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dimethylnitrosamine and Chemical and Drug Induced Liver Injury

dimethylnitrosamine has been researched along with Chemical and Drug Induced Liver Injury in 101 studies

*Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. [MeSH]

Research

Studies (101)

Timeframe	Studies, this research(%)	All Research%
pre-1990	50 (49.50)	18.7374
1990's	14 (13.86)	18.2507
2000's	14 (13.86)	29.6817
2010's	22 (21.78)	24.3611
2020's	1 (0.99)	2.80

Authors

Authors	Studies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Hussein, MA; M Abd El-Halim, S; M Soliman, S; Mamdouh, MA; Mosallam, S	1
Chen, Y; Dai, R; Deng, Y; Guo, Y; Liu, X; Meng, W; Shi, Y; Su, J; Suheryani, I; Sun, L; Zhao, S	1
George, J; Tsuchishima, M; Tsutsumi, M	1
Rana, K; Rana, SVS; Rani, V; Verma, Y	1
Du, XW; Geng, NZ; Jiang, DY; Kuang, HX; Liu, CG; Wang, XL; Zhang, SX; Zhou, YY	1
Cheng, AC; Ho, CT; Hung, WL; Pan, MH; Sun, PP; Tsai, CY; Tsai, ML; Yang, CC	1
Ho, CT; Lai, CS; Lee, YL; Li, S; Pan, MH; Tsai, CY; Wan, X; Weerawatanakorn, M	1
Fukuda, N; Fukushima, A; Inami, M; Matsumoto, Y; Moriyama, M; Soma, M; Tsunemi, A; Ueno, T; Yamada, T	1
Bak, J; Cheong, KO; Chung, HY; Je, NK; Kim, KW; Lee, C; Moon, JO; Shin, DS; Yoon, S	1
Chen, Y; Duan, X; Gao, Y; Li, J; Xu, Y; Zhang, K; Zhong, M; Zhu, H	1
Ezhilarasan, D; Karthikeyan, S	1
Chen, QL; Liu, P; Lu, YY; Song, YN; Su, SB; Wang, ZT; Yang, L; Zhang, GB	1
Han, X; Peng, J; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L; Zhang, W; Zheng, L	1
Choi, MJ; Kim, JM; Lee, DH; Lee, KW; Park, YH; Zheng, HM	1
Farombi, EO; Shrotriya, S; Surh, YJ	1
Ahmad, R; Ahmed, S; Hasnain, AU; Khan, NU	1
Hong, SS; Hong, SW; Jung, KH; Lee, DH; Zheng, HM	1
Chikamoto, J; Kanie, S; Nagayama, S; Nishimura, T; Yoshisue, K	1
Fang, H; Li, G; Miyamura, M; Sun, C; Teng, Y; Yokota, J; Yoshioka, S; Zhang, Y	1
Karthikeyan, S; Priya, S; Vijayalakshmi, P; Vivekanandan, P	1
DeAngelo, AB; George, MH; Hobbie, KR; Law, JM	1
Abdel-Rahman, MK	1
Chiu, JD; Deleve, LD; Gaarde, WA; van de Ven, G; Wang, L; Wang, X	1
Hinton, DE; Kullman, SW; Law, JM; Van Wettere, AJ	1
Chen, X; Liu, C; Lu, L; Lu, Y; Lv, Z; Pan, Q; Xu, Q; Yang, Z	1
Alvaro, D; Benedetti, A; Candelaresi, C; Caradonna, Z; Folli, F; Macarri, G; Marzioni, M; Ridolfi, F; Saccomanno, S; Svegliati-Baroni, G; Trozzi, L	1
AFZELIUS, BA; ARRHENIUS, E; GUSTAFSSON, RG; MUKHERJEE, T	1
LEE, KY; LIJINSKY, W; MAGEE, PN	1
BORNSTEIN, S; HALBREICH, A; MAGER, J	2
George, J; Stern, R	1
Hashimoto, O; Nakamura, T; Sakamoto, M; Sakata, R; Sata, M; Torimura, T; Ueno, H; Ueno, T	1
Enzan, H; Guo, LM; Hamauzu, T; Hayashi, Y; Hiroi, M; Jin, YL; Kuroda, N; Miyazaki, E; Saibara, T; Shen, ZS; Toi, M	1
Jung, HS; Kim, EK; Kim, EY; Lee, HS; Soh, Y; Sohn, NW; Sohn, Y	1
Hideaki, E; Jin, YL; Shi, SH; Zhou, Q	1
Akamatsu, S; Hayashi, S; Isoda, K; Kagaya, N; Kawase, M; Kobayashi, M; Kondoh, M; Tagawa, Y; Tamesada, M; Watanabe, A; Yagi, K	1
Kärki, NT; Saarni, HU; Sotaniemi, EA; Stengård, J	1
Saarni, HU; Sotaniemi, EA; Stengård, JH	1
Botta, GC; Contini, S; Mazzoni, MP; Pezzarossa, A; Sansoni, P	1
Harrold, D; Rogers, Q; Schaeffer, M; Stern, J; Strombeck, DR; Wheeldon, E	1
Beppu, T; Hanano, M; Iga, T; Kawasaki, S; Sugiyama, Y; Umekita, N; Wada, T	1
Chung, HR; Lorr, NA; Miller, KW; Yang, CS	1
Hughes, H; Mitchell, JR; Smith, CV	1
Boatto, R; Carrella, G; De Anna, D; Frassetto, A; Massarelli, G; Menghi, R; Soro, P; Spissu, M; Uzzau, A	1
Bassir, O; Maduagwu, EN	1
Castro, JA; Diaz Gomez, MI; Godoy, HM	1
Besserer, K; Goerttler, K; Heymer, B; Mittmeyer, HJ; Oehmichen, M; Pedal, I; Schmähl, D	1
Frenzel, H; Gellert, J; Haydn, M; Moreno, F; Oldiges, H; Strohmeyer, G; Teschke, R	1
Armstrong, D; Helgebostad, A; Koppang, N; Rimeslåtten, H	1
Anosa, VO; Maduagwu, EN	1
Ditschuneit, H; Fussgaenger, RD	1
Aze, Y; Hagino, M; Hamanaka, N; Kondo, K; Ogawa, M; Sagawa, K; Suzuki, A; Tanaka, M; Terawaki, T; Yasuda, N	1
Boothe, DM; Brown, SA; Calvin, JA; Corrier, DE; Cullen, JM; Green, RA; Jenkins, WL	1
Ayukawa, K; Isobe, H; Nagase, S; Nawata, H; Sakai, H	1
Boothe, DM; Boothe, HW; Howe, LM	1
Ha-Kawa, SK; Kouda, K; Tanaka, Y	2
Matsuzawa, A; Oyaizu, T; Senzaki, H; Shikata, N; Tsubura, A	1
Butterworth, BE; Constan, AA; Everitt, JI; Pluta, LJ; Recio, L; Sprankle, CS; Templin, MV; Wong, BA	1
Bhattacharjee, A; Lappi, VR; Rutherford, MS; Schook, LB	1
Kaneko, T; Sato, A; Wang, PY; Wang, Y	1
Horn, TL; O'Brien, TD; Rutherford, MS; Schook, LB	1
Hasegawa, H; Itoh, J; Nagata, H; Okabe, T; Osamura, RY; Takekoshi, S; Watanabe, K; Yasuda, M	1
Enjoji, M; Kato, M; Kotoh, K; Nakamuta, M; Nakashima, Y; Nawata, H; Ohta, S; Sugimoto, R; Tada, S; Tsuruta, S	1
Chopra, P; Das, PK; Dhar, A; Nayak, NC	1
Siegers, CP; Strubelt, O; Völpel, M	1
Matas, AJ; Najarian, JS; Numata, M; Simmons, RL; Sutherland, DE	1
Best, R; Bird, J; Lewis, DA; Parrott, DP	1
Dashman, T; Kamm, JJ	1
Benhanou, M; Bénichou, J; Perrin, N; Testas, P; Vieillefond, A	1
Nafstad, I; Skaare, JU	1
Astill, BD; Mulligan, LT	1
Dahle, HK; Nafstad, I; Skaare, JU	1
Burns, JJ; Conney, AH; Dashman, T; Kamm, JJ	1
Castro, JA; D'Acosta, N; de Castro, CR; de Fenos, OM; de Ferreyra, EC; Díaz Gómez, MI	1
Highman, B; Maling, HM; Saul, W; Sipes, IG; Stripp, B; Williams, MA	1
Pound, AW	1
Benhamou, M; Benichou, J; Ghika, I; Jan, D; Ollier, A; Testas, P; Trivin, F; Viellefond, A	1
Khan, S; Lauriault, VV; O'Brien, PJ	1
Eskelson, CD; Mufti, SI; Odeleye, OE; Watson, RR	1
Rangga-Tabbu, C; Sleight, SD	1
Fujiwara, K; Masaki, N; Nagoshi, S; Ogata, I; Ohta, Y; Oka, Y; Sato, Y; Takatsuki, K; Tomiya, T; Yamada, S	1
