dimethylnitrosamine has been researched along with Disease Models, Animal in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (16.33) | 18.7374 |
| 1990's | 16 (16.33) | 18.2507 |
| 2000's | 26 (26.53) | 29.6817 |
| 2010's | 35 (35.71) | 24.3611 |
| 2020's | 5 (5.10) | 2.80 |
| Authors | Studies |
|---|---|
| Hussein, MA; M Abd El-Halim, S; M Soliman, S; Mamdouh, MA; Mosallam, S | 1 |
| Chen, T; Cui, L; Li, L; Li, Z; Qiao, T; Sun, C; Wu, K; Xu, F | 1 |
| George, J; Tsuchishima, M; Tsutsumi, M | 1 |
| Ahmad, R; Husain, H; Waseem, M | 1 |
| Chen, Y; Dai, R; Deng, Y; Guo, Y; Liu, X; Meng, W; Shi, Y; Su, J; Suheryani, I; Sun, L; Zhao, S | 1 |
| Dai, R; Deng, Y; Ke, M; Liu, X; Meng, W; Suheryani, I | 1 |
| Charoensuk, L; Dangtakot, R; Intuyod, K; Pinlaor, P; Pinlaor, S; Wongsena, W | 1 |
| Aleksandrov, VA; Bespalov, VG | 1 |
| Chamgramol, Y; Hongsrichan, N; Khuntikeo, N; Pairojkul, C; Pinlaor, P; Pinlaor, S; Rucksaken, R; Techasen, A; Yongvanit, P | 1 |
| He, Q; Li, R; Liang, T; Xu, L; Zhang, K; Zheng, N | 1 |
| Boonjaraspinyo, S; Boonmars, T; Chamgramol, Y; Juasook, A; Laummaunwai, P; Pairojkul, C; Sudsarn, P; Wongchalee, N | 1 |
| Hou, Y; Jiang, D; Li, X | 1 |
| Chen, CM; Chen, HL; Cheng, WT; Chong, KY; Tang, TY; Tung, YT; Yang, SH | 1 |
| Lee, U; Oh, E | 1 |
| Ling, QF; Liu, CY; Shang, MM; Wu, XP; Zhang, Q | 1 |
| Choi, MK; Han, JM; Kim, HG; Lee, JS; Park, HJ; Son, CG; Wang, JH | 1 |
| Choi, MH; Hong, ST; Jang, JJ; Kim, WH; Uddin, MH | 1 |
| Choi, MH; Hong, ST; Jang, JJ; Jin, Y; Li, S; Uddin, MH | 1 |
| Chai, NL; Chen, SW; Fan, KX; Linghu, EQ; Zhang, XB | 1 |
| Han, JK; Hong, ST; Jang, JJ; Kim, JH; Uddin, MH; Woo, H | 1 |
| Chen, P; Gan, R; Guo, C; Huang, J; Huo, Y; Li, J; Lu, J; Wan, L; Yang, Q | 1 |
| Chai, CY; Chen, WC; Chen, YK; Cheng, YJ; Ko, HJ; Lin, HS; Liu, YP; Wu, CC; Wu, DC; Wu, IC; Wu, MT | 1 |
| Gaudio, E; Latella, G; Pompili, S; Sferra, R; Speca, S; Vetuschi, A | 1 |
| Choi, CY; Choi, JH; Chung, YC; Jeong, HG; Jin, SW; Kim, HG; Kim, YA; Lee, GH | 1 |
| Jang, JH; Kang, KJ; Kang, YN; Kim, YH; Lee, IS | 1 |
| Aoki, H; Kunisada, T; Moriwaki, H; Motohashi, T; Nagaki, M; Suetsugu, A | 1 |
| Fujimoto, J; Hirakawa, K; Hirano, T; Horiguchi, K; Ueki, T | 1 |
| Ha, JR; Kim, DH; Kim, DY; Oh, SW | 1 |
| Chen, YX; Hou, JL; Hu, PF; Lin, Y; Ning, BF; Shen, WF; Xie, WF; Yin, C; Yue, HY; Zhang, JP; Zhang, X; Zhong, W | 1 |
| Cho, HY; Kim, HK; Yang, TH | 1 |
| Kang, JK; Shin, JW; Son, CG; Wang, JH | 1 |
| Henry, C; Larue, B; Lechner, JF; McIntyre, CM; Riedl, KM; Rocha, CM; Schwartz, SJ; Stoner, GD; Wang, LS | 1 |
| Aoyagi, S; Kage, M; Kinoshita, H; Morinaga, A; Ogata, T | 1 |
| Chen, H; Croce, CM; Farber, JL; Fong, LY; Huang, K; Jiang, Y; Liu, XP; Smalley, KJ; Taccioli, C; Wan, SG | 1 |
| Liu, C; Liu, P; Lv, J; Wang, L; Yan, X; Zeng, Z | 1 |
| Abdelrahim, M; Abudayyeh, A; Baker, CH; Basha, R; Herrera, LJ; Kaja, S; Maliakal, C; Maliakal, P; Safe, S; Sankpal, UT | 1 |
| Choi, HJ; Hyon, MK; Kang, BC; Kwon, E | 1 |
| Karthikeyan, S; Priya, S; Vijayalakshmi, P; Vivekanandan, P | 1 |
| DeAngelo, AB; George, MH; Hobbie, KR; Law, JM | 1 |
| Bhudhisawasdi, V; Boonjaraspinyo, S; Boonmars, T; Kaewkes, S; Loilome, W; Nagano, I; Sithithaworn, P; Takahashi, Y; Wu, Z; Yongvanit, P | 1 |
| Leu, YL; Pan, TL; Wang, PW; Wu, TH; Wu, TS | 1 |
| Becker, K; Boger, RJ; Ehrenberg, KR; Hahn, M; Hövelmeyer, N; Jäger, D; Longerich, T; Schuchmann, M; Schulze-Bergkamen, H; Urbanik, T; Waisman, A; Wörns, MA | 1 |
| Hinton, DE; Kullman, SW; Law, JM; Van Wettere, AJ | 1 |
| Chen, X; Liu, C; Lu, L; Lu, Y; Lv, Z; Pan, Q; Xu, Q; Yang, Z | 1 |
| Chang, CC; Hsieh, SJ; Hsu, SL; Huang, CY; Lai, JM; Su, LJ; Tseng, TL; Wu, YC; Yang, CH | 1 |
