dinitrochlorobenzene has been researched along with Acquired Immunodeficiency Syndrome in 13 studies
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dinitrochlorobenzene (DNCB) is an inexpensive contact sensitizing agent that stimulates cell-mediated immunity when applied to the skin." | 2.68 | Topical immune modulation with dinitrochlorobenzene in HIV disease: a controlled trial from Brazil. ( Margulis, SB; Stricker, RB; Traub, A, 1997) |
| "In contrast, AIDS developed in 5 of the 11 noncompliant patients and four of these patients died." | 1.29 | Clinical and immunologic evaluation of HIV-infected patients treated with dinitrochlorobenzene. ( Dumlao, C; Elswood, BF; Epstein, WL; Goldberg, B; Henry, J; Stricker, RB; Van Elk, J; Winger, EE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McLeod, WA | 2 |
| Jeffries, E | 1 |
| Boyko, W | 1 |
| Arnott, NM | 1 |
| Stricker, RB | 6 |
| Goldberg, B | 3 |
| Elswood, BF | 3 |
| Dumlao, C | 1 |
| Van Elk, J | 1 |
| Henry, J | 1 |
| Winger, EE | 1 |
| Epstein, WL | 2 |
| Stone, OJ | 1 |
| Traub, A | 1 |
| Margulis, SB | 1 |
| Marion, SA | 1 |
| Schechter, MT | 1 |
| Weaver, MS | 1 |
| Boyko, WJ | 1 |
| Willoughby, B | 1 |
| Douglas, B | 1 |
| Craib, KJ | 1 |
| O'Shaughnessy, M | 1 |
| Madhok, R | 1 |
| Gracie, A | 1 |
| Lowe, GD | 1 |
| Burnett, A | 1 |
| Froebel, K | 1 |
| Follett, E | 1 |
| Forbes, CD | 1 |
| Rietmeijer, CA | 1 |
| Cohn, DL | 1 |
| Mills, LB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Epidermal Langerhans Cell Population in AIDS / ARC Patients by the Topical Application of a Potent Contact Allergen (1-Chloro-2,4-Dinitro-Chlorobenzene) (DNCB)[NCT00002031] | 0 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dinitrochlorobenzene and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Topical immune modulation (TIM): a novel approach to the immunotherapy of systemic disease.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Administration, Topical; Anti-HIV Agents | 1997 |
Dendritic cells and dinitrochlorobenzene (DNCB): a new treatment approach to AIDS.
Topics: Acquired Immunodeficiency Syndrome; Dendritic Cells; Dinitrochlorobenzene; HIV; Humans; Langerhans C | 1991 |
1 trial available for dinitrochlorobenzene and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Topical immune modulation with dinitrochlorobenzene in HIV disease: a controlled trial from Brazil.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Administration, Cutaneous; Adult; Anti-H | 1997 |
10 other studies available for dinitrochlorobenzene and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Screening for acquired immune deficiency syndrome with dinitrochlorobenzene.
Topics: Acquired Immunodeficiency Syndrome; Dinitrochlorobenzene; Humans; Male; Nitrobenzenes; Prospective S | 1984 |
Screening for acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Dinitrochlorobenzene; Humans; Nitrobenzenes | 1983 |
Host-directed therapy for AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Dinitrochlorobenzene; Humans | 1995 |
Clinical and immunologic evaluation of HIV-infected patients treated with dinitrochlorobenzene.
Topics: Acquired Immunodeficiency Syndrome; Antigens, CD; CD4-CD8 Ratio; Dinitrochlorobenzene; Flow Cytometr | 1994 |
Delayed-type hypersensitivity and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Dinitrochlorobenzene; Humans; Hypersensitivity, Delayed | 1994 |
Inducing viral immunity without a vaccine--possible use with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Dermatitis, Contact; Dermatitis, Toxicodendron; Dinitrochloroben | 1993 |
Evidence that prior immune dysfunction predisposes to human immunodeficiency virus infection in homosexual men.
Topics: Acquired Immunodeficiency Syndrome; Candida; Dinitrochlorobenzene; Disease Susceptibility; Homosexua | 1989 |
Impaired cell mediated immunity in haemophilia in the absence of infection with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Blood Coagulation Factors; Dinitrochlorobenzene; Hemophilia A; H | 1986 |
Severe allergic contact dermatitis from dinitrochlorobenzene in a patient with human immunodeficiency virus infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; Dermatitis, Contact; Dinitrochlorobenzene; Humans; Male | 1988 |
Stimulation of T-cellular immunity by cutaneous application of dinitrochlorobenzene.
Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Dinitrochlorobenzene; Humans; Nitrobenz | 1986 |