diminazene has been researched along with African Sleeping Sickness in 214 studies
Diminazene: An effective trypanocidal agent.
diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with diminazene aceturate reversed the reproductive abnormalities caused by the parasite." | 2.78 | Effects of Trypanosoma brucei infection and diminazene aceturate therapy on testicular morphology and function of Nigerian local dogs. ( Ezeh, IO; Ezeokonkwo, RC; Idika, IK; Iheagwam, CN; Obi, CF; Obidike, RI; Omoja, VU, 2013) |
| "05) in packed cell volume (PCV) was encountered in the infected untreated controls and those treated at day 8 post-infection with a sub-optimal dosage of diminazene aceturate (Berenil) at 3." | 2.74 | Effects of melarsamine hydrochloride (Cymelarsan) and diminazene aceturate (Berenil) on the pathology of experimental Trypanosoma brucei infection in red fronted gazelles (Gazella rufifrons). ( Aliyu, MM; Ibrahim, UI; Mbaya, AW; Nwosu, CO; Taiwo, VO, 2009) |
| " When this third group was treated, the frequency of trypanosomes resistant to the drug dosage was estimated to be less than 1 in 10(3)." | 2.68 | Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense. ( Mamman, M; Murphy, NB; Peregrine, AS; Williams, DJ, 1995) |
| ", when the same flies were allowed to feed on clean goats, the resultant infections were sensitive to treatment with the same drug dosage when administered 24 h following infection." | 2.67 | Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats. ( Katende, J; Mamman, M; Moloo, SK; Peregrine, AS, 1993) |
| "Diminazene was first described in 1955." | 2.38 | Pharmacology of diminazene: a review. ( Mamman, M; Peregrine, AS, 1993) |
| "African Trypanosomiasis is a debilitating disease in both humans and animals that occurs in sub-Saharan Africa and has a severe negative impact on the livelihood of people in the affected areas." | 1.91 | African trypanosome infection patterns in cattle in a farm setting in Southern Ghana. ( Ekloh, W; Gwira, TM; Sunter, JD, 2023) |
| " Judicious treatment of confirmed trypanosomiasis cases with correct dosage would still be effective in controlling the disease since the observed resistance was at the population and not clonal level." | 1.91 | Variation of sensitivity of Trypanosoma evansi isolates from Isiolo and Marsabit counties of Kenya to locally available trypanocidal drugs. ( Alusi, PM; Auma, JE; Chemuliti, JK; Kurgat, RK; Mdachi, RE; Mugunieri, LG; Mukiria, PW; Ogolla, KO; Okoth, SO; Wamwiri, FN; Wanjala, KB, 2023) |
| "Control of African trypanosomiasis relies on chemotherapy, but the development of resistance and the problem of drug residues require research for alternatives." | 1.46 | Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense. ( Ademola, IO; Odeniran, PO, 2017) |
| " Thereafter mice were monitored for relapse of parasitemia after which they were treated with melarsoprol at a dosage of 3." | 1.40 | Kenyan purple tea anthocyanins and coenzyme-Q10 ameliorate post treatment reactive encephalopathy associated with cerebral human African trypanosomiasis in murine model. ( Isaac, AO; Nyariki, JN; Rashid, K; Wachira, FN, 2014) |
| "Aloe-emodin was obtained by oxidative hydrolysis of aloin, while rhein was subsequently derived from aloe-emodin by oxidation." | 1.40 | Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolense field isolate. ( Asres, K; Bisrat, D; Terefe, G; Tewabe, Y, 2014) |
| "African trypanosomiasis is a major disease of economic and public health importance affecting agricultural and human development." | 1.40 | Evaluation of in vivo antitrypanosomal activity of crude extracts of Artemisia abyssinica against aTrypanosoma congolense isolate. ( Feyera, T; Shibeshi, W; Terefe, G, 2014) |
| "Human African trypanosomiasis, also known as sleeping sickness, affects the CNS at the late stage of the disease." | 1.32 | Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. ( Bradley, B; de Felipe, C; Gettinby, G; Hunt, SP; Kennedy, PG; Leeman, SE; Murray, M; Rodgers, J, 2003) |
| " Following the free of charge treatment of the adult cattle at intervals of 7 weeks and at a dosage of 15 ml/100 kg body weight, there was an increase in the average packed cell volume in the herd although the decline in the incidence of trypanosomal infections was more prolonged." | 1.32 | A large-scale trial to evaluate the efficacy of a 1% pour-on formulation of cyfluthrin (Cylence, Bayer) in controlling bovine trypanosomosis in Eastern Zambia. ( Jooste, R; Lumamba, D; Mubanga, J; Munsimbwe, L; Van den Bossche, P, 2004) |
| "Diminazene was rapidly accumulated through a single transporter, with a K(m) of 0." | 1.32 | The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes. ( Anderson, LF; Barrett, MP; Burchmore, RJ; de Koning, HP; Stewart, M; Wallace, LJ, 2004) |
| "The treatment of late-stage human African trypanosomiasis is complicated by a post-treatment reactive encephalopathy, also referred to as a 'reactive arsenical encephalopathy', that may be fatal." | 1.30 | The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis. ( Burke, JM; Gichuki, CW; Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J, 1997) |
| "It is concluded that tissue culture rinderpest vaccine does not cause immunosuppression and can safely be used in cattle likely to be exposed to tsetse flies and trypanosomosis." | 1.30 | Rinderpest vaccination and the incidence and development of trypanosomosis in cattle. ( Dolan, RB; Munga, L; Ndung'u, EK; Rossiter, PB; Stevenson, P, 1999) |
| " These finding indicate that the majority of the relapse trypanosomes were susceptible the the drug dosage used for selecting the population and that, surprisingly, the calculated proportion of organisms which survived drug exposure varied inversely with the inoculum size." | 1.29 | Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate. ( Gettinby, G; Kemei, S; Mamman, M; Murphy, NB; Peregrine, AS, 1995) |
| " There were no significant differences between the values of pharmacokinetic parameters for the noninfected cattle and the values for cattle with a chronic T." | 1.29 | Comparative pharmacokinetics of diminazene in noninfected Boran (Bos indicus) cattle and Boran cattle infected with Trypanosoma congolense. ( Aliu, YO; Mamman, M; Peregrine, AS, 1993) |
| "When diminazene aceturate was administered at a standard dose of 3." | 1.29 | The effects of hyperosmolar agents lithium chloride and sucrose on the brain concentration of diminazene aceturate in rats. ( Anika, SM; Asuzu, IU; Odika, IE, 1995) |
| "The treatment of late-stage African sleeping sickness in man is often complicated by a post-treatment reactive encephalopathy." | 1.28 | Subcurative chemotherapy and fatal post-treatment reactive encephalopathies in African trypanosomiasis. ( Adams, JH; Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M, 1992) |
| "The treatment of human African sleeping sickness is complicated by a post-treatment meningoencephalitis that may be fatal." | 1.28 | The use of azathioprine to ameliorate post-treatment encephalopathy associated with African trypanosomiasis. ( Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M, 1992) |
