dimethylnitrosamine has been researched along with Cirrhosis, Liver in 154 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (7.14) | 18.7374 |
| 1990's | 1 (0.65) | 18.2507 |
| 2000's | 58 (37.66) | 29.6817 |
| 2010's | 76 (49.35) | 24.3611 |
| 2020's | 8 (5.19) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, G; Chen, J; Hu, Y; Liu, P; Liu, W; Liu, Y; Mu, Y; Xu, Y; Yang, H; Zhang, C; Zhang, D; Zhang, H; Zhang, L | 1 |
| Aoyama, Y; Inaguma, S; Kato, H; Komura, M; Matsuo, Y; Nagayasu, Y; Naiki-Ito, A; Takahashi, S; Takiguchi, S; Tomita, M; Tsuda, H; Xiaochen, K | 1 |
| George, J; Tsuchishima, M; Tsutsumi, M | 5 |
| Choi, BH; Hada, B; Karmacharya, MB; Kim, KH; Park, SR | 1 |
| Jin Nam, M; Lee, CM; Moon, SH; Park, SH | 1 |
| Bao, L; Bo, A; Dong, Z; Li, S; Ma, R; Si, L | 1 |
| Choi, BK; Hur, YH; Katoch, N; Kim, HB; Kim, HJ; Kim, JW; Park, JA; Woo, EJ | 1 |
| Ahmad, R; Husain, H; Waseem, M | 1 |
| Gao, GY; Liu, CH; Liu, P; Peng, Y; Tao, YY; Yang, T; Zheng, XY | 1 |
| Rana, K; Rana, SVS; Rani, V; Verma, Y | 1 |
| Dai, R; Deng, Y; Ke, M; Liu, X; Meng, W; Suheryani, I | 1 |
| Jiang, HJ; Li, W; Pu, XP; Sun, Y; Yang, YF; Zhao, X; Zheng, XY | 1 |
| George, J | 2 |
| Choi, BK; Hwang, ES; Kim, HB; Kim, HJ; Kim, JW; Kwon, OI; Kyung, EJ; Lee, S; Lim, SM; Woo, EJ | 1 |
| Cho, SK; Kim, MA; Kim, MK; Lee, DH; Yang, SG; Yim, JH | 1 |
| Chen, Y; Mo, Q; Wang, Y; Zhou, G; Zhou, Z | 1 |
| Jin, JY; Li, YY; Liu, SY; Ma, YM; Wang, GF; Wang, TM; Wang, YH; Wang, ZT; Wu, JS; Yang, L; Zheng, M | 1 |
| Cheng, AC; Ho, CT; Lee, MF; Liou, WS; Liu, ML; Pan, MH; Tsai, ML | 1 |
| Deng, Y; Hu, G; Liu, B; Peng, Y; Shen, H; Tao, L; Wang, Z; Yang, H; Zhao, M; Zhu, T | 1 |
| Choi, CY; Choi, JH; Chung, YC; Hwang, YP; Jeong, HG; Jin, SW; Khanal, T; Kim, HG; Lee, KJ; Lee, YC | 1 |
| Bunte, RM; Jiang, X; Kang, Y; Mao, HQ; Narmada, BC; Nugraha, B; Peng, Q; Sakban, RB; So, PT; Tucker-Kellogg, L; Venkatraman, L; Yu, H | 1 |
| He, Q; Li, R; Liang, T; Xu, L; Zhang, K; Zheng, N | 1 |
| Chen, SW; Chen, YX; Fan, TT; Lv, J; Qian, H; Shi, J; Song, CY; Xie, WF; Zheng, ZW | 1 |
| Elshazly, SM; Mahmoud, AA | 1 |
| Li, W; Pu, XP; Sun, H; Sun, Y; Wang, YH; Yang, YF; Zhao, X; Zheng, XY | 1 |
| Kuang, D; Liu, J; Liu, R; Shi, X; Sun, X; Yang, W; Zeng, Y; Zhang, T; Zhang, Y; Zhu, X | 1 |
| Chen, CM; Chen, HL; Cheng, WT; Chong, KY; Tang, TY; Tung, YT; Yang, SH | 1 |
| Duan, B; Mu, W; Qiu, B; Qiu, W; Shi, C; Sun, X; Wang, X; Wei, F; Zhang, J | 1 |
| Lee, U; Oh, E | 1 |
| Endo, K; Hori, T; Iwaisako, K; Jobara, K; Kaido, T; Uchida, Y; Uemoto, S | 1 |
| Chang, JC; Chang, WC; Chang, WP; Chien, SC; Hsu, SC; Lin, CH; Lin, PH; Pei, JK; Wu, YC | 1 |
| Chen, BM; Chen, X; He, M; Li, CY; Liu, LQ; Wang, YH; Zhao, CX | 1 |
| Ahmad, A; Ahmad, R | 1 |
| Cheng, AC; Ho, CT; Hung, WL; Pan, MH; Sun, PP; Tsai, CY; Tsai, ML; Yang, CC | 1 |
| Jang, HJ; Kim, KS; Kim, YC; Kwon, SY; Lee, JH; Lee, JY; Na, YC; Yang, HJ | 1 |
| Huang, CH; Leu, YL; Pan, TL; Wang, PW; Wu, TH; Wu, YR; You, JS | 1 |
| Chai, X; Gao, Q; Ji, W; Li, X; Lin, X; Peng, Z; Qian, L; Su, C; Wu, Q; Xu, Y | 1 |
| Fukuda, N; Fukushima, A; Inami, M; Matsumoto, Y; Moriyama, M; Soma, M; Tsunemi, A; Ueno, T; Yamada, T | 1 |
| Ji, G; Li, B; Xin, X; Xu, M; Yan, G; Yu, H | 1 |
| Chen, X; Liu, C; Lu, Y; Miao, H; Tang, B; Wang, L; Xu, Q; Yang, Z | 1 |
| Li, D; Li, J; Liu, M; Liu, Y; Liu, Z; Ren, G; Song, L; Xu, P; Yang, Y; Yuan, Q; Zhang, Y | 1 |
| Chen, Y; Duan, X; Gao, Y; Li, J; Xu, Y; Zhang, K; Zhong, M; Zhu, H | 1 |
| Gu, L; Han, X; Peng, J; Qi, Y; Tao, X; Xu, L; Xu, Y; Yin, L | 1 |
| Jia, L; Xiao, S; Zhang, J; Zhang, X | 1 |
| Chen, L; Guo, YZ; Hao, HY; Ji, CG; Jiang, HQ; Li, AD; Ma, JJ; Qi, W; Wang, J; Wang, Y; Zhang, D | 1 |
| Nesi, RT; Pinho, RA; Silveira, PC; Thirupathi, A | 1 |
| Duan, XH; Feng, Q; Hu, YY; Li, XM; Liu, L; Liu, P; Ma, X; Peng, JH; Sun, ZL; Tian, HJ | 1 |
| Chooi, KF; Kuppan Rajendran, DB; Phang, SS; Toh, HH | 1 |
| Cai, XB; Feng, Y; Lu, LG; Qu, Y; Xu, MY; Ying, HY | 1 |
| Chai, NL; Chen, SW; Fan, KX; Linghu, EQ; Zhang, XB | 1 |
| Akahoshi, T; Eto, H; Hamano, N; Hashizume, M; Hyodo, F; Kawano, T; Kosem, N; Murata, M; Nakata, R; Narahara, S; Piao, JS | 1 |
| Chen, P; Gan, R; Guo, C; Huang, J; Huo, Y; Li, J; Lu, J; Wan, L; Yang, Q | 1 |
| Chen, GF; Cheng, Y; Mai, JY; Ping, J; Wang, MF | 1 |
| Gaudio, E; Latella, G; Pompili, S; Sferra, R; Speca, S; Vetuschi, A | 1 |
| Choi, CY; Choi, JH; Chung, YC; Jeong, HG; Jin, SW; Kim, HG; Kim, YA; Lee, GH | 1 |
| Chen, HL; Leng, AJ; Lu, LQ; Pang, BY; Xiang, Y; Xie, QL; Zhang, Y; Zhu, Y | 1 |
| Chen, YW; Guo, JZ; He, Y; Hu, ZF; Li, KM; Li, P; Pan, L; Xiao, C; Xiong, JP | 1 |
| Hong, SS; Jung, KH; Kwon, SW; Lee, DH; Lee, HS; Park, IS | 1 |
| Liu, P; Tang, ZP; Wang, XB | 1 |
| Jang, JH; Kang, KJ; Kang, YN; Kim, YH; Lee, IS | 1 |
| Chae, YR; Jung, YS; Kim, SK; Kim, YC; Park, JH; Seo, JM | 1 |
| Chun, J; Fujita, R; Iitsuka, S; Ikeda, H; Inoue, Y; Ishii, I; Kume, Y; Nishikawa, T; Ohtomo, N; Omata, M; Shimosawa, T; Tanoue, Y; Tomiya, T; Watanabe, N; Yatomi, Y | 1 |
| Ishigaki, N; Jin, H; Sakaida, I; Terai, S; Uchida, K; Yamamoto, N | 1 |
| Aoki, H; Kunisada, T; Moriwaki, H; Motohashi, T; Nagaki, M; Suetsugu, A | 1 |
| Fukuchi, H; Ichinose, M; Tanaka, H; Ueda, H | 1 |
| Davey, AK; Gu, XY; Wang, JP; Xie, J; Yang, MF; Zhang, SJ; Zhang, XH; Zhu, RM | 1 |
