dinitrochlorobenzene has been researched along with Allergy, Drug in 55 studies
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Excerpt | Relevance | Reference |
---|---|---|
"We observed that L-fucose could suppress the skin reaction of allergic contact dermatitis induced by dinitrochlorobenzene." | 7.66 | Suppression of allergic contact dermatitis by alpha-L-fucose. ( Baba, T; Hasegawa, S; Hori, Y, 1980) |
"Quantitative techniques of sensitization to 2,4-dinitrochlorobenzene (DNCB) was used to determine in psoriasis the intensity and frequency of allergic reactions to DNCB following primary challenge with 2,000 microgram allergen and secondary challenge with decreasing doses of DNCB." | 7.65 | Immunological studies in psoriasis. The quantitative evaluation of cell-mediated immunity in patients with psoriasis by experimental sensitization to 2,4-dinitrochlorobenzene. ( Haftek, M; Obalek, S; Sliński, W, 1977) |
"In the present study, immunopharmacological effects of clonidine-TTS on allergic contact dermatitis (ACD) to non-related, established contact sensitizers were investigated in guinea pigs." | 3.67 | Suppressive effects of transdermal clonidine administration on contact hypersensitivity reactions in guinea pigs. ( de Groot, J; Goeptar, AR; Lang, M; Scheper, RJ; van Tol, RG, 1988) |
" No statistically significant difference in delayed hypersensitivity response to dinitrochlorobenzene was found between indomethacin-treated, tumor-bearing and control groups." | 3.67 | Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch. ( Gould, AR; Grant, FT; Miller, RL; Perry, DA, 1985) |
"Inflammation of the colon is associated with increased production of prostaglandins (PG) and thromboxanes (Tx), and these eicosanoids may contribute to the inflammatory, secretory, and motility dysfunctions in colitis." | 3.67 | Hypersensitive prostaglandin and thromboxane response to hormones in rabbit colitis. ( Hauser, CJ; Kao, HW; Locke, R; Patterson, JB; Zipser, RD, 1985) |
"The nonspecific cell-mediated immunocompetence of 51 patients with gestational trophoblastic disease (GTD), including 16 patients with hydatid mole (HM), 24 with nonmetastatic trophoblastic neoplasia (NTN) and 15 with metastatic TN (MTN), was studied with the use of both in vitro and in vivo parameters of cell-mediated immunity (CMI) such as lymphocyte blastogenic response to phytohemagglutinin (PHA), subpopulation constitution, and delayed cutaneous hypersensitivity responses to 2,4-dinitrochlorobenzene (DNCB) and to purified protein derivative of tuberculin (PPD)." | 3.66 | Clinical studies on cell-mediated immunity in gestational trophoblastic disease: nonspecific cellular immunocompetence in patients with hydatid mole and trophoblastic neoplasia. ( Fujisaki, S; Sasaki, T, 1981) |
"We observed that L-fucose could suppress the skin reaction of allergic contact dermatitis induced by dinitrochlorobenzene." | 3.66 | Suppression of allergic contact dermatitis by alpha-L-fucose. ( Baba, T; Hasegawa, S; Hori, Y, 1980) |