| "Diminazene aceturate was more efficient and provided a 40 mg-kg dose was utilised, it was possible to reduce the period of DFMO to approximately 12 days." | 1.28 | Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO). ( Jennings, FW, 1992) |
| "0 micrograms/ml in combination with diminazene aceturate or isometamidium chloride." | 1.28 | The effect of verapamil alone and in combination with trypanocides on multidrug-resistant Trypanosoma brucei brucei. ( Kaminsky, R; Zweygarth, E, 1991) |
| " The study shows that low doses of diminazene at rates of 2 mg/kg and 1 mg/kg, when combined with piroxicam at a dosage rate of 0." | 1.28 | Combination therapy of trypanosomiasis using diminazene and non-steroidal anti-inflammatory drugs. ( Abatan, MO, 1991) |
| "Diminazene aceturate was administered intravenously at 3." | 1.28 | The influence of Trypanosoma congolense infection on the disposition kinetics of diminazene aceturate in the dog. ( Anika, SM; Onyeyili, PA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (34.11) | 18.7374 |
| 1990's | 68 (31.78) | 18.2507 |
| 2000's | 24 (11.21) | 29.6817 |
| 2010's | 41 (19.16) | 24.3611 |
| 2020's | 8 (3.74) | 2.80 |
| Authors | Studies |
|---|---|
| Fotie, J | 1 |
| Kaiser, M | 1 |
| Delfín, DA | 1 |
| Manley, J | 1 |
| Reid, CS | 1 |
| Paris, JM | 1 |
| Wenzler, T | 1 |
| Maes, L | 1 |
| Mahasenan, KV | 1 |
| Li, C | 1 |
| Werbovetz, KA | 1 |
| Fueyo González, FJ | 1 |
| Ebiloma, GU | 2 |
| Izquierdo García, C | 1 |
| Bruggeman, V | 1 |
| Sánchez Villamañán, JM | 1 |
| Donachie, A | 1 |
| Balogun, EO | 1 |
| Inaoka, DK | 1 |
| Shiba, T | 1 |
| Harada, S | 1 |
| Kita, K | 1 |
| de Koning, HP | 4 |
| Dardonville, C | 1 |
| Soudah, B | 1 |
| Essodina, T | 1 |
| Toï, N | 1 |
| Balabadi, D | 1 |
| Yao, L | 1 |
| Martin Bienvenu, S | 1 |
| Wendemanegde Ernest, S | 1 |
| Kolawole, BJ | 1 |
| Nwoha, RIO | 1 |
| Erin, JP | 1 |
| Orakpoghenor, O | 1 |
| Ekloh, W | 1 |
| Sunter, JD | 1 |
| Gwira, TM | 2 |
| Okello, I | 3 |
| Mafie, E | 3 |
| Nzalawahe, J | 3 |
| Eastwood, G | 3 |
| Mboera, LEG | 3 |
| Hakizimana, JN | 3 |
| Ogola, K | 3 |
| Mdachi, RE | 3 |
| Ogolla, KO | 1 |
| Auma, JE | 2 |
| Wamwiri, FN | 1 |
| Kurgat, RK | 2 |
| Wanjala, KB | 1 |
| Mugunieri, LG | 1 |
| Alusi, PM | 1 |
| Chemuliti, JK | 2 |
| Mukiria, PW | 1 |
| Okoth, SO | 1 |
| Mewamba, EM | 1 |
| Farikou, O | 1 |
| Kamga, RMN | 1 |
| Magang, MEK | 1 |
| Tume, C | 1 |
| Tiofack, AAZ | 1 |
| Ravel, S | 1 |
| Simo, G | 1 |
| Ndung'u, K | 1 |
| Murilla, GA | 2 |
| Thuita, JK | 2 |
| Ngae, GN | 1 |
| Gitonga, PK | 1 |
| Thungu, DK | 1 |
| Carruthers, LV | 1 |
| Munday, JC | 1 |
| Steketee, P | 1 |
| Jayaraman, S | 1 |
| Campagnaro, GD | 1 |
| Ungogo, MA | 1 |
| Lemgruber, L | 1 |
| Donachie, AM | 1 |
| Rowan, TG | 1 |
| Peter, R | 1 |
| Morrison, LJ | 1 |
| Barrett, MP | 3 |
| Suganuma, K | 2 |
| Molefe, NI | 1 |
| Inoue, N | 2 |
| Mulandane, FC | 1 |
| Fafetine, J | 1 |
| Van Den Abbeele, J | 7 |
| Clausen, PH | 10 |
| Hoppenheit, A | 3 |
| Cecchi, G | 3 |
| Oosthuizen, M | 1 |
| Delespaux, V | 11 |
| Neves, L | 2 |
| Bassi, PB | 1 |
| de Araújo, FF | 1 |
| Garcia, GC | 1 |
| Vinícius da Silva, M | 1 |
| Oliveira, CJF | 1 |
| Bittar, ER | 1 |
| de Souza Gomes, M | 1 |
| Rodrigues do Amaral, L | 1 |
| Costa E Silva, MF | 1 |
| Nascentes, GAN | 1 |
| Rodrigues Junior, V | 1 |
| Martins-Filho, OA | 1 |
| Araújo, MSS | 1 |
| Bittar, JFF | 1 |
| Adeleye, OE | 1 |
| Ale, JM | 1 |
| Sogebi, EOA | 1 |
| Durotoye, LA | 1 |
| Adeleye, AI | 1 |
| Adeyemi, SO | 1 |
| Olukunle, JO | 1 |
| Bengaly, Z | 4 |
| Vitouley, SH | 1 |
| Somda, MB | 1 |
| Zongo, A | 1 |
| Têko-Agbo, A | 1 |
| Adam, Y | 1 |
| Sidibé, I | 7 |
| Bayala, B | 1 |
| Belem, AMG | 1 |
| Tchamdja, E | 2 |
| Kulo, AE | 2 |
| Batawui, K | 2 |
| Bauer, B | 7 |
| Den Abbeele, JV | 1 |
| Kuriakose, SM | 1 |
| Onyilagha, C | 2 |
| Singh, R | 2 |
| Jia, P | 2 |
| Uzonna, JE | 4 |
| Waiswa, C | 3 |
| Wangoola, MR | 1 |
| Odeniran, PO | 2 |
| Macleod, ET | 2 |
| Ademola, IO | 2 |
| Welburn, SC | 3 |
| Amisigo, CM | 1 |
| Antwi, CA | 1 |
| Adjimani, JP | 1 |
| Obi, CF | 1 |
| Obidike, RI | 1 |
| Ezeh, IO | 1 |
| Omoja, VU | 2 |
| Iheagwam, CN | 1 |
| Idika, IK | 1 |
| Ezeokonkwo, RC | 3 |
| Kobo, PI | 1 |
| Ayo, JO | 1 |
| Aluwong, T | 1 |
| Zezi, AU | 1 |
| Maikai, V | 1 |
| Ambali, SF | 1 |
| Rashid, K | 1 |
| Wachira, FN | 1 |
| Nyariki, JN | 1 |
| Isaac, AO | 1 |
| Tewabe, Y | 1 |
| Bisrat, D | 1 |
| Terefe, G | 3 |
| Asres, K | 1 |
| Feyera, T | 1 |
| Shibeshi, W | 1 |
| Allamanda, P | 1 |
| Hakimi, H | 1 |
| Zhou, M | 1 |
| Angeles, JM | 1 |
| Kawazu, S | 1 |
| Chekwube, AI | 1 |
| Onyema, EI | 1 |
| Ikenna, UE | 1 |
| Muhanguzi, D | 2 |
| Picozzi, K | 3 |
| Hatendorf, J | 2 |
| Thrusfield, M | 2 |
| Kabasa, JD | 2 |
| Moti, Y | 1 |
| De Deken, R | 3 |
| Thys, E | 1 |
| Duchateau, L | 1 |
| Dagnachew, S | 1 |
| Abebe, G | 4 |
| Barry, D | 1 |
| McCulloch, R | 1 |
| Goddeeris, B | 1 |
| Cnops, J | 1 |
| Bockstal, V | 1 |
| De Trez, C | 1 |
| Miquel, MC | 1 |
| Radwanska, M | 1 |
| Magez, S | 1 |
| Waema, MW | 1 |
| Maina, NW | 1 |
| Ngotho, M | 3 |
| Karanja, SM | 2 |
| Gachie, BM | 1 |
| Maranga, DN | 1 |
| Kagira, JM | 4 |
| Cossic, BGA | 1 |
| Adjahoutonon, B | 1 |
| Gloaguen, P | 1 |
| Dibanganga, GL | 1 |
| Maganga, G | 1 |
| Leroy, P | 1 |
| Vitouley, HS | 5 |
| Bankolé, AA | 1 |
| Adomefa, K | 1 |
| Marcotty, T | 5 |
| Dinka, H | 1 |
| Masumu, J | 1 |
| Van den Bossche, P | 7 |
| Geerts, S | 4 |
| Mbaya, AW | 2 |
| Aliyu, MM | 1 |
| Nwosu, CO | 2 |
| Taiwo, VO | 1 |
| Ibrahim, UI | 1 |
| Jensen, HE | 1 |
| Farah, IO | 2 |
| Hau, J | 2 |
| Sykes, ML | 1 |
| Avery, VM | 1 |
| Kroubi, M | 1 |
| Daulouede, S | 1 |
| Karembe, H | 1 |
| Jallouli, Y | 1 |
| Howsam, M | 1 |
| Mossalayi, D | 1 |
| Vincendeau, P | 1 |
| Betbeder, D | 1 |
| Kariuki, C | 1 |
| Maina, N | 2 |
| Mwangangi, DM | 1 |
| Kumshe, HA | 1 |
| Batista, JS | 2 |
| Rodrigues, CM | 1 |
| Olinda, RG | 1 |
| Silva, TM | 1 |
| Vale, RG | 1 |
| Câmara, AC | 1 |
| Rebouças, RE | 1 |
| Bezerra, FS | 1 |
| García, HA | 1 |
| Teixeira, MM | 2 |
| Anaga, AO | 1 |
| Obidike, IR | 1 |
| Ihedioha, TE | 1 |
| Umeakuana, PU | 1 |
| Mhomga, LI | 1 |
| Asuzu, IU | 4 |
| Anika, SM | 5 |
| Mungube, EO | 2 |
| Allegye-Cudjoe, E | 2 |
| Diall, O | 2 |
| Bocoum, Z | 1 |
| Diarra, B | 2 |
| Randolph, TF | 1 |
| Geysen, D | 2 |
| Chitanga, S | 1 |
| Namangala, B | 1 |
| Sow, A | 1 |
| Séré, M | 1 |
| Diallo, A | 1 |
| Nebié, RL | 1 |
| Ouédraogo, M | 1 |
| Akoda, GK | 1 |
| Nweze, NE | 1 |
| Anene, BM | 2 |
| Boucoum, Z | 1 |
| Sanogo, Y | 1 |
| Randolph, T | 1 |
| Zessin, KH | 2 |
| Adeyemi, OS | 1 |
| Sulaiman, FA | 1 |
| Kuriakose, S | 1 |
| Muleme, HM | 1 |
| Olila, D | 1 |
| McDermott, JJ | 2 |
| Eisler, MC | 1 |
| Mitema, ES | 1 |
| Patzelt, RJ | 1 |
| Poetzsch, CJ | 1 |
| Mehlitz, D | 4 |
| Peregrine, AS | 15 |
| Olbrich, C | 1 |
| Gessner, A | 1 |
| Kayser, O | 1 |
| Müller, RH | 1 |
| Kennedy, PG | 5 |
| Rodgers, J | 3 |
