dimethylhydrazines has been researched along with Colonic Neoplasms in 744 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 491 (65.99) | 18.7374 |
| 1990's | 189 (25.40) | 18.2507 |
| 2000's | 31 (4.17) | 29.6817 |
| 2010's | 26 (3.49) | 24.3611 |
| 2020's | 7 (0.94) | 2.80 |
| Authors | Studies |
|---|---|
| Ashraf, GM; Karthika, C; Rahman, MH; Sajini, DV; Sureshkumar, R | 1 |
| Chantana, W; Chantarasuwan, B; Chewonarin, T; Hu, R; Pitchakarn, P; Subhawa, S; Temviriyanukul, P | 1 |
| Panjeta, A; Preet, S | 1 |
| Roberts, JE | 1 |
| Hassan, ESG; Hassanein, NM; Sayed Ahmed, HM | 1 |
| Rafraf, M; Shojaei-Zarghani, S; Yari Khosroushahi, A | 1 |
| Barbosa Araújo, AR; Ferreira, NH; Francielli De Oliveira, P; Furtado, RA; Leandro, LF; Pauletti, PM; Tavares, DC; Uyemura, SA | 1 |
| Casas-Solís, J; Castro-Félix, P; Del Rosario Huizar-López, M; Irecta-Nájera, CA; Santerre, A | 1 |
| De, A; Keshari, AK; Kumar, D; Kumar, U; Nath, S; Prakash, A; Rai, A; Raj, V; Rawat, A; Saha, S; Sahdev, AK; Samanta, A; Singh, AK | 1 |
| Devi, U; Gautam, S; Kaithwas, G; Kumar, A; Pandey, R; Raghav, N; Rawat, JK; Roy, S; Sammi, SR; Singh, M; Yadav, RK | 1 |
| Barbisan, LF; Caetano, BFR; Carvalho, RF; de Moraes, LN; de Moura, NA; Rodrigues, MAM | 1 |
| Wang, P; Wang, Q; Xiao, Z | 1 |
| Kuznietsova, HM; Ogloblya, OV; Rybalchenko, VK | 1 |
| Anastácio, LR; Correia, MI; Liboredo, JC; Nicoli, JR; Pelúzio, Mdo C; Penido, LC; Valente, FX | 1 |
| Hijová, E; Hrčková, G; Štofilová, J; Szabadosova, V | 1 |
| Elias Junior, J; Fernandes, CR; Garcia, SB; Kannen, V; Modiano, P; Moreira, MC; Waaga-Gasser, AM | 1 |
| Bose, A; Elyagoby, A; Wong, TW | 1 |
| Agnihotri, N; Kansal, S; Vaiphei, K | 1 |
| Ahmed, ES; El-Waseef, AM; Osman, NH; Said, UZ | 1 |
| Anandasadagopan, SK; Ganapasam, S; Sekar, V | 1 |
| Manchen, S; Roberts, PC; Schmelz, EM; Simon, KW; Vespremi, MJ | 1 |
| Jia, W; Liu, YM; Qiu, YP; Su, MM; Wu, DZ; Zhao, AH | 1 |
| Davis, CD; Ross, SA; Uthus, EO; Zeng, H | 1 |
| El-Lateef, BM; Gomaa, NF; Ismail, HM; Omar, RM; Sheta, M; Yousef, MI | 1 |
| Fan, D; Jin, H; Mei, Q; Wang, Z; Xu, R | 1 |
| Kang, L; Ren, G; Tian, K; Wang, Z; Xu, G; Xu, X; Yu, W; Yuan, H | 1 |
| Chadha, VD; Dhawan, DK; Malhotra, A; Nair, P | 1 |
| Choi, YS; Min, WK; Sung, HY | 1 |
| Dong, L; Ji, G; Shi, H; Wu, D | 1 |
| Aggarwal, R; Agnihotri, N; Kansal, S; Negi, AK; Sandhir, R; Sarotra, P; Sharma, G | 1 |