"Quantitative techniques of sensitization to 2,4-dinitrochlorobenzene (DNCB) was used to determine in psoriasis the intensity and frequency of allergic reactions to DNCB following primary challenge with 2,000 microgram allergen and secondary challenge with decreasing doses of DNCB." | 3.65 | Immunological studies in psoriasis. The quantitative evaluation of cell-mediated immunity in patients with psoriasis by experimental sensitization to 2,4-dinitrochlorobenzene. ( Haftek, M; Obalek, S; Sliński, W, 1977) |
"A group of 220 patients with mycosis fungoides (MF) and other lymphomatous diseases was treated with sustained topical applications of dilute aqueous solutions of mechlorethamine hydrochloride for intervals ranging in excess of seven years." | 3.65 | Topical chemotherapy and immunotherapy of mycosis fungoides: intermediate-term results. ( Asbell, SO; Grekin, DA; Johnson, WC; Van Scott, EJ; Vonderheid, EC, 1977) |
"We have evaluated a subchronic model of contact hypersensitivity in the guinea pig to mimic human chronic/recurrent eczema." | 1.28 | Repeated application of dinitrochlorobenzene to the ears of sensitized guinea pigs: a preliminary characterization of a potential new animal model for contact eczema in humans. ( Bouclier, M; Boyera, N; Burg, G; Cavey, D; Hensby, C; Rossio, P, 1992) |
" A dose-response profile was obtained with D & C Yellow No." | 1.27 | The sensitization potential of D & C Yellow No. 11 in guinea pigs. ( DiPasquale, LC; Palazzolo, MJ, 1983) |
"Indomethacin was not observed to produce any significant effect upon hamster buccal pouch carcinogenesis." | 1.27 | Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch. ( Gould, AR; Grant, FT; Miller, RL; Perry, DA, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 40 (72.73) | 18.7374 |
1990's | 9 (16.36) | 18.2507 |
2000's | 5 (9.09) | 29.6817 |
2010's | 1 (1.82) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Fukuyama, T | 1 |
Tajima, Y | 1 |
Ueda, H | 1 |
Hayashi, K | 1 |
Kosaka, T | 1 |
Logani, MK | 1 |
Anga, A | 1 |
Szabo, I | 1 |
Agelan, A | 1 |
Irizarry, AR | 1 |
Ziskin, MC | 1 |
ROSENTHAL, SA | 1 |
BAER, RL | 1 |
Ju, C | 2 |
McCoy, JP | 1 |
Chung, CJ | 1 |
Graf, ML | 1 |
Pohl, LR | 2 |
Yu, WG | 1 |
Lin, P | 1 |
Pan, H | 1 |
Xiao, L | 1 |
Gong, EC | 1 |
Mei, L | 1 |
Hopkins, JE | 1 |
Naisbitt, DJ | 1 |
Humphreys, N | 1 |
Dearman, RJ | 3 |
Kimber, I | 4 |
Park, BK | 1 |
Maxwell, MH | 1 |
Manna, V | 1 |
Marks, R | 1 |
Holt, P | 1 |
Chase, MW | 1 |
Sasaki, T | 1 |
Fujisaki, S | 1 |
Lübbe, D | 1 |
Schwartze, G | 1 |
Wozniak, KD | 1 |
Palazzolo, MJ | 1 |
DiPasquale, LC | 1 |
Arlette, JP | 1 |
Fritzler, MJ | 1 |
Fukushiro, S | 2 |
Honeyman, J | 1 |
Saavedra, T | 1 |
Villagra, R | 1 |
Cabezas, AM | 1 |
Awad, P | 1 |
Moss, C | 2 |
Friedmann, PS | 3 |
Shuster, S | 2 |
Baskies, AM | 1 |
Chretien, PB | 1 |