| Boonmars, T; Hiraku, Y; Khoontawad, J; Pairojkul, C; Pinlaor, P; Pinlaor, S; Roytrakul, S; Rucksaken, R; Wongkham, C | 1 |
| Ding, Y; Hashimoto, Y; Hong, T; Imamura, M; Kaganoi, J; Kawabe, A; Komoto, I; Li, ZG; Shimada, Y | 1 |
| Imamura, M; Itami, A; Kaganoi, J; Kawabe, A; Komoto, I; Li, ZG; Maeda, M; Sato, F; Shimada, Y | 1 |
| Enzan, H; Guo, LM; Hayashi, Y; Hiroi, M; Jin, YL; Kuroda, N; Miyazaki, E; Nakayama, H; Saibara, T; Toi, M; Zhang, YH | 1 |
| Cui, X; Fukuno, H; Honda, H; Inoue, H; Ito, S; Itonaga, M; Lu, G; Shimizu, I; Tamaki, K | 1 |
| Cui, HY; Hu, YY; Jiang, ZH; Li, FH; Liu, C; Liu, CH; Liu, P; Xu, LM; Yuan, JL | 1 |
| Fujiwara, Y; Fukushima, S; Hirohashi, K; Lee, S; Morimura, K; Osugi, H; Suehiro, S; Takemura, M | 1 |
| Hioki, K; Hirose, M; Ishii, Y; Kanki, K; Kodama, Y; Kuroiwa, Y; Kurokawa, Y; Nishikawa, A; Nomura, T; Umemura, T | 1 |
| Hanai, S; Loilome, W; Miwa, M; Sithithaworn, P; Sripa, B; Tepsiri, N; Wongkham, C; Yongvanit, P | 1 |
| Iwahashi, M; Muragaki, Y; Nakamori, M; Ooshima, A; Ozawa, S; Uchiyama, K; Ueda, K; Ueno, H; Yamaue, H | 1 |
| Hsu, SL; Huang, CY; Huang, SF; Su, LJ; Tseng, HH; Yang, JS | 1 |
| Deguchi, A; Himoto, T; Inoue, H; Kimura, Y; Kita, Y; Kuriyama, S; Kurokohchi, K; Masaki, T; Ogawa, M; Takano, J; Uchida, N; Watanabe, S; Yokoyama, F; Yoneyama, H; Yoshiji, H | 1 |
| El-Sewedy, SM; Hashem, SA; Hussein, NG; Saad, AA | 1 |
| Fitzgerald, DJ; Robinson, NI | 1 |
| Nii, A; Ogawa, S; Ohara, F; Sakiyama, Y; Tsuchiya, M | 1 |
| Kärki, NT; Saarni, HU; Sotaniemi, EA; Stengård, J | 1 |
| Raĭkhlin, NT; Timoshenko, IV; Turusov, VS | 1 |
| Ungar, H | 1 |
| Frank, N; Frei, E; Maduagwu, EN; Preussmann, R; Spiegelhalder, B | 1 |
| Garro, AJ; Lieber, CS; Seitz, HK | 1 |
| Imada, O; Wargovich, MJ | 1 |
| Ichida, T; Matsuda, Y; Matsumoto, K; Nakamura, T | 1 |
| Broitman, S; Newberne, PM; Schrager, TF | 1 |
| DeYoung, BR; Khare, L; Sabourin, CL; Stoner, GD; Wagner, BA | 1 |
| Fujiwara, K; Ogata, I; Tomiya, T | 1 |
| Gertman, PM; Madden, JW; Peacock, EE | 1 |
| Calès, P; Fort, J; Kaassis, M; Moal, F; Oberti, F; Pilette, C; Veal, N; Vuillemin, E | 1 |
| Chang, KW; Lin, SC; Sarraj, S; Solt, D; Tsai, PI | 1 |
| Bacus, JV; Bacus, JW; Boone, CW; Kagan, V; Kelloff, GJ; Morse, MA; Stoner, GD | 1 |
| Benedetti, A; Jansen, P; Moshage, H; Saccomanno, S; Svegliati-Baroni, G; van Goor, H | 1 |
| Fong, LY; Magee, PN; Nguyen, VT; Pegg, AE | 1 |
| Arutiunov, AI; Zabezhinskiĭ, MA | 1 |
| Cai, WM; Liu, RH; Weng, HL | 1 |
| Marsh, WH; Parsa, I | 1 |
| Berman, JJ; Rice, JM | 1 |
| Bates, RR | 1 |
| Hard, GC | 3 |
| Benhamou, M; Benichou, J; Ghika, I; Jan, D; Ollier, A; Testas, P; Trivin, F; Viellefond, A | 1 |
| Aleksandrov, VA; Bardadze, KI; Beniashvili, DSh; Bespalov, VG; Petrov, AS; Sartaniia, MS | 1 |
| Aleksandrov, VA; Bespalov, VG; Petrov, AS; Troian, DN | 1 |
| Benedetti, A; Jezequel, AM; Mancini, R; Orlandi, F; Paolucci, F; Trozzi, L | 1 |
| Dobbs, BR; Fraser, R; Rogers, GW | 1 |
| Everitt, J; Goldsworthy, TL; Walker, C; Wolf, DC | 1 |
| Boothe, DM; Boothe, HW; Corrier, DE; Cullen, JM; Green, RA; Jenkins, WL; Weise, D | 1 |
| Baraldi, M; Casciarri, I; Germini, M; Tofanetti, O; Ventura, E; Vezzelli, C; Zeneroli, ML | 1 |
| Kennedy, AR; Newberne, PM; von Hofe, E | 1 |
| Bogers, WM; Daha, MR; Muizert, Y; Stad, RK; van Es, LA | 1 |
| Mufti, SI | 1 |
| Amberger, H | 1 |
| Baxter, JN; Day, DW; Grandison, A; Jenkins, SA; Shields, R; Taylor, I | 1 |
| D'Ambrosio, SM; Glaser, R; Kiecolt-Glaser, JK; Tarr, KL; Thorn, BE | 1 |
5 review(s) available for dimethylnitrosamine and Disease Models, Animal
| Article | Year |
|---|---|
Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Disease Susceptibility; Fibroblasts; Fibrosis; Hepatic Stellate Cells; Hepatocytes; Humans; Liver Cirrhosis; Macromolecular Substances; Methylation; Rodentia | 2020 |
[Update on animal models of esophageal carcinoma].
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Humans; Neoplasm Transplantation | 2014 |
Pharmacokinetic changes of drugs in a rat model of liver cirrhosis induced by dimethylnitrosamine, alone and in combination with diabetes mellitus induced by streptozotocin.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Dimethylnitrosamine; Disease Models, Animal; Humans; Liver Cirrhosis; Microsomes, Liver; Pharmacokinetics; Rats; Species Specificity; Streptozocin | 2015 |
Esophageal carcinogenesis in the rat: a model for aerodigestive tract cancer.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Humans; Rats | 1993 |
Chemical carcinogenesis and the pancreas.
Topics: 4-Hydroxyaminoquinoline-1-oxide; Adenocarcinoma; Adenoma; Aminoquinolines; Animals; Bile; Carcinogens; Carcinogens, Environmental; Dimethylnitrosamine; Disease Models, Animal; Duodenum; Humans; Liver; Methylnitrosourea; Nitrosamines; Nitrosomethylurethane; Organ Specificity; Pancreas; Pancreatic Ducts; Pancreatic Neoplasms; Precancerous Conditions; Stomach Neoplasms | 1975 |
1 trial(s) available for dimethylnitrosamine and Disease Models, Animal
| Article | Year |
|---|---|
Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.
Topics: Animals; Antineoplastic Agents; Biopsy; Carbon Tetrachloride; Dimethylnitrosamine; Disease Models, Animal; Female; Hepatitis B, Chronic; Humans; Hyaluronic Acid; Hydroxyproline; Interferon-gamma; Liver; Liver Cirrhosis; Liver Function Tests; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2001 |
92 other study(ies) available for dimethylnitrosamine and Disease Models, Animal
| Article | Year |
|---|---|
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats.
Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Inflammation Mediators; Liposomes; Liver Function Tests; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Receptors, CCR2; STAT3 Transcription Factor; Surface Properties; Vaccinium macrocarpon; Vascular Endothelial Growth Factor A | 2022 |
Anticancer effects and possible mechanisms of lycopene intervention on N-methylbenzylnitrosamine induced esophageal cancer in F344 rats based on PPARγ
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antioxidants; Apoptosis; Cell Transformation, Neoplastic; Cyclooxygenase 2; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Esophagus; Inflammation Mediators; Lycopene; Male; NF-kappa B; Oxidative Stress; PPAR gamma; Rats, Inbred F344; Signal Transduction | 2020 |
Proteomic and molecular evidences of Il1rl2, Ric8a, Krt18 and Hsp90b1 modulation during experimental hepatic fibrosis and pomegranate supplementation.
Topics: Animals; Biomarkers; Dietary Supplements; Dimethylnitrosamine; Disease Models, Animal; Fruit and Vegetable Juices; Gene Expression Profiling; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Keratin-18; Liver Cirrhosis; Male; Membrane Glycoproteins; Nuclear Proteins; Plant Extracts; Pomegranate; Proteomics; Rats; Receptors, Interleukin; Tandem Mass Spectrometry | 2021 |
Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats.
Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2017 |
Differential Proteomic Analysis of Dimethylnitrosamine (DMN)-Induced Liver Fibrosis.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Male; Mitochondria; Oxidative Stress; Proteomics; Rats; Rats, Sprague-Dawley | 2017 |
Melatonin suppresses eosinophils and Th17 cells in hamsters treated with a combination of human liver fluke infection and a chemical carcinogen.