Ala-Kokko, L; Ryhänen, L; Stenbäck, F	1
Hashimoto, N; Ishikawa, Y; Utsunomiya, J	1
Fujiwara, K; Hirata, K; Ogata, I; Ohta, Y	1
Aurousseau, AM; Belleville, J; Clendinnen, G; Cornillon, B; Eloy, R; Paul, J	1
Kärki, NT; Keinänen, K; Saarni, HU; Sotaniemi, EA; Stenbäck, F; Stengård, JH	1
Fujiwara, K; Hayashi, S; Mishiro, S; Ogata, I; Ohta, Y; Oka, H; Oka, Y; Sato, Y; Takatsuki, K; Yamada, S	1
Arndt, K; Haschek, WM; Jeffery, EH	1
Iwai, M; Shimazu, T	1
Fujiwara, K; Kuwata, S; Nishi, T; Nosaka, K; Ogata, I; Ohta, Y; Oka, H	1
Fujiwara, K; Masaki, N; Ogata, I; Ohta, Y; Oka, H; Oka, Y; Sato, Y; Takatsuki, K	1
Fujiwara, K; Hirata, K; Masaki, N; Ogata, I; Ohta, Y; Oka, H; Oka, Y; Sato, Y; Yamada, S	1
Longo, S; Mastantuono, A; Persico, G; Spagnuolo, S; Tesauro, R; Ventriglia, R	1
Doolittle, DJ; Muller, G; Scribner, HE	1
Butler, WH; Pritchard, DJ; Sulsh, S; Wright, MG	1
Berger, ML; Shertzer, HG; Tabor, MW	1
Landon, EJ; Naukam, RJ; Rama Sastry, BV	1

Other Studies

101 other study(ies) available for dimethylnitrosamine and Chemical and Drug Induced Liver Injury

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats. Drug delivery, 2022, Volume: 29, Issue:1 Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Inflammation Mediators; Liposomes; Liver Function Tests; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Receptors, CCR2; STAT3 Transcription Factor; Surface Properties; Vaccinium macrocarpon; Vascular Endothelial Growth Factor A	2022
Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats. Drug development research, 2017, Volume: 78, Issue:3-4 Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta	2017
MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice. Journal of cellular and molecular medicine, 2017, Volume: 21, Issue:12 Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Collagen Type I; Connective Tissue Growth Factor; Dimethylnitrosamine; Female; Gene Expression Regulation; Hepatic Stellate Cells; Hyaluronic Acid; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Mice; Mice, Knockout; Primary Cell Culture; Proteolysis; Signal Transduction; Transforming Growth Factor beta1	2017
Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat. Chemico-biological interactions, 2018, Nov-01, Volume: 295 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Lipid Peroxidation; Liver Cirrhosis; Male; Nanoparticles; Oxidative Stress; Particle Size; Rats; Rats, Wistar; Zinc Oxide	2018
Metabolomic profiling for identification of potential biomarkers in the protective effects of modified Sinisan against liver injury in dimethylnitrosamine treated rats. Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:11 Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Drugs, Chinese Herbal; Liver; Male; Metabolomics; Phytotherapy; Protective Agents; Rats; Rats, Wistar	2013
Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats. Food & function, 2014, Volume: 5, Issue:11 Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Fruit; Garcinia; Liver; Liver Cirrhosis; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Terpenes; Transforming Growth Factor beta1	2014
Protective effect of theaflavin-enriched black tea extracts against dimethylnitrosamine-induced liver fibrosis in rats. Food & function, 2015, Volume: 6, Issue:6 Topics: Animals; Anticarcinogenic Agents; Biflavonoids; Bile Ducts, Intrahepatic; Biomarkers; Camellia sinensis; Carcinogens; Carcinoma, Hepatocellular; Catechin; Chemical and Drug Induced Liver Injury; Dietary Supplements; Dimethylnitrosamine; Food Handling; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms; Male; Oxidation-Reduction; Plant Extracts; Plant Leaves; Protective Agents; Random Allocation; Rats, Sprague-Dawley	2015
Reduction of Dimethylnitrosamine-Induced Liver Fibrosis by the Novel Gene Regulator PI Polyamide Targeting Transforming Growth Factor β1 Gene. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:12 Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; End Stage Liver Disease; Fibrosis; Gene Silencing; Hepatic Stellate Cells; Imidazoles; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta	2015
Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. Archives of pharmacal research, 2016, Volume: 39, Issue:2 Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Dimethylnitrosamine; Guaiacol; Hep G2 Cells; Hepatic Stellate Cells; Humans; Hydroxyproline; Inflammation Mediators; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction	2016
Hepatoprotective effects of Dicliptera chinensis polysaccharides on dimethylnitrosamine-induced hepatic fibrosis rats and its underlying mechanism. Journal of ethnopharmacology, 2016, Feb-17, Volume: 179 Topics: Acanthaceae; Animals; Chemical and Drug Induced Liver Injury; Colchicine; Collagen; Cytokines; Dimethylnitrosamine; Liver; Liver Cirrhosis; Liver Function Tests; Male; Necrosis; Polysaccharides; Protective Agents; Rats; Rats, Sprague-Dawley	2016
Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats. Chinese journal of natural medicines, 2016, Volume: 14, Issue:1 Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Glutathione; Male; Protective Agents; Rats; Rats, Wistar; Silybin; Silymarin	2016
