dinitrochlorobenzene has been researched along with Malignant Melanoma in 79 studies
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-nine selected patients with recurrent melanoma (37 locoregional and 22 locoregional and haematogenic) were treated with a combination of topical dinitrochlorobenzene (DNCB) and systemic dacarbazine (DTIC)." | 9.08 | Topical dinitrochlorobenzene combined with systemic dacarbazine in the treatment of recurrent melanoma. ( Hart, AA; Israels, SP; Kroon, BB; Nieweg, OE; Rümke, P; Strobbe, LJ, 1997) |
| "Eighteen patients with multiple recurrences of malignant melanoma without evident distant spread were randomly assigned to treatment with either intralesional Bacillus Calmette-Guerin (BCG) or intralesional dinitrochlorobenzene (DNCB)." | 9.04 | Intralesional treatment of recurrent metastatic cutaneous malignant melanoma: a randomized prospective study of intralesional Bacillus Calmette-Guerin versus intralesional dinitrochlorobenzene. ( Cohen, MH; Felix, EL; Herberman, RB; Jessup, JM; Weese, JL, 1978) |
| "To scrutinize published data from small mono-centric studies and case reports which implicated high response rates and promising survival times for a combination therapy consisting of epifocal dinitrochlorobenzene (DNCB) and dacarbazine (DTIC) for metastasized melanoma." | 7.74 | Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group. ( Becker, JC; Beiteke, U; Bröcker, EB; Durani, B; Jünger, M; Junghans, V; Kortüm, AK; Mauch, C; Remling, R; Schadendorf, D; Schulze, HJ; Terheyden, P, 2007) |
| "An empirically established chemoimmunotherapy for metastatic melanoma combines the systemic administration of the chemotherapeutic agent dacarbazine (DTIC) with the epifocal application of the contact sensitizer 2,4-dinitrochlorobenzene (DNCB) on cutaneous metastases." | 7.71 | Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response. ( Becker, JC; Bröcker, EB; Fischer, WH; Kirst, A; Lutz, WK; Wack, C, 2002) |
| "Non-specific local immunotherapy using 2,4-dinitrochlorobenzene (DNCB) was combined with additional excision of the primary melanoma." | 7.67 | Immunosurgical approach to the treatment of malignant melanoma using 2,4-dinitrochlorobenzene (DNCB). ( István, M; Lukács, L, 1984) |
| "35 patients with malignant melanomas in different stages were treated with dinitrochlorobenzene according to Malek-Mansour in the last three years." | 7.66 | [Treatment of malignant melanoma with dinitrochlorobenzene ointment]. ( Ehring, F; Loth, H, 1978) |
| "Subcutaneous (s." | 5.31 | Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response. ( Becker, JC; Bröcker, EB; Fischer, WH; Kirst, A; Lutz, WK; Wack, C, 2002) |
| "Distant metastases may react--but normally these metastases cannot be removed." | 5.26 | [Treatment of malignant melanoma with dinitrochlorobenzene ointment]. ( Ehring, F; Loth, H, 1978) |
| "Studies of primary sensitization and delayed hypersensitivity reactions to 2,4-dintrochlorobenzene (DNCB) and recall antigens were conducted in 71 patients with melanoma who were receiving BCG (Tice strain) immunotherapy by scarification." | 5.26 | Effect of BCG (Tice strain) on primary sensitization to 2,4-dinitrochlorobenzene and on established delayed hypersensitivity in human malignant melanoma. ( Gutterman, JU; Hersh, EM; Mavligit, GM, 1976) |
| "Fifty-nine selected patients with recurrent melanoma (37 locoregional and 22 locoregional and haematogenic) were treated with a combination of topical dinitrochlorobenzene (DNCB) and systemic dacarbazine (DTIC)." | 5.08 | Topical dinitrochlorobenzene combined with systemic dacarbazine in the treatment of recurrent melanoma. ( Hart, AA; Israels, SP; Kroon, BB; Nieweg, OE; Rümke, P; Strobbe, LJ, 1997) |