| Bradley, B | 2 |
| Hunt, SP | 1 |
| Gettinby, G | 3 |
| Leeman, SE | 1 |
| de Felipe, C | 1 |
| Murray, M | 12 |
| BAUER, F | 1 |
| WHITESIDE, EF | 1 |
| HAWKING, F | 1 |
| HUTCHINSON, MP | 1 |
| WATSON, HJ | 1 |
| Munsimbwe, L | 1 |
| Mubanga, J | 1 |
| Jooste, R | 1 |
| Lumamba, D | 1 |
| Anderson, LF | 1 |
| Stewart, M | 1 |
| Burchmore, RJ | 1 |
| Wallace, LJ | 1 |
| Gall, Y | 1 |
| Woitag, T | 1 |
| McDermott, J | 1 |
| Magona, JW | 1 |
| Mayende, JS | 1 |
| Okiria, R | 1 |
| Okuna, NM | 1 |
| Schukken, YH | 1 |
| van Schaik, G | 1 |
| Rowlands, GJ | 6 |
| Nagda, SM | 4 |
| Mulatu, W | 6 |
| d'Ieteren, GD | 6 |
| Dhollander, S | 1 |
| Bos, J | 1 |
| Kora, S | 1 |
| Sanneh, M | 1 |
| Gaye, M | 1 |
| Leak, S | 1 |
| Berkvens, D | 1 |
| Mmesirionye, TI | 1 |
| Tettey, JN | 1 |
| Brock, JM | 1 |
| Kibona, SN | 1 |
| Matemba, L | 1 |
| Kaboya, JS | 1 |
| Lubega, GW | 2 |
| Akinwale, OP | 1 |
| Nock, IH | 1 |
| Esievo, KA | 1 |
| Edeghere, HU | 1 |
| Olukosi, YA | 1 |
| Jamal, S | 1 |
| Sigauque, I | 1 |
| Macuamule, C | 1 |
| Penzhorn, BL | 1 |
| Riet-Correa, F | 1 |
| Madruga, CR | 1 |
| Simões, SD | 1 |
| Maia, TF | 1 |
| Ngure, RM | 1 |
| Eckersall, PD | 2 |
| Jennings, FW | 15 |
| Mburu, J | 1 |
| Burke, J | 3 |
| Mungatana, N | 1 |
| Gray, GD | 3 |
| Hajduk, SL | 1 |
| Whitelaw, DD | 5 |
| Nantulya, VM | 3 |
| Doyle, JJ | 1 |
| Jenni, L | 4 |
| Sizemore, RC | 1 |
| Mansfield, JM | 1 |
| Dukes, P | 1 |
| Abaru, DE | 1 |
| Liwo, DA | 1 |
| Isakina, D | 1 |
| Okori, EE | 1 |
| Wellde, BT | 3 |
| Chumo, DA | 3 |
| Küpper, W | 1 |
| Wolters, M | 1 |
| Urquhart, GM | 5 |
| Gilbert, RJ | 2 |
| Logan, LL | 1 |
| Goodwin, JT | 1 |
| Tembely, S | 1 |
| Craig, TM | 1 |
| Emerole, GO | 1 |
| Thabrew, MI | 1 |
| Van Marck, EA | 1 |
| Mulumba, P | 1 |
| Beckers, A | 1 |
| Gigase, P | 1 |
| Wéry, M | 1 |
| Ikede, BO | 2 |
| Akpavie, SO | 2 |
| Newton, BA | 1 |
| Joshua, RA | 2 |
| Elamin, EA | 1 |
| Homeida, AM | 1 |
| Adam, SE | 1 |
| Mahmoud, MM | 1 |
| Haase, M | 1 |
| Bernard, S | 1 |
| Guidot, G | 1 |
| Murray, PK | 1 |
| Miller, BM | 1 |
| Mills, JN | 1 |
| Valli, VE | 1 |
| Boo, KS | 1 |
| Forsberg, CM | 1 |
| Omukuba, JN | 1 |
| Cagnolati, V | 1 |
| Mamman, M | 7 |
| Murphy, NB | 4 |
| Kemei, S | 1 |
| Egbe-Nwiyi, TN | 2 |
| Antia, RE | 2 |
| Stevenson, P | 4 |
| Sones, KR | 1 |
| Gicheru, MM | 1 |
| Mwangi, EK | 1 |
| Williams, DJ | 1 |
| Mabbott, NA | 1 |
| Sutherland, IA | 1 |
| Sternberg, JM | 1 |
| Bruneel, H | 1 |
| van den Eeckhout, A | 1 |
| Molisho, D | 1 |
| Degroof, D | 1 |
| Pépin, J | 2 |
| Burudi, EM | 1 |
| Majiwa, PA | 3 |
| Mbiuki, SM | 2 |
| Kinabo, LD | 1 |
| Gray, MA | 2 |
| Kimarua, RW | 1 |
| Kihurani, DO | 1 |
| Mogoa, E | 1 |
| Nguhiu-Mwangi, J | 1 |
| Mbithi, PM | 1 |
| Authié, E | 3 |
| Leak, SG | 4 |
| Codjia, V | 1 |
| Aliu, YO | 2 |
| Milord, F | 1 |
| Moloo, SK | 12 |
| Bacchi, CJ | 2 |
| Nathan, HC | 2 |
| Yarlett, N | 1 |
| Goldberg, B | 1 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
| Saric, M | 1 |
| Clarkson, AB | 1 |
| Katende, J | 1 |
| Odika, IE | 2 |
| Mwangi, SM | 1 |
| McOdimba, F | 1 |
| Logan-Henfrey, L | 1 |
| Agbe, A | 1 |
| Yielding, KL | 1 |
| Obwolo, MJ | 1 |
| Bwangamoi, O | 1 |
| Mandebvu, E | 1 |
| Yongsheng, Y | 1 |
| Yongchun, O | 1 |
| Chengmai, R | 1 |
| Yuanguo, C | 1 |
| Fenqin, Z | 1 |
| Coulibaly, L | 1 |
| Hecker, PA | 1 |
| Katunguka-Rwakishaya, E | 2 |
| Holmes, PH | 5 |
| Mulugeta, W | 1 |
| Wilkes, J | 1 |
| Masake, R | 1 |
| Diack, A | 1 |
| Gichuki, CW | 1 |
| Hunter, CA | 3 |
| Burke, JM | 1 |
| Enyaru, JC | 1 |
| Matovu, E | 1 |
| Kaminsky, R | 5 |
| Kaushik, RS | 2 |
| Gordon, JR | 2 |
| Tabel, H | 4 |
| Leendertz, FH | 1 |
| Blankenburg, A | 1 |
| Tietjen, U | 1 |
| Rossiter, PB | 1 |
| Munga, L | 1 |
| Ndung'u, EK | 1 |
| Dolan, RB | 3 |
| Amsler-Delafosse, S | 1 |
| Kaboré, I | 2 |
| Kamuanga, M | 1 |
| Goossens, B | 1 |
| Osaer, S | 1 |
| Ndao, M | 1 |
| Van Winghem, J | 1 |
| Silva, RA | 1 |
| Ramirez, L | 1 |
| Souza, SS | 1 |
| Ortiz, AG | 1 |
| Pereira, SR | 1 |
| Dávila, AM | 1 |
| Mattioli, RC | 1 |
| Faye, JA | 1 |
| Büscher, P | 1 |
| Afewerk, Y | 1 |
| Tilahun, G | 1 |
| Gow, JW | 1 |
| McComb, C | 1 |
| Assefa, E | 1 |
| Williamson, J | 1 |
| Roelants, GE | 1 |
| Pearson, TW | 2 |
| Morrison, WI | 1 |
| Mayor-Withey, KS | 1 |
| Lundin, LB | 1 |
| Staak, C | 1 |
| Lohding, A | 1 |
| Chizyuka, HG | 1 |
| Griffin, L | 1 |
| Allonby, EW | 1 |
| Soto, KV | 1 |
| Moreira, R | 1 |
| Chunosoff, L | 1 |
| Hutner, SH | 1 |
| Ruppol, JF | 1 |
| Raether, W | 1 |
| Seidenath, H | 1 |
| Clarkson, MJ | 1 |
| Penhale, WJ | 1 |
| Edwards, G | 1 |
| Farrell, PJ | 1 |
| Mohamed-Ahmed, MM | 1 |
| Rahman, AH | 1 |
| Abdel Karim, EI | 1 |
| Ainanshe, OA | 1 |
| Münstermann, S | 1 |
| Mbura, RJ | 1 |
| Maloo, SH | 1 |
| Löhr, KF | 1 |
| van Velthuysen, ML | 1 |
| Bruijn, JA | 1 |
| van Leer, EH | 1 |
| Fleuren, GJ | 1 |
| Claxton, JR | 1 |
| Leperre, P | 1 |
| Rawlings, P | 1 |
| Snow, WF | 1 |
| Dwinger, RH | 2 |
| Adams, JH | 1 |
| Chitambo, H | 2 |
| Arakawa, A | 2 |
| Ono, T | 1 |
| Silayo, RS | 1 |
| Olaho-Mukani, W | 1 |
| Munyua, WK | 2 |
| Njogu, AR | 5 |
| Zweygarth, E | 5 |
| Abatan, MO | 1 |
| Onyeyili, PA | 4 |
| Egwu, GO | 1 |
| Zaria, LT | 1 |
| Orjiude, BA | 1 |
| Onwualu, JE | 1 |
| Paling, RW | 2 |
| Scott, JR | 2 |
| McOdimba, FA | 1 |
| Kutuza, SB | 1 |
| Okech, G | 1 |
| Alushula, H | 2 |
| Mutugi, M | 1 |
| Sayer, PD | 3 |
| Webster, P | 2 |
| Knowles, G | 1 |
| Ibitayo, AI | 1 |
| Mwangi, DM | 1 |
| Hopkins, J | 1 |
| Luckins, AG | 2 |
| Lindqvist, KJ | 1 |
| Reardon, MJ | 1 |
| Onyango, F | 1 |
| Muriithi, RM | 1 |
| Roberts, LM | 1 |
| Kamar, KK | 1 |
| Preston, JM | 1 |
| Kovatch, RM | 1 |
| Higgs, J | 1 |
| Wosu, LO | 1 |
| Ibe, CC | 1 |
| Chuma, F | 1 |
| Rogers, DJ | 1 |
| Jefferies, D | 2 |
| Waitumbi, JN | 1 |
| Brown, HC | 1 |
| Mbwambo, HA | 1 |
| Mella, PN | 1 |
| Lekaki, KA | 1 |
| Wilson, AJ | 2 |
| Gatuta, GM | 1 |
| Mgutu, SP | 1 |
| Malu, MN | 1 |
| Gardiner, PR | 3 |
| Vos, GJ | 2 |
| Nelson, RT | 1 |
| Otesile, EB | 1 |
| Kaggwa, E | 1 |
| Mugera, GM | 1 |
| Röttcher, D | 3 |
| Schönefeld, A | 1 |
| Bafort, JM | 1 |
| Schmidt, H | 1 |
| Molyneux, DH | 1 |
| Reiter, I | 1 |
| Büttner, M | 1 |
| Seitz, A | 1 |
| Takeya, M | 1 |
| Reinwald, E | 1 |
| Risse, HJ | 1 |
| Rae, P | 1 |
| Dehoux, JP | 1 |
| Makumyaviri, AM | 1 |
| Demey, F | 1 |
| Verhulst, A | 1 |
| Medina, EA | 1 |
| Ventura, FA | 1 |
| Champalimaud, JL | 1 |
| Black, SJ | 1 |
| Sendashonga, CN | 1 |
| Koch, GL | 1 |
| Shapiro, SZ | 1 |
| Egbunike, GN | 1 |
| Akol, GW | 1 |
| Moulton, JE | 1 |
| Mitchell, LA | 1 |
| Poltera, AA | 1 |
| Brighouse, G | 1 |
| Bovell, D | 1 |
| Rudin, W | 1 |
| Schillinger, D | 1 |
5 reviews available for diminazene and African Sleeping Sickness
| Article | Year |
|---|---|
Molecular tools for the rapid detection of drug resistance in animal trypanosomes.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; Drug Resistance; Phenanthridines; Trypanocidal Agents; | 2008 |
Pharmacology of existing drugs for animal trypanosomiasis.