Huangqi decoction alleviates dimethylnitrosamine-induced liver fibrosis: An analysis of bile acids metabolic mechanism. Journal of ethnopharmacology, 2016, Aug-02, Volume: 189 Topics: Animals; Astragalus propinquus; Bile Acids and Salts; Biomarkers; Cell Proliferation; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Dimethylnitrosamine; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Hepatic Stellate Cells; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Mass Spectrometry; Metabolomics; Protective Agents; Rats, Wistar; RNA, Messenger	2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. Environmental toxicology and pharmacology, 2016, Volume: 45 Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Dimethylnitrosamine; Dioscorea; Diosgenin; Interferon-Stimulated Gene Factor 3, gamma Subunit; Male; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Toll-Like Receptor 4	2016
Protective effects of Centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats. Molecular medicine reports, 2016, Volume: 14, Issue:5 Topics: Animals; Antioxidants; Catalase; Centella; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Humans; Inflammation; Interleukin-10; Liver; Malondialdehyde; Medicine, Chinese Traditional; Oxidative Stress; Plant Extracts; Plant Leaves; Rats; Superoxide Dismutase; Triterpenes	2016
Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1. Life sciences, 2009, Jan-30, Volume: 84, Issue:5-6 Topics: Animals; Antioxidants; Blotting, Western; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Dimethylnitrosamine; Electrophoretic Mobility Shift Assay; Flavonoids; Glutathione; Lipid Peroxidation; Male; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Transcription Factor AP-1	2009
Operculina turpethum attenuates N-nitrosodimethylamine induced toxic liver injury and clastogenicity in rats. Chemico-biological interactions, 2009, Oct-07, Volume: 181, Issue:2 Topics: Actins; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Convolvulaceae; Dimethylnitrosamine; Dose-Response Relationship, Drug; Liver; Male; Muscle, Smooth; Mutagens; Organ Size; Plant Extracts; Rats; Rats, Wistar	2009
Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. Journal of pineal research, 2009, Volume: 47, Issue:2 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Down-Regulation; Glutathione Peroxidase; Glutathione Transferase; Heme Oxygenase-1; Isoenzymes; Liver; Liver Diseases; Male; Malondialdehyde; Melatonin; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase	2009
Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:12 Topics: Animals; Antineoplastic Agents; Area Under Curve; Chemical and Drug Induced Liver Injury; Dihydrouracil Dehydrogenase (NADP); Dimethylnitrosamine; Drug Combinations; Fluorouracil; Kidney; Liver; Liver Diseases; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Tegafur	2009
Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats. Journal of pharmaceutical and biomedical analysis, 2010, Sep-21, Volume: 53, Issue:1 Topics: Animals; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Drugs, Chinese Herbal; Fibrosis; Flowers; Gas Chromatography-Mass Spectrometry; Lonicera; Metabolomics; Phytotherapy; Rats; Rats, Wistar; Time Factors	2010
Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats. Toxicology and industrial health, 2011, Volume: 27, Issue:10 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Free Radical Scavengers; Lipid Peroxidation; Liver; Liver Function Tests; Male; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar	2011
Neoplastic and nonneoplastic liver lesions induced by dimethylnitrosamine in Japanese medaka fish. Veterinary pathology, 2012, Volume: 49, Issue:2 Topics: Animals; Animals, Genetically Modified; Biliary Tract Neoplasms; Biomarkers; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fish Diseases; Liver; Liver Neoplasms; Male; Mutagenicity Tests; Oryzias; Rats; Signal Transduction; Species Specificity; Transforming Growth Factor beta	2012
Can apricot kernels fatty acids delay the atrophied hepatocytes from progression to fibrosis in dimethylnitrosamine (DMN)-induced liver injury in rats? Lipids in health and disease, 2011, Jul-07, Volume: 10 Topics: Animals; Atrophy; Catalase; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Assays; Fatty Acids; Glutathione Peroxidase; Hepatocytes; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Malondialdehyde; Organ Size; Plant Oils; Prunus; Rats; Seeds; Superoxide Dismutase	2011
Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology, 2012, Volume: 143, Issue:6 Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Movement; Cell Proliferation; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Endothelial Cells; Hepatectomy; Liver; Models, Animal; Rats; Rats, Inbred Lew; Stem Cells; Time Factors; Vascular Endothelial Growth Factor A	2012
Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury. Toxicologic pathology, 2013, Volume: 41, Issue:5 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Female; Fish Proteins; Gene Expression; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Microscopy, Electron, Transmission; Oryzias; Phenotype	2013
Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats. BMC complementary and alternative medicine, 2012, Dec-13, Volume: 12 Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzoates; Bridged-Ring Compounds; Chemical and Drug Induced Liver Injury; Collagen Type I; Desmin; Dimethylnitrosamine; Disease Models, Animal; Glucosides; Hydroxyproline; Kidney; Liver; Liver Cirrhosis; Lung; Macrophages; Male; Monoterpenes; Paeonia; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Spleen; Tumor Necrosis Factor-alpha	2012
Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis. Journal of hepatology, 2003, Volume: 39, Issue:4 Topics: Animals; Bile Ducts; Cell Division; Chemical and Drug Induced Liver Injury; Cholestasis; Dimethylnitrosamine; Enzyme Activation; Hepatocytes; Immunohistochemistry; Intracellular Membranes; JNK Mitogen-Activated Protein Kinases; Liver; Liver Diseases; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction	2003
EFFECTS OF CARCINOGENIC AMINES ON AMINO ACID INCORPORATION BY LIVER SYSTEMS. II. A MORPHOLOGICAL AND BIOCHEMICAL STUDY ON THE EFFECT OF DIMETHYLNITROSAMINE. Cancer research, 1963, Volume: 23 Topics: Amines; Amino Acids; Carbon Isotopes; Carcinogens; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Electrons; Hepatitis; Leucine; Liver; Liver Glycogen; Liver Neoplasms; Microscopy; Microscopy, Electron; Mitochondria; Nitrosamines; Proteins; Rats; Research; Toxicology	1963
METHYLATION OF RIBONUCLEIC ACIDS OF LIVER AND OTHER ORGANS IN DIFFERENT SPECIES TREATED WITH C14- AND H3-DIMETHYLNITROSAMINES IN VIVO. Journal of the National Cancer Institute, 1964, Volume: 32 Topics: Animals; Carbon Isotopes; Carcinogens; Chemical and Drug Induced Liver Injury; Chromatography; Cricetinae; Dimethylnitrosamine; Guanine; Guinea Pigs; Hepatitis; Kidney; Liver; Methylation; Mice; Neoplasms; Nitrosamines; Nucleotides; Proteins; Pyrimidines; Rats; Research; RNA; Spleen; Toxicology; Tritium	1964
ANTIDOTAL EFFECT OF AMINOACETONITRILE AGAINST THE BIOCHEMICAL INJURY OF THE MICROSOMAL AMINO-ACID INCORPORATING SYSTEM INDUCED IN VIVO BY CARBON TETRACHLORIDE OR DIMETHYLNITROSAMINE. Biochemical and biophysical research communications, 1965, Feb-17, Volume: 18 Topics: Amino Acids; Aminoacetonitrile; Antidotes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyanides; Dimethylnitrosamine; Hepatitis; Leucine; Liver; Microsomes; Nitrosamines; Pharmacology; Rats; Research; Toxicology	1965
ENHANCEMENT OF THE POLYURIDYLIC ACID-DIRECTED PHENYLALANINE POLYMERIZATION IN LIVER-MICROSOME PREPARATIONS FROM RATS TREATED WITH CARBON TETRACHLORIDE OR DIMETHYLNITROSAMINE. Biochimica et biophysica acta, 1965, Apr-19, Volume: 95 Topics: Amino Acids; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Hepatitis; Microsomes; Nitrosamines; Phenylalanine; Poly U; Polymerization; Polynucleotides; Rats; Research; Toxicology; Uracil Nucleotides	1965
Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury. Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 348, Issue:1-2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Body Weight; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Hyaluronic Acid; Hyaluronoglucosaminidase; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Liver Function Tests; Male; Organ Size; Rats; Rats, Wistar; Time Factors	2004
Suppression of transforming growth factor-beta results in upregulation of transcription of regeneration factors after chronic liver injury. Journal of hepatology, 2004, Volume: 41, Issue:6 Topics: Animals; Apoptosis; Blotting, Northern; Cell Division; Chemical and Drug Induced Liver Injury; Chronic Disease; Dimethylnitrosamine; Gene Transfer Techniques; Growth Substances; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Liver Diseases; Liver Regeneration; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta; Up-Regulation	2004
Vascularization in tissue remodeling after rat hepatic necrosis induced by dimethylnitrosamine. Medical molecular morphology, 2006, Volume: 39, Issue:1 Topics: Animals; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Fluorescent Antibody Technique; Immunohistochemistry; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Necrosis; Neovascularization, Physiologic; Rats; Rats, Wistar	2006
Protective effects of Cuscutae semen against dimethylnitrosamine-induced acute liver injury in Sprague-Dawley rats. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:8 Topics: Actins; Alkylating Agents; Animals; Blotting, Western; Body Weight; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Dimethylnitrosamine; Hydroxyproline; Image Processing, Computer-Assisted; Immunohistochemistry; Indicators and Reagents; Liver; Male; Organ Size; Plants, Medicinal; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Reference Standards	2007
[Morphologic observation and pathogenesis investigation of regenerated sinusoidal endothelial cells in remodelling rat hepatic necrotic tissue]. Zhonghua bing li xue za zhi = Chinese journal of pathology, 2007, Volume: 36, Issue:6 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Endothelial Cells; Liver; Liver Regeneration; Male; Necrosis; Neovascularization, Physiologic; Rats; Rats, Wistar	2007
Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:2 Topics: Alanine Transaminase; Alkylating Agents; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver Function Tests; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; Vitamin B 12; Vitamins	2008
Medroxyprogesterone acetate improvement of the hepatic drug-metabolizing enzyme system in rats after chemical liver injury. Biochemical pharmacology, 1983, Mar-15, Volume: 32, Issue:6 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Enzyme Induction; Female; Liver Regeneration; Medroxyprogesterone; Medroxyprogesterone Acetate; Microsomes, Liver; Protein Biosynthesis; Rats; Rats, Inbred Strains	1983
Effects of medroxyprogesterone acetate on hepatic glucose metabolism and microsomal enzyme activity in rats with normal and altered liver. Pharmacology, 1984, Volume: 28, Issue:1 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Female; Glucose; Glucose-6-Phosphatase; Liver Diseases; Liver Glycogen; Medroxyprogesterone; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Inbred Strains	1984