| Binderup, ML; Dragsted, LO; Langkilde, S; Markowski, J; Mortensen, A; Poulsen, M | 1 |
| Barbisan, LF; Cardozo, MT; Heidor, R; Moreno, FS; Ong, TP; Purgatto, E; Scolastici, C; Shiga, TM; Vieira, A | 1 |
| Casto, BC; Knobloch, TJ; Lubet, RA; Pereira, MA; Steele, VE; Warner, BM; Weghorst, CM | 1 |
| Du, J; Kanwar, SS; Levi, E; Majumdar, AP; Nautiyal, J; Yu, Y | 1 |
| He, B; Liu, Y; Mu, Y; Wu, K; Yang, Q; Zhou, L; Zhou, Q | 1 |
| Agnihotri, N; Bhatnagar, A; Kansal, S; Negi, AK | 1 |
| Saini, MK; Sanyal, SN | 1 |
| Sadik, NA; Shaker, OG | 1 |
| Chintana, PY; Srimuangwong, K; Suksamrarn, A; Tocharus, C; Tocharus, J | 1 |
| Mełeń-Mucha, G; Niewiadomska, H | 1 |
| Ma, QY; Rowlands, BJ; Williamson, KE | 1 |
| Goldmann, U; Haier, J; Hotz, B; Keilholz, U; Runkel, N | 1 |
| Billings, PC; Kennedy, AR; Newberne, PM; Wan, XS | 1 |
| Hagio, M; Ishizuka, S; Mohara, M; Sakai, H; Takeuchi, A; Yamada, K | 1 |
| Cheng, JL; Futakuchi, M; Hirose, M; Iwata, T; Kasai, M; Ogawa, K; Shirai, T; Tokudome, S | 1 |
| Bankova, V; Bazo, AP; Darros, BR; de Lima, RO; Said, RA; Salvadori, DM; Sforcin, JM | 1 |
| Agner, AR; Bazo, AP; Ribeiro, LR; Salvadori, DM | 1 |
| Arthur, JR; Drew, JE; Duncan, G; Duthie, GG; Farquharson, AJ; Lufty, A; Morrice, PC; Reid, MD; Rucklidge, GJ; Russell, WR | 1 |
| Barcia, JJ; Berriel, E; Detjen, G; Gonzalez, M; Hill, M; Navarrete, H; Osinaga, E; Rondan, M; Ubillos, L | 1 |
| Song, Y; Wang, XL; Zhang, Z | 1 |
| Kickhoefer, VA; Kitchen, C; Raval-Fernandes, S; Rome, LH | 1 |
| Arakaki, J; Inamine, M; Kaneshiro, T; Kinjo, T; Morioka, T; Nabandith, V; Nishimaki, T; Suzui, M; Yoshimi, N | 1 |
| Lee, NK; Paik, HD; Park, E; Park, JS | 1 |
| Fukura, M; Hayashi, N; Takase, S; Tsuchishima, M; Tsutsumi, M; Yano, H | 1 |
| Liu, M; Xie, W; Zhai, Y; Zhou, J | 1 |
| Arikawa, AY; Gallaher, DD | 1 |
| Chicote, SR; Garcia, SB; Modiano, P; Oliveira, EC; Pinto, AM; Turatti, A; Vespúcio, MV | 1 |
| Demarzo, MM; Fernandes, CR; Garcia, SB; Herrero, FA; Martins, LV; Perez, SE; Turatti, A | 1 |
| Choi, YS; Sung, HY | 1 |
| Toth, B | 2 |
| Clapp, NK; Henke, MA; London, JF; Shock, TL | 1 |
| Gurkalo, VK | 1 |
| Barkla, DH; Tutton, PJ | 13 |
| Kishino, Y; Sumi, T | 1 |
| Chiu, JF; Gootnick, D; Pumo, D | 1 |
| Jensen, WE; Karlin, DA; O'Donnell, RT | 1 |
| Dahl, EP; Malt, RA; Ross, JS; Terpstra, OT; Williamson, RC | 1 |
| Aiso, S; Golberg, L; Hirono, I; Ueno, I; Yamaji, T | 1 |
| Au, JL; Rustum, Y; Walker, JS | 1 |