| Catitti, V; D'Angelo, A; Flanders, KC; Gaudio, E; Latella, G; Sferra, R; Vetuschi, A; Zanninelli, G | 1 |
| Ha, JR; Kim, DH; Kim, DY; Oh, SW | 1 |
| Chen, YX; Hou, JL; Hu, PF; Lin, Y; Ning, BF; Shen, WF; Xie, WF; Yin, C; Yue, HY; Zhang, JP; Zhang, X; Zhong, W | 1 |
| Cho, HY; Kim, HK; Yang, TH | 1 |
| Jung, HS; Kim, EY; Kim, SY; Kim, YB; Lee, HS; Lim, CS; Soh, Y; Sohn, NW; Sohn, Y | 1 |
| Gang, J; Jiao, S; Li, G; Miyamura, M; Nomachi, Y; Sun, CH; Sun, G; Teng, Y; Yokota, J; Yoshioka, S; Zhang, Y | 1 |
| Kang, JK; Shin, JW; Son, CG; Wang, JH | 1 |
| Aoyagi, S; Kage, M; Kinoshita, H; Morinaga, A; Ogata, T | 1 |
| Lee, ES; Moon, JO; Shin, MO; Yoon, S | 1 |
| Anderson, RA; Cho, IJ; Han, CY; Hwang, SJ; Kim, EH; Kim, SG; Kim, YW; Lee, CH; Lee, YS | 1 |
| Hu, Y; Jian, P; Liu, C; Liu, P; Peng, J; Sun, M; Tao, Q; Wu, JZ; Yang, W | 1 |
| Choi, HJ; Hyon, MK; Kang, BC; Kwon, E | 1 |
| Chen, CM; Chen, HL; Chen, JY; Cheng, JC; Kao, ST; Lin, CF; Lin, HJ | 1 |
| Chen, C; Guo, J; He, J; Li, WQ; Li, YM; Liu, HM; Xia, QM; Xu, MD; Yu, HY; Zhu, L | 1 |
| Abdel-Rahman, MK | 1 |
| Chen, YW; Fan, JG; Ge, WS; Wang, YJ; Wu, JX | 1 |
| Dou, K; Li, Y; Liu, X; Shi, M; Wang, D; Wang, X; Wu, L; Xia, N; Yang, J; Yao, L; Zhang, H; Zheng, J | 1 |
| Chen, G; Hu, X; Liu, C; Liu, P; Mu, Y; Sun, M; Wang, G; Zhang, L | 1 |
| Duan, X; Feng, Q; Fu, Q; Hu, Y; Li, X; Peng, J | 1 |
| Chen, CM; Chen, HL; Chen, JY; Cheng, JC; Lin, CF; Lin, HJ; Tung, YT | 1 |
| Enzan, H; Hayashi, Y; Jin, YL; Liu, HG; Tian, C; Zhou, Q | 1 |
| Aukkanimart, R; Boonmars, T; Juasook, A; Loilome, W; Namwat, N; Sriraj, P; Sudsarn, P; Veteewuthacharn, K; Wonkchalee, O; Wu, Z | 1 |
| Ammanniti, S; Catitti, V; Frieri, G; Gaudio, E; Latella, G; Melideo, D; Pompili, S; Sferra, R; Vetuschi, A | 1 |
| Hinton, DE; Kullman, SW; Law, JM; Van Wettere, AJ | 1 |
| Chen, X; Liu, C; Lu, L; Lu, Y; Lv, Z; Pan, Q; Xu, Q; Yang, Z | 1 |
| Chung, HW; Hong, SS; Ju, HK; Kim, JM; Kwon, SW; Lee, HS; Lim, J; Lim, SC; Park, JH | 1 |
| Cheng, AC; Chien, LL; Ho, CT; Lee, MF; Ma, NJ; Pan, MH; Sun, PP; Tsai, ML | 1 |
| Chang, CC; Hsieh, SJ; Hsu, SL; Huang, CY; Lai, JM; Su, LJ; Tseng, TL; Wu, YC; Yang, CH | 1 |
| Cui, T; Hamada, A; Kusunose, M; Kyotani, S; Miyamura, M; Nishioka, Y; Ono, M; Yoshioka, S | 1 |
| Bendia, E; Benedetti, A; Candelaresi, C; Di Sario, A; Kleemann, HW; Macarri, G; Marzioni, M; Pigini, P; Schindler, U; Taffetani, S; Trozzi, L | 1 |
| Horie, T; Nakajo, M; Okita, K; Sakaida, I; Sonaka, I; Yokoya, F | 1 |
| BARNES, JM; MAGEE, PN | 1 |
| Etani, Y; Kondou, H; Michigami, T; Miyoshi, Y; Mushiake, S; Ozono, K | 1 |
| Lee, MH; Moon, JO; Yoon, S | 1 |
| Funakoshi, F; Hitomi, M; Kita, Y; Kuriyama, S; Kurokohchi, K; Masaki, T; Uchida, N; Watanabe, S; Yoshiji, H | 1 |
| Aydin, S; Aytekin, H; Canbakan, B; Mert, A; Ozaras, R; Ozbay, G; Senturk, H; Tahan, V; Uzun, H; Yildirim, B | 1 |
| George, J; Stern, R | 1 |
| Chayama, K; Imamura, M; Ogawa, T; Sasaguri, Y; Ueno, H | 1 |
| Boullay, V; Brusq, JM; de Gouville, AC; Gauthier, JM; Gellibert, F; Huet, S; Krysa, G; Laroze, A; Loriolle, F; Papworth, SA; Pilot, J | 1 |
| Chai, CY; Lin, CC; Liu, SY; Weng, TC; Yen, MH | 1 |
| Chen, WY; Chiu, YT; Lee, WJ; Lin, SY; Sheu, WH; Wu, HS | 1 |
| Chiu, YT; Hsu, YC; Huang, YT; Lee, CY; Lin, YL; Shiao, MS | 1 |
| Enjoji, M; Kohjima, M; Kotoh, K; Morizono, S; Nakamuta, M; Tsuruta, S | 1 |
| Chen, R; Lei, JX; Li, SN; Xiang, P; Yu, WH; Zhang, XM; Zhao, DC | 1 |
| Jang, JJ; Kim, HS; Kim, MR; Lee, MJ; Lee, MS | 1 |
| Bae, SK; Kim, JW; Kim, SG; Kim, T; Lee, I; Lee, MG; Lee, SJ | 1 |
| Bertho-Ruault, C; de Gouville, AC; Gellibert, F; Grygielko, ET; Huet, S; Laping, NJ; Mathews, N; Nguyen, VL; Patikis, A; Woolven, J | 1 |
| Deguchi, A; Inoue, H; Kita, Y; Kuriyama, S; Masaki, T; Morishita, A; Nakai, S; Tsujimoto, T; Uchida, N; Watanabe, S; Yokoyama, F; Yoshiji, H | 1 |
| Imose, M; Kimura, K; Moriwaki, H; Mukai, T; Nagaki, M; Satake, S; Takai, S | 1 |
| Enzan, H; Guo, L; Hayashi, Y; Hiroi, M; Jin, Y; Kuroda, N; Miyazaki, E; Toi, M | 1 |
| Hsu, SL; Huang, CY; Huang, SF; Su, LJ; Tseng, HH; Yang, JS | 1 |
| Cho, CK; Cho, JH; Han, SH; Hu, XP; Lee, MM; Lee, YW; Oh, SM; Shin, JW; Son, CG; Son, JY; Wang, JH; Yoo, HS | 1 |
| Aburatani, H; Kawada, N; Takahara, Y; Takahashi, M; Wagatsuma, H; Yamaguchi, M; Yokoya, F; Zhang, QW | 1 |
| Deguchi, A; Himoto, T; Inoue, H; Kimura, Y; Kita, Y; Kuriyama, S; Kurokohchi, K; Masaki, T; Ogawa, M; Takano, J; Uchida, N; Watanabe, S; Yokoyama, F; Yoneyama, H; Yoshiji, H | 1 |
| Li, FH; Liu, P; Xiong, WG; Xu, GF | 1 |
| Chen, Y; Ge, WH; He, JY | 1 |
| Chen, YF; Gerlitz, B; Grinnell, B; Jakubowski, JA; Saha, JK; Sandusky, GE; Xia, J | 1 |
| Chiu, YT; Hsu, YC; Huang, YT; Lin, YL | 1 |
| Kimura, K; Moriwaki, H; Mukai, T; Nagaki, M; Ogiso, T; Takai, S; Tsukada, Y | 1 |
| Chen, CF; Horng, LY; Huang, CH; Wu, RT | 1 |
| Nii, A; Ogawa, S; Ohara, F; Sakiyama, Y; Tsuchiya, M | 1 |
| Akamatsu, S; Hayashi, S; Isoda, K; Kagaya, N; Kawase, M; Kobayashi, M; Kondoh, M; Tagawa, Y; Tamesada, M; Watanabe, A; Yagi, K | 1 |
| Abe, T; Kaneko, H; Matsuura, Y; Nishibe, Y; Suzuki, H; Takaku, H | 1 |
| Bompart, G; Bourbon, P; Dophuoc, H | 1 |
| Besserer, K; Goerttler, K; Heymer, B; Mittmeyer, HJ; Oehmichen, M; Pedal, I; Schmähl, D | 1 |
| Ditschuneit, H; Fussgaenger, RD | 1 |