Hepatocellular transplantation in rats with toxic induced liver failure: results of iso-, allo- and xenografts. The Italian journal of surgical sciences, 1983, Volume: 13, Issue:1 Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver; Liver Diseases; Liver Transplantation; Male; Necrosis; Rats; Rats, Inbred Strains; Spleen; Time Factors; Transplantation Immunology; Transplantation, Heterologous; Transplantation, Homologous; Transplantation, Isogeneic	1983
Plasma amino acid, glucagon, and insulin concentrations in dogs with nitrosamine-induced hepatic disease. American journal of veterinary research, 1983, Volume: 44, Issue:11 Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Dog Diseases; Dogs; Glucagon; Insulin; Liver; Liver Diseases; Necrosis	1983
Hepatic transport of indocyanine green in dogs chronically intoxicated with dimethylnitrosamine. Toxicology and applied pharmacology, 1984, Sep-15, Volume: 75, Issue:2 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Body Weight; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Dogs; Drug Interactions; Indocyanine Green; Injections, Intravenous; Kinetics; Liver; Liver Diseases	1984
Potentiation of the hepatotoxicity of N-nitrosodimethylamine by fasting, diabetes, acetone, and isopropanol. Toxicology and applied pharmacology, 1984, Volume: 73, Issue:3 Topics: 1-Propanol; Acetone; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Dimethylnitrosamine; Drug Synergism; Enzyme Induction; Fasting; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains	1984
Free radicals in vivo. Covalent binding to lipids. Molecular pharmacology, 1984, Volume: 26, Issue:1 Topics: Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Dimethylnitrosamine; Free Radicals; Furans; Furosemide; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred ICR; Rats; Rats, Inbred Strains	1984
[Hepatocellular regeneration induced with insulin and glucagon after acute necrosis caused by dimethylnitrosamine]. Chirurgia e patologia sperimentale, 1982, Volume: 30, Issue:2 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Drug Combinations; Glucagon; Insulin; Liver Regeneration; Necrosis; Rats; Rats, Inbred Strains	1982
A comparative assessment of toxic effects of dimethylnitrosamine in six different species. Toxicology and applied pharmacology, 1980, Volume: 53, Issue:2 Topics: Animals; Body Weight; Cats; Cercopithecus; Chemical and Drug Induced Liver Injury; Diet; Dimethylnitrosamine; Ducks; Guinea Pigs; Haplorhini; Liver Function Tests; Lizards; Male; Organ Size; Rats; Species Specificity	1980
Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury. Archives of toxicology, 1981, Volume: 47, Issue:3 Topics: Animals; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Activation; Formaldehyde; Liver; Male; Microsomes, Liver; Nucleic Acids; Rats	1981
[Studies on comprehensive evaluation of toxic liver injury (author's transl)]. Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1981, Volume: 99 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Hematologic Tests; Liver; Liver Diseases; Male; p-Dimethylaminoazobenzene; Rats; Rats, Inbred Strains	1981
Fatal nitrosamine poisoning. Archives of toxicology, 1982, Volume: 50, Issue:2 Topics: Adult; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Food Analysis; Humans; Liver; Liver Cirrhosis	1982
Decreased hepatotoxicity of dimethylnitrosamine (DMN) following chronic alcohol consumption. Advances in experimental medicine and biology, 1980, Volume: 132 Topics: Alanine Transaminase; Alcoholism; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Glutamate Dehydrogenase; Humans; Rats	1980
Toxic and carcinogenic effects of dimethylnitrosamine (DMNA) in the blue fox (Alopex lagopus). Acta veterinaria Scandinavica, 1981, Volume: 22, Issue:3-4 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Foxes; Hemangiosarcoma; Liver; Liver Diseases; Liver Neoplasms; Male; Necrosis; Neoplasms, Experimental	1981
Hepatotoxicity of dimethylnitrosamine in cats and lizards. Toxicology letters, 1981, Volume: 9, Issue:1 Topics: Animals; Cats; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver; Lizards; Male	1981
Lethal exitus of a patient with N-nitrosodimethylamine poisoning, 2.5 years following the first ingestion and signs of intoxication. Oncology, 1980, Volume: 37, Issue:4 Topics: Adult; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Hemorrhage; Homicide; Humans; Liver Cirrhosis; Organ Size	1980
[Inhibitory effects of prostaglandin E1.alpha-cyclodextrin (PGE1.CD) on dimethylnitrosamine-induced acute liver damage in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1995, Volume: 105, Issue:4 Topics: Acute Disease; alpha-Cyclodextrins; Alprostadil; Animals; Chemical and Drug Induced Liver Injury; Cyclodextrins; Dimethylnitrosamine; Infusions, Intravenous; Liver Diseases; Male; Rats; Rats, Wistar	1995
Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease. American journal of veterinary research, 1994, Volume: 55, Issue:2 Topics: Analysis of Variance; Animals; Antipyrine; Caffeine; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Dimethylnitrosamine; Dogs; Female; Liver; Liver Diseases; Male; Reference Values	1994
Inhibition of nitric oxide production increases dimethylnitrosamine-induced liver injury in rats. Journal of hepatology, 1995, Volume: 23, Issue:5 Topics: Animals; Arginine; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Inhibitors; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar	1995