| "Eighteen patients with multiple recurrences of malignant melanoma without evident distant spread were randomly assigned to treatment with either intralesional Bacillus Calmette-Guerin (BCG) or intralesional dinitrochlorobenzene (DNCB)." | 5.04 | Intralesional treatment of recurrent metastatic cutaneous malignant melanoma: a randomized prospective study of intralesional Bacillus Calmette-Guerin versus intralesional dinitrochlorobenzene. ( Cohen, MH; Felix, EL; Herberman, RB; Jessup, JM; Weese, JL, 1978) |
| "To scrutinize published data from small mono-centric studies and case reports which implicated high response rates and promising survival times for a combination therapy consisting of epifocal dinitrochlorobenzene (DNCB) and dacarbazine (DTIC) for metastasized melanoma." | 3.74 | Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group. ( Becker, JC; Beiteke, U; Bröcker, EB; Durani, B; Jünger, M; Junghans, V; Kortüm, AK; Mauch, C; Remling, R; Schadendorf, D; Schulze, HJ; Terheyden, P, 2007) |
| "An empirically established chemoimmunotherapy for metastatic melanoma combines the systemic administration of the chemotherapeutic agent dacarbazine (DTIC) with the epifocal application of the contact sensitizer 2,4-dinitrochlorobenzene (DNCB) on cutaneous metastases." | 3.71 | Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response. ( Becker, JC; Bröcker, EB; Fischer, WH; Kirst, A; Lutz, WK; Wack, C, 2002) |
| "Delayed cutaneous hypersensitivity to 2,3-dinitrochlorobenzene (DNCB) was tested in 419 patients with malignant melanoma to determine whether DNCB reactivity was associated with prognosis." | 3.66 | DNCB reactivity and prognosis in 419 patients with malignant melanoma. ( Braun, DW; Camacho, ES; Fortner, JG; Golbey, RB; Oettgen, HF; Pinsky, CM; Wanebo, HJ, 1981) |
| "Cell factors of nonspecific immunity were estimated in 99 patients with different stages of melanoblastoma by delayed hypersensitivity skin test to tuberculin and DNCB (2,4-dinitrochlorobenzene)." | 3.66 | [Skin reactions of delayed hypersensitivity in melanoblastoma]. ( Khachaturian, LM; Korosteleva, TA; Potapenkova, LS; Ryzhkov, VI, 1979) |
| "Report on the application of a dinitrochlorobenzene ointment of 61 postoperative melanoma patients exhibiting clinical stages I and II." | 3.66 | [Adjuvant DNCB immunotherapy in malignant melanoma]. ( Djawari, D; Weidner, F, 1979) |
| "35 patients with malignant melanomas in different stages were treated with dinitrochlorobenzene according to Malek-Mansour in the last three years." | 3.66 | [Treatment of malignant melanoma with dinitrochlorobenzene ointment]. ( Ehring, F; Loth, H, 1978) |
| "Patients with malignant skin melanoma were given different kinds of immunotherapy; nonspecific immunotherapy with BCG vaccine, adaptive immunotherapy with methotrexate or phytohemagglutinin activated autolymphocytes, and also a combination of polychemotherapy with BCG." | 3.65 | [Immunological reactions of skin melanoma patients to nonspecific and adaptive immunotherapy]. ( Iavorskiĭ, VV; Kadagidze, ZG; Kupin, VI; Malaev, SG; Trapeznikov, NN, 1977) |
| "Patients with Hodgkin's disease tend to have depressed responses to both newly encountered and recall antigens." | 2.35 | Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions. ( Burdick, JF; Herberman, RB; Wells, SA, 1975) |
| "Testing of delayed hypersensitivity responses to recall antigens, newly encountered antigens and tumor antigens has contributed to the understanding of several immunologic factors in human neoplasia." | 2.35 | Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions. ( Burdick, JF; Herberman, RB; Wells, SA, 1975) |