| Chandrakasan, G; George, J | 1 |
| Hirakawa, K; Ikebe, T; Ikeda, K; Kaneda, K; Kawada, N; Nakatani, K; Sowa, M; Wang, YQ | 1 |
| Benedetti, A; Jansen, P; Moshage, H; Saccomanno, S; Svegliati-Baroni, G; van Goor, H | 1 |
| Enjoji, M; Iwamoto, H; Nakamuta, M; Nakashima, Y; Nawata, H; Sugimoto, R; Tada, S | 1 |
| Enjoji, M; Iwamoto, H; Kato, M; Nakamuta, M; Nakashima, Y; Nawata, H; Sugimoto, R; Tada, S | 1 |
| Ha, JR; Kang, KW; Kim, CW; Kim, ND; Kim, SG | 1 |
| Altomare, E; Caruso, ML; Grattagliano, I; Pirrelli, M; Serviddio, G; Valentini, AM; Vendemiale, G | 1 |
| Cho, H; Jeon, SH; Kim, S; Kim, WH; Lee, JH; Paik, WK; Park, H; Yun, C | 1 |
| Cai, WM; Liu, RH; Weng, HL | 1 |
| Casini, A; Ceni, E; Crabb, DW; Galli, A; Mello, T; Ridolfi, F; Salzano, R; Surrenti, C; Svegliati-Baroni, G; Trozzi, L | 1 |
| Levy, M; Richard, C | 1 |
| Allotey, JB; Levy, M | 1 |
| Popper, H | 1 |
| Bengmark, S; Borjesson, B; Olin, T | 1 |
| Ala-Kokko, L; Brocks, D; Kivirikko, KI; Savolainen, ER | 1 |
| Ala-Kokko, L; Kivirikko, KI; Myers, JC; Pihlajaniemi, T; Savolainen, ER | 1 |
| Baxter, JN; Day, DW; Grandison, A; Jenkins, SA; Shields, R; Taylor, I | 1 |
3 review(s) available for dimethylnitrosamine and Cirrhosis, Liver
| Article | Year |
|---|---|
Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Disease Susceptibility; Fibroblasts; Fibrosis; Hepatic Stellate Cells; Hepatocytes; Humans; Liver Cirrhosis; Macromolecular Substances; Methylation; Rodentia | 2020 |
Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis.
Topics: Actins; Animals; Antioxidants; Collagen; Cytokines; Dimethylnitrosamine; Extracellular Matrix; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Oxidative Stress; Reactive Oxygen Species; Wound Healing | 2019 |
Pharmacokinetic changes of drugs in a rat model of liver cirrhosis induced by dimethylnitrosamine, alone and in combination with diabetes mellitus induced by streptozotocin.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Dimethylnitrosamine; Disease Models, Animal; Humans; Liver Cirrhosis; Microsomes, Liver; Pharmacokinetics; Rats; Species Specificity; Streptozocin | 2015 |
1 trial(s) available for dimethylnitrosamine and Cirrhosis, Liver
| Article | Year |
|---|---|
Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.
Topics: Animals; Antineoplastic Agents; Biopsy; Carbon Tetrachloride; Dimethylnitrosamine; Disease Models, Animal; Female; Hepatitis B, Chronic; Humans; Hyaluronic Acid; Hydroxyproline; Interferon-gamma; Liver; Liver Cirrhosis; Liver Function Tests; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2001 |
150 other study(ies) available for dimethylnitrosamine and Cirrhosis, Liver
| Article | Year |
|---|---|
Hepatoprotective effect of genistein against dimethylnitrosamine-induced liver fibrosis in rats by regulating macrophage functional properties and inhibiting the JAK2/STAT3/SOCS3 signaling pathway.
Topics: Animals; Dimethylnitrosamine; Genistein; Hepatic Stellate Cells; Janus Kinase 2; Liver; Liver Cirrhosis; Macrophages; Rats; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein | 2021 |
Lactoferrin Prevents Hepatic Injury and Fibrosis via the Inhibition of NF-κB Signaling in a Rat Non-Alcoholic Steatohepatitis Model.
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Connexins; Cytokines; Dimethylnitrosamine; Fibrosis; Gap Junction beta-1 Protein; Lactoferrin; Liver; Liver Cirrhosis; Liver Neoplasms; Male; NF-kappa B; Non-alcoholic Fatty Liver Disease; Rats; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2021 |
Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis.
Topics: Animals; Body Weight; Catechin; Collagen Type I; Collagen Type IV; Dimethylnitrosamine; Fibrosis; Hepatic Stellate Cells; Hyaluronic Acid; Liver; Liver Cirrhosis; Malondialdehyde; Osteopontin; Rats | 2022 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) shows therapeutic effect on dimethylnitrosamine (DMN)-induced liver fibrosis in rats.
Topics: Animals; Body Weight; Collagen Type I; Dimethylnitrosamine; Granulocyte-Macrophage Colony-Stimulating Factor; Liver; Liver Cirrhosis; Peroxisome Proliferator-Activated Receptors; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1 | 2022 |
Effects of hepatocyte growth factor gene-transfected mesenchymal stem cells on dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Caspase 3; Cell- and Tissue-Based Therapy; Cells, Cultured; Dimethylnitrosamine; Fetal Blood; Hepatocyte Growth Factor; Humans; Hydrogen Peroxide; Liver Cirrhosis; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Transfection | 2019 |
Identification lncRNA LOC102551149/miR-23a-5p pathway in hepatic fibrosis.
Topics: Animals; Blotting, Western; Cell Line; Dimethylnitrosamine; Gene Knockdown Techniques; Hepatic Stellate Cells; Liver Cirrhosis; MicroRNAs; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Real-Time Polymerase Chain Reaction; RNA, Long Noncoding | 2020 |
MR-Based Electrical Conductivity Imaging of Liver Fibrosis in an Experimental Rat Model.
Topics: Animals; Dimethylnitrosamine; Electric Conductivity; Liver; Liver Cirrhosis; Male; Prospective Studies; Rats; Rats, Sprague-Dawley | 2021 |
Proteomic and molecular evidences of Il1rl2, Ric8a, Krt18 and Hsp90b1 modulation during experimental hepatic fibrosis and pomegranate supplementation.