Topics: Animals; Arsenicals; Diminazene; Ethidium; Phenanthridines; Quinolinium Compounds; Suramin; Trypanoc | 1993 |
Pharmacology of diminazene: a review.
Topics: Animals; Animals, Domestic; Diminazene; Drug Resistance; Drug Therapy, Combination; Humans; Trypanoc | 1993 |
The treatment of human African trypanosomiasis.
Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocid | 1994 |
Trypanosomiasis 'risk' or 'challenge': a review.
Topics: Africa, Eastern; Africa, Western; Animals; Cattle; Diminazene; Humans; Risk; Trypanocidal Agents; Tr | 1985 |
11 trials available for diminazene and African Sleeping Sickness
| Article | Year |
|---|---|
Probiotic administration enhanced antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with
Topics: Animals; Diminazene; Dogs; Female; Hemoglobins; Male; Parasitemia; Probiotics; Trypanocidal Agents; | 2022 |
Resistance to trypanocidal drugs in cattle populations of Zambezia Province, Mozambique.
Topics: Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Diminazene; Drug Resistance, Multiple; Mo | 2018 |
Effects of Trypanosoma brucei infection and diminazene aceturate therapy on testicular morphology and function of Nigerian local dogs.
Topics: Animals; Antiprotozoal Agents; Diminazene; Dog Diseases; Dogs; Male; Nigeria; Parasitemia; Testis; T | 2013 |
Collateral benefits of restricted insecticide application for control of African trypanosomiasis on Theileria parva in cattle: a randomized controlled trial.
Topics: Animals; Cattle; Diminazene; Endemic Diseases; Female; Insecticides; Male; Pyrethrins; Theileria par | 2014 |
Effects of melarsamine hydrochloride (Cymelarsan) and diminazene aceturate (Berenil) on the pathology of experimental Trypanosoma brucei infection in red fronted gazelles (Gazella rufifrons).
Topics: Animals; Antelopes; Arsenicals; Diminazene; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanos | 2009 |
Is trypanocidal drug resistance a threat for livestock health and production in endemic areas? Food for thoughts from Sahelian goats infected by Trypanosoma vivax in Bobo Dioulasso (Burkina Faso).
Topics: Animals; Burkina Faso; Diminazene; Drug Resistance; Female; Goat Diseases; Goats; Hematocrit; Parasi | 2012 |
Susceptibility of West African Dwarf goats and WAD x Saanen crosses to experimental infection with Trypanosoma congolense.
Topics: Animals; Antibodies, Protozoan; Antiprotozoal Agents; Body Weight; Crosses, Genetic; Diminazene; Enz | 2005 |
Comparison of isometamidium chloride and homidium bromide as prophylactic drugs for trypanosomiasis in cattle at Nguruman, Kenya.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Kenya; Male; Phenanthridines; Seasons; Trypa | 1995 |
Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense.
Topics: Animals; Antibodies, Protozoan; Diminazene; Drug Resistance; Flow Cytometry; Goat Diseases; Goats; M | 1995 |
Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Diminazene; Drug Administration Schedule; Drug | 1993 |
The influence of supplementation with cotton seed cake on the resistance of Ugandan goats to primary and secondary challenges with Trypanosoma congolense and on their response to treatment.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Diminazene; Food, Fortified; Goat | 1997 |
198 other studies available for diminazene and African Sleeping Sickness
| Article | Year |
|---|---|
Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.
Topics: Acetates; Animals; Cells, Cultured; Esters; Humans; Mice; Molecular Structure; Myoblasts; Quinolines | 2010 |
Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.
Topics: Cell Line; Drug Discovery; Humans; Hydroxybenzoates; Membrane Potential, Mitochondrial; Mitochondria | 2017 |
Assessment of α-Cypermethrin Pour-On Application and Diminazene Aceturate for Treating Trypanosome-Related Diseases Caused by Tsetse Flies on Cattle in Mô, Togo.
Topics: Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Diminazene; Heteroptera; Pyrethrins; Togo | 2022 |
African trypanosome infection patterns in cattle in a farm setting in Southern Ghana.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Farms; Female; Ghana; Humans; Trypanocidal Agents; Try | 2023 |
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Kenya; Mice; Phylogeny; Trypanocidal Agents; Trypanosoma cong | 2023 |
Variation of sensitivity of Trypanosoma evansi isolates from Isiolo and Marsabit counties of Kenya to locally available trypanocidal drugs.
Topics: Animals; Camelus; Chlorides; Diminazene; Drug Resistance; Kenya; Mice; Phenanthridines; Trypanocidal | 2023 |
Molecular identification of diminazene aceturate-resistant strains of Trypanosoma congolense in naturally infected domestic animals of Yoko in the centre region of Cameroon.
Topics: Animals; Cameroon; Cattle; Cattle Diseases; Cross-Sectional Studies; Diminazene; Drug Resistance; Sh | 2020 |
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentam | 2020 |
Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Folic Acid Transporters; Membrane Potential, Mitochond | 2021 |
An ATP-Based Luciferase Viability Assay for Animal African Trypanosomes Using a 96-Well Plate.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Diminazene; Drug Evaluation, Preclinical; Humans; In | 2017 |
Parasitological and immunological evaluation of cattle experimentally infected with Trypanosoma vivax.
Topics: Adaptive Immunity; Animals; Antibodies, Protozoan; Biomarkers; Cattle; Cattle Diseases; Diminazene; | 2018 |
Effects of Trypanosoma brucei brucei infection and diminazene aceturate administration on the blood pressure, heart rate, and temperature of Wistar albino rats.
Topics: Animals; Blood Pressure; Body Temperature; Diminazene; Heart Rate; Male; Rats; Rats, Wistar; Trypano | 2018 |
Drug quality analysis of isometamidium chloride hydrochloride and diminazene diaceturate used for the treatment of African animal trypanosomosis in West Africa.
Topics: Africa, Western; Animals; Chromatography, High Pressure Liquid; Diminazene; Livestock; Phenanthridin | 2018 |
How rational drug use reduces trypanosome infections in cattle in chemo-resistance hot-spot villages of northern Togo.
Topics: Albendazole; Animals; Antimicrobial Stewardship; Cattle; Diminazene; Drug Resistance; Insecticides; | 2019 |
Diminazene aceturate (Berenil) downregulates Trypanosoma congolense-induced proinflammatory cytokine production by altering phosphorylation of MAPK and STAT proteins.
Topics: Animals; Cattle; Cell Line, Transformed; Cytokines; Diminazene; Female; Humans; Inflammation Mediato | 2019 |
Sustaining Efforts of Controlling Zoonotic Sleeping Sickness in Uganda Using Trypanocidal Treatment and Spray of Cattle with Deltamethrin.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; Humans; Insect Vectors; Insecticides; Nitriles; Pyreth | 2019 |
Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; DNA, Intergenic; Drug Resistance; Farms; Nigeria; Poly | 2019 |
In vitro anti-trypanosomal effects of selected phenolic acids on Trypanosoma brucei.
Topics: Animals; Cell Proliferation; Cell Survival; Deferoxamine; Diminazene; Drug Resistance; Gallic Acid; | 2019 |
Flavonoid mixture ameliorates increase in erythrocyte osmotic fragility and malondialdehyde concentration induced by Trypanosoma brucei brucei-infection in Wistar rats.
Topics: Animals; Diminazene; Diosmin; Erythrocytes; Male; Malondialdehyde; Osmotic Fragility; Parasitemia; R | 2014 |
Kenyan purple tea anthocyanins and coenzyme-Q10 ameliorate post treatment reactive encephalopathy associated with cerebral human African trypanosomiasis in murine model.
Topics: Animals; Anthocyanins; Body Weight; Central Nervous System Diseases; Diminazene; Female; Hematocrit; | 2014 |
Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolense field isolate.
Topics: Animals; Anthraquinones; Diminazene; Dose-Response Relationship, Drug; Emodin; Female; Mice; Molecul | 2014 |
Evaluation of in vivo antitrypanosomal activity of crude extracts of Artemisia abyssinica against aTrypanosoma congolense isolate.
Topics: Animals; Artemisia; Diminazene; Female; Humans; Male; Mice; Parasitemia; Phytotherapy; Plant Compone | 2014 |
Establishment of ATP-based luciferase viability assay in 96-well plate for Trypanosoma congolense.
Topics: Adenosine Triphosphate; Animals; Cell Division; Dimethyl Sulfoxide; Diminazene; High-Throughput Scre | 2014 |
Effect of diminazene aceturate, levamisole and vitamin C combination therapy in rats experimentally infected with Trypanosoma brucei brucei.
Topics: Animals; Ascorbic Acid; Body Temperature; Body Weight; Diminazene; Drug Therapy, Combination; Hemogl | 2014 |
Improvements on restricted insecticide application protocol for control of Human and Animal African Trypanosomiasis in eastern Uganda.
Topics: Albendazole; Animals; Cattle; Cattle Diseases; Diminazene; Female; Humans; Insect Control; Insectici | 2014 |
PCR and microsatellite analysis of diminazene aceturate resistance of bovine trypanosomes correlated to knowledge, attitude and practice of livestock keepers in South-Western Ethiopia.
Topics: Agriculture; Animals; Cattle; Cattle Diseases; Diminazene; Drug Resistance; Ethiopia; Health Knowled | 2015 |
In vivo experimental drug resistance study in Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia.
