dinitrochlorobenzene has been researched along with Dermatitis, Allergic Contact in 96 studies
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Dermatitis, Allergic Contact: A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aims to investigate the effects of ozonated oil on treating 2,4-dinitrochlorobenzene (DNCB)-induced allergic contact dermatitis (ACD) and the underling mechanisms." | 8.31 | Ozonated oil alleviates dinitrochlorobenzene-induced allergic contact dermatitis via inhibiting the FcεRI/Syk signaling pathway. ( Fu, Z; Gao, L; Lu, J; Tan, L; Xie, Y; Yu, X; Zeng, J; Zeng, L; Zhou, L, 2023) |
| "Indirubin might be a useful treatment for allergic contact dermatitis via regulating the co-expression of T helper (Th) 1 and 2 cell-mediated immune responses." | 7.79 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| "Indirubin treatment suppressed skin inflammation in DNCB-exposed mice." | 7.79 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| "The anti-inflammatory activity of topical nanocrystalline silver cream was assessed and compared with the effects of topical steroids and currently available immunosuppressants using a guinea pig model of allergic contact dermatitis." | 7.72 | Anti-inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a guinea pig model. ( Alroy, J; Bhol, KC; Schechter, PJ, 2004) |
| "Indirubin treatment suppressed skin inflammation in DNCB-exposed mice." | 5.39 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| "Indirubin might be a useful treatment for allergic contact dermatitis via regulating the co-expression of T helper (Th) 1 and 2 cell-mediated immune responses." | 5.39 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| " This study aims to investigate the effects of ozonated oil on treating 2,4-dinitrochlorobenzene (DNCB)-induced allergic contact dermatitis (ACD) and the underling mechanisms." | 4.31 | Ozonated oil alleviates dinitrochlorobenzene-induced allergic contact dermatitis via inhibiting the FcεRI/Syk signaling pathway. ( Fu, Z; Gao, L; Lu, J; Tan, L; Xie, Y; Yu, X; Zeng, J; Zeng, L; Zhou, L, 2023) |
| "2,4-Dinitrochlorobenzene (DNCB) is widely used in human clinical studies and in experimental animal studies to evoke allergic contact dermatitis." | 3.80 | Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist. ( Chapman, H; Koivisto, A; Lauerma, AI; Lindstedt, K; Saarnilehto, M; Savinko, T, 2014) |
| "Indirubin might be a useful treatment for allergic contact dermatitis via regulating the co-expression of T helper (Th) 1 and 2 cell-mediated immune responses." | 3.79 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| "Indirubin treatment suppressed skin inflammation in DNCB-exposed mice." | 3.79 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| "Offspring of toluene diisocyanate but not dinitrochlorobenzene-treated mothers developed an asthmatic phenotype following allergen sensitization and challenge, seen as increased Penh values, airway inflammation, bronchoalveolar lavage total cell counts and eosinophilia, and Th2 cytokine imbalance in the lung." | 3.74 | Maternal allergic contact dermatitis causes increased asthma risk in offspring. ( Arredouani, MS; Fedulov, A; Hubeau, C; Kobzik, L; Lim, RH, 2007) |
| "The anti-inflammatory activity of topical nanocrystalline silver cream was assessed and compared with the effects of topical steroids and currently available immunosuppressants using a guinea pig model of allergic contact dermatitis." | 3.72 | Anti-inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a guinea pig model. ( Alroy, J; Bhol, KC; Schechter, PJ, 2004) |