Topics: Animals; Biomarkers; Dietary Supplements; Dimethylnitrosamine; Disease Models, Animal; Fruit and Vegetable Juices; Gene Expression Profiling; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Keratin-18; Liver Cirrhosis; Male; Membrane Glycoproteins; Nuclear Proteins; Plant Extracts; Pomegranate; Proteomics; Rats; Receptors, Interleukin; Tandem Mass Spectrometry | 2021 |
MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Collagen Type I; Connective Tissue Growth Factor; Dimethylnitrosamine; Female; Gene Expression Regulation; Hepatic Stellate Cells; Hyaluronic Acid; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Mice; Mice, Knockout; Primary Cell Culture; Proteolysis; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
[Effect of Fuzheng Huayu capsule on serum metabolomics in rats with liver fibrosis induced by dimethylnitrosamine].
Topics: Animals; Dimethylnitrosamine; Drugs, Chinese Herbal; Liver; Liver Cirrhosis; Metabolome; Rats; Rats, Wistar; Serum | 2016 |
Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Lipid Peroxidation; Liver Cirrhosis; Male; Nanoparticles; Oxidative Stress; Particle Size; Rats; Rats, Wistar; Zinc Oxide | 2018 |
Differential Proteomic Analysis of Dimethylnitrosamine (DMN)-Induced Liver Fibrosis.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Male; Mitochondria; Oxidative Stress; Proteomics; Rats; Rats, Sprague-Dawley | 2017 |
Antioxidant, antiapoptotic and amino acid balance regulating activities of 1,7-dihydroxy-3,4,8-trimethoxyxanthone against dimethylnitrosamine-induced liver fibrosis.
Topics: Amino Acids; Animals; Antioxidants; Apoptosis; Dimethylnitrosamine; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Xanthones | 2017 |
Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry.
Topics: Animals; Dimethylnitrosamine; Glutathione; Glutathione Peroxidase; Interleukin-6; Liver Cirrhosis; Male; Mass Spectrometry; Rats; Rats, Wistar; Selenium; Transforming Growth Factor beta1 | 2018 |
Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging.
Topics: Animals; Anti-Inflammatory Agents; Curcumin; Dimethylnitrosamine; Electric Conductivity; Lactulose; Liver; Liver Cirrhosis; Rats; Rats, Sprague-Dawley | 2018 |
Ramalin, an antioxidant compound derived from Antarctic lichen, prevents progression of liver fibrosis induced by dimethylnitrosamine (DNM) in rats.
Topics: Animals; Antioxidants; Cell Line; Cell Proliferation; Dimethylnitrosamine; Disease Progression; Glutamates; Hepatic Stellate Cells; Humans; Liver Cirrhosis; NF-E2-Related Factor 2; Platelet-Derived Growth Factor; Rats; Response Elements; Signal Transduction | 2018 |
Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats.
Topics: Animals; Dimethylnitrosamine; Gallic Acid; Liver Cirrhosis; Male; Phosphoproteins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins | 2018 |
Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis.
Topics: Animals; Biomarkers; Dimethylnitrosamine; Liver Cirrhosis; Liver Function Tests; Male; Oxidative Stress; Rats; Rats, Wistar; Trace Elements | 2019 |
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Bile; Cytoprotection; Dimethylnitrosamine; Dose-Response Relationship, Drug; Liver Cirrhosis; Liver Cirrhosis, Experimental; Random Allocation; Rats; Rats, Wistar; Ursidae | 2019 |
Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Dimethylnitrosamine; Gene Expression; Humans; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Rats; Rats, Sprague-Dawley; Stilbenes; Transforming Growth Factor beta1 | 2013 |
The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways.
Topics: Animals; Blotting, Western; Cell Proliferation; Dimethylnitrosamine; Hepatic Stellate Cells; JNK Mitogen-Activated Protein Kinases; Liver Cirrhosis; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 8; Models, Animal; p38 Mitogen-Activated Protein Kinases; Pyridones; Random Allocation; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2013 |
Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes.
Topics: Actins; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Collagen Type I; Cyclooxygenase 2; Dimethylnitrosamine; Glutamate-Cysteine Ligase; Glutathione Transferase; Heme Oxygenase (Decyclizing); Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Malondialdehyde; Matrix Metalloproteinase 13; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; NF-kappa B; Plant Extracts; Plant Roots; Platycodon; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha | 2013 |
Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis.
Topics: Animals; Bile Ducts; Dimethylnitrosamine; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Hepatic Stellate Cells; Hepatocyte Growth Factor; Humans; Liposomes; Liver; Liver Cirrhosis; Rats; Transgenes | 2013 |
Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect.
Topics: Animals; Cell Line; Dimethylnitrosamine; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Hepatocytes; Isoflavones; Liver; Liver Cirrhosis; Male; Molecular Structure; Pueraria; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2013 |
Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats.
Topics: Alkaloids; Animals; Bile Ducts; Cell Proliferation; Cells, Cultured; Collagen; Coloring Agents; Dimethylnitrosamine; Hydroxyproline; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4 | 2014 |
Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Dimethylnitrosamine; Hesperidin; Liver Cirrhosis; Male; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species | 2014 |
Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Cell Survival; Dimethylnitrosamine; Glutathione; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Liver; Liver Cirrhosis; Male; Malondialdehyde; Protective Agents; Rats, Wistar; Reactive Oxygen Species; Serum Albumin; Superoxide Dismutase; Swertia; Xanthones | 2014 |
The role of phospholipase D1 in liver fibrosis induced by dimethylnitrosamine in vivo.
Topics: Actins; Animals; Dimethylnitrosamine; Disease Progression; Down-Regulation; Liver; Liver Cirrhosis; Male; Phospholipase D; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2014 |
Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation.
Topics: Animals; Body Weight; Dimethylnitrosamine; Disease Models, Animal; Hydroxyproline; Lactoferrin; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ultrasonography | 2014 |
Measurement of hydroxyproline in collagen with three different methods.
Topics: Animals; Bleomycin; Chromatography, High Pressure Liquid; Collagen; Colorimetry; Dimethylnitrosamine; Hydroxyproline; Liver; Liver Cirrhosis; Lung; Mass Spectrometry; Rats; Rats, Wistar | 2014 |
Whey-hydrolyzed peptide-enriched immunomodulating diet prevents progression of liver cirrhosis in rats.
Topics: Animals; Antioxidants; Cattle; Dimethylnitrosamine; Disease Progression; Glutathione; Hyaluronic Acid; Hydroxyproline; Liver; Liver Cirrhosis; Male; Milk Proteins; Necrosis; Peptides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Whey Proteins | 2014 |
A Chinese herbal medicine, jia-wei-xiao-yao-san, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Liver Cirrhosis; Male; Rats; Rats, Wistar | 2014 |
[Reverse effect of Yinchenhao decoction in dimethyl nitrosamine-induced hepatic fibrosis in rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Collagen Type IV; Dimethylnitrosamine; Drugs, Chinese Herbal; Humans; Hydroxyproline; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley | 2014 |
Resveratrol mitigate structural changes and hepatic stellate cell activation in N'-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dimethylnitrosamine; Electrophoresis, Gel, Two-Dimensional; Hepatic Stellate Cells; Liver Cirrhosis; Male; Oxidative Stress; Rats; Resveratrol; Stilbenes | 2014 |
Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Fruit; Garcinia; Liver; Liver Cirrhosis; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Terpenes; Transforming Growth Factor beta1 | 2014 |
Effects of β-sitosterol derived from Artemisia capillaris on the activated human hepatic stellate cells and dimethylnitrosamine-induced mouse liver fibrosis.
Topics: Actins; Animals; Artemisia; Cell Line; Cell Survival; Collagen Type I; Dimethylnitrosamine; Gene Expression; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Sitosterols | 2014 |
Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model.
Topics: Animals; Dimethylnitrosamine; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Liver; Liver Cirrhosis; Male; Oxidation-Reduction; Protein Carbonylation; Rats, Wistar; Rheum; Rhizome; Scutellaria baicalensis | 2015 |
A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats.
Topics: Alkaloids; Animals; Apoptosis; Cell Line; Cell Movement; Cell Proliferation; Dimethylnitrosamine; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Protective Agents; Quinolizines; Rats | 2015 |
Reduction of Dimethylnitrosamine-Induced Liver Fibrosis by the Novel Gene Regulator PI Polyamide Targeting Transforming Growth Factor β1 Gene.
Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; End Stage Liver Disease; Fibrosis; Gene Silencing; Hepatic Stellate Cells; Imidazoles; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 2015 |
MicroRNA-34a Promotes Hepatic Stellate Cell Activation via Targeting ACSL1.
