dimethylphenylpiperazinium iodide has been researched along with Neuroblastoma in 7 studies
Dimethylphenylpiperazinium Iodide: A selective nicotinic cholinergic agonist used as a research tool. DMPP activates nicotinic receptors in autonomic ganglia but has little effect at the neuromuscular junction.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The pharmacological profile for drug competition toward I-Bgt binding to these recombinant alpha7-nAChR matches that of human native alpha7-nAChR naturally expressed in SH-SY5Y human neuroblastoma cells (rank order potency methyllycaconitine>1, 1-dimethyl-4-phenylpiperazinium>(-)nicotine>cytisine>carbamylch oli ne> /=d-tubocurarine)." | 3.70 | Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line. ( Fryer, J; Herl, J; Leonard, SS; Lucero, L; Lukas, RJ; Peng, JH, 1999) |
| "Dimethylphenylpiperazinium iodide (a nicotinic agonist) evokes noradrenaline release from human neuroblastoma SH-SY5Y cells that have been pretreated with 12-O-tetradecanoylphorbol 13-acetate for 8 min." | 3.68 | Nicotinic receptor-mediated release of noradrenaline in the human neuroblastoma SH-SY5Y. ( Ball, SG; Kaye, DF; Peers, C; Reeve, HL; Vaughan, PF, 1993) |
| "Atropine was ineffective at 0." | 1.28 | Nicotinic acetylcholine receptors in human neuroblastoma (SH-SY5Y) cells. ( Gould, J; Peers, C; Reeve, HL; Vaughan, PF, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rana, B | 1 |
| McMorn, SO | 1 |
| Reeve, HL | 3 |
| Wyatt, CN | 1 |
| Vaughan, PF | 3 |
| Peers, C | 3 |
| Kaye, DF | 1 |
| Ball, SG | 1 |
| Puttfarcken, PS | 1 |
| Manelli, AM | 1 |
| Arneric, SP | 1 |
| Donnelly-Roberts, DL | 1 |
| Peng, JH | 1 |
| Lucero, L | 1 |
| Fryer, J | 1 |
| Herl, J | 1 |
| Leonard, SS | 1 |
| Lukas, RJ | 1 |
| Ridley, DL | 1 |
| Rogers, A | 1 |
| Wonnacott, S | 1 |
| Nelson, ME | 1 |
| Wang, F | 1 |
| Kuryatov, A | 1 |
| Choi, CH | 1 |
| Gerzanich, V | 1 |
| Lindstrom, J | 1 |
| Gould, J | 1 |
7 other studies available for dimethylphenylpiperazinium iodide and Neuroblastoma
| Article | Year |
|---|---|
Inhibition of neuronal nicotinic acetylcholine receptors by imipramine and desipramine.
Topics: Desipramine; Dimethylphenylpiperazinium Iodide; Electrophysiology; Humans; Imipramine; Ion Channels; | 1993 |
Nicotinic receptor-mediated release of noradrenaline in the human neuroblastoma SH-SY5Y.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cy | 1997 |
Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Blotting, No | 1999 |
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bacterial Toxins; Binding Sit | 2001 |
Functional properties of human nicotinic AChRs expressed by IMR-32 neuroblastoma cells resemble those of alpha3beta4 AChRs expressed in permanently transfected HEK cells.
Topics: Acetylcholine; Alkaloids; Azocines; Cell Line; Dimethylphenylpiperazinium Iodide; Humans; Kidney; Ne | 2001 |
Nicotinic acetylcholine receptors in human neuroblastoma (SH-SY5Y) cells.
Topics: Acetylcholine; Atropine; Cobra Neurotoxin Proteins; Dimethylphenylpiperazinium Iodide; Humans; Neuro | 1992 |