| "In both murine and human experimental systems, acute, low dose exposure of skin to ultraviolet B light (UVB) impairs the induction of allergic contact dermatitis (ACD) by haptens such as dinitrochlorobenzene (DNCB) in a significant proportion of individuals." | 3.68 | Ultrastructural studies bearing on the mechanism of UVB-impaired induction of contact hypersensitivity to DNCB in man. ( Boom, BW; Mommaas, AM; Mulder, AA; Streilein, JW; Taylor, JR; Tseng, C; Vermeer, M, 1993) |
| "Oxazolone is a well-characterised contact allergen." | 1.42 | FcRγ promotes contact hypersensitivity to oxazolone without affecting the contact sensitisation process in B6 mice. ( Nunomura, S; Ohtsubo-Yoshioka, M; Okayama, Y; Ra, C; Terui, T, 2015) |
| "2,4-Dinitrochlorobenzene is a potent immunogen capable of inducing contact sensitization in all humans exposed." | 1.40 | Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist. ( Chapman, H; Koivisto, A; Lauerma, AI; Lindstedt, K; Saarnilehto, M; Savinko, T, 2014) |
| "Indirubin treatment suppressed skin inflammation in DNCB-exposed mice." | 1.39 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| "Indirubin might be a useful treatment for allergic contact dermatitis via regulating the co-expression of T helper (Th) 1 and 2 cell-mediated immune responses." | 1.39 | Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. ( Cho, IH; Choi, YY; Kim, MH; Nam, D; Yang, G; Yang, WM, 2013) |
| " Mice were challenged on day 21 by topical application on the ears in a dose-dependent manner and dose-response data were used to calculate the elicitation potency." | 1.38 | A quantitative approach to assess the potency of skin sensitizers in the elicitation phase. ( de Jong, WH; de Klerk, A; Ezendam, J; van Loveren, H; Vermeulen, JP, 2012) |
| "This finding is intriguing as type 1 diabetes and contact allergy are two completely different diseases, although T cells are involved in both diseases." | 1.37 | Prevention of type 1 diabetes by inducing subclinical dermatitis on a small area. ( Buschard, K; Engkilde, K; Hansen, AK; Johansen, JD; Menné, T, 2011) |
| "Dinitrochlorobenzene is a skin-sensitizer only and known to induce a Th1 response, while toluene diisocyanate is both a skin and respiratory sensitizer that causes a Th2 response." | 1.34 | Maternal allergic contact dermatitis causes increased asthma risk in offspring. ( Arredouani, MS; Fedulov, A; Hubeau, C; Kobzik, L; Lim, RH, 2007) |
| "The dose-response relationships of the human immune system can be defined using the induction and elicitation of lymphocyte mediated allergic reactions to experimental contact sensitisers such as dinitrochlorobenzene (DNCB)." | 1.33 | Contact sensitisation and allergic contact dermatitis: immunobiological mechanisms. ( Friedmann, PS, 2006) |
| " Both the sensitization and challenge phases provided similar dose-response curves, demonstrating a threshold followed by a shallow linear increase and eventual plateau at increasing doses." | 1.31 | Insights into the quantitative relationship between sensitization and challenge for allergic contact dermatitis reactions. ( Kashon, ML; Luster, MI; Scott, AE; Tinkle, SS; Yucesoy, B, 2002) |
| " Elicitation of CHR, as measured by average increase in skin thickness, was suppressed significantly in goats of all dosed groups." | 1.29 | The effect of concurrent lead and cadmium exposure on the cell-mediated immune response in goats. ( Dwivedi, SK; Haneef, SS; Swarup, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.13) | 18.7374 |
| 1990's | 27 (28.13) | 18.2507 |
| 2000's | 22 (22.92) | 29.6817 |
| 2010's | 41 (42.71) | 24.3611 |
| 2020's | 3 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, Z | 1 |
| Xie, Y | 1 |
| Zeng, L | 1 |
| Gao, L | 1 |
| Yu, X | 1 |
| Tan, L | 1 |
| Zhou, L | 1 |
| Zeng, J | 1 |
| Lu, J | 1 |
| Höper, T | 1 |
| Karkossa, I | 1 |
| Dumit, VI | 1 |
| von Bergen, M | 1 |