Topics: 3' Untranslated Regions; Actins; Animals; Basic Helix-Loop-Helix Transcription Factors; Dimethylnitrosamine; Gene Expression Regulation; Gene Silencing; HEK293 Cells; Hepatic Stellate Cells; Humans; Immunohistochemistry; Liver; Liver Cirrhosis; Male; MicroRNAs; Rats; Rats, Sprague-Dawley | 2015 |
Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats.
Topics: Angiogenic Proteins; Animals; Anti-Inflammatory Agents; Cytokines; Dimethylnitrosamine; Drug Therapy, Combination; Gadolinium; Hepatic Stellate Cells; Hepatocytes; Hydroxyproline; Kupffer Cells; Liver; Liver Cirrhosis; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Rats; Rats, Wistar; Sorafenib | 2015 |
Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways.
Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Collagen Type I; Dimethylnitrosamine; Down-Regulation; Fibroblast Growth Factors; Hepatic Stellate Cells; Hydroxyproline; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2016 |
Hepatoprotective effects of Dicliptera chinensis polysaccharides on dimethylnitrosamine-induced hepatic fibrosis rats and its underlying mechanism.
Topics: Acanthaceae; Animals; Chemical and Drug Induced Liver Injury; Colchicine; Collagen; Cytokines; Dimethylnitrosamine; Liver; Liver Cirrhosis; Liver Function Tests; Male; Necrosis; Polysaccharides; Protective Agents; Rats; Rats, Sprague-Dawley | 2016 |
Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway.
Topics: Animals; Bile Ducts; Dimethylnitrosamine; Diosgenin; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Humans; Ligation; Liver Cirrhosis; Male; MAP Kinase Signaling System; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sirtuin 1 | 2016 |
Dicliptera Chinensis polysaccharides target TGF-β/Smad pathway and inhibit stellate cells activation in rats with dimethylnitrosamine-induced hepatic fibrosis.
Topics: Acanthaceae; Actins; Animals; Cell Line; Cell Proliferation; Dimethylnitrosamine; Down-Regulation; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Plant Extracts; Plants, Medicinal; Polysaccharides; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2016 |
Knockdown of Astrocyte Elevated Gene-1 Inhibits Activation of Hepatic Stellate Cells.
Topics: Animals; Apoptosis; Bile Ducts; Cell Cycle; Cell Line; Cell Proliferation; Dimethylnitrosamine; Gene Expression Regulation; Gene Knockdown Techniques; Hepatic Stellate Cells; Humans; Ligation; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Up-Regulation | 2016 |
β-Amyrin, a pentacyclic triterpene, exhibits anti-fibrotic, anti-inflammatory, and anti-apoptotic effects on dimethyl nitrosamine-induced hepatic fibrosis in male rats.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Dimethylnitrosamine; Inflammation; Liver; Liver Cirrhosis; Male; Microscopy, Electron, Transmission; Oleanolic Acid; Oxidative Stress; Rats; Rats, Wistar | 2017 |
Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways.
Topics: Amygdalin; Animals; Cordyceps; Dimethylnitrosamine; Drugs, Chinese Herbal; Gynostemma; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Plant Extracts; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2016 |
The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat.
Topics: Animals; Dimethylnitrosamine; Liver; Liver Cirrhosis; Liver Diseases; Male; Rats; Rats, Wistar | 2016 |
Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells.
Topics: Alkaloids; Animals; Cell Line; Cyclin D1; Dimethylnitrosamine; Enzyme Activation; ErbB Receptors; G1 Phase Cell Cycle Checkpoints; Hepatic Stellate Cells; Liver Cirrhosis; Matrines; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinolizines; Rats | 2016 |
Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats.
Topics: Animals; Cell Movement; Cells, Cultured; Coculture Techniques; Dimethylnitrosamine; Disease Models, Animal; Humans; In Vitro Techniques; Interleukin-10; Interleukin-4; Kupffer Cells; Liver; Liver Cirrhosis; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; Umbilical Cord | 2016 |
Noninvasive mapping of the redox status of dimethylnitrosamine-induced hepatic fibrosis using in vivo dynamic nuclear polarization-magnetic resonance imaging.
Topics: Animals; Cyclic N-Oxides; Dimethylnitrosamine; Injections, Intravenous; Liver; Liver Cirrhosis; Magnetic Resonance Imaging; Male; Mice, Inbred BALB C; Nitrogen Oxides; Oxidation-Reduction | 2016 |
Adenovirus-mediated expression of orphan nuclear receptor NR4A2 targeting hepatic stellate cell attenuates liver fibrosis in rats.
Topics: Active Transport, Cell Nucleus; Adenoviridae; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Extracellular Matrix; Gene Expression; Genetic Therapy; Genetic Vectors; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nuclear Receptor Subfamily 4, Group A, Member 2; Phosphorylation; Rats; Transduction, Genetic | 2016 |
Antifibrotic effect of total flavonoids of Astmgali Radix on dimethylnitrosamine-induced liver cirrhosis in rats.
Topics: Actins; Animals; Blotting, Western; Body Weight; Collagen Type I; Dimethylnitrosamine; Drugs, Chinese Herbal; Flavonoids; Hydroxyproline; Liver; Liver Cirrhosis; Male; Organ Size; Plant Extracts; PPAR gamma; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Uncoupling Protein 2 | 2017 |
Expression of pro-fibrotic and anti-fibrotic molecules in dimethylnitrosamine-induced hepatic fibrosis.
Topics: Animals; Connective Tissue Growth Factor; Dimethylnitrosamine; Disease Models, Animal; Integrins; Liver; Liver Cirrhosis; Mice; PPAR gamma; Smad3 Protein; TOR Serine-Threonine Kinases; Transforming Growth Factor beta | 2017 |
Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation.
Topics: Actins; Animals; Capsaicin; Collagen Type I; Dimethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; NF-kappa B; PPAR gamma; Rats, Sprague-Dawley; Smad Proteins; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2017 |
Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymalstem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice.
Topics: Actins; Animals; beta Catenin; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Dimethylnitrosamine; Drugs, Chinese Herbal; Female; Hepatocyte Growth Factor; Hepatocytes; Liver; Liver Cirrhosis; Male; Mesenchymal Stem Cells; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, CXCR4; Transcription Factor RelA; Up-Regulation | 2017 |
[Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat].
Topics: Animals; Aspartate Aminotransferases; Collagen Type IV; Dimethylnitrosamine; Hyaluronic Acid; Laminin; Lipid Peroxidation; Liver Cirrhosis; Malondialdehyde; Oleanolic Acid; Rats; Saponins; Superoxide Dismutase | 2008 |
Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Actins; Animals; Antioxidants; Body Weight; Collagen Type I; Dimethylnitrosamine; Flavonoids; Liver; Liver Cirrhosis; Liver Function Tests; Male; Organ Size; Phytotherapy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1 | 2009 |
[Intervening and therapeutic effect of cordyceps mycelia extract on liver cirrhosis induced by dimethylnitrosamine in rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biological Factors; Cordyceps; Dimethylnitrosamine; Humans; Liver; Liver Cirrhosis; Male; Moths; Mycelium; Random Allocation; Rats; Rats, Wistar; Treatment Outcome | 2008 |
Reevaluation of experimental model of hepatic fibrosis induced by hepatotoxic drugs: an easy, applicable, and reproducible model.
Topics: Animals; Carbon Tetrachloride Poisoning; Dimethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Thioacetamide | 2008 |
Alleviation of dimethylnitrosamine-induced liver injury and fibrosis by betaine supplementation in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Betaine; Dimethylnitrosamine; Liver; Liver Cirrhosis; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2009 |
Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Female; Hepatocytes; Liver; Liver Cirrhosis; Liver Regeneration; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proliferating Cell Nuclear Antigen; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors | 2009 |
Continuos intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat.
Topics: Actins; Animals; Atrial Natriuretic Factor; Cell Line; Dimethylnitrosamine; Gene Expression; Infusions, Intravenous; Liver Cirrhosis; Male; Procollagen; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1 | 2009 |
Differentiation of mouse hepatic progenitor cells induced by hepatocyte nuclear factor-4 and cell transplantation in mice with liver fibrosis.
Topics: Adenoviridae; Animals; Apolipoprotein A-I; Apolipoprotein C-III; Cell Differentiation; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; Fetal Stem Cells; Gene Transfer Techniques; Genetic Therapy; Hepatectomy; Hepatocyte Nuclear Factor 4; Hepatocytes; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pregnane X Receptor; Receptors, Steroid; Stem Cell Transplantation; Transfection | 2008 |
Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine.
