dinitrobenzenes and Chronic-Disease

Topics: Animals; Antibodies, Monoclonal; Basophils; Binding, Competitive; Chronic Disease; Dinitrobenzenes; Histamine Release; Humans; Immunoglobulin E; Kinetics; Leukemia; Mast Cells; Mice; Rats; Receptors, IgE; Receptors, Immunologic

We describe a patient with chronic actinic dermatitis whose photopatch tests revealed reactions to musk ketone and musk ambrette, both of which were found in his aftershave lotion. Minimal erythema doses of UVA and UVB were decreased. After initial unsuccessful treatment with PUVA therapy the patient was successfully treated with a combination of cyclosporine and PUVA.

Topics: Chronic Disease; Cyclosporine; Dinitrobenzenes; Drug Therapy, Combination; Humans; Ketones; Male; Middle Aged; Perfume; Photosensitivity Disorders; PUVA Therapy

Musk ambrette, a contact and photocontact allergen, is a synthetic fragrance present in aftershave lotions and many toiletries. Thirty-four patients with contact and photocontact allergy to musk ambrette were studied. All had a facial eczema. Four distinctive clinical pictures were seen. These were plaques of eczema, jawline (mandibular) dermatitis, acute contact dermatitis and chronic actinic dermatitis. Twenty-six patients were light sensitive by history and 10 were diagnosed by clinical criteria as having chronic actinic dermatitis. Patch and photopatch testing to musk ambrette showed that seven patients had pure photocontact dermatitis to musk ambrette. Eight patients had contact dermatitis to musk ambrette but this was exacerbated by irradiation. Cross reaction with moskene occurred. Scrupulous avoidance of musk ambrette has resulted in clinical resolution in most patients.

Topics: Acute Disease; Adult; Aged; Chronic Disease; Dermatitis, Contact; Dinitrobenzenes; Facial Dermatoses; Humans; Male; Middle Aged; Nitrobenzenes; Patch Tests; Perfume; Photosensitivity Disorders; Ultraviolet Rays

Specificity of plasmacellular infiltration was studied using a guinea pig peritoneal inflammation model. Acute and chronic inflammations were induced by repeated injections of either of two non-crossreacting antigens (DNP-BSA and PPD). With an enzyme-immunohistochemical sandwich procedure allowing quantitation of DNP-BSA-specific plasma cells, specificity of plasmacellular infiltration could be demonstrated. DNP-BSA-specific antibody-forming cells were found not to enter inflammatory reactions elicited by PPD. Our data support the hypothesis that virtually all plasma cells in a chronic inflammatory exudate release antibodies specific for antigens that are locally available, and that such antigens are likely to play a central role in the perpetuation of chronicity.

Topics: Animals; Antibody Specificity; Antibody-Producing Cells; Cell Movement; Chronic Disease; Dinitrobenzenes; Female; Guinea Pigs; Inflammation; Peritoneal Cavity; Plasma Cells; Serum Albumin, Bovine; Tuberculin

Photopatch tests in 47 patients with chronic actinic dermatitis (CAD) showed musk ambrette to be the only significant allergen in our standard photopatch test series. The incidence of positive patch tests to a standard series of contact allergens in this group was compared with 213 men over the age of 50 years with eczema investigated in the contact clinic. Among the photosensitive patients, there was an increased incidence of reaction to thiuram-mix (CAD 10%; controls 3%), carba mix (CAD 6%; controls 1%), nickel sulphate (CAD 6%; controls 2%) and vioform (CAD 10%; controls 0.5%). A decreased incidence of reaction to potassium dichromate (CAD 0%; controls 8%) and balsam of Peru (CAD 4%; controls 10%) was recorded.

Topics: Adult; Aged; Allergens; Chronic Disease; Dinitrobenzenes; Female; Humans; Male; Middle Aged; Patch Tests; Photosensitivity Disorders; Skin Tests

Topics: Acute Disease; Animals; Antibodies, Viral; Chronic Disease; Dinitrobenzenes; Erythrocytes; Female; Ficoll; Hemolytic Plaque Technique; Lactate dehydrogenase-elevating virus; Mice; Mice, Inbred BALB C; Sheep; T-Lymphocytes; Virus Diseases