Topics: Animals; Cattle; Cattle Diseases; Communicable Diseases; Diminazene; Drug Resistance; Ethiopia; Inse | 2015 |
Curative drug treatment of trypanosomosis leads to the restoration of B-cell lymphopoiesis and splenic B-cell compartments.
Topics: Animals; B-Lymphocyte Subsets; Bone Marrow; Diminazene; Female; Lymphopoiesis; Mice; Mice, Inbred C5 | 2015 |
Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense.
Topics: Animals; Biomarkers; Body Weight; Diminazene; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
IgM, lgG and IL-6 profiles in the Trypanosoma brucei brucei monkey model of human African trypanosomiasis.
Topics: Animals; Antigens, Protozoan; Chlorocebus aethiops; Diminazene; Disease Models, Animal; Disease Prog | 2017 |
Trypanosomiasis challenge estimation using the diminazene aceturate (Berenil) index in Zebu in Gabon.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Female; Gabon; Longitudinal Studies; Rain; Seasons; Tr | 2017 |
Cattle breeding, trypanosomosis prevalence and drug resistance in Northern Togo.
Topics: Animals; Breeding; Cattle; Cattle Diseases; Communicable Disease Control; Cross-Sectional Studies; D | 2017 |
Five-fold increase in Trypanosoma congolense isolates resistant to diminazene aceturate over a seven-year period in Eastern Zambia.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; DNA, Protozoan; Dose-Response Relationship, Drug; Drug | 2008 |
Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys.
Topics: Animals; Antigens, Protozoan; Biomarkers; Brain; Chlorocebus aethiops; Diminazene; Female; Immunoglo | 2009 |
Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.
Topics: Animals; Diminazene; Humans; Indicators and Reagents; Oxazines; Pentamidine; Sensitivity and Specifi | 2009 |
Development of a nanoparticulate formulation of diminazene to treat African trypanosomiasis.
Topics: Animals; Diminazene; Drug Delivery Systems; Drug Stability; Mice; Nanoparticles; Oxidation-Reduction | 2010 |
Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense.
Topics: Anemia, Macrocytic; Animals; Blood Platelets; Cerebrospinal Fluid; Chlorocebus aethiops; Diminazene; | 2011 |
Genital lesions in male red fronted gazelles (Gazella rufifrons) experimentally infected with Trypanosoma brucei and the effect of melarsamine hydrochloride (Cymelarsan®) and diminazene aceturate (Berenil®) in its treatment.
Topics: Animals; Antelopes; Arsenicals; Body Temperature; Diminazene; Genital Diseases, Male; Hematocrit; Hi | 2011 |
Highly debilitating natural Trypanosoma vivax infections in Brazilian calves: epidemiology, pathology, and probable transplacental transmission.
Topics: Animals; Antiprotozoal Agents; Brazil; Cattle; Cattle Diseases; Diminazene; Infectious Disease Trans | 2012 |
The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats.
Topics: Animals; Azadirachta; Diminazene; Drug Resistance; Drug Therapy, Combination; Female; Male; Parasite | 2011 |
Improved PCR-RFLP for the detection of diminazene resistance in Trypanosoma congolense under field conditions using filter papers for sample storage.
Topics: Animals; Blood Specimen Collection; Cattle; Cattle Diseases; Diminazene; DNA, Protozoan; Drug Resist | 2011 |
High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.
Topics: Africa South of the Sahara; Alleles; Animals; Antiprotozoal Agents; Diminazene; Disease Models, Anim | 2011 |
Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso.
Topics: Animals; Burkina Faso; Cattle; Cross-Sectional Studies; Diminazene; Longitudinal Studies; Phenanthri | 2012 |
Investigation of the antitrypanosomal activity of Buchholzia coriacea seed extract against a field strain of Trypanosoma congolense.
Topics: Administration, Oral; Animals; Capparaceae; Diminazene; Dose-Response Relationship, Drug; Female; He | 2011 |
Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali.
Topics: Animals; Antiprotozoal Agents; Cattle; Cattle Diseases; Cross-Sectional Studies; Diminazene; Drug Re | 2012 |
Biochemical and morphological changes in Trypanosoma brucei brucei-infected rats treated with homidium chloride and diminazene aceturate.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Diminazene; Ethidi | 2012 |
Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection.
Topics: Animals; Cytokines; Diminazene; Enzyme-Linked Immunosorbent Assay; Female; Forkhead Transcription Fa | 2012 |
Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda.
Topics: Animals; Cattle; Diminazene; Disease Models, Animal; Drug Resistance; Ethidium; Female; Goat Disease | 2002 |
Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate.
Topics: Blood-Brain Barrier; Diminazene; Drug Carriers; Drug Compounding; Drug Stability; Humans; Lipids; Mi | 2002 |
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice.
Topics: Animals; Diminazene; Disease Models, Animal; Hippocampus; Meningoencephalitis; Mice; Mice, Inbred C5 | 2003 |
[Trypanosomiasis and babesiasis in Africa and their treatment with the new preparation berenil].
Topics: Africa; Amidines; Aniline Compounds; Animals; Apicomplexa; Babesiosis; Cattle; Cattle Diseases; Colo | 1955 |
A strain of Trypanosoma congolense directly resistant to berenil.
Topics: Animals; Antiparasitic Agents; Azo Compounds; Diminazene; Trypanosoma congolense; Trypanosomiasis; T | 1963 |
DRUG-RESISTANCE OF TRYPANOSOMA CONGOLENSE AND OTHER TRYPANOSOMES TO QUINAPYRAMINE, PHENANTHRIDINES, BERENIL AND OTHER COMPOUNDS IN MICE.
Topics: Animals; Antiprotozoal Agents; Diminazene; Mice; Phenanthridines; Quinolines; Quinolinium Compounds; | 1963 |
Berenil in the treatment of Trypanosoma gambiense infection in man.
Topics: Amidines; Aniline Compounds; Animals; Black People; Diminazene; Humans; Trypanosoma brucei gambiense | 1962 |
A large-scale trial to evaluate the efficacy of a 1% pour-on formulation of cyfluthrin (Cylence, Bayer) in controlling bovine trypanosomosis in Eastern Zambia.
Topics: Administration, Topical; Animals; Cattle; Diminazene; Hematocrit; Incidence; Insecticides; Nitriles; | 2004 |
The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.
Topics: Adenosine; Animals; Biological Transport, Active; Diminazene; Drug Resistance; Female; Kinetics; Mut | 2004 |
Trypanocidal failure suggested by PCR results in cattle field samples.
Topics: Animals; Cattle; Diminazene; Drug Resistance, Microbial; Parasitic Sensitivity Tests; Phenanthridine | 2004 |
Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda.
Topics: Animals; Cattle; Diminazene; Female; Insect Control; Male; Phenanthridines; Time Factors; Treatment | 2004 |
Transition models to assess risk factors for new and persistent trypanosome infections in cattle-analysis of longitudinal data from the Ghibe Valley, southwest Ethiopia.
Topics: Age Factors; Animals; Cattle; Diminazene; Ethiopia; Female; Incidence; Insect Control; Insect Vector | 2004 |
A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.
Topics: Animals; Diminazene; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Resistance | 2006 |
Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.
Topics: Animals; Diminazene; Drug Resistance; Humans; Mass Screening; Melarsoprol; Phenanthridines; Recurren | 2006 |
Study on the susceptibility of Sahel goats to experimental Trypanosoma vivax infection.
Topics: Animals; Diminazene; Disease Susceptibility; Goat Diseases; Goats; Male; Nigeria; Parasitemia; Rando | 2006 |
The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride.
Topics: Animals; Diminazene; Drug Resistance; Ethidium; Mice; Mozambique; Parasitic Sensitivity Tests; Phena | 2005 |
Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system.
Topics: Abortion, Veterinary; Animals; Antibodies, Protozoan; Brain; Brazil; Cattle; Cattle Diseases; Dimina | 2007 |
Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients.
Topics: Animals; Diminazene; Drug Resistance, Multiple; Humans; Kenya; Melarsoprol; Mice; Parasitic Sensitiv | 2007 |
Acute phase response in mice experimentally infected with Trypanosoma congolense: a molecular gauge of parasite-host interaction.
Topics: Acute-Phase Proteins; Acute-Phase Reaction; Anemia; Animals; Diminazene; Disease Models, Animal; Fem | 2008 |
Relapse of monomorphic and pleomorphic Trypanosoma brucei infections in the mouse after chemotherapy.
Topics: Amidines; Animals; Brain; Diminazene; Female; Mice; Recurrence; Time Factors; Trypanosoma brucei bru | 1982 |
Chemotherapy of Trypanosoma brucei in mice with diminazene aceturate. Variation in the aparasitaemic period over 5 years.
Topics: Amidines; Animals; Blood; Diminazene; Freezing; Mice; Preservation, Biological; Time Factors; Trypan | 1982 |
Studies on Trypanosoma (nannomonas) congolense IV. Experimental immunization of mice against tsetse fly challenge.
Topics: Animals; Diminazene; Epitopes; Female; Immunization; Insect Bites and Stings; Mice; Trypanosoma; Try | 1980 |
Lymphocyte function in experimental African trypanosomiasis. VII. Loss of antigen-nonspecific suppressor-T-cell activity.
Topics: Animals; Antibody Formation; Antigens, Ly; Diminazene; Immune Tolerance; Male; Mice; Mice, Inbred C5 | 1984 |
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei.
Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoen | 1984 |
Retrospective long-term study of effects of berenil by follow-up of patients treated since 1965.
Topics: Adolescent; Adult; Amidines; Cerebrospinal Fluid; Child; Child, Preschool; Diminazene; Female; Follo | 1984 |
Persistence of Berenil in cattle.
Topics: Amidines; Animals; Cattle; Diminazene; Kenya; Male; Trypanocidal Agents; Trypanosomiasis, African; T | 1983 |
Observation on drug resistance of Trypanosoma (Nannomonas) congolense and Trypanosoma (Duttonella) vivax in cattle at a feedlot in the Northern Ivory Coast.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Male; Phenanthridines; Quaternary Ammonium Compounds; | 1983 |
The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice.