| Schubert, K | 1 |
| Haase, A | 1 |
| Lee, B | 1 |
| Hong, S | 1 |
| Kim, M | 1 |
| Kim, EY | 1 |
| Park, HJ | 1 |
| Jung, HS | 1 |
| Kim, JH | 1 |
| Sohn, Y | 1 |
| Chen, C | 1 |
| Liu, X | 2 |
| Li, Y | 1 |
| Liang, H | 1 |
| Li, K | 1 |
| Li, J | 1 |
| Cheng, C | 1 |
| Zhong, S | 1 |
| Li, L | 1 |
| Wang, Y | 1 |
| Jeong, NH | 1 |
| Yang, EJ | 1 |
| Jin, M | 1 |
| Lee, JY | 1 |
| Choi, YA | 1 |
| Park, PH | 1 |
| Lee, SR | 1 |
| Kim, SU | 1 |
| Shin, TY | 1 |
| Kwon, TK | 1 |
| Jang, YH | 1 |
| Song, KS | 1 |
| Kim, SH | 3 |
| Choi, YY | 2 |
| Kim, MH | 2 |
| Lee, H | 1 |
| Jo, SY | 1 |
| Yang, WM | 2 |
| Viazovaia, EA | 1 |
| Gileva, IP | 1 |
| Toporkova, LB | 1 |
| Shchelkunov, SN | 1 |
| Orlovskaya, IA | 1 |
| Kavasi, RM | 2 |
| Berdiaki, A | 2 |
| Spyridaki, I | 1 |
| Papoutsidakis, A | 1 |
| Corsini, E | 6 |
| Tsatsakis, A | 2 |
| Tzanakakis, GN | 2 |
| Nikitovic, D | 2 |
| Galbiati, V | 4 |
| Cornaghi, L | 1 |
| Papale, A | 4 |
| Donetti, E | 1 |
| Marinovich, M | 4 |
| Choi, JK | 2 |
| Oh, HM | 1 |
| Lee, S | 1 |
| Park, JW | 1 |
| Khang, D | 1 |
| Lee, SW | 1 |
| Lee, WS | 1 |
| Rho, MC | 1 |
| Newell, L | 1 |
| Polak, ME | 1 |
| Perera, J | 1 |
| Owen, C | 1 |
| Boyd, P | 1 |
| Pickard, C | 2 |
| Howarth, PH | 1 |
| Healy, E | 2 |
| Holloway, JW | 1 |
| Friedmann, PS | 3 |
| Ardern-Jones, MR | 1 |
| Wang, C | 3 |
| Yuan, J | 2 |
| Wu, HX | 2 |
| Chang, Y | 2 |
| Wang, QT | 2 |
| Wu, YJ | 2 |
| Liu, LH | 1 |
| Wei, W | 3 |
| Park, G | 2 |
| Oh, MS | 1 |
| Yamashita, K | 2 |
| Shinoda, S | 1 |
| Hagiwara, S | 1 |
| Itagaki, H | 1 |
| Morimoto, T | 1 |
| Higaki, T | 2 |
| Ota, M | 1 |
| Inawaka, K | 1 |
| Kawamura, S | 1 |
| Bungo, T | 1 |
| Galli, CL | 3 |
| Saarnilehto, M | 1 |
| Chapman, H | 1 |
| Savinko, T | 1 |
| Lindstedt, K | 1 |
| Lauerma, AI | 1 |
| Koivisto, A | 1 |
| Smulders, S | 1 |
| Golanski, L | 1 |
| Smolders, E | 1 |
| Vanoirbeek, J | 1 |
| Hoet, PH | 1 |
| van der Veen, JW | 2 |
| Hodemaekers, H | 1 |
| Reus, AA | 1 |
| Maas, WJ | 1 |
| van Loveren, H | 3 |
| Ezendam, J | 3 |
| Popov Aleksandrov, A | 1 |
| Mirkov, I | 4 |
| Demenesku, J | 1 |
| Ninkov, M | 1 |
| Zolotarevski, L | 3 |
| Kataranovski, D | 3 |
| Kataranovski, M | 5 |
| Nunomura, S | 1 |
| Ohtsubo-Yoshioka, M | 1 |
| Okayama, Y | 1 |
| Terui, T | 1 |
| Ra, C | 1 |
| Zhou, P | 2 |
| Yang, XD | 1 |
| Yu, J | 2 |
| Shi, D | 2 |
| Li, X | 1 |
| Li, D | 2 |
| Zhao, Q | 1 |
| Shen, Y | 2 |
| Yan, H | 1 |
| Fu, H | 2 |
| Zheng, H | 2 |
| Lu, G | 2 |
| Qiu, Y | 2 |
| Liu, W | 2 |
| Yang, X | 1 |
| Jia, X | 1 |
| Asenso, J | 1 |
| Xiao, F | 1 |
| Wang, Q | 1 |
| Li, T | 1 |
| Mei, H | 1 |
| Chen, G | 1 |
| Oh, DS | 1 |
| Lee, MG | 1 |
| Lee, CE | 1 |
| Kim, YU | 1 |
| Kummer, E | 1 |
| Ku, HO | 2 |
| Jeong, SH | 2 |
| Kang, HG | 2 |
| Pyo, HM | 2 |
| Cho, JH | 2 |
| Son, SW | 2 |
| Kim, HR | 2 |
| Lee, KJ | 1 |
| Ryu, DY | 2 |
| Fukuyama, T | 1 |
| Ueda, H | 1 |
| Hayashi, K | 1 |
| Tajima, Y | 1 |
| Shuto, Y | 1 |
| Saito, TR | 1 |
| Harada, T | 1 |
| Kosaka, T | 1 |
| Ju, C | 1 |
| Yun, SM | 1 |
| Paramasivan, P | 1 |
| Lai, C | 1 |
| Ardern-Jones, M | 1 |
| Zhang, EY | 1 |
| Chen, AY | 1 |
| Zhu, BT | 1 |
| van Triel, JJ | 1 |
| Arts, JH | 3 |
| Muijser, H | 1 |
| Kuper, CF | 3 |
| Madsen, JT | 2 |
| Vogel, S | 2 |
| Karlberg, AT | 1 |
| Simonsson, C | 1 |
| Johansen, JD | 4 |
| Andersen, KE | 3 |
| dos Santos, GG | 1 |
| Spiekstra, SW | 1 |
| Sampat-Sardjoepersad, SC | 1 |
| Reinders, J | 1 |
| Scheper, RJ | 1 |
| Gibbs, S | 1 |
| Sørensen, JA | 1 |
| Nielsen, JB | 1 |
| von Bonin, A | 1 |
| Rausch, A | 1 |
| Mengel, A | 1 |
| Hitchcock, M | 1 |
| Krüger, M | 1 |
| von Ahsen, O | 1 |
| Merz, C | 1 |
| Röse, L | 1 |
| Stock, C | 1 |
| Martin, SF | 1 |
| Leder, G | 1 |
| Döcke, WD | 1 |
| Asadullah, K | 1 |