| "Patients with solid tumors are more likely to be deficient only in the response to newly encountered antigens." | 2.35 | Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions. ( Burdick, JF; Herberman, RB; Wells, SA, 1975) |
| "Subcutaneous (s." | 1.31 | Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response. ( Becker, JC; Bröcker, EB; Fischer, WH; Kirst, A; Lutz, WK; Wack, C, 2002) |
| "However, central nervous system (CNS) metastases continue to develop in these patients and represent the single most frequent cause of death." | 1.26 | Failure of adjuvant immunotherapy to prevent central nervous system metastases in malignant melanoma patients. ( Eilber, FR; Grooms, GA; Morton, DL, 1977) |
| "The DNCB-method in malignant melanoma is yet in the experimental stage and is not recommended for general use in practice." | 1.26 | [Adjuvant DNCB immunotherapy in malignant melanoma]. ( Djawari, D; Weidner, F, 1979) |
| "3 melanoma patients suffering from skin metastases were treated by epifocal DNCB-application." | 1.26 | [Adjuvant DNCB immunotherapy in malignant melanoma]. ( Djawari, D; Weidner, F, 1979) |
| "The personal series consists of 140 cancer patients followed up over a period of some 3 years and submitted prior to the start of treatment to the DNCB skin test." | 1.26 | [The DNCB skin test and its comparison with the radioimmunological determination of CEA in some types of neoplasms]. ( Bianucci, P; De Rossi, O; Pastorino, G, 1979) |
| "Distant metastases may react--but normally these metastases cannot be removed." | 1.26 | [Treatment of malignant melanoma with dinitrochlorobenzene ointment]. ( Ehring, F; Loth, H, 1978) |
| "Anergy demonstrated by delayed hypersensitivity skin testing appears to reflect increasing tumor burden, rather than a preexisting deficiency that can be used to predict patients at high risk for the development of recurrent disease." | 1.26 | Malignant melanoma. Delayed hypersensitivity skin testing. ( Campion, JF; Gumport, SL; Harris, MN; Roses, DF, 1979) |
| "Immunotherapy against cancer in animals has been established." | 1.25 | Immunotherapy of malignancy in humans. Current status. ( Eilber, FR; Holmes, EC; Morton, DL, 1975) |
| "Six of 13 normal donors and 2 of 9 cancer patients had a fall in blood lymphocyte count which was below the lower limit of the range of change in control donors immediately following leukapheresis, but all returned to control range within 24 hours." | 1.25 | Effects on cancer patients of leukapheresis with the continuous-flow blood cell separator. I. Hematologic and immunologic parameters in vivo. ( Pilch, YH; Roth, JA; Silverstein, M; Veltman, LL; Waldman, SR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (86.08) | 18.7374 |
| 1990's | 7 (8.86) | 18.2507 |
| 2000's | 3 (3.80) | 29.6817 |
| 2010's | 1 (1.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trowbridge, RM | 1 |
| Mitkov, MV | 1 |
| Pittelkow, MR | 1 |
| Agrawal, DK | 1 |
| Wack, C | 1 |
| Kirst, A | 1 |
| Becker, JC | 3 |
| Lutz, WK | 1 |
| Bröcker, EB | 4 |
| Fischer, WH | 1 |
| von Nida, J | 1 |
| Quirk, C | 1 |
| Terheyden, P | 1 |
| Kortüm, AK | 1 |
| Schulze, HJ | 1 |
| Durani, B | 1 |
| Remling, R | 1 |
| Mauch, C | 1 |
| Junghans, V | 1 |
| Schadendorf, D | 1 |
| Beiteke, U | 1 |
| Jünger, M | 1 |
| Thiers, BH | 1 |
| Heid, E | 2 |
| Grosshans, E | 1 |
| Laplanche, G | 1 |
| Caussade, P | 1 |
| Lukács, L | 1 |
| István, M | 1 |
| Przybilla, B | 1 |
| Burg, G | 2 |
| Thieme, C | 1 |
| Korosteleva, TA | 2 |
| Vagner, RI | 1 |
| Veresova, OV | 1 |
| Potapenkova, LS | 2 |
| Dionigi, R | 1 |
| Dominioni, L | 1 |
| Gnes, F | 1 |
| Bonera, A | 1 |
| Prati, U | 1 |
| Scarponi, A | 1 |
| Robustelli Della Cuna, G | 1 |
| Pavesi, L | 1 |
| Campani, M | 1 |
| Moszkowska, G | 1 |
| Jassem, J | 1 |
| Kondrat, W | 1 |