| Agrez, MV; Anderson, RE; Cortese, DA; Ilstrup, DM; Laws, ER; Lieber, MM; Shorter, RG; Wharen, RE | 1 |
| Hard, GC; Magee, PN; Nyce, JW; Schwartz, AG | 1 |
| Bleday, RS; Deasy, JM; Lahey, SJ; Milford, E; Rayner, AA; Rodrick, ML; Ross, DS; Steele, G; Wilson, RE | 1 |
| Martin, MS | 2 |
| Brown, RA; Fleiszer, DM; Murray, D; Richards, GK | 1 |
| Loven, DP; Stevens, RH | 1 |
| Freeman, HJ; Kim, YS; Spiller, GA | 2 |
| Abraham, R; Barbolt, TA; Rodgers, JB | 1 |
| Fisher, ER; McCoy, MM; Paulson, JD | 1 |
| Freeman, HJ; Spiller, GA | 1 |
| Asp, NG; Bauer, HG; Dahlqvist, A; Fredlund, PE; Nyman, M; Oste, R | 1 |
| Bennink, MR; Glauert, HP; Sander, CH | 1 |
| Hanson, D; Reddy, BS; Smith-Barbaro, P | 1 |
| Loven, DP; Singh, D; Stevens, RH | 1 |
| Miyayama, H; Takemiya, M; Takeuchi, T | 1 |
| Brown, RA; Fleiszer, DM; Murray, D; Richards, GK; Sloan, DA | 2 |
| Fukushima, S; Ito, N; Kurata, Y; Nakanowatari, J; Shirai, T | 1 |
| Jacobs, LR | 1 |
| Barnes, DS; Berry, SG; Clapp, NK; Oberst, DL; Scott, DA | 1 |
| Prizont, R | 2 |
| Bouter, S; Kerklaan, PR; Mohn, GR | 1 |
| Jensen, OM; McMichael, AJ; Parkin, DM; Zaridze, DG | 1 |
| Diekema, KA; King, WW; Kingsnorth, AN; Malt, RA; McCann, PP; Ross, JS | 1 |
| Gutschmidt, S; Sandforth, F | 1 |
| Clark, CG; Cruse, JP; Lewin, MR | 5 |
| Dudley, HA; Phillips, RK; Quill, DS | 1 |
| Caignard, A; Martin, F; Martin, M; Reisser, D; Thomas, B | 1 |
| Choluj, B; Hladík, V; Vozenílek, J | 1 |
| Nee, J; O'Higgins, N; Osborne, DH; Purdy, S | 1 |
| Ito, A; Naito, M; Naito, Y; Nakamura, K; Takahashi, H; Yamamoto, S | 1 |
| Laumonier, A; Roussel, F; Tayot, J | 1 |
| Tsukada, K | 1 |
| Csuka, O; Sugár, J; Szentirmay, Z | 1 |
| Dempo, K; Kaku, T; Kikuchi, K; Sato, N | 1 |
| Howarth, AE; Pihl, E | 1 |
| Deschner, EE; Hakissian, M; Herrmann, SL; Long, FC | 1 |
| Autrup, H; James, JT | 1 |
| Patil, K; Toth, B | 1 |
| Bruce, WR; Medline, A; Wargovich, MJ | 1 |
| Bara, J; Burtin, P; Daher, N; Decaëns, C; Rosa, B | 1 |
| Goude, AG; Gridley, DS; Kettering, JD; Nutter, RL; Slater, JM | 1 |
| James, JT; Shamsuddin, AM; Trump, BF | 1 |
| Bara, J; Burtin, P; Decaens, C | 1 |
| King, VP; Lahey, SJ; Madara, J; Munroe, AE; Ravikumar, TS; Ross, DS; Steele, G; Wilson, RE; Wright, D | 1 |
| Locniskar, M; Nauss, KM; Newberne, PM; Pavlina, T | 1 |
| Sunter, JP | 1 |
| Rainey, JB; Williamson, RC | 1 |
| Andres, ML; Aprecio, RM; Gridley, DS; Kettering, JD; Nutter, RL; Slater, JM | 1 |
| House, AK; Maley, MA | 1 |
| Barkla, DH; Tutton, PM | 1 |