Topics: Animals; Anticarcinogenic Agents; Bile Duct Neoplasms; Cholangiocarcinoma; Cricetinae; Cytokines; Dimethylnitrosamine; Disease Models, Animal; Eosinophils; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Immunosuppressive Agents; Inflammation Mediators; Liver; Melatonin; Opisthorchiasis; Opisthorchis; Oxidative Stress; RNA, Messenger; T-Lymphocytes, Regulatory; Th17 Cells | 2018 |
[Anticarcinogenic effect of potassium salts of glucaric and glucuronic acid in induced models of cervical and esophageal tumors].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Calcium Compounds; Carcinogens; Cell Transformation, Neoplastic; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Female; Glucaric Acid; Glucuronic Acid; Mice; Potassium Compounds; Salts; Uterine Cervical Neoplasms | 2012 |
Annexin A1: A new immunohistological marker of cholangiocarcinoma.
Topics: Animals; Annexin A1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Biopsy; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line, Tumor; Cholangiocarcinoma; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Liver Neoplasms; Male; Mesocricetus; Middle Aged; Opisthorchis; RNA Interference; RNA, Messenger; Tissue Array Analysis; Transfection | 2013 |
Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect.
Topics: Animals; Cell Line; Dimethylnitrosamine; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Hepatocytes; Isoflavones; Liver; Liver Cirrhosis; Male; Molecular Structure; Pueraria; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2013 |
Sex differences in opisthorchiosis and the development of cholangiocarcinoma in Syrian hamster model.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; Female; Humans; Liver; Liver Function Tests; Male; Mesocricetus; Opisthorchiasis; Opisthorchis; Parasite Egg Count; Sex Factors; Thailand | 2014 |
Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation.
Topics: Animals; Body Weight; Dimethylnitrosamine; Disease Models, Animal; Hydroxyproline; Lactoferrin; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ultrasonography | 2014 |
Hepatoprotective effects of loach (Misgurnus anguillicaudatus) lyophilized powder on dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Cypriniformes; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis, Experimental; Male; Powders; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2021 |
Comparison of TGF-β, PDGF, and CTGF in hepatic fibrosis models using DMN, CCl4, and TAA.
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Dimethylnitrosamine; Disease Models, Animal; Immunohistochemistry; Lipid Peroxidation; Liver Cirrhosis, Experimental; Male; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Thioacetamide; Transforming Growth Factor beta | 2016 |
Involvement of PSMD10, CDK4, and Tumor Suppressors in Development of Intrahepatic Cholangiocarcinoma of Syrian Golden Hamsters Induced by Clonorchis sinensis and N-Nitrosodimethylamine.
Topics: Animals; Cholangiocarcinoma; Clonorchiasis; Clonorchis sinensis; Cricetinae; Cyclin-Dependent Kinase 4; Dimethylnitrosamine; Disease Models, Animal; Humans; Male; Mesocricetus; Proteasome Endopeptidase Complex; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 2015 |
C3H/He Mice as an Incompatible Cholangiocarcinoma Model by Clonorchis sinensis, Dicyclanil and N-Nitrosodimethylamine.
Topics: Animals; Bile Ducts; Body Weight; Cholangiocarcinoma; Clonorchiasis; Clonorchis sinensis; Dimethylnitrosamine; Disease Models, Animal; Histocytochemistry; Juvenile Hormones; Liver; Male; Mice, Inbred C3H; Spleen | 2016 |
Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats.
Topics: Animals; Cell Movement; Cells, Cultured; Coculture Techniques; Dimethylnitrosamine; Disease Models, Animal; Humans; In Vitro Techniques; Interleukin-10; Interleukin-4; Kupffer Cells; Liver; Liver Cirrhosis; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; Umbilical Cord | 2016 |
In-vivo monitoring of development of cholangiocarcinoma induced with C. sinensis and N-nitrosodimethylamine in Syrian golen hamsters using ultrasonography and magnetic resonance imaging: a preliminary study.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Clonorchiasis; Cocarcinogenesis; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; Disease Progression; Magnetic Resonance Imaging; Male; Mesocricetus; Ultrasonography | 2017 |
Adenovirus-mediated expression of orphan nuclear receptor NR4A2 targeting hepatic stellate cell attenuates liver fibrosis in rats.
Topics: Active Transport, Cell Nucleus; Adenoviridae; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Extracellular Matrix; Gene Expression; Genetic Therapy; Genetic Vectors; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nuclear Receptor Subfamily 4, Group A, Member 2; Phosphorylation; Rats; Transduction, Genetic | 2016 |
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Topics: Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Dimethylnitrosamine; Disease Models, Animal; Disease Progression; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Male; Microarray Analysis; Rats; Sodium-Potassium-Exchanging ATPase; Up-Regulation | 2016 |
Expression of pro-fibrotic and anti-fibrotic molecules in dimethylnitrosamine-induced hepatic fibrosis.
Topics: Animals; Connective Tissue Growth Factor; Dimethylnitrosamine; Disease Models, Animal; Integrins; Liver; Liver Cirrhosis; Mice; PPAR gamma; Smad3 Protein; TOR Serine-Threonine Kinases; Transforming Growth Factor beta | 2017 |
Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation.
Topics: Actins; Animals; Capsaicin; Collagen Type I; Dimethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; NF-kappa B; PPAR gamma; Rats, Sprague-Dawley; Smad Proteins; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2017 |
Reevaluation of experimental model of hepatic fibrosis induced by hepatotoxic drugs: an easy, applicable, and reproducible model.
Topics: Animals; Carbon Tetrachloride Poisoning; Dimethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Thioacetamide | 2008 |
Differentiation of mouse hepatic progenitor cells induced by hepatocyte nuclear factor-4 and cell transplantation in mice with liver fibrosis.