| Kopacz, A | 1 |
| Goszczyńska, E | 1 |
| Camacho, ES | 1 |
| Pinsky, CM | 3 |
| Braun, DW | 1 |
| Golbey, RB | 1 |
| Fortner, JG | 2 |
| Wanebo, HJ | 3 |
| Oettgen, HF | 2 |
| Ehring, E | 1 |
| Loth, H | 2 |
| Giuliano, AE | 1 |
| Moseley, HS | 1 |
| Irie, RF | 1 |
| Golub, SH | 3 |
| Morton, DL | 7 |
| Djawari, D | 2 |
| Körner, E | 1 |
| Haneke, E | 1 |
| Duchková, H | 5 |
| Peska, J | 1 |
| Richter, J | 5 |
| Kubíková, M | 3 |
| Vohryzková, E | 1 |
| Moróc, A | 1 |
| Král, V | 1 |
| Inbar, M | 1 |
| Merimsky, O | 1 |
| Adler, A | 1 |
| Stein, JA | 1 |
| Okano-Mitani, H | 1 |
| Ikai, K | 1 |
| Imamura, S | 1 |
| Strobbe, LJ | 1 |
| Hart, AA | 1 |
| Rümke, P | 1 |
| Israels, SP | 1 |
| Nieweg, OE | 1 |
| Kroon, BB | 1 |
| Trcka, J | 1 |
| Kämpgen, E | 2 |
| Schwaaf, A | 1 |
| Göring, HD | 1 |
| Zierner, A | 1 |
| Kröning, Y | 1 |
| Trebing, D | 1 |
| Schneider, I | 1 |
| Aulepp, H | 1 |
| Gartmann, H | 1 |
| Burdick, JF | 1 |
| Wells, SA | 1 |
| Herberman, RB | 2 |
| Holmes, EC | 1 |
| Eilber, FR | 2 |
| Pritchard, DJ | 1 |
| Ritts, RE | 1 |
| Taylor, WF | 1 |
| Miller, GC | 1 |
| Dodd, MJ | 1 |
| Clark, WH | 1 |
| Mastrangelo, MJ | 2 |
| Ainsworth, AM | 1 |
| Berd, D | 2 |
| Bellet, RE | 2 |
| Bernardino, EA | 1 |
| Grooms, GA | 1 |
| Schieferstein, G | 1 |
| Goodnight, JE | 1 |
| Wilson, EJ | 1 |
| Aranha, GV | 1 |
| McKhann, CF | 1 |
| Simmons, RL | 1 |
| Grage, TB | 1 |
| Ryzhkov, VI | 1 |
| Khachaturian, LM | 1 |
| Weidner, F | 1 |
| Bianucci, P | 1 |
| Pastorino, G | 1 |
| De Rossi, O | 1 |
| Ehring, F | 1 |
| Cohen, MH | 3 |
| Jessup, JM | 2 |
| Felix, EL | 2 |
| Weese, JL | 1 |
| Knopf, B | 1 |
| Wätzig, V | 2 |
| Knöll, B | 1 |
| Roses, DF | 1 |
| Campion, JF | 1 |
| Harris, MN | 1 |
| Gumport, SL | 1 |
| Tritsch, H | 1 |
| Jewell, WR | 1 |
| Thomas, JH | 1 |
| Sterchi, JM | 1 |
| Morse, PA | 1 |
| Humphrey, LJ | 1 |
| Gutterman, JU | 2 |
| Mavligit, G | 1 |
| Reed, R | 1 |
| Richman, S | 1 |
| McBride, CE | 1 |
| Hersh, EM | 2 |
| Klein, E | 1 |
| Rosner, D | 1 |
| Holtermann, OA | 1 |
| Stoll, HL | 1 |
| Song, SY | 1 |
| Braun-Falco, O | 1 |
| Tarpley, JL | 1 |
| Twomey, PL | 1 |
| Catalona, WJ | 1 |
| Chretien, PB | 1 |
| Rangel, DM | 1 |
| Gersten, MJ | 1 |
| Hadden, EM | 1 |
| Kaplan, MH | 1 |
| Armstrong, D | 1 |
| Hadden, JW | 1 |
| Trapeznikov, NN | 1 |
| Iavorskiĭ, VV | 1 |
| Kadagidze, ZG | 1 |
| Malaev, SG | 1 |
| Kupin, VI | 1 |
| Kokoschka, EM | 2 |
| Cerni, C | 1 |
| Micksche, M | 2 |
| Mavligit, GM | 1 |
| Tomaszewski, MM | 1 |
| Castermans, A | 2 |
| Vanwijck, R | 2 |
| Illig, L | 1 |
| Paul, E | 1 |
| Hirshaut, Y | 1 |
| Miké, V | 1 |
| Schottenfeld, D | 1 |
| Bouillenne, C | 1 |
| Malek-Mansour, S | 2 |
| Florman, AL | 1 |
| Holzman, RS | 1 |
| Bolton, PM | 1 |
| Vanwicjk, R | 1 |
| Rustin, P | 1 |
| Castermans-Elias, S | 1 |
| Bulkley, GB | 1 |
| Banks, PM | 1 |
| Char, DH | 1 |
| Ketcham, AS | 1 |
| Scherbel, VG | 1 |
| Weidemann, G | 1 |
| Waldman, SR | 1 |
| Roth, JA | 1 |
| Silverstein, M | 1 |
| Veltman, LL | 1 |
| Pilch, YH | 1 |
| Claudy, AL | 1 |
| Viac, J | 1 |
| Pelletier, N | 1 |
| Fouad-Wassef, N | 1 |
| Alario, A | 1 |
| Thivolet, J | 1 |
| Bigel, P | 1 |
| Robez, OG | 1 |
| Guenthner, TM | 1 |
| Whalen, R | 1 |
| Jevtović-Todorović, V | 1 |
| Sigg, C | 1 |
| Schnyder, UW | 1 |
| Valsecchi, R | 1 |
| Foiadelli, L | 1 |
| Reseghetti, A | 1 |
| Cainelli, T | 1 |
| Budzanowska, E | 1 |
| Pawlicki, M | 1 |
| Munzarová, M | 1 |
| Mechl, Z | 1 |
| Kovarík, J | 1 |
| Kolcová, V | 1 |
| Mayerhausen, W | 2 |
| Remy, W | 2 |
| Dorn, R | 1 |
| Ulm, K | 1 |
| O'Connell, TX | 1 |
12 reviews available for dinitrochlorobenzene and Malignant Melanoma
| Article | Year |
|---|---|
Immunomodulation of malignant melanoma by contact sensitizing agents.