Topics: Animals; Antipyrine; Bilirubin; Dimethylnitrosamine; Edaravone; Free Radical Scavengers; Histocytochemistry; Liver Cirrhosis; Rats; Severity of Illness Index | 2009 |
Involvement of 90-kuD ribosomal S6 kinase in collagen type I expression in rat hepatic fibrosis.
Topics: Animals; Cell Proliferation; Collagen Type I; Dimethylnitrosamine; Hepatic Stellate Cells; Liver Cirrhosis; Male; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering | 2009 |
Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice.
Topics: Actins; Aging; Animals; CD3 Complex; Connective Tissue Growth Factor; Dimethylnitrosamine; Fibrillar Collagens; Immunohistochemistry; Liver; Liver Cirrhosis; Mice; Mice, Knockout; Severity of Illness Index; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1 | 2009 |
Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Benzodioxoles; Body Weight; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Female; Hepatic Stellate Cells; Hydroxyproline; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Molecular Structure; Prothrombin Time; Rats; Rats, Sprague-Dawley; Survival Analysis; Thiazoles | 2009 |
Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats.
Topics: Adenoviridae; Animals; Becaplermin; Bone Morphogenetic Protein 4; Cadherins; Cell Proliferation; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; Hepatic Stellate Cells; Ligation; Liver; Liver Cirrhosis; Mitogen-Activated Protein Kinase 3; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; RNA, Small Interfering; Signal Transduction; Smad1 Protein; Transforming Growth Factor beta1; Vimentin | 2009 |
Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Line; Cell Proliferation; Collagen Type I; Dimethylnitrosamine; Disease Models, Animal; Hepatic Stellate Cells; Hydroxyproline; Lipid Peroxides; Liver Cirrhosis; Male; Plant Extracts; Rats; Rats, Inbred Strains; Tea; Treatment Outcome | 2009 |
Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats.
Topics: Actins; Animals; Cinnamomum aromaticum; Connective Tissue Growth Factor; Cytoprotection; Dimethylnitrosamine; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Liver Function Tests; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2010 |
Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dimethylnitrosamine; Drugs, Chinese Herbal; Flowers; Lipid Peroxidation; Liver Cirrhosis; Liver Diseases; Lonicera; Male; Mass Spectrometry; Rats; Rats, Wistar | 2010 |
Experimental evidence for the protective effects of coffee against liver fibrosis in SD rats.
Topics: Animals; Antioxidants; Body Weight; Coffea; Coffee; Cytokines; Dimethylnitrosamine; Disease Models, Animal; Gene Expression; Hepatic Stellate Cells; Hydroxyproline; Liver; Liver Cirrhosis; Macrophages; Male; Malondialdehyde; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type II; Organ Size; Phytotherapy; Plant Extracts; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Seeds | 2010 |
Comparison of liver regeneration after a splenectomy and splenic artery ligation in a dimethylnitrosamine-induced cirrhotic rat model.
Topics: Alanine Transaminase; Animals; Bilirubin; Biomarkers; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Ki-67 Antigen; Ligation; Liver; Liver Cirrhosis; Liver Regeneration; Male; Rats; Rats, Wistar; Splenectomy; Splenic Artery; Time Factors; Transforming Growth Factor beta1 | 2010 |
Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Alkylating Agents; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury, Chronic; Dimethylnitrosamine; Down-Regulation; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Organ Size; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Messenger; Stilbenes; Transforming Growth Factor beta1; Weight Loss | 2010 |
E-cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation.
Topics: Actins; Animals; Cadherins; Dimethylnitrosamine; Epithelial-Mesenchymal Transition; Female; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Mice; Phosphorylation; Rats; rhoA GTP-Binding Protein; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2010 |
Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen Type I; Dimethylnitrosamine; Fibrosis; Hepatic Stellate Cells; Inflammation; Kupffer Cells; Lipopolysaccharides; Liver Cirrhosis; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2010 |
Dimethylnitrosamine-induced liver fibrosis and recovery in NOD/SCID mice.
Topics: Actins; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Dimethylnitrosamine; Disease Models, Animal; Immunohistochemistry; Liver Cirrhosis; Male; Mice; Mice, Inbred NOD; Mice, SCID; Random Allocation; Serum Albumin | 2011 |
Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine-induced liver fibrosis.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Base Sequence; Blotting, Western; Collagen Type I; Dimethylnitrosamine; DNA Primers; Drugs, Chinese Herbal; Gene Expression; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinase-1 | 2011 |
The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Coenzyme A Ligases; Dimethylnitrosamine; Liver Cirrhosis; MicroRNAs; Oligonucleotide Array Sequence Analysis; Rats; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2011 |
Can apricot kernels fatty acids delay the atrophied hepatocytes from progression to fibrosis in dimethylnitrosamine (DMN)-induced liver injury in rats?
Topics: Animals; Atrophy; Catalase; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Assays; Fatty Acids; Glutathione Peroxidase; Hepatocytes; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Malondialdehyde; Organ Size; Plant Oils; Prunus; Rats; Seeds; Superoxide Dismutase | 2011 |
Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells.
Topics: Animals; Cell Cycle; Cell Line; Cell Proliferation; Dimethylnitrosamine; Gene Silencing; Hepatic Stellate Cells; HMGB1 Protein; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; RNA, Small Interfering | 2011 |
NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats.
Topics: Adenoviridae; Animals; Cell Line; Cell Proliferation; Dimethylnitrosamine; Extracellular Matrix; Gene Expression Regulation, Enzymologic; Hepatic Stellate Cells; Hepatocytes; Humans; Liver; Liver Cirrhosis; Matrix Metalloproteinase 2; Phosphorylation; Rats; Signal Transduction; Smad Proteins; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1; Tumor Suppressor Proteins | 2011 |
Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis.
Topics: Animals; Apoptosis; Caspase 3; Dimethylnitrosamine; Drugs, Chinese Herbal; Fibrosis; Hepatocytes; Humans; Kupffer Cells; Liver Cirrhosis; Male; Protective Agents; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2012 |
[Effect of gypenosides on DMN-induced liver fibrosis in rats].
Topics: Animals; Body Weight; Dimethylnitrosamine; Glutathione; Glutathione Peroxidase; Gynostemma; Hydroxyproline; Liver; Liver Cirrhosis; Male; Malondialdehyde; Organ Size; Plant Extracts; Rats; Rats, Wistar | 2012 |
A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation.
Topics: Actins; Animals; Apoptosis; Calcium; Caspase 12; Caspase 3; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type I, alpha 1 Chain; Dimethylnitrosamine; Drugs, Chinese Herbal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Phytotherapy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ultrasonography | 2012 |
[Effects of mast cells on degradation of collagen fibers in dimethylnitrosamine-induced hepatic fibrosis of rat].
Topics: Actins; Animals; Cell Count; Dimethylnitrosamine; Liver Cirrhosis; Male; Mast Cells; Matrix Metalloproteinase 2; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-2; Tryptases | 2012 |
Immunosuppressive prednisolone enhances early cholangiocarcinoma in Syrian hamsters with liver fluke infection and administration of N-nitrosodimethylamine.
Topics: Animals; Bile Duct Neoplasms; Cell Transformation, Neoplastic; Cholangiocarcinoma; Chronic Disease; Cocarcinogenesis; Cricetinae; Cyclooxygenase 2; Dimethylnitrosamine; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Liver; Liver Cirrhosis; Liver Neoplasms; Mesocricetus; Opisthorchiasis; Prednisolone | 2013 |
Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Boswellia; Camphanes; Collagen; Dimethylnitrosamine; Drugs, Chinese Herbal; Female; Liver Cirrhosis; Male; Mice; Panax notoginseng; Plant Extracts; Salvia miltiorrhiza; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1 | 2012 |
Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Female; Fish Proteins; Gene Expression; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Microscopy, Electron, Transmission; Oryzias; Phenotype | 2013 |
Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzoates; Bridged-Ring Compounds; Chemical and Drug Induced Liver Injury; Collagen Type I; Desmin; Dimethylnitrosamine; Disease Models, Animal; Glucosides; Hydroxyproline; Kidney; Liver; Liver Cirrhosis; Lung; Macrophages; Male; Monoterpenes; Paeonia; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Spleen; Tumor Necrosis Factor-alpha | 2012 |
Investigation of metabolite alteration in dimethylnitrosamine-induced liver fibrosis by GC-MS.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Dimethylnitrosamine; Gas Chromatography-Mass Spectrometry; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley | 2013 |
Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Actins; Administration, Oral; Animals; Collagen; Curcumin; Dietary Supplements; Dimethylnitrosamine; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2013 |
Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro.
