCT02631993] | 47 participants (Actual) | Observational | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dinitrochlorobenzene and Psoriasis
| Article | Year |
|---|---|
[Disorders of immune regulation in psoriasis].
Topics: Autoantibodies; B-Lymphocytes; Complement C3; Concanavalin A; Cornea; Dinitrochlorobenzene; Humans; | 1980 |
[Role of Langerhans cells in the development of contact hypersensitivity of the skin].
Topics: Animals; Antigen-Antibody Complex; Cell Communication; Complement System Proteins; Dermatitis, Conta | 1985 |
Immunological aspects of psoriasis and alopecia areata.
Topics: Adolescent; Adult; Aged; Alopecia Areata; Dermatitis, Contact; Dinitrochlorobenzene; Female; Humans; | 1985 |
21 other studies available for dinitrochlorobenzene and Psoriasis
| Article | Year |
|---|---|
Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases.
Topics: Animals; Base Sequence; Dermatitis; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dinitrochlorob | 2011 |
[Toxic reaction and sensitization to 2,4-dinitrochlorobenzene in psoriasis patients].
Topics: Dinitrochlorobenzene; Humans; Nitrobenzenes; Postoperative Complications; Psoriasis | 1953 |
Inhibition of delayed hypersensitivity reaction in skin (DNCB test) by 8-methoxypsoralen photochemotherapy. Possible basis for pseudo-promoting action in skin carcinogenesis?
Topics: Adolescent; Adult; Aged; Cocarcinogenesis; Dinitrochlorobenzene; Female; Furocoumarins; Humans; Immu | 1980 |
Quantitation of sensitization and responsiveness to dinitrochlorobenzene in normal subjects.
Topics: Dermatitis, Contact; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Humans; Immunity, Cellu | 1983 |
PUVA: gambling with a system.
Topics: Animals; Dinitrochlorobenzene; DNA Repair; Humans; Immunosuppression Therapy; Photochemotherapy; Pso | 1982 |
How does PUVA inhibit delayed cutaneous hypersensitivity?
Topics: Dermatitis, Contact; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Drug Hypersensitivity; | 1982 |
Influence of retinoid Ro 10-9359 on cell-mediated immunity in vivo.
Topics: Dinitrochlorobenzene; Etretinate; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Imm | 1982 |
Impaired contact hypersensitivity in untreated psoriasis and the effects of photochemotherapy and dithranol/UV-B.
Topics: Adult; Aged; Anthralin; Dermatitis, Contact; Dinitrochlorobenzene; Dose-Response Relationship, Immun | 1981 |
Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene.
Topics: Dinitrochlorobenzene; Endothelium, Vascular; Fibroblasts; Humans; Immunohistochemistry; Inflammation | 1999 |
Immunological studies in psoriasis. The quantitative evaluation of cell-mediated immunity in patients with psoriasis by experimental sensitization to 2,4-dinitrochlorobenzene.
Topics: Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Hypersensitivity, Delayed; Immunity, Cellular; | 1977 |
[Immunological aspects of psoriasis (author's transl)].
Topics: Adolescent; Adult; Aged; Dinitrochlorobenzene; Female; Humans; Immunoglobulins; Lymphocyte Activatio | 1979 |
Inflammatory and immune cell function in psoriasis--a subtle disorder I. In vivo and in vitro survey.
Topics: Dinitrochlorobenzene; Humans; Immunity, Cellular; In Vitro Techniques; Inflammation; Lymphocytes; Ps | 1978 |
Restoration of normal experimental DNCB hypersensitivity development in symptom-free patients with psoriasis.
Topics: Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Immunity, Cellular; Nitrobenzenes; Psoriasis; R | 1978 |
Restoration of normal experimental DNCB hypersensitivity development in symptom-free patients with psoriasis.
Topics: Dinitrochlorobenzene; Dose-Response Relationship, Immunologic; Humans; Immunity, Cellular; Immunizat | 1978 |
Failure to induce tolerance to mechlorethamine hydrochloride.
Topics: Dermatitis, Contact; Dinitrochlorobenzene; Humans; Immune Tolerance; Mechlorethamine; Mycosis Fungoi | 1977 |
Cell-mediated immunity in the rheumatoid diseases. I. Skin testing and mitogenic responses in sero-negative arthritides.
Topics: Adult; Aged; Arthritis; Arthritis, Reactive; Dinitrochlorobenzene; Dose-Response Relationship, Drug; | 1975 |
[Cellular immunity in psoriasis].
Topics: Age Factors; B-Lymphocytes; Cell Count; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Imm | 1976 |
2,4-dinitrochlorobenzene sensitization of psoratic patients.
Topics: Dermatitis, Contact; Dinitrochlorobenzene; Humans; Immunity, Cellular; Middle Aged; Nitrobenzenes; P | 1975 |
2,4-dinitrochlorobenzene sensitization of psoriatic patients.
Topics: Age Factors; Dinitrochlorobenzene; Humans; Middle Aged; Nitrobenzenes; Patch Tests; Psoriasis; Time | 1975 |
Antigenic stimulation during ultraviolet therapy in man does not result in immunological tolerance.
Topics: Antigens; Dinitrochlorobenzene; Humans; Immune Tolerance; Immunization; Psoriasis; PUVA Therapy; Ult | 1989 |
Recovery of cutaneous immune responsiveness after PUVA therapy.
Topics: Dinitrochlorobenzene; Dose-Response Relationship, Immunologic; Female; Humans; Hypersensitivity, Del | 1988 |