Topics: Animals; CD8-Positive T-Lymphocytes; Cyclopropanes; Dinitrochlorobenzene; Humans; Immunity, Cellular | 2014 |
Immunotherapy of malignant melanoma.
Topics: Antigens, Neoplasm; BCG Vaccine; Cholera Vaccines; Clinical Trials as Topic; Dacarbazine; Dinitrochl | 1982 |
[Dinitrochlorobenzene. Therapeutic use].
Topics: Alopecia Areata; Carcinoma, Basal Cell; Dermatitis, Contact; Dinitrochlorobenzene; Humans; Hypersens | 1984 |
Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions.
Topics: Antigens; Antigens, Neoplasm; Arthus Reaction; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Coloni | 1975 |
Current concepts of the biology of human cutaneous malignant melanoma.
Topics: Antibodies, Neoplasm; Antigens, Neoplasm; Chromosome Aberrations; Dinitrochlorobenzene; Female; Huma | 1977 |
[The immunology of malignant melanoma (author's transl)].
Topics: Animals; Antibodies, Neoplasm; Cricetinae; Dinitrochlorobenzene; Humans; Immunization; Immunoglobuli | 1978 |
The role of immunotherapy in the management of patients with malignant melanoma.
Topics: Bacterial Vaccines; BCG Vaccine; Corynebacterium; Dacarbazine; Dinitrochlorobenzene; Drug Therapy, C | 1979 |
[Development in the immunotherapy of malignant melanoma].
Topics: Adjuvants, Immunologic; Antibodies, Neoplasm; Antigens, Neoplasm; BCG Vaccine; Cytotoxicity Tests, I | 1976 |
Immunology and immunotherapy of human-malignant melanoma: historic review and perspectives for the future.
Topics: Animals; Antibodies, Neoplasm; Antibody Formation; BCG Vaccine; Cell Migration Inhibition; Dinitroch | 1975 |
Nonspecific enhancers of resistance in man.
Topics: Adjuvants, Immunologic; Animals; Ascorbic Acid; Bacteria; BCG Vaccine; Dinitrochlorobenzene; Endotox | 1975 |
DNCB sensitivity in cancer patients. A review based on sequential testing in 430 patients.
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Dinitrochlorob | 1975 |
Cancer immunotherapy: an overview.
Topics: Adult; Aged; Antibodies, Neoplasm; Antigens, Neoplasm; Antineoplastic Agents; BCG Vaccine; Dinitroch | 1974 |
5 trials available for dinitrochlorobenzene and Malignant Melanoma
| Article | Year |
|---|---|
Immunotherapy of malignant melanoma.
Topics: Antigens, Neoplasm; BCG Vaccine; Cholera Vaccines; Clinical Trials as Topic; Dacarbazine; Dinitrochl | 1982 |
Evaluation of the immune status in vivo by the 2,4-dinitro-1-chlorobenzene contact allergy time (DNCB-CAT).
Topics: Adult; Aged; Aging; Dermatitis, Contact; Dinitrochlorobenzene; Female; Humans; Immunity, Cellular; I | 1983 |
Topical dinitrochlorobenzene combined with systemic dacarbazine in the treatment of recurrent melanoma.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemoth | 1997 |
Intralesional treatment of recurrent metastatic cutaneous malignant melanoma: a randomized prospective study of intralesional Bacillus Calmette-Guerin versus intralesional dinitrochlorobenzene.
Topics: Adult; Aged; Antigens; Antigens, Neoplasm; BCG Vaccine; Cell Migration Inhibition; Dinitrochlorobenz | 1978 |
Randomized trial of Bacillus Calmette-Guérin (percutaneous administration) as surgical adjuvant immunotherapy for patients with stage-II melanoma.
Topics: BCG Vaccine; Dinitrochlorobenzene; Female; Humans; Immunotherapy; Injections; Male; Melanoma; Middle | 1976 |
63 other studies available for dinitrochlorobenzene and Malignant Melanoma
| Article | Year |
|---|---|
Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarb | 2002 |
Successful treatment of in-transit melanoma metastases using topical 2-4 dinitrochlorobenzene.