Weiss, JF | 1 |
Makuch, RW | 1 |
Beveridge, RA | 1 |
Catalona, WJ | 1 |
Spiegel, HE | 1 |
Hasegawa, S | 1 |
Baba, T | 1 |
Hori, Y | 1 |
Vonderheid, EC | 2 |
Ekbote, SK | 1 |
Kerrigan, K | 1 |
Kalmanson, JD | 1 |
Van Scott, EJ | 2 |
Rook, AH | 1 |
Abrams, JT | 1 |
Gaspard, I | 1 |
Kerdine, S | 1 |
Pallardy, M | 1 |
Lebrec, H | 1 |
Pabst, HF | 1 |
Urtasun, RC | 1 |
Hamilton, DN | 1 |
Ledger, V | 1 |
Diamandopoulos, AA | 1 |
Gibb, I | 1 |
Robert, F | 1 |
Lozada, JA | 1 |
Muñiz, FJ | 1 |
Obalek, S | 1 |
Haftek, M | 2 |
Sliński, W | 1 |
Sharma, D | 1 |
Gupta, RM | 1 |
Kadian, V | 1 |
Nakagawa, S | 1 |
Gotoh, M | 1 |
Kohda, M | 1 |
Namba, M | 1 |
Tanioku, K | 1 |
Halliday, WJ | 2 |
Noonan, FP | 2 |
Eriksen, K | 1 |
Gliński, W | 1 |
Obałek, S | 1 |
Mohammad, AR | 1 |
Mincer, HH | 1 |
Johnson, WC | 1 |
Grekin, DA | 1 |
Asbell, SO | 1 |
Adolphs, HD | 1 |
Steffens, L | 1 |
Krawiec, DR | 1 |
Gaafar, SM | 1 |
Ivanov, VV | 1 |
Malaviya, AN | 1 |
Sehgal, KL | 1 |
Kumar, R | 1 |
Dingley, HB | 1 |
Heid, E | 1 |
Bigel, P | 1 |
Robez, OG | 1 |
Hartman, A | 1 |
Hoedemaeker, PJ | 1 |
Nater, JP | 1 |
Cumberbatch, M | 1 |
Gould, SJ | 1 |
Peters, SW | 1 |
Basketter, DA | 1 |
Boyera, N | 1 |
Cavey, D | 1 |
Bouclier, M | 1 |
Burg, G | 1 |
Rossio, P | 1 |
Hensby, C | 1 |
Bentley, AN | 1 |
Ward, RK | 1 |
Baker, D | 1 |
Turk, JL | 1 |
Ciaceri, G | 1 |
Yoshikawa, T | 1 |
Rae, V | 1 |
Bruins-Slot, W | 1 |
Van den Berg, JW | 1 |
Taylor, JR | 1 |
Streilein, JW | 1 |
Rees, JL | 1 |
Matthews, JN | 1 |
Higashi, A | 1 |
Chen, C | 1 |
Matsuda, I | 1 |
Goeptar, AR | 1 |
de Groot, J | 1 |
Lang, M | 1 |
van Tol, RG | 1 |
Scheper, RJ | 1 |
Onoda, S | 1 |
Picut, CA | 1 |
Lee, CS | 1 |
Lewis, RM | 1 |
Krysiak, B | 1 |
Gould, AR | 1 |
Miller, RL | 1 |
Grant, FT | 1 |
Perry, DA | 1 |
Simpson, JM | 1 |
Zipser, RD | 1 |
Patterson, JB | 1 |
Kao, HW | 1 |
Hauser, CJ | 1 |
Locke, R | 1 |
Mandel, MA | 1 |
Kiehn, C | 1 |
1 review available for dinitrochlorobenzene and Allergy, Drug
Article | Year |
---|---|
The induction of tolerance to allergenic chemicals.
Topics: Allergens; Animals; Antibodies; Antibody Formation; Binding, Competitive; Citraconic Anhydrides; Der | 1982 |
2 trials available for dinitrochlorobenzene and Allergy, Drug
Article | Year |
---|---|
Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans.
Topics: Adult; Aged; Dermatitis, Contact; Dinitrochlorobenzene; Disease Susceptibility; Dose-Response Relati | 1990 |
The influence of area of application on sensitization by dinitrochlorobenzene.
Topics: Dermatitis, Contact; Dinitrochlorobenzene; Dose-Response Relationship, Immunologic; Drug Hypersensit | 1990 |
52 other studies available for dinitrochlorobenzene and Allergy, Drug
Article | Year |
---|---|
Prior exposure to immunosuppressive organophosphorus or organochlorine compounds aggravates the T(H)1- and T(H)2-type allergy caused by topical sensitization to 2,4-dinitrochlorobenzene and trimellitic anhydride.