| Zügel, U | 1 |
| Popov, A | 3 |
| Miljković, D | 1 |
| Belij, S | 2 |
| Lee, CS | 1 |
| Yi, EH | 1 |
| Huh, SR | 1 |
| Sung, SH | 1 |
| Chung, MH | 1 |
| Ye, SK | 1 |
| Cao, YP | 1 |
| Ma, PC | 1 |
| Liu, WD | 1 |
| Zhou, WQ | 1 |
| Tao, Y | 1 |
| Zhang, ML | 1 |
| Li, LJ | 1 |
| Chen, ZY | 1 |
| Engkilde, K | 1 |
| Hansen, AK | 1 |
| Menné, T | 2 |
| Buschard, K | 1 |
| Vermeulen, JP | 2 |
| de Klerk, A | 1 |
| de Jong, WH | 1 |
| Gremmer, ER | 1 |
| Yang, G | 1 |
| Cho, IH | 1 |
| Nam, D | 1 |
| Sheasgreen, J | 1 |
| Scott, AE | 1 |
| Kashon, ML | 1 |
| Yucesoy, B | 1 |
| Luster, MI | 1 |
| Tinkle, SS | 1 |
| Suda, A | 1 |
| Yamashita, M | 1 |
| Tabei, M | 1 |
| Taguchi, K | 1 |
| Vohr, HW | 1 |
| Tsutsui, N | 1 |
| Suzuki, R | 1 |
| Kikuchi, K | 1 |
| Sakaguchi, K | 1 |
| Mochizuki, K | 1 |
| Nakamura, K | 1 |
| Kato, H | 2 |
| Okamoto, M | 1 |
| Nakamura, Y | 2 |
| Fukumori, Y | 1 |
| Nakai, K | 1 |
| Kaneko, H | 1 |
| Kandolf-Sekulovic, L | 1 |
| Pavlovic, MD | 1 |
| WITTEN, VH | 1 |
| MARCH, CH | 1 |
| EISEN, HN | 1 |
| TABACHNICK, M | 1 |
| Yoshida, Y | 1 |
| Duan, H | 1 |
| Nakayama, J | 1 |
| Furue, M | 1 |
| Bhol, KC | 1 |
| Alroy, J | 1 |
| Schechter, PJ | 1 |
| Shigemi, F | 1 |
| Kitamura, Y | 1 |
| Ishimura, J | 1 |
| Takeda, K | 1 |
| Betts, CJ | 1 |
| Dearman, RJ | 4 |
| Heylings, JR | 1 |
| Kimber, I | 4 |
| Basketter, DA | 5 |
| Hanneman, KK | 1 |
| Scull, HM | 1 |
| Cooper, KD | 2 |
| Baron, ED | 2 |
| Lim, RH | 1 |
| Arredouani, MS | 1 |
| Fedulov, A | 1 |
| Kobzik, L | 1 |
| Hubeau, C | 1 |
| Carlsen, BC | 1 |
| Stierum, RH | 1 |
| Boorsma, A | 1 |
| Schijf, MA | 1 |
| Prinsen, M | 1 |
| Bruijntjes, JP | 1 |
| Bloksma, N | 2 |
| Lucas, CR | 1 |
| Ke, MS | 1 |
| Matsui, MS | 1 |
| Maes, D | 1 |
| Stevens, SR | 1 |
| Singhal, N | 1 |
| Kar, S | 1 |
| Srinivas, CR | 1 |
| Rao, SG | 1 |
| Kolde, G | 1 |
| Galliaerde, V | 1 |
| Desvignes, C | 1 |
| Peyron, E | 1 |
| Kaiserlian, D | 1 |
| Sugiura, H | 1 |
| Uehara, M | 1 |
| Garrigue, JL | 1 |
| Nicolas, JF | 1 |
| Fraginals, R | 1 |
| Benezra, C | 1 |
| Bour, H | 1 |
| Schmitt, D | 1 |
| Chen, H | 1 |
| Maibach, HI | 1 |
| Zachariae, R | 1 |
| Bjerring, P | 1 |
| Mommaas, AM | 1 |
| Mulder, AA | 1 |
| Vermeer, M | 1 |
| Boom, BW | 1 |
| Tseng, C | 1 |
| Taylor, JR | 1 |
| Streilein, JW | 2 |
| Hilton, J | 2 |
| Gerberick, GF | 2 |
| Ryan, CA | 1 |
| Scholes, EW | 2 |
| Ladics, GS | 1 |
| Loveless, SE | 1 |
| House, RV | 1 |
| Haneef, SS | 1 |
| Swarup, D | 1 |
| Dwivedi, SK | 1 |
| Kimura, T | 1 |
| Smith, KJ | 1 |
| Vidmar, D | 1 |
| Skelton, HG | 1 |
| Hackley, BE | 1 |
| Whitmore, SE | 1 |
| Morison, WL | 1 |
| Brand, CU | 4 |
| Hunziker, T | 1 |
| Yawalkar, N | 3 |
| Braathen, LR | 4 |
| Rietschel, RL | 1 |
| Ballmer-Weber, BK | 1 |
| Dai, R | 1 |
| Mallon, E | 1 |
| Powell, S | 1 |
| Mortimer, P | 1 |
| Ryan, TJ | 1 |
| Kishida, F | 1 |
| Nakatsuka, I | 1 |
| Göring, HD | 1 |
| Zierner, A | 1 |
| Kröning, Y | 1 |
| Trebing, D | 1 |
| Kämpgen, E | 1 |
| Bröcker, EB | 1 |
| Spoor, SM | 1 |
| Traidl, C | 1 |
| Jugert, F | 1 |
| Krieg, T | 1 |
| Merk, H | 1 |
| Hunzelmann, N | 1 |
| Hunger, RE | 1 |
| Tuschl, H | 1 |
| Kovac, R | 1 |
| Weber, E | 1 |
| Satoh, T | 1 |
| Yokozeki, H | 1 |
| Nishioka, K | 1 |
| Smith, HR | 1 |
| Kelly, DA | 1 |
| Young, AR | 1 |
| Basketter, DB | 1 |
| McFadden, JP | 1 |
| Cumberbatch, M | 1 |
| Gould, SJ | 1 |
| Peters, SW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nickel Desensitization Using Topical Therapy[NCT01413477] | 24 participants (Anticipated) | Interventional | 2011-08-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dinitrochlorobenzene and Dermatitis, Allergic Contact
| Article | Year |
|---|---|
Inflammatory and immune mechanisms in contact hypersensitivity (CHS) in rats.