Topics: Adenoviridae; Animals; Apolipoprotein A-I; Apolipoprotein C-III; Cell Differentiation; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; Fetal Stem Cells; Gene Transfer Techniques; Genetic Therapy; Hepatectomy; Hepatocyte Nuclear Factor 4; Hepatocytes; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pregnane X Receptor; Receptors, Steroid; Stem Cell Transplantation; Transfection | 2008 |
Treating liver cirrhosis in dogs with hepatocyte growth factor gene therapy via the hepatic artery.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Dogs; Enzyme-Linked Immunosorbent Assay; Genetic Therapy; Genetic Vectors; Hepatic Artery; Hepatocyte Growth Factor; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Plasmids; Statistics, Nonparametric | 2009 |
Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Benzodioxoles; Body Weight; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Female; Hepatic Stellate Cells; Hydroxyproline; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Molecular Structure; Prothrombin Time; Rats; Rats, Sprague-Dawley; Survival Analysis; Thiazoles | 2009 |
Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats.
Topics: Adenoviridae; Animals; Becaplermin; Bone Morphogenetic Protein 4; Cadherins; Cell Proliferation; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; Hepatic Stellate Cells; Ligation; Liver; Liver Cirrhosis; Mitogen-Activated Protein Kinase 3; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; RNA, Small Interfering; Signal Transduction; Smad1 Protein; Transforming Growth Factor beta1; Vimentin | 2009 |
Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Line; Cell Proliferation; Collagen Type I; Dimethylnitrosamine; Disease Models, Animal; Hepatic Stellate Cells; Hydroxyproline; Lipid Peroxides; Liver Cirrhosis; Male; Plant Extracts; Rats; Rats, Inbred Strains; Tea; Treatment Outcome | 2009 |
Experimental evidence for the protective effects of coffee against liver fibrosis in SD rats.
Topics: Animals; Antioxidants; Body Weight; Coffea; Coffee; Cytokines; Dimethylnitrosamine; Disease Models, Animal; Gene Expression; Hepatic Stellate Cells; Hydroxyproline; Liver; Liver Cirrhosis; Macrophages; Male; Malondialdehyde; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type II; Organ Size; Phytotherapy; Plant Extracts; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Seeds | 2010 |
Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats.
Topics: Animals; Antigens, CD34; Apoptosis; Beta vulgaris; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Food Coloring Agents; Humans; Leukocyte Common Antigens; Male; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Water | 2010 |
Comparison of liver regeneration after a splenectomy and splenic artery ligation in a dimethylnitrosamine-induced cirrhotic rat model.
Topics: Alanine Transaminase; Animals; Bilirubin; Biomarkers; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Ki-67 Antigen; Ligation; Liver; Liver Cirrhosis; Liver Regeneration; Male; Rats; Rats, Wistar; Splenectomy; Splenic Artery; Time Factors; Transforming Growth Factor beta1 | 2010 |
Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Calgranulin A; Carcinogens; Cyclooxygenase 2; Dimethylnitrosamine; Disease Models, Animal; Disease Progression; Esophageal Neoplasms; Female; Gene Deletion; Inflammation; Male; Mice; Mice, Knockout; Stomach Neoplasms; Tongue Neoplasms; Zinc | 2011 |
[Effect of fuzheng huayu recipe and huangqi tang on DMN-induced experimental liver cirrhosis in rats].
Topics: Animals; Body Weight; Dimethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Liver; Liver Cirrhosis, Experimental; Organ Size; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2010 |
Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Line; Cell Survival; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Humans; ortho-Aminobenzoates; Proto-Oncogene Proteins c-met; Rats; Rats, Inbred F344; Sp Transcription Factors; Tumor Burden | 2012 |
Dimethylnitrosamine-induced liver fibrosis and recovery in NOD/SCID mice.
Topics: Actins; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Dimethylnitrosamine; Disease Models, Animal; Immunohistochemistry; Liver Cirrhosis; Male; Mice; Mice, Inbred NOD; Mice, SCID; Random Allocation; Serum Albumin | 2011 |
Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Free Radical Scavengers; Lipid Peroxidation; Liver; Liver Function Tests; Male; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar | 2011 |
Neoplastic and nonneoplastic liver lesions induced by dimethylnitrosamine in Japanese medaka fish.
Topics: Animals; Animals, Genetically Modified; Biliary Tract Neoplasms; Biomarkers; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fish Diseases; Liver; Liver Neoplasms; Male; Mutagenicity Tests; Oryzias; Rats; Signal Transduction; Species Specificity; Transforming Growth Factor beta | 2012 |
Overexpression of PDGFA and its receptor during carcinogenesis of Opisthorchis viverrini-associated cholangiocarcinoma.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Transformation, Neoplastic; Cholangiocarcinoma; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Mesocricetus; Opisthorchiasis; Opisthorchis; Platelet-Derived Growth Factor; Real-Time Polymerase Chain Reaction; Receptor, Platelet-Derived Growth Factor alpha; Reverse Transcriptase Polymerase Chain Reaction; Rodent Diseases; Thailand | 2012 |
Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway.
Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Checkpoints; Cell Death; Collagen; Dimethylnitrosamine; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Hepatic Stellate Cells; Liver; Liver Diseases; Muscle, Smooth; Phytotherapy; Plant Extracts; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Scutellaria baicalensis | 2012 |
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.