Topics: Animals; Cell Proliferation; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Humans; Insecticid | 2011 |
Effect of millimeter waves on cyclophosphamide induced suppression of the immune system.
Topics: Administration, Topical; Animals; Body Weight; Bone Marrow Cells; Cyclophosphamide; Dinitrochloroben | 2002 |
ACTIVELY ACQUIRED TOLERANCE TO DINITROCHLOROBENZENE. TESTS IN NEWBORN GUINEA PIGS.
Topics: Animals; Animals, Newborn; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Guinea Pigs; Humans; | 1963 |
Tolerogenic role of Kupffer cells in allergic reactions.
Topics: 2,4-Dinitrophenol; Animals; Cattle; Dendritic Cells; Dinitrochlorobenzene; Dinitrophenols; Drug Hype | 2003 |
Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity.
Topics: Animals; Dinitrochlorobenzene; Drug Hypersensitivity; Gastrointestinal Tract; Hypersensitivity, Dela | 2004 |
Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells.
Topics: Animals; Anti-Infective Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; D | 2005 |
Histochemical identification of tissue eosinophils in the inflammatory response of the fowl (Gallus domesticus).
Topics: Animals; Chickens; Citraconic Anhydrides; Dinitrochlorobenzene; Drug Hypersensitivity; Eosinophil Pe | 1984 |
Involvement of immune mechanisms in the pathogenesis of rosacea.
Topics: Adult; Aged; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Fluorescent Antibody Technique; Hu | 1982 |
Clinical studies on cell-mediated immunity in gestational trophoblastic disease: nonspecific cellular immunocompetence in patients with hydatid mole and trophoblastic neoplasia.
Topics: Adult; Azides; B-Lymphocytes; Dinitrochlorobenzene; DNA; Drug Hypersensitivity; Female; Humans; Hyda | 1981 |
[Epidermal reactivity of DNP (dinitrophenyl) compounds following epidermal DNCB (2,4-dinitrochlorobenzene) sensitization].
Topics: Dinitrobenzenes; Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Nitrobenzenes; Skin Tests | 1984 |
The sensitization potential of D & C Yellow No. 11 in guinea pigs.
Topics: Animals; Coloring Agents; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Drug Hypersensitiv | 1983 |
Reduced skin threshold to irritation in the presence of allergic contact dermatitis in the guinea pig.
Topics: Animals; Dermatitis, Atopic; Dermatitis, Contact; Dinitrochlorobenzene; Drug Hypersensitivity; Femal | 1984 |
[Studies on the flare up reaction and the retest reaction in contact sensitivity to DNCB (author's transl)].
Topics: Animals; Dinitrochlorobenzene; Drug Hypersensitivity; Guinea Pigs; Male; Nitrobenzenes | 1980 |
[Cellular immunodeficiency in superficial mycoses and cutaneous viroses].
Topics: Adolescent; Adult; Aged; Child; Dermatomycoses; Dinitrochlorobenzene; Drug Hypersensitivity; Humans; | 1981 |
How does PUVA inhibit delayed cutaneous hypersensitivity?
Topics: Dermatitis, Contact; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Drug Hypersensitivity; | 1982 |
Serum glycoproteins in cancer patients: first report of correlations with in vitro and in vivo parameters of cellular immunity.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Glycopro | 1980 |
Suppression of allergic contact dermatitis by alpha-L-fucose.
Topics: Animals; Dermatitis, Contact; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Fucose; Guinea Pi | 1980 |
The prognostic significance of delayed hypersensitivity to dinitrochlorobenzene and mechlorethamine hydrochloride in cutaneous T cell lymphoma.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Dinitrochlorobenzene; Disease P | 1998 |
Quantitation of cytokine mRNA expression as an endpoint for prediction and diagnosis of xenobiotic-induced hypersensitivity reactions.