Topics: Animals; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Inflammation; Lymphocyte Act | 2012 |
Patients with multiple contact allergies: a review.
Topics: Allergens; Cross Reactions; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Susceptibili | 2008 |
Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatological science.
Topics: Animals; Blood Cell Count; Breeding; Dermatitis, Allergic Contact; Dermatology; Dihydroxyphenylalani | 1996 |
6 trials available for dinitrochlorobenzene and Dermatitis, Allergic Contact
| Article | Year |
|---|---|
Repeated low-dose skin exposure is an effective sensitizing stimulus, a factor to be taken into account in predicting sensitization risk.
Topics: Adult; Analysis of Variance; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Dose-Response Relat | 2010 |
Effect of topical vitamin D analogue on in vivo contact sensitization.
Topics: Administration, Cutaneous; Allergens; Calcitriol; Dermatitis, Allergic Contact; Dinitrochlorobenzene | 2006 |
Increase and decrease of delayed cutaneous reactions obtained by hypnotic suggestions during sensitization. Studies on dinitrochlorobenzene and diphenylcyclopropenone.
Topics: Adult; Cyclopropanes; Denmark; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Double-Blind Meth | 1993 |
Ultraviolet-induced suppression of the primary allergic reaction. Four times the minimal erythema dose of ultraviolet B administered 24 hours prior to sensitization.
Topics: Adolescent; Adult; Buttocks; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Forearm; Humans; Im | 1995 |
Evidence for altered cell-mediated immunity in postmastectomy lymphoedema.
Topics: Adult; Aged; Breast Neoplasms; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Dose-Response Rel | 1997 |
Interleukin-12 expression in human afferent lymph derived from the induction phase of allergic contact dermatitis.
Topics: Adult; Cyclopropanes; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Female; Humans; Interleuki | 1998 |
87 other studies available for dinitrochlorobenzene and Dermatitis, Allergic Contact
| Article | Year |
|---|---|
Ozonated oil alleviates dinitrochlorobenzene-induced allergic contact dermatitis via inhibiting the FcεRI/Syk signaling pathway.
Topics: Animals; Cytokines; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dinitrochlorobenzene; Interleu | 2023 |
A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways.
Topics: Allergens; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Humans; Metabolic Networks and Pathwa | 2023 |
Topics: Animals; Apoptosis; Bone Morphogenetic Protein 2; Calbindins; Calcium; Cell Line; Core Binding Facto | 2021 |
Effects of Acupuncture on 1-chloro-2,4-dinitrochlorobenzene-induced Allergic Contact Dermatitis in Mice.
Topics: Acupuncture Therapy; Animals; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease | 2017 |
Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents; Antigens, Dermatophagoides; Cell Line; Cytokines; Dermatitis, All | 2018 |
(R)-(+)-pulegone suppresses allergic and inflammation responses on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice model.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Cyclohexane Monoterpenes; Cytokines; Dermat | 2018 |
Anti-inflammatory Effects of Variola Virus TNF Decoy Receptor in an Experimental Model of Contact Dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Model | 2018 |
Contact allergen (PPD and DNCB)-induced keratinocyte sensitization is partly mediated through a low molecular weight hyaluronan (LMWHA)/TLR4/NF-κB signaling axis.
Topics: Allergens; Cell Line; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Humans; Hyaluronan Synthas | 2019 |
Study on the inflammasome nlrp3 and blimp-1/nlrp12 after keratinocyte exposure to contact allergens.
Topics: Allergens; CARD Signaling Adaptor Proteins; Caspase 1; Cell Line; Dermatitis, Allergic Contact; Dini | 2019 |
Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Antigens, Dermatophagoides; Cell Line; Cytokine | 2013 |
Sensitization via healthy skin programs Th2 responses in individuals with atopic dermatitis.
Topics: Adult; Allergens; Cells, Cultured; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dinitrochlorobe | 2013 |
Rutin suppresses atopic dermatitis and allergic contact dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Dermatitis, Allergic Contact; Dermatitis | 2013 |
Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines.
