dinitrochlorobenzene has been researched along with Colitis in 11 studies
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dinitrochlorobenzene-induced colitis in guinea-pigs may be immunologically mediated: animals must be presensitised to dinitrochlorobenzene to develop colitis, sensitivity can be passively transferred by lymphocytes and the injury can be mitigated by immunosuppression." | 7.66 | Dinitrochlorobenzene-induced colitis in the guinea-pig: studies of colonic lamina propria lymphocytes. ( Falchuk, ZM; Glick, ME, 1981) |
| " To determine if these changes result in differences in functional properties of mucin, inhibition of adherence of piliated Escherichia coli, strain RDEC-1 (serotype O15:H-), by mucin purified from distal colons of normal rabbits was compared with inhibition by mucin from colons of rabbits with dinitrochlorobenzene-induced colitis." | 3.68 | Effect of colonic inflammation on mucin inhibition of Escherichia coli RDEC-1 binding in vitro. ( Gaginella, TS; Mack, DR; Sherman, PM, 1992) |
| " We measured PLA2 activity in the peritoneal leukocytes and eicosanoid content in the peritoneal cavity of rats with experimental colitis induced by dinitrochlorobenzene, immune complex-mediated colitis, and acetic acid-induced colitis." | 3.68 | Increased phospholipase A2 activity in peritoneal leukocytes in rat experimental colitis. ( Biondi, RJ; Murthy, SN, 1992) |
| "Inflammation of the colon is associated with increased production of prostaglandins (PG) and thromboxanes (Tx), and these eicosanoids may contribute to the inflammatory, secretory, and motility dysfunctions in colitis." | 3.67 | Hypersensitive prostaglandin and thromboxane response to hormones in rabbit colitis. ( Hauser, CJ; Kao, HW; Locke, R; Patterson, JB; Zipser, RD, 1985) |
| "An immune colitis based on a delayed-type hypersensitivity reaction was induced in dinitrochlorobenzene (DNCB)-sensitized guinea-pigs by intrarectal challenge with DNCB." | 3.66 | Changes in colonic tissue levels of inflammatory mediators in a guinea-pig model of immune colitis. ( Lewis, AJ; Norris, AA; Zeitlin, IJ, 1982) |
| "Dinitrochlorobenzene-induced colitis in guinea-pigs may be immunologically mediated: animals must be presensitised to dinitrochlorobenzene to develop colitis, sensitivity can be passively transferred by lymphocytes and the injury can be mitigated by immunosuppression." | 3.66 | Dinitrochlorobenzene-induced colitis in the guinea-pig: studies of colonic lamina propria lymphocytes. ( Falchuk, ZM; Glick, ME, 1981) |
| "Hapten-induced colitis is a widely used model for the study of the intestinal inflammation and for the testing of novel therapies." | 1.29 | Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid. ( Appleyard, CB; Beck, PL; Carter, L; Le, T; Wallace, JL, 1995) |
| "Histamine content was three times control (p less than 0." | 1.26 | Changes in colonic tissue levels of inflammatory mediators in a guinea-pig model of immune colitis. ( Lewis, AJ; Norris, AA; Zeitlin, IJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Awasthi, V | 1 |
| Goins, B | 1 |
| McManus, L | 1 |
| Klipper, R | 1 |
| Phillipsa, WT | 1 |
| Norris, AA | 2 |
| Lewis, AJ | 2 |
| Zeitlin, IJ | 2 |
| Glick, ME | 1 |
| Falchuk, ZM | 1 |
| Wallace, JL | 1 |
| Le, T | 1 |
| Carter, L | 1 |
| Appleyard, CB | 1 |
| Beck, PL | 1 |
| Mack, DR | 1 |
| Gaginella, TS | 1 |
| Sherman, PM | 1 |
| Murthy, SN | 1 |
| Biondi, RJ | 1 |
| Kaftan, SM | 1 |
| Wright, NA | 1 |
| Brown, JA | 1 |
| Zipser, RD | 2 |
| Strober, W | 1 |
| Patterson, JB | 1 |
| Kao, HW | 1 |
| Hauser, CJ | 1 |
| Locke, R | 1 |
1 review available for dinitrochlorobenzene and Colitis
| Article | Year |
|---|---|
Animal models of inflammatory bowel disease--an overview.
Topics: Animals; B-Lymphocytes; Carrageenan; Colitis; Crohn Disease; Dinitrochlorobenzene; Disease Models, A | 1985 |
10 other studies available for dinitrochlorobenzene and Colitis
| Article | Year |
|---|---|
[99mTc] liposomes for localizing experimental colitis in a rabbit model.
Topics: Animals; Colitis; Dinitrochlorobenzene; Leukocytes; Liposomes; Metabolic Clearance Rate; Organ Speci | 2003 |
Actions of anticolitic drugs on a guinea-pig model of immune colitis.
Topics: Animals; Azathioprine; Colitis; Cromolyn Sodium; Dinitrochlorobenzene; Gastrointestinal Agents; Guin | 1982 |
Changes in colonic tissue levels of inflammatory mediators in a guinea-pig model of immune colitis.
Topics: Animals; Colitis; Dinitrochlorobenzene; Dinoprostone; Guinea Pigs; Histamine; Inflammation; Intestin | 1982 |
Dinitrochlorobenzene-induced colitis in the guinea-pig: studies of colonic lamina propria lymphocytes.
Topics: Animals; Colitis; Colon; Concanavalin A; Cytotoxicity, Immunologic; Dinitrochlorobenzene; Guinea Pig | 1981 |
Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid.
Topics: Animals; Benzenesulfonates; Colitis; Dinitrochlorobenzene; Disease Models, Animal; Haptens; Male; Ne | 1995 |
Effect of colonic inflammation on mucin inhibition of Escherichia coli RDEC-1 binding in vitro.
Topics: Animals; Bacterial Adhesion; Colitis; Colon; Dinitrochlorobenzene; Escherichia coli; Guinea Pigs; Le | 1992 |
Increased phospholipase A2 activity in peritoneal leukocytes in rat experimental colitis.
Topics: Acetates; Acetic Acid; Animals; Arthus Reaction; Colitis; Dexamethasone; Dinitrochlorobenzene; Disea | 1992 |
Studies on the mechanisms of mucous cell depletion in experimental colitis.
Topics: Acetates; Animals; Cell Count; Colitis; Dinitrochlorobenzene; Guinea Pigs; Intestinal Mucosa; Male; | 1989 |
Prostaglandin regulation of colonic blood flow in rabbit colitis.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Output; Colitis; Colon; Dinitrochlorobenze | 1987 |
Hypersensitive prostaglandin and thromboxane response to hormones in rabbit colitis.
Topics: Animals; Carbon Radioisotopes; Colitis; Colon; Dinitrochlorobenzene; Drug Hypersensitivity; Hormones | 1985 |