Topics: Animals; Antiprotozoal Agents; Chronic Disease; Diminazene; Drug Therapy, Combination; Female; Mice; | 1983 |
Studies in rabbits on the disposition and trypanocidal activity of the anti-trypanosomal drug, diminazene aceturate (Berenil).
Topics: Amidines; Animals; Diminazene; Kinetics; Rabbits; Tissue Distribution; Trypanosomiasis, African | 1983 |
Maintaining zebu Maure cattle in a tsetse infested area of Mali.
Topics: Animals; Body Weight; Cattle; Diminazene; Female; Male; Mali; Phenanthridines; Trypanosomiasis, Afri | 1984 |
Response of the rat's hepatic drug-metabolizing enzyme system to chemotherapy of Trypanosoma b. brucei infections with Berenil and Suramin.
Topics: Amidines; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Diminazene; Female; Glutamate Deh | 1984 |
Relapsed parasitaemia following chemotherapy of chronic T. brucei infections in mice and its relation to cerebral trypanosomes.
Topics: Animals; Antiprotozoal Agents; Brain; Chronic Disease; Diminazene; Mice; Recurrence; Trypanosoma bru | 1983 |
Studies of choroid plexus involvement in chronic infections of mice with Trypanosoma brucei gambiense.
Topics: Animals; Antiprotozoal Agents; Choroid Plexus; Chronic Disease; Diminazene; Mice; Nifurtimox; Trypan | 1983 |
Delay in resolution of trypanosome-induced genital lesions in male rabbits infected with Trypanosoma brucei and treated with diminazene aceturate.
Topics: Amidines; Animals; Antiprotozoal Agents; Diminazene; Genital Diseases, Male; Genitalia, Male; Male; | 1982 |
Pharmacokinetics and efficacy of the trypanocide diminazene aceturate (Berenil) in rabbits.
Topics: Amidines; Animals; Antiprotozoal Agents; Diminazene; Kinetics; Rabbits; Trypanosomiasis, African | 1982 |
Diminazene aceturate in the treatment of experimentally induced Trypanosoma brucei brucei infection in domestic chickens.
Topics: Amidines; Animals; Antiprotozoal Agents; Chickens; Diminazene; Humans; Mice; Poultry Diseases; Trypa | 1982 |
The efficacy of berenil (diminazene aceturate) against Trypanosoma evansi infection in mice.
Topics: Amidines; Animals; Antiprotozoal Agents; Blood; Diminazene; Female; Male; Mice; Mice, Inbred Strains | 1982 |
Trypanosomiasis in Zebu cattle. Reappearance of Trypanosoma congolense in brain tissue after treatment with Berenil.
Topics: Africa, Western; Amidines; Animals; Brain; Cattle; Diminazene; Female; Male; Mice; Mice, Inbred Stra | 1981 |
'Berenil' and nitroimidazole combinations in the treatment of Trypanosoma brucei infection with central nervous system involvement.
Topics: Amidines; Animals; Benzamidines; Central Nervous System Diseases; Diminazene; Ethidium; Female; Isox | 1980 |
The quantitation of trypanosoma congolense in calves. III. A quantitative comparison of trypanosomes in jugular vein and microvasculature and tests of dispersing agents.
Topics: Animals; Animals, Newborn; Brain; Capillaries; Cattle; Dexamethasone; Diminazene; Jugular Veins; Liv | 1980 |
Disposition of diminazene aceturate (Berenil) in trypanosome-infected pregnant and lactating cows.
Topics: Animals; Animals, Suckling; Cattle; Diminazene; Female; Lactation; Milk; Pregnancy; Pregnancy Compli | 1995 |
Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Hal | 1995 |
Use of monoclonal antibodies for detecting T brucei brucei infection in splenectomised dogs.
Topics: Animals; Antibodies, Monoclonal; Antigens, Protozoan; Antiprotozoal Agents; Diminazene; Dog Diseases | 1995 |
Variations in packed red cell volume and trypanosome prevalence and relationships with reproductive traits in east African Zebu cows exposed to drug-resistant trypanosomes.
Topics: Abortion, Veterinary; Animals; Cattle; Diminazene; Drug Resistance; Ethiopia; Female; Hematocrit; In | 1995 |
Suppressor macrophages in Trypanosoma brucei infection: nitric oxide is related to both suppressive activity and lifespan in vivo.
Topics: Animals; Antiprotozoal Agents; Apoptosis; Diminazene; DNA Damage; Female; Immune Tolerance; Immunoth | 1995 |
[Control of Trypanosoma gambiense trypanosomiasis. Evaluation of a strategy based on the treatment of serologically suspected cases with a single dose of diminazene].
Topics: Agglutination Tests; Democratic Republic of the Congo; Diminazene; Humans; Incidence; Melarsoprol; T | 1994 |
Response of diminazene-resistant and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occurring as a mixed infection in goats.
Topics: Animals; Base Sequence; Diminazene; DNA, Protozoan; Drug Resistance; Goat Diseases; Goats; Molecular | 1994 |
Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Kenya; Phenanthridines; Trypanocidal Agents; | 1993 |
Trypanosoma brucei, T. congolense and T. vivax infections in horses on a farm in Kenya.
Topics: Animals; Diminazene; Disease Outbreaks; Horse Diseases; Horses; Kenya; Trypanocidal Agents; Trypanos | 1994 |
Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 2. Factors associated with variations in trypanosome prevalence, incidence of new infections and prevalence of recurrent infections.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethiopia; Female; Male; Prevalence; Recurrence; Trypan | 1993 |
Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of populations of Trypanosoma congolense resistant to diminazene, isometamidium and homidium.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Ethiopia; Phenanthridines; Species Specifici | 1993 |
Comparative pharmacokinetics of diminazene in noninfected Boran (Bos indicus) cattle and Boran cattle infected with Trypanosoma congolense.
Topics: Acute Disease; Animals; Cattle; Chronic Disease; Diminazene; Female; Trypanosoma congolense; Trypano | 1993 |
Relapse of Trypanosoma congolense infection in goats after diminazene aceturate is not a result of invasion of the central nervous system.
Topics: Animals; Diminazene; Goat Diseases; Goats; Male; Recurrence; Trypanocidal Agents; Trypanosoma congol | 1994 |
Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.
Topics: Animals; Arsenicals; Diminazene; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Eflo | 1994 |
The effect of trypanocidal drug treatment on the haematological changes in Trypanosoma brucei brucei infected splenectomised dogs.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Diminazene; Dog Diseases; Dogs; Erythrocyte Count; Erythroc | 1993 |
The chemotherapeutic efficacy of diminazene aceturate and lithium chloride against relapse infection of Trypanosoma brucei brucei in rats.
Topics: Animals; Blood-Brain Barrier; Dexamethasone; Diminazene; Drug Therapy, Combination; Female; Lithium | 1995 |
The effect of Trypanosoma brucei brucei infection on rabbit plasma iron and zinc concentrations.
Topics: Acute-Phase Reaction; Animals; Diminazene; Hematocrit; Iron; Leukocyte Count; Male; Rabbits; Trypano | 1995 |
Kinetoplasts play an important role in the drug responses of Trypanosoma brucei.
Topics: Acriflavine; Animals; Azides; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Ethidiu | 1995 |
The effects of hyperosmolar agents lithium chloride and sucrose on the brain concentration of diminazene aceturate in rats.
Topics: Animals; Blood-Brain Barrier; Brain; Diminazene; Female; Lithium Chloride; Male; Permeability; Rats; | 1995 |
Resistance to diminazine aceturate by Trypanosoma congolense from cattle in the Zambezi Valley of Zimbabwe.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; Drug Resistance; Trypanocidal Agents; Trypanosoma cong | 1995 |
Trypanocidal value of liposomal diminazene in experimental Trypanosoma brucei evansi infection in mice.
Topics: Animals; Diminazene; Drug Carriers; Guinea Pigs; Liposomes; Mice; Trypanocidal Agents; Trypanosoma b | 1996 |
Effect of tsetse control on trypanosome prevalence in livestock: problems of experimental design and statistical interpretation--a case study in northern Côte d'Ivoire.
Topics: Animal Husbandry; Animals; Cattle; Cote d'Ivoire; Diminazene; Insect Control; Insect Vectors; Sheep; | 1996 |
Susceptibility of three breeds of Ugandan goats to experimental infection with Trypanosoma congolense.
Topics: Anemia; Animals; Body Weight; Breeding; Diminazene; Disease Susceptibility; Goat Diseases; Goats; Gr | 1997 |
Long-term occurrence of Trypanosoma congolense resistant to diminazene, isometamidium and homidium in cattle at Ghibe, Ethiopia.
Topics: Animals; Biological Assay; Cattle; Chromosomes; Diminazene; Drug Resistance, Microbial; Drug Resista | 1997 |
Effect of diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense in Glossina morsitans centralis.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Female; Goats; Insect Vectors; Male; Mice; Parasitemia | 1997 |
The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis.
Topics: Animals; Brain; Brain Diseases; Diminazene; Eflornithine; Female; Mice; Mice, Inbred Strains; Polyam | 1997 |
Response of a T. b. rhodesiense stock with reduced drug susceptibility in vitro to treatment in mice and cattle.
Topics: Animals; Cattle; Diminazene; DNA, Protozoan; Drug Resistance; Male; Mice; Phenanthridines; Polymeras | 1998 |
Immunoregulation in experimental murine Trypanosoma congolense infection: anti-IL-10 antibodies reverse trypanosome-mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice.
Topics: Animals; Diminazene; Disease Susceptibility; Female; Interleukin-10; Life Expectancy; Lymphocyte Act | 1998 |
A drug incubation Glossina infectivity test (DIGIT) to assess the susceptibility of Trypanosoma congolense bloodstream forms to trypanocidal drugs (Xenodiagnosis).
Topics: Animals; Diminazene; Drug Resistance, Multiple; Goat Diseases; Goats; Insect Vectors; Phenanthridine | 1999 |
Cytokines and antibody responses during Trypanosoma congolense infections in two inbred mouse strains that differ in resistance.
