dinitrobenzenes and Rhinitis--Allergic--Seasonal

Topics: Animals; Antibody-Producing Cells; B-Lymphocytes; Dinitrobenzenes; Freund's Adjuvant; Humans; Immunoglobulin E; Immunoglobulin G; Mice; Rabbits; Rats; Rhinitis, Allergic, Seasonal; T-Lymphocytes

In guinea pigs, an IgE antibody was produced by intraperitoneal injection of antigen (DNP-As) containing Al(OH)3 and booster inhalation of the antigen into the nasal cavity. Experimental allergic rhinitis was induced by the perfusion of antigen solution into the nasal cavities of actively sensitized guinea pigs. Severity of allergic rhinitis was assessed by determining release of histamine and leakage of dye into the nasal cavity. The antigen-induced release of histamine was significantly increased at 0 to 15 minutes following antigen administration but then decreased with time. The antigen-induced leakage of dye was sustained for 60 minutes after administration of the antigen. These results suggest that the DNP-As-induced allergic rhinitis model in guinea pigs is instrumental in evaluating the effect of various factors on allergic rhinitis.

Topics: Animals; Antigens, Helminth; Ascaris suum; Coloring Agents; Dinitrobenzenes; Disease Models, Animal; Guinea Pigs; Haptens; Histamine Release; Immunoglobulin E; Male; Nasal Cavity; Passive Cutaneous Anaphylaxis; Reference Values; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal

Topics: Allergens; Animals; Antigens, Plant; B-Lymphocytes; Cell Differentiation; Dinitrobenzenes; Hookworm Infections; Humans; Immunoglobulin E; Mice; Nippostrongylus; Phytotherapy; Plant Proteins; Pollen; Polyglutamic Acid; Polylysine; Rats; Receptors, IgE; Receptors, Immunologic; Rhinitis, Allergic, Seasonal; T-Lymphocytes; T-Lymphocytes, Regulatory