Topics: Animals; Apoptosis; Body Weight; Cytokines; Dimethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herbal; Ferns; Hepatic Stellate Cells; Inflammation; Kupffer Cells; Liver; Liver Cirrhosis; Male; Organ Size; Plant Extracts; Rats; Spleen | 2013 |
Effects of extract derived from Eriobotrya japonica on liver function improvement in rats.
Topics: Animals; Dimethylnitrosamine; Eriobotrya; Liver; Liver Cirrhosis; Male; Plant Extracts; Rats; Rats, Wistar; Seeds | 2002 |
Selective Na+/H+ exchange inhibition by cariporide reduces liver fibrosis in the rat.
Topics: Animals; Bile Ducts; Cell Division; Cells, Cultured; Dimethylnitrosamine; Enzyme Activation; Guanidines; Ligation; Liver; Liver Cirrhosis; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Sodium-Hydrogen Exchangers; Sulfones | 2003 |
L-cysteine administration prevents liver fibrosis by suppressing hepatic stellate cell proliferation and activation.
Topics: Animals; Biomarkers; Cell Division; Cells, Cultured; Cysteine; Dimethylnitrosamine; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley | 2003 |
Some toxic properties of dimethylnitrosamine.
Topics: Dimethylnitrosamine; Humans; Liver Cirrhosis; Liver Diseases; Solvents | 1954 |
A blocking peptide for transforming growth factor-beta1 activation prevents hepatic fibrosis in vivo.
Topics: Animals; Atrophy; Dimethylnitrosamine; Disease Progression; DNA-Binding Proteins; Hydroxyproline; Liver; Liver Cirrhosis; Male; Necrosis; Peptides; Phosphorylation; Rats; Rats, Sprague-Dawley; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Body Weight; Dimethylnitrosamine; Flavanones; Flavonoids; Image Processing, Computer-Assisted; Immunohistochemistry; Lipid Peroxidation; Liver Cirrhosis; Liver Function Tests; Male; Malondialdehyde; Organ Size; Rats; Rats, Sprague-Dawley | 2004 |
Proliferative capability of hepatocytes and expression of G1-related cell cycle molecules in the development of liver cirrhosis in rats.
Topics: Animals; Cell Cycle Proteins; Cell Division; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinases; Dimethylnitrosamine; Extracellular Matrix; G1 Phase; Hepatocytes; Liver; Liver Cirrhosis; Male; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Tumor Suppressor Proteins | 2004 |
Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Antioxidants; Dimethylnitrosamine; Glutathione; Hydroxyproline; Lipid Peroxidation; Liver Cirrhosis; Liver Function Tests; Male; Malondialdehyde; Melatonin; Rats; Rats, Wistar; Superoxide Dismutase | 2004 |
Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Body Weight; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Hyaluronic Acid; Hyaluronoglucosaminidase; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Liver Function Tests; Male; Organ Size; Rats; Rats, Wistar; Time Factors | 2004 |
Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.
Topics: Animals; Chemokine CCL2; Chemotaxis; Dimethylnitrosamine; Liver; Liver Cirrhosis; Macrophages; Male; Models, Animal; Monocytes; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2005 |
Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.
Topics: Activin Receptors, Type I; Acute Disease; Animals; Cell Line, Tumor; Chronic Disease; Dimethylnitrosamine; Hepatectomy; Humans; Liver Cirrhosis; Liver Regeneration; Male; Mice; Mice, Transgenic; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta | 2005 |
The hepatoprotective effect of Bupleurum kaoi, an endemic plant to Taiwan, against dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Bupleurum; Dimethylnitrosamine; Liver Cirrhosis; Male; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Taiwan | 2005 |
Different tumor necrosis factor-alpha-associated leptin expression in rats with dimethylnitrosamine and bile duct ligation-induced liver cirrhosis.
Topics: Adipose Tissue; Animals; Bile Ducts; Bilirubin; Blotting, Western; Dimethylnitrosamine; Eating; Epididymis; Gene Expression; Immunoassay; Leptin; Ligation; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats.
Topics: Actins; Animals; Cell Line; Connective Tissue Growth Factor; Dimethylnitrosamine; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Liver; Liver Cirrhosis; Male; Plant Extracts; Procollagen; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Salvia miltiorrhiza; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Remote delivery and expression of soluble type II TGF-beta receptor in muscle prevents hepatic fibrosis in rats.
Topics: Actins; Animals; Body Weight; Collagen Type I; Dimethylnitrosamine; Gene Expression Regulation; Humans; Interleukin-10; Interleukin-12; Liver Cirrhosis; Male; Muscles; Organ Size; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Solubility | 2005 |
Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Differentiation; Dimethylnitrosamine; Hematopoietic Stem Cell Transplantation; Hepatocytes; Liver Cirrhosis; Male; Mesoderm; Rats; Rats, Inbred F344 | 2005 |
Cell cycle protein profile of the hepatic stellate cells(HSCs)in dimethylnitrosamine-induced rat hepatic fibrosis.
Topics: Animals; Cell Cycle Proteins; Cell Proliferation; Dimethylnitrosamine; Liver; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; S Phase | 2005 |
Pharmacokinetics and therapeutic effects of oltipraz after consecutive or intermittent oral administration in rats with liver cirrhosis induced by dimethylnitrosamine.
Topics: Administration, Oral; Alkylating Agents; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Creatinine; Dimethylnitrosamine; Half-Life; Hematocrit; Liver; Liver Cirrhosis; Male; Organ Size; Pyrazines; Rats; Rats, Wistar; Schistosomicides; Thiones; Thiophenes | 2006 |
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.
Topics: Activin Receptors, Type I; Acute Disease; Administration, Oral; Animals; Benzamides; Collagen Type I; Collagen Type I, alpha 1 Chain; Dimethylnitrosamine; Fibrosis; Kidney; Liver Cirrhosis; Male; Models, Molecular; Protein Serine-Threonine Kinases; Puromycin Aminonucleoside; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Messenger; Structure-Activity Relationship | 2006 |
Relationship between the proliferative capability of hepatocytes and the intrahepatic expression of hepatocyte growth factor and c-Met in the course of cirrhosis development in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Proliferation; Dimethylnitrosamine; Gene Expression; Hepatocyte Growth Factor; Hepatocytes; Immunohistochemistry; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Male; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-met; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2006 |
Prevention of hepatic fibrosis in nonobese diabetic mice: a critical role for interferon-gamma.
Topics: Animals; Dimethylnitrosamine; Female; Interferon-gamma; Liver Cirrhosis; Mice; Mice, Inbred ICR; Mice, Inbred NOD | 2006 |
Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis.
Topics: Animals; Ascites; Body Weight; Calcium; Dimethylnitrosamine; Liver; Liver Cirrhosis; Magnesium; Male; Minerals; Organ Size; Potassium; Rats; Rats, Wistar | 2006 |
Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine.
Topics: Actins; Animals; Collagen Type I; Dimethylnitrosamine; Hepatocytes; Injections, Intraperitoneal; Iron; Liver; Liver Cirrhosis; Macrophages; Male; Rats; Rats, Wistar; RNA, Messenger; Spectrophotometry, Atomic; Transforming Growth Factor beta1 | 2006 |
Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis.
Topics: Animals; Dimethylnitrosamine; Disease Models, Animal; Gene Expression Profiling; Liver; Liver Cirrhosis; Male; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reference Values | 2006 |
An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats.
Topics: Animals; Dimethylnitrosamine; Drugs, Chinese Herbal; Gene Expression; Hydroxyproline; Lipid Peroxidation; Liver; Liver Cirrhosis; Liver Diseases; Male; Organ Size; Rats; Rats, Wistar; Spleen | 2006 |
Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cells, Cultured; Dimethylnitrosamine; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Genetic Markers; Hepatocytes; Kupffer Cells; Liver Cirrhosis; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Sequential assessment of the intrahepatic expression of epidermal growth factor and transforming growth factor-beta1 in hepatofibrogenesis of a rat cirrhosis model.
Topics: Animals; Collagen; Dimethylnitrosamine; Disease Models, Animal; Disease Progression; Epidermal Growth Factor; Extracellular Matrix; Liver Cirrhosis; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1 | 2007 |
[Effects of corydyceps polysaccharide on liver fibrosis induced by DMN in rats].