Topics: Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Benzoates; Bridged-Ring Compounds; Cyto | 2013 |
Inhibitory effects of Juglans mandshurica leaf on allergic dermatitis-like skin lesions-induced by 2,4-dinitrochlorobenzene in mice.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Biphenyl Compounds; Cytokines; Dermatitis, Allergic | 2014 |
Development of LLNA:DAE: a new local lymph node assay that includes the elicitation phase, discriminates borderline-positive chemicals, and is useful for cross-sensitization testing.
Topics: Animals; Benzoquinones; Cross Reactions; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Dinitro | 2014 |
Effect of simultaneous exposure to mixture of two skin sensitizers on skin sensitization response in guinea pigs and mice.
Topics: Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Female; Guinea Pigs; Mice; Mice, Inbred | 2014 |
Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes.
Topics: Acyclic Monoterpenes; Allergens; Caspase 1; Cell Line; Cell Survival; Cytokines; Dermatitis, Allergi | 2014 |
Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist.
Topics: Calcium Channels; Dermatitis, Allergic Contact; Dinitrochlorobenzene; HEK293 Cells; Humans; Irritant | 2014 |
Nano-TiO2 modulates the dermal sensitization potency of dinitrochlorobenzene after topical exposure.
Topics: Administration, Cutaneous; Allergens; Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; I | 2015 |
Human relevance of an in vitro gene signature in HaCaT for skin sensitization.
Topics: Adult; Allergens; Cyclopropanes; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Female; Gene Ex | 2015 |
Hyaluronan regulates chemical allergen-induced IL-18 production in human keratinocytes.
Topics: Antioxidants; Aristolochic Acids; Cell Adhesion Molecules; Cell Line; Dermatitis, Allergic Contact; | 2015 |
Strain differences in contact hypersensitivity reaction to dinitrochlorobenzene (DNCB) in rats.
Topics: Animals; Cell Proliferation; Cell Survival; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Dose | 2015 |
FcRγ promotes contact hypersensitivity to oxazolone without affecting the contact sensitisation process in B6 mice.
Topics: Adjuvants, Immunologic; Animals; Dendritic Cells; Dermatitis, Allergic Contact; Dermatitis, Contact; | 2015 |
Total glucosides of paeony inhibit the inflammatory responses of mice with allergic contact dermatitis by restoring the balanced secretion of pro-/anti-inflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Dermatitis, Allergic Contact; Dini | 2015 |
Oral administration of paeoniflorin attenuates allergic contact dermatitis by inhibiting dendritic cell migration and Th1 and Th17 differentiation in a mouse model.
Topics: Administration, Oral; Animals; Cell Differentiation; Cell Movement; Cytokines; Dendritic Cells; Derm | 2015 |
Effect of 6'-acetylpaeoniflorin on dinitrochlorobenzene-induced allergic contact dermatitis in BALB/c mice.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Dermatitis, Allergic Contact; Dinitrochlorobenze | 2016 |
Paeoniflorin suppresses IL-6/Stat3 pathway via upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Dendritic Cells; Dermatitis, Allergic Contact; D | 2016 |
6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf2 pathway.
Topics: Animals; Catechols; Cell Line; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Humans | 2016 |
Understanding chemical allergen potency: role of NLRP12 and Blimp-1 in the induction of IL-18 in human keratinocytes.
Topics: Allergens; Cell Line; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Down-Regulation; Gene Expr | 2017 |
Intracellular expression of cytokines and granzyme B in auricular lymph nodes draining skin exposed to irritants and sensitizers.
Topics: Animals; Cytokines; Dermatitis, Allergic Contact; Dermatitis, Contact; Diagnosis, Differential; Dini | 2008 |
Use of long term dermal sensitization followed by intratracheal challenge method to identify low-dose chemical-induced respiratory allergic responses in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene | 2008 |
The role of haptic macrophages in regulation of idiosyncratic drug reactions.
Topics: Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Dinitrophenols; Disease Models, Animal; | 2009 |
Gene expression profiles and pathways in skin inflammation induced by three different sensitizers and an irritant.
Topics: Allergens; Animals; Cytokines; Dermatitis, Allergic Contact; Dermatitis, Contact; Dinitrochlorobenze | 2009 |
Mechanism of dinitrochlorobenzene-induced dermatitis in mice: role of specific antibodies in pathogenesis.
Topics: Animals; Antibodies; B-Lymphocytes; Cell Differentiation; Cytokines; Dermatitis, Allergic Contact; D | 2009 |
Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB).
Topics: Administration, Inhalation; Allergens; Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; | 2010 |
Ethosome formulations of known contact allergens can increase their sensitizing capacity.
Topics: Allergens; Animals; Cell Proliferation; Chemistry, Pharmaceutical; Dermatitis, Allergic Contact; Din | 2010 |
A potential in vitro epidermal equivalent assay to determine sensitizer potency.
Topics: Allergens; Animal Testing Alternatives; Cell Survival; Cells, Cultured; Dermatitis, Allergic Contact | 2011 |
Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes.