Topics: Animals; Biliary Tract Diseases; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Dimethylnitrosamine; Disease Models, Animal; Exons; Fibrosis; Gene Deletion; Genetic Predisposition to Disease; Homeostasis; In Vitro Techniques; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenobarbital; Phenotype; Risk Factors | 2012 |
Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Female; Fish Proteins; Gene Expression; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Microscopy, Electron, Transmission; Oryzias; Phenotype | 2013 |
Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzoates; Bridged-Ring Compounds; Chemical and Drug Induced Liver Injury; Collagen Type I; Desmin; Dimethylnitrosamine; Disease Models, Animal; Glucosides; Hydroxyproline; Kidney; Liver; Liver Cirrhosis; Lung; Macrophages; Male; Monoterpenes; Paeonia; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Spleen; Tumor Necrosis Factor-alpha | 2012 |
Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro.
Topics: Animals; Apoptosis; Body Weight; Cytokines; Dimethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herbal; Ferns; Hepatic Stellate Cells; Inflammation; Kupffer Cells; Liver; Liver Cirrhosis; Male; Organ Size; Plant Extracts; Rats; Spleen | 2013 |
Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cholangiocarcinoma; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; Male; Mesocricetus; Opisthorchiasis; Opisthorchis; Orosomucoid; Proteomics | 2012 |
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol.
Topics: Animals; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenase 2; Dimethylnitrosamine; Dinoprostone; Disease Models, Animal; Esophageal Neoplasms; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Resveratrol; RNA, Messenger; Stilbenes; Transcription, Genetic | 2002 |
Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats.
Topics: Animals; Anticarcinogenic Agents; Catechin; Cyclin D1; Cyclooxygenase 1; Cyclooxygenase 2; Dimethylnitrosamine; Dinoprostone; Disease Models, Animal; DNA Primers; Enzyme-Linked Immunosorbent Assay; Esophageal Neoplasms; Esophagus; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urokinase-Type Plasminogen Activator | 2002 |
Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine.
Topics: Actins; Animals; Cell Division; Cell Movement; Desmin; Dimethylnitrosamine; Disease Models, Animal; Hemorrhage; Injections, Intraperitoneal; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Liver Regeneration; Male; Necrosis; Rats; Rats, Wistar | 2003 |
Antioxidant and antiapoptotic activities of idoxifene and estradiol in hepatic fibrosis in rats.
Topics: Administration, Oral; Animals; Antioxidants; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Dimethylnitrosamine; Disease Models, Animal; Drug Therapy, Combination; Estradiol; Estrogen Antagonists; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glutathione Peroxidase; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Liver Cirrhosis, Experimental; Male; Malondialdehyde; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Superoxide Dismutase; Tamoxifen | 2004 |
[Effects of Fuzheng Huayu recipe on renal toxic interstitial fibrosis in rats].
Topics: Animals; Creatinine; Dimethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herbal; Fibrosis; Hydroxyproline; Kidney; Male; Nephritis, Interstitial; Rats; Rats, Wistar; Renal Insufficiency | 2004 |
Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Squamous Cell; Dimethylnitrosamine; Disease Models, Animal; DNA, Single-Stranded; Esophageal Neoplasms; Immunohistochemistry; Irinotecan; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Tumor Suppressor Protein p53 | 2004 |
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Antioxidants; Benzo(a)pyrene; Butylated Hydroxytoluene; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Incidence; Lung Neoplasms; Male; Methylcholanthrene; Mice; Mice, Transgenic; Oncogene Protein p21(ras) | 2006 |
Altered gene expression in Opisthorchis viverrini-associated cholangiocarcinoma in hamster model.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Blotting, Northern; Cholangiocarcinoma; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Mesocricetus; Neoplasm Proteins; Nitrosamines; Opisthorchiasis; Opisthorchis | 2006 |
Combination gene therapy of HGF and truncated type II TGF-beta receptor for rat liver cirrhosis after partial hepatectomy.
Topics: Adenoviridae; Animals; Combined Modality Therapy; Dimethylnitrosamine; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Hepatectomy; Hepatocyte Growth Factor; Humans; Liver Cirrhosis, Experimental; Protein Serine-Threonine Kinases; Rats; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta | 2006 |
Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Gene Expression Profiling; Liver; Liver Cirrhosis; Male; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reference Values | 2006 |
Sequential assessment of the intrahepatic expression of epidermal growth factor and transforming growth factor-beta1 in hepatofibrogenesis of a rat cirrhosis model.
Topics: Animals; Collagen; Dimethylnitrosamine; Disease Models, Animal; Disease Progression; Epidermal Growth Factor; Extracellular Matrix; Liver Cirrhosis; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1 | 2007 |
The effect of dimethylnitrosamine on the activities of renal prenolsulfotransferase and arylsulfatases A and B in Schistosona mansoni infected mice.
Topics: Animals; Arylsulfotransferase; Biotransformation; Carcinogenicity Tests; Carcinogens; Cerebroside-Sulfatase; Cocarcinogenesis; Cytosol; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Kidney; Kidney Function Tests; Kidney Neoplasms; Lysosomes; Male; Mice; N-Acetylgalactosamine-4-Sulfatase; Schistosomiasis mansoni; Time Factors | 1998 |
Development of a tolerable daily intake for N-nitrosodimethylamine using a modified benchmark dose methodology.