Topics: Animals; Collagen Type IV; Cordyceps; Dimethylnitrosamine; Hydroxyproline; Liver; Liver Cirrhosis; Male; Malondialdehyde; Matrix Metalloproteinase 2; Polysaccharides; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tissue Inhibitor of Metalloproteinase-2 | 2006 |
Iron deposition and fat accumulation in dimethylnitrosamine-induced liver fibrosis in rat.
Topics: Alanine Transaminase; Animals; Collagen; Dimethylnitrosamine; Female; Hydroxyproline; Iron; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 2007 |
Study of plasma protein C and inflammatory pathways: biomarkers for dimethylnitrosamine-induced liver fibrosis in rats.
Topics: Animals; Biomarkers; C-Reactive Protein; Chemokines; Dimethylnitrosamine; Fibrinolytic Agents; gamma-Glutamyltransferase; Haptoglobins; Humans; Hyaluronic Acid; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Liver Cirrhosis; Macrophage Colony-Stimulating Factor; Neutrophils; Protein C; Rats; Rats, Sprague-Dawley; Serum Albumin; Time Factors | 2007 |
Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats.
Topics: Actins; Animals; Collagen; Dimethylnitrosamine; Drug Combinations; Drugs, Chinese Herbal; Glycyrrhiza; Immunohistochemistry; Intercellular Adhesion Molecule-1; Ligusticum; Liver; Liver Cirrhosis; Male; NF-kappa B; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Salvia miltiorrhiza; Silymarin; Transcription, Genetic; Transforming Growth Factor beta1 | 2008 |
Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta.
Topics: Animals; Antibodies; Dimethylnitrosamine; Granulocyte Colony-Stimulating Factor; Immunization, Passive; Interleukin-1beta; Liver Cirrhosis; Liver Regeneration; Mice; Mice, Inbred ICR; RNA, Messenger; Survival Rate; Up-Regulation | 2007 |
Chinese herb Radix Polygoni Multiflori as a therapeutic drug for liver cirrhosis in mice.
Topics: Alkylating Agents; Animals; Cell Proliferation; Cell Separation; Cell Survival; Chromatography, High Pressure Liquid; Coculture Techniques; Collagen; Dimethylnitrosamine; Drugs, Chinese Herbal; Glyceraldehyde-3-Phosphate Dehydrogenases; Hepatocyte Growth Factor; Hepatocytes; Hydroxyproline; Kupffer Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Phagocytosis; Platelet-Derived Growth Factor; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Pathophysiological characteristics of dimethylnitrosamine-induced liver fibrosis in acute and chronic injury models: a possible contribution of KLF5 to fibrogenic responses.
Topics: Actins; Acute Disease; Alanine Transaminase; Animals; Chronic Disease; Collagen Type I; Dimethylnitrosamine; Disease Models, Animal; Kruppel-Like Transcription Factors; Liver; Liver Cirrhosis; Male; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Up-Regulation | 2008 |
Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury.
Topics: Alanine Transaminase; Alkylating Agents; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver Function Tests; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; Vitamin B 12; Vitamins | 2008 |
Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Collagen; Dimethylnitrosamine; Female; Hepatocyte Growth Factor; Interferon-gamma; Liver; Liver Cirrhosis; Mice; Mice, Inbred BALB C; Models, Animal; Nucleopolyhedroviruses; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen; Transfection; Transforming Growth Factor beta | 2008 |
[Effect of HF on the hepatic metabolism of dimethylnitrosamine in the rat].
Topics: Animals; Benzopyrene Hydroxylase; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Hydrofluoric Acid; Liver; Liver Cirrhosis; Male; Oxidoreductases, N-Demethylating; Proteins; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Fatal nitrosamine poisoning.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Food Analysis; Humans; Liver; Liver Cirrhosis | 1982 |
Lethal exitus of a patient with N-nitrosodimethylamine poisoning, 2.5 years following the first ingestion and signs of intoxication.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Hemorrhage; Homicide; Humans; Liver Cirrhosis; Organ Size | 1980 |
Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen.
Topics: Animals; Carcinogens; Collagen; Dimethylnitrosamine; Electrophoresis, Polyacrylamide Gel; Liver; Liver Cirrhosis; Macromolecular Substances; Male; Pepsin A; Protein Denaturation; Rats; Rats, Wistar; Reference Values; Solubility; Time Factors | 1996 |
Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats.
Topics: Actins; Angiogenesis Inhibitors; Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Cyclin-Dependent Kinases; Cyclins; Cyclohexanes; Dimethylnitrosamine; Liver; Liver Cirrhosis; Male; Muscle, Smooth; O-(Chloroacetylcarbamoyl)fumagillol; Platelet-Derived Growth Factor; Rats; Rats, Inbred F344; Receptor, Platelet-Derived Growth Factor beta; Sesquiterpenes | 2000 |
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.
Topics: Animals; Ascorbic Acid; Cell Division; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; Drug Interactions; Free Radicals; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penicillamine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine | 2001 |
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Actins; Amides; Animals; Body Weight; Collagen; Dimethylnitrosamine; Enzyme Inhibitors; Hydroxyproline; Intracellular Signaling Peptides and Proteins; Liver; Liver Cirrhosis; Male; Muscle, Smooth; Organ Size; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; RNA, Messenger | 2001 |
Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Blotting, Northern; Body Weight; Collagen; Dimethylnitrosamine; Hydroxyproline; Liver Cirrhosis; Male; Pyridones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2001 |
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
Topics: Animals; Dimethylnitrosamine; Enzyme Inhibitors; Liver; Liver Cirrhosis; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transaminases; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha.
Topics: Acetylcysteine; Animals; Dimethylnitrosamine; Free Radical Scavengers; Interferon-alpha; Liver Cirrhosis; Male; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2001 |
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.
Topics: Acetates; Acute Disease; Ammonia; Animals; Arginine; Behavior, Animal; Carbamoyl-Phosphate Synthase (Ammonia); Dimethylnitrosamine; Drug Synergism; Glutamates; Liver Cirrhosis; Male; Poisoning; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
Topics: Animals; Benzhydryl Compounds; Bile Ducts; Carbon Tetrachloride; Cell Division; Cells, Cultured; Collagen; Dimethylnitrosamine; DNA; Epoxy Compounds; Fibronectins; Hypoglycemic Agents; Ligation; Liver; Liver Cirrhosis; Male; Phenols; Pioglitazone; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Mobilization of ascites in cirrhotic dogs following furosemide or mannitol diuresis.
Topics: Animals; Ascites; Central Venous Pressure; Dimethylnitrosamine; Diuresis; Dogs; Extracellular Space; Female; Furosemide; Kidney; Liver Cirrhosis; Male; Mannitol; Plasma Volume; Time Factors | 1978 |
Temporal relationships between urinary salt retention and altered systemic hemodynamics in dogs with experimental cirrhosis.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Carbon Monoxide; Dimethylnitrosamine; Dogs; Glomerular Filtration Rate; Liver Cirrhosis; Sodium; Vascular Resistance | 1978 |
[Experimental liver cirrhosis].
Topics: Animals; Dimethylnitrosamine; Dogs; Ethanol; Ethionine; Haplorhini; Liver; Liver Cirrhosis; Rats | 1976 |
Transposition of the spleen in rats with portal hypertension.
Topics: Animals; Collateral Circulation; Constriction; Dimethylnitrosamine; Hypertension, Portal; Liver Cirrhosis; Male; Mesenteric Veins; Portography; Rats; Renal Veins; Spleen; Splenic Vein; Transplantation, Autologous | 1976 |
Serum concentrations of the N-terminal propeptide of type III procollagen and two type IV collagen fragments and gene expression of the respective collagen types in liver in rats with dimethylnitrosamine-induced hepatic fibrosis.
Topics: Animals; Chromatography, Gel; Collagen; Dimethylnitrosamine; Female; Liver; Liver Cirrhosis; Peptide Fragments; Procollagen; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA, Messenger | 1988 |
Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat.
Topics: Animals; Collagen; Dimethylnitrosamine; DNA; Female; Genes; Liver; Liver Cirrhosis; Proteins; Rats; Rats, Inbred Strains; RNA, Messenger | 1987 |
A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat.
Topics: Animals; Ascites; Dimethylnitrosamine; Disease Models, Animal; Hemodynamics; Hypertension, Portal; Liver Cirrhosis; Male; Rats; Rats, Inbred Strains; Time Factors | 1985 |