Topics: Animals; Antibodies, Protozoan; Antiprotozoal Agents; Cytokines; Diminazene; Epitopes, B-Lymphocyte; | 1999 |
Rinderpest vaccination and the incidence and development of trypanosomosis in cattle.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; Enzyme-Linked Immunosorbent Assay; Female; Hematocrit; | 1999 |
Improvement of cattle productivity through rapid alleviation of African animal trypanosomosis by integrated disease management practices in the agropastoral zone of Yalé, Burkina Faso.
Topics: Animals; Burkina Faso; Cattle; Diminazene; Female; Hematocrit; Humans; Insect Control; Insect Vector | 1999 |
The susceptibility of Djallonké and Djallonké-Sahelian crossbred sheep to Trypanosoma congolense and helminth infection under different diet levels.
Topics: Animal Feed; Animals; Anthelmintics; Antibodies, Protozoan; Antiprotozoal Agents; Crosses, Genetic; | 1999 |
Hematology of natural bovine trypanosomosis in the Brazilian Pantanal and Bolivian wetlands.
Topics: Abortion, Veterinary; Anemia, Hypochromic; Anemia, Macrocytic; Animals; Bolivia; Brazil; Cattle; Dia | 1999 |
Susceptibility of N'Dama cattle to experimental challenge and cross-species superchallenges with bloodstream forms of Trypanosoma congolense and T. vivax.
Topics: Animals; Cattle; Diminazene; Disease Susceptibility; Gambia; Hematocrit; Male; Parasitemia; Random A | 1999 |
Estimating the effects of tsetse control on livestock productivity--a case study in southwest Ethiopia.
Topics: Administration, Topical; Animals; Body Weight; Cattle; Diminazene; Drug Resistance; Ectoparasitic In | 1999 |
Multiple-drug resistant Trypanosoma congolense populations in village cattle of Metekel district, north-west Ethiopia.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; Disease Models, Animal; Drug Resistance, Microbial; Dr | 2000 |
Cytokines and the acute phase response in post-treatment reactive encephalopathy of Trypanosoma brucei brucei infected mice.
Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Cytokines; Diminazene; Disease Models, Animal; | 2001 |
Drug-resistant Trypanosoma congolense in naturally infected donkeys in north Omo Zone, southern Ethiopia.
Topics: Animals; Cross-Sectional Studies; Diminazene; Drug Resistance, Multiple; Equidae; Ethiopia; Female; | 2001 |
Chemotherapy of African trypanosomiasis.
Topics: Arsenicals; Diminazene; Humans; Suramin; Triazines; Trypanocidal Agents; Trypanosomiasis, African | 1976 |
Immune depression in trypanosome-infected mice. IV. Kinetics of suppression and alleviation by the trypanocidal drug Berenil.
Topics: Amidines; Animals; Diminazene; Female; Fluorescent Antibody Technique; Immunity; Immunosuppression T | 1979 |
The complement fixation test and African trypanosomiasis: I. Experimental infection and re-infection in cattle before and after treatment.
Topics: Animals; Antibodies; Antibody Specificity; Cattle; Complement Fixation Tests; Diminazene; Male; Recu | 1979 |
The brain as a source of relapsing Trypanosoma brucei infection in mice after chemotherapy.
Topics: Amidines; Animals; Brain; Diminazene; Female; Mice; Trypanosoma brucei brucei; Trypanosomiasis, Afri | 1979 |
The economic effects of trypanosomiasis in sheep and goats at a range research station in Kenya.
Topics: Animals; Benzamides; Diminazene; Goats; Kenya; Phenanthridines; Sheep; Sheep Diseases; Trypanosomias | 1979 |
Curative effects of the antipiroplasms amicarbalide and imidocarb on Trypanosoma brucei infection in mice.
Topics: Amidines; Animals; Carbanilides; Chemical Phenomena; Chemistry; Diminazene; Female; Imidocarb; Male; | 1979 |
The relationship between duration of infection with Trypanosoma brucei in mice and the efficacy of chemotherapy.
Topics: Amidines; Animals; Diminazene; Drug Resistance, Microbial; Ethidium; Female; Mice; Recurrence; Time | 1977 |
[Follow-up study of therapy of trypanosomiasis in Kimpangu (Republic of Zaire)].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Diminazene; Drug Evaluation; Female; Follow-Up Stu | 1977 |
Trypanocidal effect of diamidine 98/202 in experimental Trypanosoma rhodesiense infection of the stumptailed macaque (Macaca arctoides).
Topics: Amidines; Animals; Blood-Brain Barrier; Cerebrospinal Fluid; Diminazene; Drug Resistance, Microbial; | 1976 |
Serum protein changes in cattle infected with Trypanosoma vivax.
Topics: Animals; Antibodies; Blood Proteins; Cattle; Cattle Diseases; Diminazene; Immunoglobulin G; Immunogl | 1975 |
Multiple drug-resistant bovine trypanosomes in South Darfur Province, Sudan.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Phenanthridines; Sudan; Time Factors; Trypan | 1992 |
Isolation of drug-resistant strains of Trypanosoma congolense from the lower Shabelle region of southern Somalia.
Topics: Animals; Animals, Domestic; Cattle; Diminazene; Drug Resistance; Mice; Phenanthridines; Recurrence; | 1992 |
Trypanosomiasis control in Boran cattle in Kenya: a comparison between chemoprophylaxis and a parasite detection and intravenous treatment method using isometamidium chloride.
Topics: Animals; Cattle; Diminazene; Drug Administration Schedule; Female; Injections, Intramuscular; Inject | 1992 |
Pathogenesis of trypanosomiasis-induced glomerulonephritis in mice.
Topics: Animals; Antibodies; Basement Membrane; Diminazene; Female; Glomerulonephritis; Kidney Glomerulus; M | 1992 |
Trypanosomiasis in cattle in Gambia: incidence, prevalence and tsetse challenge.
Topics: Animals; Breeding; Cattle; Diminazene; Female; Gambia; Incidence; Insect Vectors; Male; Prevalence; | 1992 |
Subcurative chemotherapy and fatal post-treatment reactive encephalopathies in African trypanosomiasis.
Topics: Adolescent; Adult; Animals; Arsenicals; Brain; Brain Diseases; Child; Child, Preschool; Diminazene; | 1992 |
Development of multiple drug resistance of Trypanosoma congolense in Zebu cattle under high natural tsetse fly challenge in the pastoral zone of Samorogouan, Burkina Faso.
Topics: Animals; Burkina Faso; Cattle; Diminazene; Drug Resistance; Prevalence; Recurrence; Trypanocidal Age | 1992 |
In vivo assessment of drug sensitivity of African trypanosomes using the akinetoplastic induction test.
Topics: Animals; Cattle; Diminazene; Mice; Phenanthridines; Rosaniline Dyes; Staining and Labeling; Toluidin | 1992 |
Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate.
Topics: Animals; Chromatography, High Pressure Liquid; Diminazene; Drug Administration Schedule; Goat Diseas | 1992 |
An enzyme-linked immunosorbent assay (ELISA) for the detection of trypanosomal antigens in goat serum using a monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Antigens, Protozoan; Diminazene; Enzyme-Linked Immunosorbent Assay; | 1992 |
The use of azathioprine to ameliorate post-treatment encephalopathy associated with African trypanosomiasis.
Topics: Animals; Azathioprine; Brain Diseases; Diminazene; Disease Models, Animal; Female; Mice; Mice, Inbre | 1992 |
Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO).
Topics: Animals; Arsenicals; Central Nervous System Diseases; Diminazene; Drug Administration Schedule; Drug | 1992 |
Evaluation of DL-alpha-difluoromethylornithine against susceptible and drug-resistant Trypanosoma brucei brucei.
Topics: Animals; Arsenicals; Culture Media; Diminazene; Drug Antagonism; Drug Synergism; Drug Therapy, Combi | 1991 |
The effect of verapamil alone and in combination with trypanocides on multidrug-resistant Trypanosoma brucei brucei.
Topics: Animals; Diminazene; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Female; Male; Mi | 1991 |
Combination therapy of trypanosomiasis using diminazene and non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diminazene; Drug Therapy, Combination; Mice; Pheny | 1991 |
DL-alpha-difluoromethylornithine (DFMO)-Berenil combination: therapeutic and prophylactic activity against Trypanosoma brucei brucei infection in mice.
Topics: Animals; Diminazene; Drug Therapy, Combination; Eflornithine; Mice; Trypanocidal Agents; Trypanosoma | 1991 |
Efficacy of combination of DFMO and diminazene aceturate in the treatment of late stage Trypanosoma brucei brucei infection in rats.
Topics: Animals; Brain Diseases; Diminazene; Drug Synergism; Drug Therapy, Combination; Eflornithine; Female | 1991 |
Therapeutic effect of Berenil and Samorin in mice infected with four trypanosome populations isolated from Zambian cattle.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Mice; Phenanthridines; Trypanocidal Agents; Trypanosom | 1991 |
Susceptibility of N'Dama and Boran cattle to sequential challenges with tsetse-transmitted clones of Trypanosoma congolense.
Topics: Anemia; Animals; Antibodies, Protozoan; Antiprotozoal Agents; Body Weight; Cattle; Diminazene; Disea | 1991 |
Expression of resistance to isometamidium and diminazene in Trypanosoma congolense in Boran cattle infected by Glossina morsitans centralis.
Topics: Amidines; Animals; Cattle; Diminazene; Disease Reservoirs; Drug Resistance; Goats; Insect Vectors; M | 1990 |
Homidium bromide as a chemoprophylactic for cattle trypanosomiasis in Kenya.
Topics: Animals; Cattle; Diminazene; Ethidium; Hematocrit; Kenya; Male; Trypanocidal Agents; Trypanosoma con | 1990 |
Trypanosoma brucei evansi: dyskinetoplasia and loss of infectivity after long-term in vitro cultivation.
Topics: Animals; Diminazene; DNA, Circular; DNA, Kinetoplast; Female; Male; Mice; Microscopy, Electron; Phen | 1990 |
Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Genetic Variation; Isoenzymes; Mice; Phenanthridines; | 1991 |
Cellular phenotypes in Trypanosoma congolense infected sheep: the local skin reaction.