| Cole, DA; Stevens, RH | 1 |
| Ird, EA; Smirnova, IO | 1 |
| Clark, CG; Cruse, JP; Danzi, M; Lewin, MR | 1 |
| Drago, JR; Joehl, RJ | 1 |
| Celik, C; Lewis, DA; Mittleman, A | 1 |
| Morishita, Y; Tsukada, T | 1 |
| Kamiya, J; Morioka, Y; Muto, T; Saito, Y | 1 |
| Chawan, CB; Pulusani, SR; Rao, DR; Shackelford, LA | 1 |
| Kishino, H | 1 |
| Freeman, HJ | 4 |
| Amodeo, P; Morgenstern, L; Vimadalal, S | 1 |
| Condon, RE; Jones, FE; Komorowski, RA | 1 |
| Abate, S; Califano, G; Danzi, M; Ferulano, GP | 1 |
| Askew, AR; Reibelt, LD; Visona, A | 1 |
| Appleton, DR; Senior, PV; Sunter, JP; Watson, AJ | 1 |
| Kaibara, N; Kimura, O; Koga, S; Miyano, Y; Okamoto, T; Tamura, H; Yurugi, E | 1 |
| Koval, TM | 1 |
| Calderisi, RN; Freeman, HJ | 1 |
| A-Kareem, AM; Brown, RA; Fleiszer, DM; Richards, GK; Senterman, MK | 1 |
| Eder, M; Kirscheneder, C; Weitz, H; Wiebecke, B | 1 |
| Meier, J; Metzger, U; Uhlschmid, G; Weihe, H | 1 |
| Gilbert, JM; Kark, AE; Slavin, G; Thompson, EM | 2 |
| Böse-Younes, H; Schümann, S; Siegers, CP; Thies, E; Younes, M | 1 |
| Nelson, RL | 1 |
| Alun, ML; Duvander, A; Nylander, G; Rubio, CA; Sveander, M; Wallin, B | 1 |
| Naito, Y | 2 |
| Cole, DA; Graves, JM; Rana, RS; Stevens, RH | 1 |
| Cole, DA; Meek, ES; Stevens, RH | 1 |
| Corasanti, JG; Hobika, GH; Markus, G | 1 |
| Amberger, H; Bachmann, U; Habs, M; Schmähl, D; Wagner, I | 1 |
| Hamada, S | 1 |
| Felkner, IC; Wargovich, MJ | 1 |
| Freeman, HJ; Scudamore, CH | 1 |
| Gedigk, P; Hattori, T; Helpap, B | 1 |
| Costa, NL; Traynor, OJ; Wood, CB | 2 |
| Jacobs, MM | 2 |
| Beeley, JG; Carachi, R | 1 |
| Mitsuoka, T; Mizutani, T | 1 |
| Düben, W; Otten, G; Roll, U; Wendt, O | 1 |
| Fang, WF; Newaz, SN; Strobel, HW | 1 |
| Locniskar, M; Nauss, KM; Newberne, PM | 3 |
| Daugherty, JP | 1 |
| Altmann, GG; Snow, AD | 1 |
| Fujita, Y; Imai, H; Imaki, S; Kageyama, N; Kasuga, M; Majima, S; Sakita, M; Tamai, M | 1 |
| Deasy, JM; Lahey, SJ; Madara, J; Ross, DS; Steele, G; Wilson, RE | 1 |
| Nylander, G; Rubio, CA; Santos, M | 1 |
| Blackman, KE; Diwan, BA | 2 |
| Loven, DP; Oberley, LW; Rousseau, FM; Stevens, RH | 1 |
| Richards, TC | 2 |
| Goldin, BR; Gorbach, SL | 1 |
| House, AK | 1 |
| Nylander, G; Rubio, CA | 2 |
| Kowal, EP; Markus, G | 1 |
| Blackman, KE; Diwan, BA; Szakal, AK | 1 |
| Dujardin-Loits, RM; Maskens, AP | 1 |
| Husberg, BS; Konrad, P; Sjögren, HO | 1 |
| Richards, TC; Tacha, DE | 1 |