Topics: Administration, Topical; Aged; Biopsy, Needle; Combined Modality Therapy; Dinitrochlorobenzene; Dise | 2003 |
Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dinitrochlorobenzene; Dise | 2007 |
Immunosurgical approach to the treatment of malignant melanoma using 2,4-dinitrochlorobenzene (DNCB).
Topics: Adult; Combined Modality Therapy; Dinitrochlorobenzene; Female; Humans; Immunotherapy; Male; Melanom | 1984 |
[Correlation of the level of humoral cytotoxins and delayed hypersensitivity skin reactions with survival of patients with melanoma of the skin].
Topics: Adult; Aged; Antibody Formation; Cytotoxins; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed | 1983 |
Sequential evaluation of immunoreactivity in patients with melanoma undergoing surgery and adjuvant therapy.
Topics: Adult; Aged; Chemotaxis, Leukocyte; Dinitrochlorobenzene; Female; Humans; Immunity, Cellular; Immuno | 1980 |
Some aspects of cell-mediated hypersensitivity in patients with melanoma.
Topics: Adult; Aged; Dinitrochlorobenzene; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Le | 1980 |
DNCB reactivity and prognosis in 419 patients with malignant melanoma.
Topics: Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Melanoma; Neoplasm Metastasis; Neoplasm Rec | 1981 |
DNCB skin test in cases of malignant melanoma.
Topics: Dinitrochlorobenzene; Humans; Melanoma; Nitrobenzenes; Skin Neoplasms; Skin Tests | 1981 |
Immunologic aspects of unknown primary melanoma.
Topics: Adult; Aged; Antibody Formation; Dinitrochlorobenzene; Female; Humans; Hypersensitivity, Delayed; Im | 1980 |
[Cross allergies following sensitization with dinitrochlorbenzol (DNCB)].
Topics: Cross Reactions; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Immunotherapy; Melanoma; N | 1980 |
[Skin tests and malignant melanoma].
Topics: Adult; Child; Dinitrochlorobenzene; Humans; Melanoma; Skin Tests; Tuberculin Test | 1980 |
[Vitiligo and malignant melanoma].
Topics: BCG Vaccine; Dinitrochlorobenzene; Female; Humans; Male; Melanoma; Vitiligo | 1980 |
DNCB for local control of malignant melanoma: don't forget a winning horse!
Topics: Adjuvants, Immunologic; Adult; Dinitrochlorobenzene; Humans; Irritants; Male; Melanoma | 1996 |
Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4.
Topics: Dinitrochlorobenzene; Enzyme Inhibitors; Epoxide Hydrolases; Ethylmaleimide; Glutathione Transferase | 1997 |
[Immunochemotherapy of malignant melanoma. Epifocal administration of dinitrochlorobenzene (DNCB) combined with systemic chemotherapy with dacarbazine (DTIC)].
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Combined Modality Th | 1998 |
Effective combined immunochemotherapy with dinitrochlorobenzene and fotemustine in skin and brain metastases of melanoma.
Topics: Allergens; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dermatitis, Allergic C | 1998 |
[Histological and histochemical studies on melanoma metastases under immunobiological and cytostatic therapy].
Topics: Antineoplastic Agents; BCG Vaccine; Bleomycin; Cytarabine; Dinitrochlorobenzene; Fluorouracil; Human | 1976 |
Immunotherapy of malignancy in humans. Current status.
Topics: Adjuvants, Immunologic; Antigens, Neoplasm; BCG Vaccine; Carcinoma, Basal Cell; Carcinoma, Squamous | 1975 |
A prospective study of immune responsiveness in human melanoma. I. Assessment of initial pretreatment status with stage of disease.
Topics: Dinitrochlorobenzene; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; In Vitro Techni | 1978 |
BCG in cancer therapy: theoretical bases of immunotherapy.
Topics: Antigens, Neoplasm; BCG Vaccine; Dinitrochlorobenzene; Humans; Immunity, Cellular; Immunotherapy; Ly | 1979 |
Failure of adjuvant immunotherapy to prevent central nervous system metastases in malignant melanoma patients.
Topics: Adjuvants, Immunologic; BCG Vaccine; Brain Neoplasms; Dinitrochlorobenzene; Humans; Immunotherapy; L | 1977 |
Immunologic testing as a guide to cancer management.
Topics: Antibody Formation; Antigen-Antibody Complex; Breast Neoplasms; Colonic Neoplasms; Complement System | 1979 |
Effect of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea adjuvant therapy on the immune response of patients with malignant melanoma.
Topics: Adult; Aged; Antibody Formation; Antigens; Dinitrochlorobenzene; Escherichia coli; Female; Hemocyani | 1979 |
Recall skin-test antigens and the prognosis of stage I melanoma.