Topics: Animals; Benchmarking; Carcinogenicity Tests; Carcinoma, Hepatocellular; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemangiosarcoma; Humans; Liver Neoplasms, Experimental; Male; Maximum Allowable Concentration; Models, Biological; Models, Theoretical; Nitrosamines; Rats; Rats, Wistar; Risk Assessment; Species Specificity; Water Pollutants, Chemical | 2007 |
Pathophysiological characteristics of dimethylnitrosamine-induced liver fibrosis in acute and chronic injury models: a possible contribution of KLF5 to fibrogenic responses.
Topics: Actins; Acute Disease; Alanine Transaminase; Animals; Chronic Disease; Collagen Type I; Dimethylnitrosamine; Disease Models, Animal; Kruppel-Like Transcription Factors; Liver; Liver Cirrhosis; Male; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Up-Regulation | 2008 |
Medroxyprogesterone acetate improvement of the hepatic drug-metabolizing enzyme system in rats after chemical liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Enzyme Induction; Female; Liver Regeneration; Medroxyprogesterone; Medroxyprogesterone Acetate; Microsomes, Liver; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1983 |
[Experimental models of embryonic nephroblastomas (Wilms' tumor)].
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Enzyme Activation; Ethylnitrosourea; Female; Kidney Neoplasms; Neoplasms, Experimental; Pregnancy; Rats; Time Factors; Wilms Tumor | 1980 |
Primary portal venopathy in the golden hamster treated with low doses of dimethylnitrosamine.
Topics: Animals; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; Hepatic Veins; Liver; Male; Mesocricetus; Phlebitis; Portal Vein; Thrombosis; Time Factors | 1984 |
Nitrosamine metabolism in kwashiorkor rats.
Topics: Animals; Cytochrome P-450 CYP2E1; Dimethylnitrosamine; Disease Models, Animal; Kwashiorkor; Male; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains | 1983 |
Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.
Topics: Alcoholism; Animals; Biotransformation; Dietary Carbohydrates; Dietary Fats; Dimethylnitrosamine; Disease Models, Animal; Enzyme Induction; Ethanol; Female; Humans; Male; Microsomes, Liver; Mutagens; Rats | 1981 |
Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats.
Topics: Animals; Chronic Disease; Collagenases; Dimethylnitrosamine; Disease Models, Animal; Hepatocyte Growth Factor; Liver Cirrhosis, Experimental; Liver Failure; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1995 |
Esophageal carcinogenesis in the rat: zinc deficiency, DNA methylation and alkyltransferase activity.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Dimethylnitrosamine; Disease Models, Animal; DNA Methylation; DNA, Neoplasm; Esophageal Neoplasms; Esophagus; Male; Necrosis; O(6)-Methylguanine-DNA Methyltransferase; Papilloma; Rats; Rats, Sprague-Dawley; Zinc | 1997 |
Alterations in the expression of alpha6beta4 integrin and p21/WAF1/Cip1 in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis.
Topics: Animals; Antigens, Surface; Biomarkers, Tumor; Blotting, Northern; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dimethylnitrosamine; Disease Models, Animal; Disease Progression; Esophageal Neoplasms; Esophagus; Fluorescent Antibody Technique; Integrin alpha6beta4; Integrins; Male; Polymerase Chain Reaction; Precancerous Conditions; Rats; Rats, Inbred F344; RNA, Messenger; Transcription, Genetic | 1998 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal; Hepatocyte Growth Factor; Liver; Liver Regeneration; Male; Mitotic Index; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha | 1998 |
Dimethylnitrosamine-induced hepatic cirrhosis: a new canine model of an ancient human disease.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Dogs; Female; Humans; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Lymphatic System; Male; Portal System | 1970 |
Spleno-renal shunt blood flow is an accurate index of collateral circulation in different models of portal hypertension and after pharmacological changes in rats.
Topics: Animals; Carbon Tetrachloride; Collateral Circulation; Dimethylnitrosamine; Disease Models, Animal; Hemodynamics; Hypertension, Portal; Ligation; Male; Octreotide; Portal Vein; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reproducibility of Results; Somatostatin; Splenorenal Shunt, Surgical; Vasoconstrictor Agents | 2000 |
P53 expression, p53 and Ha-ras mutation and telomerase activation during nitrosamine-mediated hamster pouch carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cheek; Cricetinae; Dimethylnitrosamine; Disease Models, Animal; DNA Mutational Analysis; DNA, Neoplasm; Enzyme Activation; Gene Expression; Genes, p53; Genes, ras; Immunohistochemistry; Male; Mesocricetus; Mouth Neoplasms; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Precancerous Conditions; Telomerase; Tumor Suppressor Protein p53 | 2000 |
Chemoprevention with theaflavins of rat esophageal intraepithelial neoplasia quantitatively monitored by image tile analysis.
Topics: Animals; Chemoprevention; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Esophageal Neoplasms; Flavins; Image Processing, Computer-Assisted; Male; Rats; Rats, Inbred F344; Sensitivity and Specificity; Tea | 2000 |
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.
Topics: Animals; Ascorbic Acid; Cell Division; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; Drug Interactions; Free Radicals; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penicillamine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine | 2001 |
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Division; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; Diet; Dimethylnitrosamine; Disease Models, Animal; Drug Interactions; Eflornithine; Enzyme Inhibitors; Esophageal Neoplasms; Genes, bcl-2; Immunohistochemistry; Male; Polyamines; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Zinc | 2001 |
[Morphologic study of renal carcinogenesis in rats induced by dimethylnitrosamine].