Topics: Administration, Cutaneous; Adult; Allergens; Chemistry, Pharmaceutical; Dermatitis, Allergic Contact | 2011 |
Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases.
Topics: Animals; Base Sequence; Dermatitis; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dinitrochlorob | 2011 |
Contact allergic response to dinitrochlorobenzene (DNCB) in rats: insight from sensitization phase.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Dermatitis, Allergic Contact; Dinitrochloro | 2011 |
Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Proliferation; Dermatitis, Allergic Contact; Dini | 2011 |
Evaluation of the skin sensitization potential of chemicals in THP-1/keratinocyte co-cultures.
Topics: Animal Testing Alternatives; B7-2 Antigen; Benzalkonium Compounds; Cell Line, Tumor; Cell Survival; | 2012 |
Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats.
Topics: Administration, Cutaneous; Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Granulocytes | 2012 |
Prevention of type 1 diabetes by inducing subclinical dermatitis on a small area.
Topics: Animals; Dermatitis, Allergic Contact; Diabetes Mellitus, Type 1; Dinitrochlorobenzene; Ear, Externa | 2011 |
A quantitative approach to assess the potency of skin sensitizers in the elicitation phase.
Topics: Administration, Topical; Allergens; Animals; Cell Proliferation; Dermatitis, Allergic Contact; Dinit | 2012 |
Induction of skin sensitization is augmented in Nrf2-deficient mice.
Topics: Allergens; Animals; Cell Count; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Irritants; Local | 2013 |
Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Di | 2013 |
Use of differential display-polymerase chain reaction to identify genes selectively modulated by chemical allergens in reconstituted human epidermis.
Topics: Allergens; Biomarkers; Cell Culture Techniques; Dermatitis, Allergic Contact; Dinitrochlorobenzene; | 2002 |
Insights into the quantitative relationship between sensitization and challenge for allergic contact dermatitis reactions.
Topics: Adjuvants, Immunologic; Animals; Cyclobutanes; Dermatitis, Allergic Contact; Dinitrochlorobenzene; D | 2002 |
Local lymph node assay with non-radioisotope alternative endpoints.
Topics: Allergens; Animals; Benzocaine; Bromodeoxyuridine; Cell Count; Dermatitis, Allergic Contact; Dinitro | 2002 |
Peptide-binding assessment using mass spectrometry as a new screening method for skin sensitization.
Topics: Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Glutathione; Guinea Pigs; Mass Spectrom | 2003 |
Immunomodulatory effects of low-intensity near-infrared laser irradiation on contact hypersensitivity reaction.
Topics: Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Ear, External; Enzyme-Linked Immunosorb | 2003 |
Studies of the mechanism of allergic eczematous contact dermatitis. II. Use of C14 labelled 2:4-dinitrochlorobenzene in guinea pigs.
Topics: Animals; Dermatitis, Allergic Contact; Dermatitis, Contact; Dinitrochlorobenzene; Guinea Pigs; Nitro | 1958 |
Elicitation of allergic contact dermatitis in the guinea pig; the distribution of bound dinitrobenzene groups within the skin and quantitative determination of the extent of combination of 2,4-dinitro-chlorobenzene with epidermal protein in vivo.
Topics: Animals; Dermatitis; Dermatitis, Allergic Contact; Dermatitis, Contact; Dinitrobenzenes; Dinitrochlo | 1958 |
Lymphadenosis benigna cutis induced by iatrogenic contact dermatitis from dinitrochlorobenzene.
Topics: Adult; AIDS-Related Complex; Allergens; Arm; Dermatitis, Allergic Contact; Diagnosis, Differential; | 2003 |
Anti-inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a guinea pig model.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Allergic Co | 2004 |
Tissue fibrinolytic activity of allergic contact dermatitis.
Topics: Biopsy, Needle; Culture Techniques; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Fibrinolysis | 1977 |
Contact sensitisation and allergic contact dermatitis: immunobiological mechanisms.
Topics: Dermatitis, Allergic Contact; Dinitrochlorobenzene; Dose-Response Relationship, Immunologic; Humans; | 2006 |
Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience.
Topics: Allergens; Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Models, Animal; Dose | 2006 |
Maternal allergic contact dermatitis causes increased asthma risk in offspring.
Topics: Animals; Asthma; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Models, Animal; Disease | 2007 |
The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat.
Topics: Administration, Cutaneous; Allergens; Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; F | 2008 |
Immune protective effect of a moisturizer with DNA repair ingredients.
Topics: Administration, Cutaneous; Adult; Dermatitis, Allergic Contact; Dinitrochlorobenzene; DNA Damage; DN | 2008 |
Effect of allergic contact dermatitis on wound healing.
Topics: Allergens; Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Guinea Pigs; Wound Healing | 1995 |
Effects of immunological responsiveness on Langerhans cell behavior in contact sensitization.
Topics: Administration, Cutaneous; Animals; Cell Adhesion; Cyclopropanes; Dermatitis, Allergic Contact; Dini | 1994 |
Oral tolerance to haptens: intestinal epithelial cells from 2,4-dinitrochlorobenzene-fed mice inhibit hapten-specific T cell activation in vitro.