Topics: Adult; Aged; Antigens; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Intradermal Tests; M | 1979 |
[Skin reactions of delayed hypersensitivity in melanoblastoma].
Topics: Adult; Aged; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Immunity, | 1979 |
[Adjuvant DNCB immunotherapy in malignant melanoma].
Topics: Adult; Aged; Dinitrochlorobenzene; Female; Humans; Male; Melanoma; Melphalan; Middle Aged; Neoplasm | 1979 |
[The DNCB skin test and its comparison with the radioimmunological determination of CEA in some types of neoplasms].
Topics: Breast Neoplasms; Carcinoembryonic Antigen; Dinitrochlorobenzene; Female; Gastrointestinal Neoplasms | 1979 |
[Treatment of malignant melanoma with dinitrochlorobenzene ointment].
Topics: Aged; Dinitrochlorobenzene; Female; Humans; Melanoma; Middle Aged; Neoplasm Metastasis; Nitrobenzene | 1978 |
[Contribution to treatment of malignant melanoblastoma by the local application of DNCB (author's transl)].
Topics: Administration, Topical; Aged; Dinitrochlorobenzene; Female; Humans; Immunity, Cellular; Melanoma; N | 1978 |
[Studies on the immune status of melanoma patients: cell-mediated immune reactions in intracutaneous and epicutaneous tests in the lymphocyte transformation test and the leukocyte-migration inhibition test before and during BCG immunotherapy (author's tra
Topics: Adult; Aged; BCG Vaccine; Cell Migration Inhibition; Dinitrochlorobenzene; Humans; Immunity, Cellula | 1978 |
Malignant melanoma. Delayed hypersensitivity skin testing.
Topics: Adult; Aged; Antigens; Dinitrochlorobenzene; Female; Follow-Up Studies; Humans; Hypersensitivity, De | 1979 |
Critical analysis of treatment of stage II and stage III melanoma patients with immunotherapy.
Topics: Antigens, Neoplasm; B-Lymphocytes; Blood Transfusion; Dinitrochlorobenzene; Female; Humans; Immune A | 1976 |
Nonspecific antigen reactions.
Topics: Administration, Topical; Antibody Formation; Antigens; Antineoplastic Agents; BCG Vaccine; Breast Ne | 1976 |
[1-Chloro-2,4-dinitrobenzene ointment for sensitization, testing and therapy of malignant melanoma patients].
Topics: Aged; Chemical Phenomena; Chemistry; Dinitrochlorobenzene; Female; Humans; Male; Melanoma; Middle Ag | 1977 |
Suppression of cellular immunity by anesthesia and operation.
Topics: Adenocarcinoma; Adult; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Carcino | 1977 |
Demonstration of lymphocyte blastogenesis--inhibiting factors in sera of melanoma patients.
Topics: Adolescent; Adult; Aged; Dinitrochlorobenzene; Female; Humans; In Vitro Techniques; Lymphocyte Activ | 1977 |
Immunologic defects in melanoma patients: lack of effect of BCG therapy.
Topics: BCG Vaccine; Dinitrochlorobenzene; Humans; Lectins; Leukocyte Count; Lymphocyte Activation; Melanoma | 1977 |
[Immunological reactions of skin melanoma patients to nonspecific and adaptive immunotherapy].
Topics: Antigen-Antibody Reactions; BCG Vaccine; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Im | 1977 |
Active specific and active non-specific immunotherapy in patients with malignant melanoma.
Topics: Adult; Aged; Antigens, Neoplasm; BCG Vaccine; Cell Migration Inhibition; Dinitrochlorobenzene; Femal | 1977 |
[DNCB immunotherapy for removal of melanoma skin metastases].
Topics: Dinitrochlorobenzene; Humans; Immunotherapy; Melanoma; Neoplasm Metastasis; Nitrobenzenes; Skin Neop | 1977 |
Effect of BCG (Tice strain) on primary sensitization to 2,4-dinitrochlorobenzene and on established delayed hypersensitivity in human malignant melanoma.
Topics: Antigens; BCG Vaccine; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed; Melanoma; Nitrobenze | 1976 |
Effects of murine tumors on delayed hypersensitivity to dinitrochlorobenzene. I. Description of anergy caused by transplanted tumors.
Topics: Animals; Dinitrochlorobenzene; Female; Fibrosarcoma; Hypersensitivity, Delayed; Immune Tolerance; Im | 1976 |
[Immunotherapy of tumors: from the laboratory to the clinic].
Topics: Animals; Dinitrochlorobenzene; Humans; Immunotherapy; Melanoma; Nitrobenzenes | 1976 |
[Immunotherapy of malignant melanoma (active specific and non-specific immune stimulation) (author's transl)].