Topics: Adenoma; Animals; Carcinogens; Dimethylnitrosamine; Disease Models, Animal; Kidney Neoplasms; Male; Mesenchymoma; Rats | 2001 |
An in vitro model of pancreatic carcinoma. Morphology and in vivo growth.
Topics: Animals; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Cell Division; Dimethylnitrosamine; Disease Models, Animal; Mice; Mice, Nude; Organ Culture Techniques; Pancreatic Neoplasms; Rats | 1976 |
Mesotheliomas and proliferative lesions of the testicular mesothelium produced in Fischer, Sprague-Dawley and Buffalo rats by methyl(acetoxymethyl)nitrosamine (DMN-OAc).
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Male; Mesothelioma; Nitrosamines; Rats; Testicular Neoplasms | 1979 |
Thymus-dependent lymphocyte function in dimethylnitrosamine-induced renal carcinogenesis is not depressed.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Disease Models, Animal; Female; Immunity, Cellular; Kidney Neoplasms; Lectins; Lymphocyte Activation; Male; Nitrosamines; Rats; T-Lymphocytes; Thymidine | 1975 |
[Severe acute experimental hepatocellular insufficiency with coma. Effect of dimethylnitrosamine in dogs].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Dogs; Hepatic Encephalopathy; Nitrosamines | 1975 |
[Esophageal tumor induction in monkeys].
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Esophagoscopy; Esophagus; Female; Macaca fascicularis; Male; Nitrosamines; Papilloma; Time Factors | 1992 |
[The anticarcinogenic effects of fumaric acid on models of carcinogenesis in the esophagus, nervous system and kidney].
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chi-Square Distribution; Dimethylnitrosamine; Disease Models, Animal; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Ethylnitrosourea; Female; Fumarates; Kidney Neoplasms; Male; Nervous System Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1992 |
Quantitative analysis of proliferating sinusoidal cells in dimethylnitrosamine-induced cirrhosis. An immunohistochemical study.
Topics: Animals; Bromodeoxyuridine; Desmin; Dimethylnitrosamine; Disease Models, Animal; Immunohistochemistry; Intermediate Filaments; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Sprague-Dawley; S Phase | 1992 |
Decreased hepatic uptake of cholesterol and retinol in the dimethylnitrosamine rat model of cirrhosis.
Topics: Animals; Cholesterol; Chylomicrons; Dimethylnitrosamine; Disease Models, Animal; Liver Cirrhosis, Experimental; Male; Rats; Rats, Sprague-Dawley; Tritium; Vitamin A | 1992 |
Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.
Topics: Animals; Carcinoma, Renal Cell; Dimethylnitrosamine; Disease Models, Animal; Kidney Cortex; Kidney Neoplasms; Rats; Rats, Mutant Strains | 1992 |
Dimethylnitrosamine-induced hepatotoxicosis in dogs as a model of progressive canine hepatic disease.
Topics: Animals; Body Weight; Dimethylnitrosamine; Disease Models, Animal; Dog Diseases; Dogs; Female; Liver; Liver Diseases; Male; Microscopy, Electron; Random Allocation | 1992 |
Alterations of GABA-A and dopamine D-2 brain receptors in dogs with portal-systemic encephalopathy.
Topics: Animals; Brain; Diazepam; Dimethylnitrosamine; Disease Models, Animal; Dogs; Dopamine; Glutamate Decarboxylase; Hepatic Encephalopathy; Kinetics; Norepinephrine; Octopamine; Radioligand Assay; Receptors, Dopamine; Receptors, GABA-A; Synapses | 1991 |
Inhibition of N-nitrosomethylbenzylamine-induced esophageal neoplasms by the Bowman-Birk protease inhibitor.
Topics: Animals; Carcinogens; Carcinoma; Dimethylnitrosamine; Disease Models, Animal; Drug Antagonism; Esophageal Neoplasms; Esophagus; Hyperplasia; Male; Papilloma; Rats; Rats, Inbred Strains; Tablets; Trypsin Inhibitor, Bowman-Birk Soybean | 1991 |
Deposition of IgA is associated with macrophage influx in the kidney of rats.
Topics: Animals; Complement C3; Dimethylnitrosamine; Disease Models, Animal; Fluorescent Antibody Technique; Galactosamine; Glomerulonephritis, IGA; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Macrophages; Male; Rats; Rats, Inbred Strains | 1991 |
An animal model of immune response associated with alcohol-related cancers.
Topics: Alcoholism; Animals; Cocarcinogenesis; Dimethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Ethanol; Immunity, Cellular; Immunosuppressive Agents; Male; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains | 1990 |
Differential renal tumor response to N-ethylnitrosourea and dimethylnitrosamine in the Nb rat: basis for a new rodent model of nephroblastoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Kidney Neoplasms; Male; Ovariectomy; Placenta; Pregnancy; Rats; Wilms Tumor | 1985 |
Experimental models for the sequential analysis of chemically-induced renal carcinogenesis.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Animals; Carcinoma, Renal Cell; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Kidney Neoplasms; Mesenchymoma; Rabbits; Rats; Rats, Inbred Strains; Wilms Tumor | 1986 |
Different autochthonous models of colorectal cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitrosamine; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rectal Neoplasms | 1986 |
A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat.
Topics: Animals; Ascites; Dimethylnitrosamine; Disease Models, Animal; Hemodynamics; Hypertension, Portal; Liver Cirrhosis; Male; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Effects of stress on methyltransferase synthesis: an important DNA repair enzyme.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; DNA Repair; Female; Methyltransferases; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Rotation; Spleen; Stress, Physiological | 1985 |