Topics: Administration, Oral; Animals; Antigen-Presenting Cells; Culture Media, Conditioned; Dermatitis, All | 1995 |
Mitosis of mast cells in skin lesions of atopic dermatitis.
Topics: Adolescent; Adult; Cell Division; Cytoplasmic Granules; Dermatitis, Allergic Contact; Dermatitis, At | 1993 |
Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers.
Topics: Animals; Cell Division; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Ear, External; Edema; Eu | 1994 |
Topical application of artesunate on guinea pig allergic contact dermatitis.
Topics: Administration, Cutaneous; Animals; Artemisinins; Artesunate; Croton Oil; Dermatitis, Allergic Conta | 1994 |
Ultrastructural studies bearing on the mechanism of UVB-impaired induction of contact hypersensitivity to DNCB in man.
Topics: Cell Count; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Histocompatibility Antigens Class II | 1993 |
An international evaluation of the murine local lymph node assay and comparison of modified procedures.
Topics: Analysis of Variance; Animals; Caustics; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Dose-Re | 1995 |
The effect of concurrent lead and cadmium exposure on the cell-mediated immune response in goats.
Topics: Animals; Cadmium; Cadmium Chloride; Cadmium Poisoning; Chlorides; Dermatitis, Allergic Contact; Dini | 1995 |
Experimental assessment of the sensitizing properties of formaldehyde.
Topics: Administration, Topical; Allergens; Animals; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorob | 1996 |
Improved results of delayed-type hypersensitivity skin testing in HIV-infected patients treated with topical dinitrochlorobenzene.
Topics: Catechols; CD8-Positive T-Lymphocytes; Cytokines; Dermatitis, Allergic Contact; Dinitrochlorobenzene | 1996 |
IL-1 beta protein in human skin lymph does not discriminate allergic from irritant contact dermatitis.
Topics: Adult; Allergens; Cyclopropanes; Dermatitis, Allergic Contact; Dermatitis, Irritant; Dinitrochlorobe | 1996 |
An interlaboratory evaluation of the Buehler test for the identification and classification of skin sensitizers.
Topics: 1-Propanol; Acrolein; Allergens; Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Diseas | 1996 |
Physiologic response of chronically inflamed and accommodated human skin.
Topics: Acetylcholine; Adaptation, Physiological; Administration, Cutaneous; Antigens; Autacoids; Benzalkoni | 1995 |
sICAM-1, sE-selectin and sVCAM-1 are constitutively present in human skin lymph and increased in allergic contact dermatitis.
Topics: Adult; Cell Adhesion Molecules; Cyclopropanes; Dermatitis, Allergic Contact; Dermatitis, Irritant; D | 1997 |
Naïve, hapten-specific human T lymphocytes are primed in vitro with derivatized blood mononuclear cells.
Topics: Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Disease Models, Animal; Epitopes; Granu | 1998 |
Comparison of sex differences in guinea-pig maximization test for detection of skin-sensitizing potential using OECD recommended positive control sensitizers.
Topics: Acrolein; Animals; Benzocaine; Benzothiazoles; Dermatitis, Allergic Contact; Dinitrochlorobenzene; F | 1998 |
Effective combined immunochemotherapy with dinitrochlorobenzene and fotemustine in skin and brain metastases of melanoma.
Topics: Allergens; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Dermatitis, Allergic C | 1998 |
Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals.
Topics: Allergens; Animals; Body Weight; Bronchi; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Female | 1998 |
Inhibition of allergic contact dermatitis to DNCB but not to oxazolone in interleukin-4-deficient mice.
Topics: Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Interleukin-10; Interleukin-4; Mice; Mi | 1999 |
The HECA-452 epitope is highly expressed on lymph cells derived from human skin.
Topics: Adult; Antigens, CD1; Antigens, Differentiation, T-Lymphocyte; Antigens, Neoplasm; CD4-Positive T-Ly | 1999 |
The expression of surface markers on dendritic cells as indicators for the sensitizing potential of chemicals.
Topics: Acrolein; Allergens; Antigens, CD; Antigens, Surface; B7-2 Antigen; Cells, Cultured; Dendritic Cells | 2000 |
Pathogenic roles of eosinophils in guinea-pig contact sensitivity: regulation of dermal eosinophilia with remotely administered IL-5.
Topics: Animals; Dermatitis, Allergic Contact; Dinitrochlorobenzene; Eosinophils; Female; Guinea Pigs; Human | 2000 |
Relationship between 2,4-dinitrochlorobenzene elicitation responses and individual irritant threshold.
Topics: Adult; Arm; Buttocks; Dermatitis, Allergic Contact; Dermatitis, Irritant; Dinitrochlorobenzene; Fema | 2002 |
Influence of topical exposure to chemical allergens on murine Langerhans cells. Comparison of 2,4-dinitrochlorobenzene with trimellitic anhydride.
Topics: Administration, Topical; Allergens; Animals; Cell Count; Dermatitis, Allergic Contact; Dinitrochloro | 1992 |