Endotoxemia associated with experimentally induced multiple portosystemic shunts in dogs. American journal of veterinary research, 1997, Volume: 58, Issue:1 Topics: Animals; Blood Pressure; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Dog Diseases; Dogs; Endotoxemia; Endotoxins; Female; Liver Diseases; Male; Mutagens; Portasystemic Shunt, Surgical; Random Allocation; Surgery, Veterinary; Time Factors	1997
Stimulation of asialoglycoprotein uptake by recombinant human hepatocyte growth factor in normal and damaged rat liver. Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:12 Topics: Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Cell Nucleus; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Hepatocyte Growth Factor; Liver; Liver Diseases; Male; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Recombinant Proteins; Time Factors	1997
Studies on the mechanism of dimethylnitrosamine-induced acute liver injury in mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1997, Volume: 49, Issue:5 Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Mice, Knockout	1997
Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice. Environmental and molecular mutagenesis, 1998, Volume: 31, Issue:3 Topics: Administration, Inhalation; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Lac Operon; Liver; Liver Diseases; Liver Neoplasms, Experimental; Liver Regeneration; Mice; Mice, Transgenic; Organ Size; Precancerous Conditions; Transgenes	1998
Molecular dissection of dimethylnitrosamine (DMN)-induced hepatotoxicity by mRNA differential display. Toxicology and applied pharmacology, 1998, Volume: 150, Issue:1 Topics: Alkylating Agents; Animals; Biomarkers; Blotting, Northern; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; DNA; Female; In Situ Hybridization; Mice; Mice, Inbred Strains; Plasmids; Polymerase Chain Reaction; Protein Biosynthesis; Ribonucleases; RNA, Messenger; Up-Regulation	1998
Increased technetium-99m-GSA uptake per hepatocyte in rats with administration of dimethylnitrosamine or hepatocyte growth factor. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:8 Topics: Alkylating Agents; Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Hepatocyte Growth Factor; Humans; Liver; Male; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Pentetate; Time Factors	1998
Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology (Baltimore, Md.), 1999, Volume: 29, Issue:1 Topics: Acarbose; Acetaminophen; Alkylating Agents; Analgesics, Non-Narcotic; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Dimethylnitrosamine; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Ethanol; Immunochemistry; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Trisaccharides	1999
Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression. Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 54, Issue:1 Topics: Alkylating Agents; Animals; Apoptosis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytokines; Dimethylnitrosamine; Female; Gene Expression; Liver; Male; Mice; Mice, Knockout; Receptors, Cytokine; Receptors, Tumor Necrosis Factor; RNA, Messenger	2000
Differentiation of necrotic cell death with or without lysosomal activation: application of acute liver injury models induced by carbon tetrachloride (CCL4) and dimethylnitrosamine (DMN). The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2000, Volume: 48, Issue:10 Topics: Acid Phosphatase; Acute Disease; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; In Situ Nick-End Labeling; Lysosomes; Male; Microscopy, Confocal; Microscopy, Electron; Necrosis; Rats; Rats, Wistar	2000
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. International journal of molecular medicine, 2001, Volume: 8, Issue:5 Topics: Animals; Body Weight; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Type I; Dimethyl Sulfoxide; Dimethylnitrosamine; Fibrosis; Free Radical Scavengers; Gene Expression Regulation; Hydroxyproline; Kupffer Cells; Lipopolysaccharides; Liver; Liver Diseases; Luciferases; Male; NF-kappa B; Nitric Oxide; Organ Size; Promoter Regions, Genetic; Rats; Rats, Wistar; Recombinant Fusion Proteins; RNA, Messenger; Severity of Illness Index; Tumor Necrosis Factor-alpha; Weight Loss	2001
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine. British journal of experimental pathology, 1975, Volume: 56, Issue:2 Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Fetus; Glucose-6-Phosphatase; Hepatectomy; Liver; Liver Diseases; Necrosis; Nitrosamines; Phenobarbital; Rats; Triglycerides	1975
The antihepatotoxic activity of dithiocarb as compared with six other thio compounds in mice. Archives of toxicology, 1978, Oct-13, Volume: 41, Issue:1 Topics: Allyl Compounds; Aniline Hydroxylase; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Ditiocarb; Male; Mice; Sulfhydryl Compounds; Sulfur; Thioacetamide; Thiocarbamates	1978
Hepatocellular transplantation in acute liver failure. Surgery, 1977, Volume: 82, Issue:1 Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver; Liver Regeneration; Liver Transplantation; Male; Necrosis; Rats; Transplantation, Homologous	1977
Anti-inflammatory action following liver damage in the rat. Agents and actions, 1979, Volume: 9, Issue:2 Topics: Animals; Arthritis, Experimental; Blood Proteins; Carrageenan; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Dimethylnitrosamine; Edema; Inflammation; Liver Diseases; Male; Molecular Weight; Protease Inhibitors; Proteins; Rats	1979