Topics: Animals; Cytokines; Dendritic Cells; Dinitrochlorobenzene; Drug Hypersensitivity; Gene Expression; H | 1999 |
Immunohistochemical detection of protein adducts of 2,4-dinitrochlorobenzene in antigen presenting cells and lymphocytes after oral administration to mice: lack of a role of Kupffer cells in oral tolerance.
Topics: Administration, Oral; Animals; Dinitrochlorobenzene; Disease Models, Animal; Drug Hypersensitivity; | 2001 |
Measuring D.N.C.B. skin sensitivity.
Topics: Allergens; Dinitrochlorobenzene; Drug Hypersensitivity; Nitrobenzenes; Skin Tests | 1977 |
Dinitrochlorobenzene skin-testing.
Topics: Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Nitrobenzenes; Skin Tests | 1977 |
Evaluation of cellular mediated immunity in a normal adult population.
Topics: Adolescent; Adult; Aged; Biopsy; Child; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Humans; | 1977 |
Immunological studies in psoriasis. The quantitative evaluation of cell-mediated immunity in patients with psoriasis by experimental sensitization to 2,4-dinitrochlorobenzene.
Topics: Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Hypersensitivity, Delayed; Immunity, Cellular; | 1977 |
Clinical and immunologic study of patients of cancer cervix.
Topics: Adolescent; Adult; Age Factors; Aged; Antigens, Neoplasm; Dinitrochlorobenzene; Drug Hypersensitivit | 1979 |
Studies on the retest reaction in contact sensitivity to DNCB.
Topics: Animals; Antigens; Dinitrochlorobenzene; Drug Hypersensitivity; Eosinophils; Guinea Pigs; Humans; Hy | 1978 |
Studies of contact hypersensitivity and tolerance in vivo and in vitro. II. Regulation by serum factors.
Topics: Animals; Cell Adhesion; Cyclophosphamide; Dermatitis, Contact; Dinitrochlorobenzene; Drug Hypersensi | 1978 |
Studies of contact hypersensitivity and tolerance in vivo and in vitro. I. Basic characteristics of the reactions and confirmation of an immune response in tolerant mice.
Topics: Animals; Cell Adhesion; Cyclophosphamide; Dermatitis, Contact; Dinitrochlorobenzene; Drug Hypersensi | 1978 |
Cross allergy between paranitro compounds with special reference to DNCB and chloramphenicol.
Topics: Adolescent; Adult; Aged; Chloramphenicol; Cross Reactions; Dinitrochlorobenzene; Drug Hypersensitivi | 1978 |
Restoration of normal experimental DNCB hypersensitivity development in symptom-free patients with psoriasis.
Topics: Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Immunity, Cellular; Nitrobenzenes; Psoriasis; R | 1978 |
Dinitrochlorobenzene contact hypersensitivity in the hamster cheek pouch.
Topics: Animals; Cheek; Cricetinae; Dinitrochlorobenzene; Disease Models, Animal; Drug Hypersensitivity; Fem | 1976 |
Topical chemotherapy and immunotherapy of mycosis fungoides: intermediate-term results.
Topics: Administration, Topical; Aged; Desensitization, Immunologic; Dinitrochlorobenzene; Drug Hypersensiti | 1977 |
Evaluation of the immunocompetance of patients with transitional cell carcinoma of the bladder.
Topics: Adult; Aged; Antibody Formation; Carcinoma, Transitional Cell; Dinitrochlorobenzene; Drug Hypersensi | 1977 |
A comparative study of allergic and primary irritant contact dermatitis with dinitrochlorobenzene (DNCB) in dogs.
Topics: Administration, Topical; Animals; Dermatitis, Contact; Dinitrochlorobenzene; Dogs; Drug Hypersensiti | 1975 |
[Study of the parallergizing action on the skin of various synthetic detergents].
Topics: Animals; Detergents; Dinitrochlorobenzene; Drug Hypersensitivity; Guinea Pigs; Hypersensitivity; Ski | 1975 |
Dinitrochlorobenzene contact sensitization in pulmonary tuberculosis.