Topics: Antibody Formation; Antigens, Neoplasm; BCG Vaccine; Dinitrochlorobenzene; Humans; Hypersensitivity, | 1976 |
[The nonspecific epifocal Malek-Mansour immunotherapy of malignant cutaneous melanoma using DNCB].
Topics: Administration, Topical; Adult; Aged; Cell Transformation, Neoplastic; Dinitrochlorobenzene; Female; | 1976 |
Potentiation and arming of lymphocyte mediated immunity by sera from melanoma patients.
Topics: Agglutination Tests; Antibodies, Anti-Idiotypic; Cell Line; Cytotoxicity Tests, Immunologic; Dinitro | 1975 |
[Problems of immunotherapy in malignant melanoblastoma].
Topics: BCG Vaccine; Dinitrochlorobenzene; Female; Humans; Immunity, Cellular; Immunotherapy; Male; Melanoma | 1975 |
[Preliminary results of immuno-surgical treatment of primary melanoma (author's transl)].
Topics: Adult; Aged; Autoantibodies; Cytotoxicity Tests, Immunologic; Dinitrochlorobenzene; Female; Humans; | 1975 |
Long-term spontaneous regression of malignant melanoma with visceral metastases. Report of a case with immunologic profile.
Topics: Autoantigens; Cell Migration Inhibition; Cytotoxicity Tests, Immunologic; Dinitrochlorobenzene; Fema | 1975 |
[New method for intranodular administration of 2,4-dinitro-1-chlorobenzene].
Topics: Adjuvants, Pharmaceutic; Dimethyl Sulfoxide; Dinitrochlorobenzene; Immunotherapy; Injections; Melano | 1975 |
[Activity of 2,4 dinitrochlorbenzene skin tests during the course of immunotherapy of malignant melanomas].
Topics: BCG Vaccine; Dinitrochlorobenzene; Humans; Melanoma; Nitrobenzenes; Skin Neoplasms; Skin Tests | 1975 |
Effects on cancer patients of leukapheresis with the continuous-flow blood cell separator. I. Hematologic and immunologic parameters in vivo.
Topics: Adult; Antigens; Blood Cell Count; Blood Platelets; Cell Separation; Dinitrochlorobenzene; Female; H | 1975 |
Prognostic correlations in malignant melanoma.
Topics: Dinitrochlorobenzene; Female; Humans; Immune Adherence Reaction; Immunity, Cellular; Lymphocyte Acti | 1975 |
[The immunological status in malignant melanoma].
Topics: Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Lymphocyte Activation; Melanoma; Skin Tests | 1975 |
Direct measurement of melphalan conjugation with glutathione: studies with human melanoma cells and mammalian liver.
Topics: Animals; Dinitrochlorobenzene; Glutathione; Guinea Pigs; In Vitro Techniques; Liver; Male; Melanoma; | 1992 |
Successful immunotherapy by dinitrochlorobenzene in a case of recurrent acrolentiginous melanoma.
Topics: Administration, Topical; Aged; Dinitrochlorobenzene; Female; Foot Diseases; Humans; Immunotherapy; M | 1990 |
Generalized urticaria from DNCB.
Topics: Aged; Combined Modality Therapy; Dinitrochlorobenzene; Drug Eruptions; Female; Humans; Immunotherapy | 1986 |
An attempt at topical DNCB immunomodulation in advanced malignant melanoma.
Topics: Administration, Topical; Adult; Aged; Dinitrochlorobenzene; Female; Humans; Lymphatic Metastasis; Me | 1988 |
Skin tests with autologous cholesteryl hemisuccinate-treated tumor cells, DNCB and PPD and their relationship to prognosis in malignant melanoma patients.
Topics: Adult; Aged; Cholesterol Esters; Dinitrochlorobenzene; Female; Humans; Male; Melanoma; Middle Aged; | 1988 |
[Testing of cellular immune reactivity in melanoma patients with diphenylcyclopropenone in comparison to dinitrochlorobenzol].
Topics: Cyclopropanes; Dinitrochlorobenzene; Humans; Immune Tolerance; Immunity, Cellular; Melanoma; Patch T | 1987 |
[Decrease in immunoreactivity in melanoma. Analysis of DNCB tests in the literature].
Topics: Dinitrochlorobenzene; Humans; Immune Tolerance; Melanoma; Neoplasm Metastasis; Neoplasm Staging; Ski | 1986 |
Lymphocyte stimulation tests in cancer patients.
Topics: Adult; Carcinoma; Dinitrochlorobenzene; Humans; In Vitro Techniques; Leukocyte Count; Lymphocytes; M | 1973 |