Effects of high doses of vitamin E on dimethylnitrosamine hepatotoxicity and drug metabolism in the rat. Biochemical pharmacology, 1979, May-01, Volume: 28, Issue:9 Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Dimethylnitrosamine; Heme; Male; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Nitrosamines; Pharmaceutical Preparations; Rats; Vitamin E	1979
Comparative study of two models for experimental cirrhosis in the dog. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1978, Volume: 10, Issue:2 Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Dogs; Hepatic Veins; Ligation; Liver Cirrhosis, Experimental; Models, Biological; Nitrosamines	1978
Interaction of vitamin E and selenium with the hepatotoxic agent dimethylnitrosamine. Acta pharmacologica et toxicologica, 1978, Volume: 43, Issue:2 Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver; Male; Nitrosamines; Organ Size; Rats; Selenium; Vitamin E	1978
Phenolic antioxidants and the inhibition of hepatotoxicity from N-dimethylnitrosamine formed in situ in the rat stomach. Food and cosmetics toxicology, 1977, Volume: 15, Issue:3 Topics: Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diet; Dimethylamines; Dimethylnitrosamine; Gastric Mucosa; Liver; Liver Diseases; Male; Nitrites; Ornithine Carbamoyltransferase; Phenols; Rats	1977
Enhanced hepatotoxicity of dimethylnitrosamine by pretreatment of rats with the antioxidant ethoxyquin. Toxicology and applied pharmacology, 1977, Volume: 42, Issue:1 Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Diet; Dimethylnitrosamine; Drug Synergism; Ethoxyquin; Liver; Male; Nitrosamines; Organ Size; Proteins; Quinolines; Rats	1977
Effect of ascorbic acid on amine-nitrite toxicity. Annals of the New York Academy of Sciences, 1975, Sep-30, Volume: 258 Topics: Alanine Transaminase; Aminopyrine; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver; Liver Diseases; Necrosis; Nitrites; Nitrosamines; Rats	1975
Mechanism of dimethylnitrosamine and carbon tetrachloride-induced liver necrosis: similarities and differences. Toxicology and applied pharmacology, 1975, Volume: 32, Issue:3 Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dimethylnitrosamine; Isocitrate Dehydrogenase; Lipid Metabolism; Male; Microsomes, Liver; Necrosis; Nitrosamines; Proteins; Rats	1975
Enhanced hepatotoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by pretreatment of rats with ethanol and some comparisons with potentiation by isopropanol. Toxicology and applied pharmacology, 1975, Volume: 33, Issue:2 Topics: 1-Propanol; Acetaldehyde; Acetamides; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Drug Synergism; Ethanol; Lipid Metabolism; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitrosamines; Rats; Thioacetamide	1975
The effect of a dose of dimethylnitrosamine on the toxicity of a subsequent dose and on the toxicity of carbon tetrachloride in mice. British journal of experimental pathology, 1975, Volume: 56, Issue:3 Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Drug Interactions; Lethal Dose 50; Liver; Male; Mice; Nitrosamines; Time Factors	1975
[Severe acute experimental hepatocellular insufficiency with coma. Effect of dimethylnitrosamine in dogs]. Medecine & chirurgie digestives, 1975, Volume: 4 suppl 2 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Dogs; Hepatic Encephalopathy; Nitrosamines	1975
Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration. Chemico-biological interactions, 1992, Volume: 81, Issue:3 Topics: Animals; Carbon Disulfide; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Disulfiram; Ditiocarb; Liver Diseases; Male; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Pyrazoles; Rats; Rats, Inbred Strains	1992
Vitamin E protection against nitrosamine-induced esophageal tumor incidence in mice immunocompromised by retroviral infection. Carcinogenesis, 1992, Volume: 13, Issue:10 Topics: Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Esophageal Neoplasms; Female; Immunocompromised Host; Lipid Peroxidation; Liver; Liver Diseases; Lymph Nodes; Mice; Mice, Inbred BALB C; Murine Acquired Immunodeficiency Syndrome; Organ Size; Retroviridae Infections; Spleen; Vitamin A; Vitamin E	1992
Sequential study in rats of nasal and hepatic lesions induced by N-nitrosodimethylamine and N-nitrosopyrrolidine. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1992, Volume: 19, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Drug Synergism; Female; Liver; N-Nitrosopyrrolidine; Nasal Mucosa; Necrosis; Nose Diseases; Rats; Rats, Sprague-Dawley	1992
Insulin and glucagon therapy of acute hepatic failure. Digestive diseases and sciences, 1991, Volume: 36, Issue:6 Topics: Acetyltransferases; Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; DNA; Drug Therapy, Combination; Glucagon; Insulin; Liver; Liver Diseases; Liver Regeneration; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Inbred Strains	1991
Morphological, immunohistochemical and ultrastructural changes in dimethylnitrosamine [correction of dimenthylnitrosamine] induced liver injury. Effect of malotilate. Histology and histopathology, 1989, Volume: 4, Issue:1 Topics: Animals; Basement Membrane; Chemical and Drug Induced Liver Injury; Collagen; Dimethylnitrosamine; Female; Immunoenzyme Techniques; Immunohistochemistry; Laminin; Liver; Liver Cirrhosis, Experimental; Malonates; Microscopy, Electron; Rats; Rats, Inbred Strains	1989