| Augenlicht, LH; Kobrin, D | 1 |
| Malt, RA; Oscarson, JE; Ross, JS; Veen, HF | 2 |
| Costa, N; Traynor, OJ; Wood, CB | 1 |
| Kaibara, N; Koga, S; Takeda, R | 1 |
| Cowen, DM; Double, JA; Janik, AC; Siegerstetter, J | 1 |
| Kino, I; Nakamura, S | 1 |
| Deschner, EE; Maskens, AP | 1 |
| Krutovskikh, VA; Lanko, NS; Parfenov, YD; Turusov, VS | 1 |
| Fukushima, S; Hasegawa, R; Imaida, K; Ito, N; Katsuyama, T; Nakanowatari, J; Tatematsu, M | 1 |
| Hagihara, PF | 1 |
| Ellis, H; Filipe, MI; Scurr, JH | 1 |
| Hirota, N; Katayama, S; Reddy, BS | 1 |
| Krutovskikh, VA; Turusov, VS | 1 |
| Nakazawa, S; Oida, T | 1 |
| Clark, CG; Cruse, JP; Ferulano, GP; Lewin, MR | 3 |
| Otsuji, A | 1 |
| Zedeck, MS | 1 |
| Corson, J; Crissey, M; Gittes, R; Harte, P; Steele, G; Wilson, R | 1 |
| Curley, WH; McConnell, EE; Schiller, CM | 1 |
| Cole, DA; Graves, JM; Loven, DP; Meek, ES; Oberley, L; Rana, RS; Stevens, RH | 1 |
| Castleden, WM | 1 |
| Barthold, SW | 1 |
| Celik, C; Evans, JT; Lewis, D; Mittelman, A; Paolini, NS | 1 |
| Chiu, JF; Gabryelak, T; Pumo, DE | 1 |
| Brown, RR | 1 |
| Newberne, PM | 1 |
| Beams, FA; Forst, CF; Jacobs, MM | 1 |
| Bull, AW; Burd, AD; Nigro, ND | 1 |
| Katayama, S; Lauber, J; Levenstein, MJ; Musser, TK; Reddy, M; Silverman, J; Weisburger, H; Zelenakas, K | 1 |
| Furuya, K; Izumi, K; Kumagai, H; Otsuka, H | 1 |
| Castleden, WM; Ingram, DM | 1 |
| Delapierre, F; Halkin, E; Laumonier, R; Tayot, J | 1 |
| Fricks, CM; Mehta, RG; Moon, RC | 1 |
| Cook, MG; McNamara, P | 1 |
| Laumonier, R; Roussel, F; Tayot, J | 2 |
| Allfrey, VG; Boffa, LC; Diwan, BA; Gruss, R | 1 |
| Dawson, PA; Filipe, MI | 1 |
| Flesher, JW; Goldenberg, DM; Griffen, WO; Hagihara, PF; Hedgecock, H; Ram, MD; Sachatello, CR; Yoneda, K | 1 |
| Doertenbach, JG; Hettler, K; Ivankovic, S; Junghanns, K; Siebert, A; von Gerstenbergk, L | 1 |
| Chiu, JF; Gootnick, D; Little, BW; Pumo, DE | 1 |
| Blake, JR; Dawson, IM; Hardcastle, JD; Metcalf, MJ; Reeve, RS; Thompson, MJ | 1 |
| Furuya, K; Izumi, K; Otsuka, H | 1 |
| Appleton, DR; Hull, DL; Sunter, JP; Watson, AJ | 1 |
| Barthold, SW; Beck, D | 1 |
| Eggink, WF; Jamieson, CG; Jeppsson, BW; Li, AK; Malt, RA; Ross, JS; Schattenkerk, ME | 1 |
| Maskens, AP | 2 |
| Klein, B; Klein, T; Madar, Z; Nyska, A; Sheila, N; Weis, O; Zusman, I | 1 |
| Wu, J; Yu, B; Zhou, X | 1 |
| Kominami, R; Ohtsu, H; Okamoto, M; Yonekawa, H | 1 |
| Liu, Y; Rosenberg, DW | 1 |
| Bird, RP | 1 |
| Chen, F; Zhang, Q | 1 |