Topics: Adolescent; Adult; Dermatitis, Contact; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Humans; | 1975 |
[The immunological status in malignant melanoma].
Topics: Dinitrochlorobenzene; Drug Hypersensitivity; Humans; Lymphocyte Activation; Melanoma; Skin Tests | 1975 |
Histological aspects of DNCB sensitization and challenge tests.
Topics: Adult; Aged; Dinitrochlorobenzene; Drug Hypersensitivity; Erythema; Female; Humans; Male; Middle Age | 1976 |
Langerhans cells, antigen presentation, and the diversity of responses to chemical allergens.
Topics: Allergens; Animals; Antigen-Presenting Cells; Dermatitis, Contact; Dinitrochlorobenzene; Drug Hypers | 1992 |
Repeated application of dinitrochlorobenzene to the ears of sensitized guinea pigs: a preliminary characterization of a potential new animal model for contact eczema in humans.
Topics: Animals; Dermatitis, Contact; Dinitrochlorobenzene; Disease Models, Animal; Drug Hypersensitivity; E | 1992 |
The mechanisms and evaluation of chemically induced allergy.
Topics: Animals; Dinitrochlorobenzene; Drug Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Mice; Phth | 1992 |
Antigen-restricted antigenic competition induced by 2,4-dinitrochlorobenzene: association with depression of lymphocyte proliferation.
Topics: Animals; Cross Reactions; Dinitrochlorobenzene; Drug Hypersensitivity; Epitopes; Lymphocyte Activati | 1990 |
Sensitization studies on chondroitin sulfate.
Topics: Anaphylaxis; Animals; Body Weight; Chondroitin Sulfates; Dinitrochlorobenzene; Drug Hypersensitivity | 1991 |
Zinc status and delayed cutaneous hypersensitivity in handicapped children treated with anticonvulsants.
Topics: Adolescent; Child; Child, Preschool; Dinitrochlorobenzene; Disabled Persons; Drug Hypersensitivity; | 1987 |
Suppressive effects of transdermal clonidine administration on contact hypersensitivity reactions in guinea pigs.
Topics: Administration, Cutaneous; Animals; Blood Pressure; Clonidine; Dermatitis, Contact; Dinitrochloroben | 1988 |
The mechanisms of histological incontinence of pigment: light and electron microscopic studies of lesions and patch test sites in female facial melanosis and DNCB reactions in guinea pigs.
Topics: Aged; Animals; Dinitrochlorobenzene; Drug Hypersensitivity; Eugenol; Face; Female; Guinea Pigs; Huma | 1987 |
Ultrastructural and phenotypic changes in Langerhans cells induced in vitro by contact allergens.
Topics: Allergens; Animals; Cells, Cultured; Dinitrochlorobenzene; Dose-Response Relationship, Immunologic; | 1987 |
[Neutrophil agglutination test in sensitized guinea pigs].
Topics: Animals; Dinitrochlorobenzene; Drug Hypersensitivity; Epoxy Resins; Female; Guinea Pigs; Hemagglutin | 1986 |
Indomethacin and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in the hamster buccal pouch.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cheek; Cricetinae; Dinitrochlorobenzene; Drug | 1985 |
Susceptibility and amplification of sensitivity in contact dermatitis.
Topics: Adult; Dermatitis, Contact; Dinitrochlorobenzene; Disease Susceptibility; Dose-Response Relationship | 1985 |
Hypersensitive prostaglandin and thromboxane response to hormones in rabbit colitis.
Topics: Animals; Carbon Radioisotopes; Colitis; Colon; Dinitrochlorobenzene; Drug Hypersensitivity; Hormones | 1985 |
Cutaneous reactivity in patients with cancer of the head and neck region.
Topics: Age Factors; Aged; Carcinoma, Squamous Cell; Croton Oil; Dinitrochlorobenzene; Drug Hypersensitivity | 1973 |