Effects of portacaval shunt, transposition, and dimethylnitrosamine-induced chronic liver injury on pancreatic hormones and amino acids in dog. The Journal of surgical research, 1989, Volume: 46, Issue:1 Topics: Amino Acids; Animals; Arginine; Blood Glucose; Chemical and Drug Induced Liver Injury; Chronic Disease; Dimethylnitrosamine; Dogs; Glucagon; Insulin; Liver; Liver Circulation; Liver Diseases; Pancreatic Hormones; Portacaval Shunt, Surgical; Portal Vein	1989
Hepatic sinusoidal cell destruction in the development of intravascular coagulation in acute liver failure of rats. The Journal of pathology, 1989, Volume: 158, Issue:2 Topics: Animals; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disseminated Intravascular Coagulation; Endothelium, Vascular; Fibrin; Liver; Liver Diseases; Male; Microscopy, Electron; Rats	1989
Experimental DMNA induced hepatic necrosis: early course of haemostatic disorders in the rat. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1985, Volume: 80, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver Diseases; Platelet Count; Rats; Time Factors; Vitamin K	1985
Medroxyprogesterone acetate and phenobarbital induce NADPH producing enzyme activities in rats with a chemical liver injury. Research communications in chemical pathology and pharmacology, 1985, Volume: 50, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Induction; Glucose-6-Phosphatase; Isocitrate Dehydrogenase; Malate Dehydrogenase; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; NADP; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Rats, Inbred Strains	1985
Glucagon and insulin for the treatment of hepatic failure in dimethylnitrosamine-intoxicated rats. Scandinavian journal of gastroenterology, 1988, Volume: 23, Issue:5 Topics: Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; DNA; Glucagon; Insulin; Liver; Liver Regeneration; Male; Prognosis; Proteins; Rats; Rats, Inbred Strains	1988
Mechanism of inhibition of hepatic bioactivation of paracetamol by dimethyl sulfoxide. Drug metabolism and drug interactions, 1988, Volume: 6, Issue:3-4 Topics: Acetaminophen; Animals; Bile; Biotransformation; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Dimethylnitrosamine; Female; Glucuronates; Glutathione; In Vitro Techniques; Kinetics; Lipid Peroxidation; Liver; Mice; Rats; Rats, Inbred Strains; Sulfates	1988
Effects of ventromedial and lateral hypothalamic stimulation on chemically-induced liver injury in rats. Life sciences, 1988, Volume: 42, Issue:19 Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Denervation; Dimethylnitrosamine; Electric Stimulation; Hypothalamus; Hypothalamus, Middle; Liver; Liver Diseases; Male; Rats; Rats, Inbred Strains; Sympathetic Nervous System	1988
Contribution of hepatic reticuloendothelial system to glomerular IgA deposition in rat liver injury. The American journal of pathology, 1988, Volume: 131, Issue:3 Topics: Alanine Transaminase; Animals; Carbon; Chemical and Drug Induced Liver Injury; Chemical Fractionation; Dimethylnitrosamine; Galactosamine; Immunoglobulin A; Kidney Glomerulus; Liver; Liver Diseases; Male; Molecular Weight; Mononuclear Phagocyte System; Rats; Rats, Inbred Strains	1988
Exchange blood transfusion for acute hepatic failure: its limited availability depending on the type of injury in rats. Artificial organs, 1988, Volume: 12, Issue:3 Topics: Acute Disease; Alanine Transaminase; Animals; Blood Coagulation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Exchange Transfusion, Whole Blood; Liver; Liver Diseases; Male; Protein Biosynthesis; Rats; Rats, Inbred Strains	1988
Intravascular coagulation in acute liver failure in rats and its treatment with antithrombin III. Gut, 1988, Volume: 29, Issue:8 Topics: Animals; Antithrombin III; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Liver; Liver Diseases; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Thrombosis	1988
[Hepatocellular transplant in the treatment of acute hepatic failure. An experimental study in rats]. Minerva chirurgica, 1986, Oct-15, Volume: 41, Issue:19 Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Female; Graft Rejection; Liver Diseases; Liver Transplantation; Male; Methods; Rats; Rats, Inbred Strains	1986
A comparative study of hepatic DNA repair, DNA replication and hepatotoxicity in the CD-1 mouse following multiple administrations of dimethylnitrosamine. Mutation research, 1987, Volume: 188, Issue:2 Topics: Animals; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; DNA Damage; DNA Repair; DNA Replication; Hyperplasia; Liver; Liver Function Tests; Male; Mice	1987
The assessment of chemically induced liver injury in rats. Journal of applied toxicology : JAT, 1987, Volume: 7, Issue:4 Topics: Animals; Blood Coagulation; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Erythrocytes; Liver; Male; Rats; Rats, Inbred Strains	1987
Protection from N-nitrosodimethylamine-mediated liver damage by indole-3-carbinol. Experimental and molecular pathology, 1987, Volume: 47, Issue:2 Topics: Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Indoles; Liver Diseases; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Necrosis; Ornithine Carbamoyltransferase; Oxidoreductases, N-Demethylating	1987
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents. Biochemical pharmacology, 1986, Feb-15, Volume: 35, Issue:4 Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Dimethylnitrosamine; Liver; Male; Microsomes, Liver; Necrosis; Rats; Rats, Inbred Strains; Thioacetamide	1986