| Trukhanova, LS; Turusov, VS | 1 |
| Kristiansen, E; Meyer, O; Thorup, I | 2 |
| Choh, H; Kusano, M; Nakao, K; Shibusawa, M; Takada, M; Tsunoda, A; Yokoyama, N; Yoshizawa, H | 1 |
| Bhathal, PS; Ee, HC; Erler, T; James, RJ; Young, GP | 1 |
| Carraro, S; Celener, D; Celener, FG; Fernandez, LB; Hamamura, S; Tiscornia, O | 1 |
| Biggeri, A; Caderni, G; Dolara, P; Giannini, A; Lancioni, L; Luceri, C | 1 |
| Rubio, CA; Takayama, S | 1 |
| Boyce, HW; Chen, LT; Chen, MF | 2 |
| Butler, MJ; Dunn, DM; Landers, M; Miller, MF; Pence, BC; Zhao, C | 1 |
| Broda, M; Elliott, RW; Frick, TJ; Hohman, C; Jacoby, RF; Marshall, DJ; Schlack, S; Smutko, J | 1 |
| Gershbein, LL | 2 |
| Komatsu, N; Kusano, M; Nakao, K; Shibusawa, M; Tsunoda, A; Yasuda, N; Yoshizawa, F | 1 |
| Jagadeesan, V; Rao, NJ; Sesikeran, B | 1 |
| Chiang, H; Fu, YD; Li, NG; Shao, BJ; Wu, RY | 1 |
| Fukaura, Y; Ishikawa, C; Narisawa, T; Tanida, N; Terada, K; Umezawa, A; Yazawa, K | 1 |
| Broaddus, RR; Castro, GA; Wargovich, MJ | 1 |
| Ide, A; Iwama, T; Mishima, Y; Yoshinaga, K | 1 |
| Cameron, IL; Hardman, WE | 1 |
| Alexander, J; Namork, E; Paulsen, JE; Steffensen, IL | 1 |
| Davis, AE; Patterson, F | 1 |
| Rubio, C; Shetye, J | 1 |
| Mori, H; Mori, Y; Okamoto, K; Okumura, A; Sato, S; Sugie, S; Tanaka, T; Yoshimi, N | 1 |
| Cameron, IL; Carter, JW; Hardman, WE; Lancaster, HK | 1 |
| Lam, LK; Zhang, J | 2 |
| Morozova, OV; Samoilov, DV; Turusov, VS | 1 |
| Adams, WJ; Cook, TA; Lawson, JA; Morris, DL; Nicholson, SE | 1 |
| Adams, WJ; Lawson, JA; Morris, DL | 1 |
| Frencia, L; Ghia, M; Mereto, E | 1 |
| Bird, RP; Robblee, NM | 1 |
| Jin, SJ; Li, YL | 1 |
| Dillehay, DL; Merrill, AH; Schmelz, EM; Webb, SK | 1 |
| Lachowicz, A; Pawlikowski, M; Stepień, H; Szadowska, A; Winczyk, K; Zerek-Mełeń, G | 1 |
| McGarrity, TJ; Peiffer, LP | 1 |
| Hakoi, K; Hirose, M; Ito, N; Takahashi, S; Yada, H | 1 |
| Yasuda, S | 1 |
| Salim, AS | 3 |
| Bustos Fernández, L; Bustos, D; Carraro, S; Celener, D; Montiel, M; Navigante, A; Pons, S | 1 |
| Mori, H; Morishita, Y; Shinoda, T; Tanaka, T | 1 |
| Bianchini, F; Caderni, G; Dolara, P; Luceri, C; Spagnesi, MT; Testolin, G | 1 |
| Miyaki, M; Ohtsu, H; Okamoto, M; Yonekawa, H | 1 |
| Kodaira, S; Koudaira, H; Miyaji, S; Sugawara, I; Takami, H | 1 |
| Akagi, K; Hara, Y; Hirose, M; Hoshiya, T; Ito, N; Takahashi, S | 1 |
| Gibson, PR; McIntyre, A; Young, GP | 1 |
| Clark, TD; Comer, PF; Glauert, HP | 1 |