Topics: Animals; Antibodies, Monoclonal; Diminazene; Immunophenotyping; Lymphocyte Subsets; Sheep; Sheep Dis | 1990 |
Effects of the combination of DL-alpha-difluoromethylornithine and diminazene aceturate in Trypanosoma congolense infection of dogs.
Topics: Animals; Diminazene; Dog Diseases; Dogs; Drug Therapy, Combination; Eflornithine; Female; Male; Tryp | 1990 |
Antigen-detection enzyme immunoassays for the diagnosis of Trypanosoma vivax, T. congolense and T. brucei infections in cattle.
Topics: Animals; Antigen-Antibody Complex; Antigens, Protozoan; Cattle; Diminazene; Enzyme-Linked Immunosorb | 1989 |
Natural and acquired resistance to Trypanosoma vivax in cattle.
Topics: Animals; Cattle; Diminazene; Gastrointestinal Hemorrhage; Goats; Immunity, Active; Immunity, Innate; | 1989 |
Trypanosoma congolense: erythrocyte indices, plasma iron turnover and effects of treatment in infected cattle.
Topics: Anemia, Hemolytic; Animals; Cattle; Cattle Diseases; Diminazene; Erythrocyte Count; Erythrocyte Indi | 1989 |
Use of extracts of Picralima nitida bark in the treatment of experimental trypanosomiasis: a preliminary study.
Topics: Animals; Diminazene; Drug Evaluation, Preclinical; Female; Plant Extracts; Plants, Medicinal; Rats; | 1989 |
The influence of Trypanosoma congolense infection on the disposition kinetics of diminazene aceturate in the dog.
Topics: Amidines; Animals; Diminazene; Dog Diseases; Dogs; Injections, Intravenous; Male; Regression Analysi | 1989 |
Trypanosoma brucei brucei: expression of drug resistance in vitro.
Topics: Amidines; Animals; Diminazene; Drug Resistance; Female; Male; Mice; Phenanthridines; Species Specifi | 1989 |
The effect of trypanocidal drugs on the transmission of Trypanosoma brucei brucei by Glossina morsitans centralis.
Topics: Animals; Diminazene; Pentamidine; Phenanthridines; Suramin; Trypanocidal Agents; Trypanosoma brucei | 1987 |
The effect of the trypanocidal drugs berenil and samorin on infections of Glossina morsitans centralis by Trypanosoma congolense.
Topics: Amidines; Animals; Diminazene; Insect Vectors; Male; Mice; Mice, Inbred ICR; Phenanthridines; Trypan | 1987 |
The relapse of Trypanosoma brucei brucei infections after chemotherapy in rabbits.
Topics: Amidines; Animals; Diminazene; Female; Male; Mice; Rabbits; Recurrence; Suramin; Trypanosoma brucei | 1988 |
Berenil (diminazene aceturate)-resistant Trypanosoma congolense in cattle under natural tsetse challenge at Kibaha, Tanzania.
Topics: Amidines; Animals; Cattle; Diminazene; Drug Resistance; Mice; Phenanthridines; Tanzania; Trypanocida | 1988 |
A simple epidemiological method for animal trypanosomiasis to provide relevant data for effective financial decision-making.
Topics: Age Factors; Animals; Body Weight; Cattle; Cost-Benefit Analysis; Diminazene; Female; Kenya; Male; P | 1986 |
The alternative pathway of complement in sheep during the course of infection with Trypanosoma congolense and after Berenil treatment.
Topics: Animals; Antibodies, Bacterial; Brucella abortus; Complement Activation; Complement C3; Complement F | 1986 |
Extravascular foci of Trypanosoma vivax in goats: the central nervous system and aqueous humor of the eye as potential sources of relapse infections after chemotherapy.
Topics: Animals; Aqueous Humor; Central Nervous System Diseases; Cerebrospinal Fluid; Choroid Plexus; Dimina | 1988 |
Attempts to protect goats against challenge with Trypanosoma vivax by initiation of primary infections with large numbers of metacyclic trypanosomes.
Topics: Animals; Antibodies, Protozoan; Diminazene; Goats; Male; Trypanocidal Agents; Trypanosoma; Trypanoso | 1988 |
Enhanced resistance of highly susceptible Balb/c mice to infection with Trypanosoma congolense after infection and cure.
Topics: Agglutination Tests; Animals; Antibodies, Protozoan; Antigenic Variation; Diminazene; Female; Fluore | 1987 |
Susceptibility of goats to tsetse-transmitted challenge with Trypanosoma vivax from East and West Africa.
Topics: Africa, Eastern; Africa, Western; Animals; Chronic Disease; Diminazene; Disease Susceptibility; Goat | 1988 |
Relapses in dogs experimentally infected with Trypanosoma brucei and treated with diminazene aceturate or isometamidium chloride.
Topics: Alanine Transaminase; Amidines; Animals; Antibodies, Protozoan; Aspartate Aminotransferases; Diminaz | 1988 |
The treatment of Trypanosoma (Nannomonas) simiae in pigs with diminazene aceturate in combination with a 5-substituted 2-nitroimidazole compound (Ro 15-0216).
Topics: Acetanilides; Amidines; Animals; Diminazene; Drug Therapy, Combination; Female; Male; Mice; Nitroimi | 1987 |
The sensitivity to trypanocidal drugs of Trypanosoma vivax isolated in Kenya and Somalia.
Topics: Animals; Cattle; Diminazene; Drug Resistance; Ethidium; Kenya; Male; Phenanthridines; Quinolinium Co | 1987 |
Trypanosoma congolense: host responses following tsetse transmitted infection of Kilifi isolates in goats.
Topics: Animals; Antibody Formation; Antigens, Protozoan; Cattle; Diminazene; Glucose-6-Phosphate Isomerase; | 1987 |
Failure of berenil therapy to eliminate early infections with a strain of Trypanosoma brucei from West Abaya, Ethiopia.
Topics: Amidines; Animals; Cattle; Diminazene; Ethiopia; Mice; Trypanocidal Agents; Trypanosoma brucei bruce | 1987 |
Effect of tetracycline administration on the efficacy of diminazene aceturate therapy and prophylaxis in Trypanosoma brucei infections of mice.
Topics: Amidines; Animals; Diminazene; Drug Therapy, Combination; Mice; Oxytetracycline; Rolitetracycline; T | 1987 |
Development of Trypanosoma brucei in suckling mouse brain following intracerebral injection.
Topics: Animals; Animals, Suckling; Brain; Diminazene; Injections, Intraventricular; Mice; Trypanocidal Agen | 1987 |
Trypanosoma theileri Laveran, 1902, in naturally and experimentally infected cattle: parasite isolation, serological and cellular reactions and Berenil sensitivity.
Topics: Amidines; Animals; Antibodies, Protozoan; Cattle; Diminazene; Immunity, Cellular; Trypanocidal Agent | 1987 |
Pathobiochemical alterations in experimental chronic and acute trypanosomal infection in mice.
Topics: Alkaline Phosphatase; Amidines; Animals; Aspartate Aminotransferases; Blood Cell Count; Blood Protei | 1987 |
Interference between different serodemes of Trypanosoma congolense in the establishment of superinfections in goats following transmission by tsetse.
Topics: Animals; Antibody Formation; Diminazene; Goats; Male; Neutralization Tests; Skin; Trypanosoma congol | 1986 |
[Duration of the preventive action of diminazene aceturate on experimental infection of NMRI mice with metacyclic forms of Trypanosoma brucei brucei].
Topics: Amidines; Animals; Diminazene; Female; Mice; Mice, Inbred Strains; Trypanocidal Agents; Trypanosoma | 1986 |
Computer-assisted tomographic findings in a patient with African trypanosomiasis.
Topics: Brain Diseases; Child, Preschool; Diminazene; Humans; Male; Melarsoprol; Meningoencephalitis; Recurr | 1986 |
Regulation of parasite-specific antibody responses in resistant (C57BL/6) and susceptible (C3H/HE) mice infected with Trypanosoma (trypanozoon) brucei brucei.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Diminazene; Disease Susceptibility; Female; I | 1986 |
Ejaculate characteristics of sheep infected with Trypanosoma brucei and T vivax: changes caused by treatment with diminazene aceturate.
Topics: Animals; Diminazene; Male; Semen; Sheep; Sheep Diseases; Sperm Count; Sperm Motility; Spermatozoa; T | 1987 |
Induction of protective immunity in cattle by tsetse-transmitted cloned isolates of Trypanosoma congolense.
Topics: Animals; Antibody Formation; Cattle; Diminazene; Female; Hypersensitivity; Male; Mice; Mice, Inbred | 1985 |
Relapse infection after chemotherapy in goats experimentally infected with Trypanosoma brucei: pathological changes in central nervous system.
Topics: Amidines; Animals; Blood-Brain Barrier; Central Nervous System; Choroiditis; Diminazene; Goats; Male | 1986 |
Antibody responses in resistant and susceptible inbred mice infected with Trypanosoma congolense.
Topics: Animals; Antibody Specificity; Antigens, Protozoan; Antigens, Surface; Diminazene; Disease Susceptib | 1986 |
Maternally derived immunity in young mice to infection with Trypanosoma brucei and its potentiation by Berenil chemotherapy.
Topics: Age Factors; Amidines; Animals; Animals, Suckling; Colostrum; Diminazene; Female; Immunization, Pass | 1985 |
Immunopathological aspects of trypanosomal meningoencephalitis in vervet monkeys after relapse following Berenil treatment.
Topics: Amidines; Animals; Antigen-Antibody Complex; Autoantibodies; Blood-Brain Barrier; Brain; Chlorocebus | 1985 |
Multiple drug resistance in Trypanosoma vivax in the Tana River District of Kenya.
Topics: Animals; Cattle; Diminazene; Drug Resistance, Microbial; Ethidium; Kenya; Phenanthridines; Quinolini | 1985 |
Trypanotolerance in East African Orma Boran cattle.
Topics: Animals; Cattle; Cattle Diseases; Diminazene; Immunity; Kenya; Male; Trypanosoma; Trypanosomiasis, A | 1985 |