dinaciclib and Head-and-Neck-Neoplasms

dinaciclib has been researched along with Head-and-Neck-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for dinaciclib and Head-and-Neck-Neoplasms

Article	Year
Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib. Frontiers in immunology, 2020, Volume: 11 Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival in cancer patients. Direct or indirect targeting of either of these substances seems thus reasonable to improve therapy options for patients. In this study, glioblastoma multiforme (GBM) as well as head and neck squamous cell carcinomas (HNSCC) were examined because of their different mechanisms of spontaneous and treatment-induced immune escape. Effects on gene expression and protein levels were examined. Accompanying assessment of TRP metabolites from treated GBM cell culture supernatants was conducted. Our results show a heterogeneous and inversely correlated expression profile of TRP-metabolizing genes among GBM and HNSCC cells, with low, but inducible Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclic N-Oxides; Cyclin-Dependent Kinases; Gene Expression Regulation, Neoplastic; Glioblastoma; Head and Neck Neoplasms; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indolizines; Interferon-gamma; Kynurenine; Metabolic Networks and Pathways; Neoplasms; Pyridinium Compounds; Tryptophan; Tryptophan Oxygenase	2020

Article

Year

Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib.

Frontiers in immunology, 2020, Volume: 11

Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival in cancer patients. Direct or indirect targeting of either of these substances seems thus reasonable to improve therapy options for patients. In this study, glioblastoma multiforme (GBM) as well as head and neck squamous cell carcinomas (HNSCC) were examined because of their different mechanisms of spontaneous and treatment-induced immune escape. Effects on gene expression and protein levels were examined. Accompanying assessment of TRP metabolites from treated GBM cell culture supernatants was conducted. Our results show a heterogeneous and inversely correlated expression profile of TRP-metabolizing genes among GBM and HNSCC cells, with low, but inducible

Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclic N-Oxides; Cyclin-Dependent Kinases; Gene Expression Regulation, Neoplastic; Glioblastoma; Head and Neck Neoplasms; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indolizines; Interferon-gamma; Kynurenine; Metabolic Networks and Pathways; Neoplasms; Pyridinium Compounds; Tryptophan; Tryptophan Oxygenase

2020