| Amir-Mokri, E; Brown, ME; Gershbein, LL; Rezai, VK | 1 |
| Madar, Z; Nyska, A; Timar, B; Zusman, I | 1 |
| Beaty, MM; Glauert, HP; Lee, EY | 1 |
| Alink, GM; Hollanders, VM; Koeman, JH; Kuiper, HA | 1 |
| Kawaura, A; Nishikawa, M; Shimoyama, T; Takahashi, A; Tanida, N | 1 |
| Clements, BM; McBrearty, FX; von Rueden, DG; Woratyla, S | 1 |
| Kasahara, N; Kawachi, Y; Kudo, H; Kuwa, K; Mori, T; Nagasawa, H; Sakamoto, S; Sawaki, K; Sugiura, Y; Suzuki, S | 1 |
| Bi, S; Geng, BQ; Yong, DG | 1 |
| Esumi, H; Minamoto, T; Sugimura, T; Takahashi, M; Yamashita, N; Yazawa, K | 1 |
| Brasitus, TA; Davidson, NO; Hausman, AM; Ifkovits, CA; Llor, X; Montag, A; Sitrin, MD; Skarosi, SF | 1 |
| Rosenberg, DW | 1 |
| Iwane, S; Munakata, A; Nakaji, S; Sakamoto, J; Sugawara, K | 1 |
| Goto, H; Hayakawa, T; Kanamori, S; Ozawa, T; Shimomura, Y; Sugiyama, S | 1 |
| Demant, P; Groot, PC; Hart, AA; Moen, CJ; Snoek, M | 1 |
| Abdelali, H; Bouley, C; Cassand, P; Daubeze, M; Narbonne, JF; Soussotte, V | 1 |
| Alexander, J; Paulsen, JE; Steffensen, IL | 1 |
| Fukami, H; Inada, K; Kusakabe, M; Masui, T; Nakanishi, H; Sakakura, T; Tatematsu, M; Yamamoto, M | 1 |
| Cameron, IL; Garza, J; Hardman, WE | 1 |
| Chu, CY; Hsu, JD; Tseng, TH; Wang, CJ | 1 |
| Bird, RP; Demant, P; Hart, AA; Moen, CJ; van der Valk, MA | 1 |
| Lowe, RM; Mullen, CA; Petropoulos, D | 1 |
| Freeman, HJ; Godin, DV; Moghadasian, MH | 1 |
| Inagake, M; Iwata, Y; Matsumoto, H; Miyazawa, T; Nakagawa, K; Nakatani, H; Nishimura, H; Nishino, H; Takahashi, T; Yamane, T | 1 |
| Pan, H; Wu, J; Zheng, S | 1 |
| Goldin, BR; Gualtieri, LJ; Moore, RP | 1 |
| Garcia, SB; Muccillo, G; Oliveira, JS; Pinto, LZ; Zucoloto, S | 1 |
| Ikeda, N; Mizuno, M; Okada, H; Tomoda, J; Tsuji, T | 1 |
| Adams, J; Dillehay, DL; Merrill, AH; Reiter, A; Schmelz, EM; Webb, SK | 1 |
| Domizlaff, I; Ji, S; Moretti, M; Neudecker, C; Pool-Zobel, BL; Rowland, I; Rumney, C; Scassellati-Sforzolini, R; Schillinger, U; Vilarini, I | 1 |
| Anisimov, VN; Muratov, EI; Popovich, IG | 1 |
| Higashi, T; Kinugasa, N; Nakatsukasa, H; Nishimura, Y; Nouso, K; Satoh, Y; Shiota, T; Tsuji, T; Uematsu, S; Yoshida, K | 1 |
| Eggermont, AM; Marquet, RL; Van de Vrie, W | 1 |
| Choi, SW; Dallal, GE; Graeme-Cook, F; Kim, YI; Mason, JB; Salomon, RN; Smith, DE | 1 |
| Fölsch, UR; Löser, C; Starp, F | 1 |
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| Andrianopoulos, G; Nelson, RL; Tanure, JC | 1 |
| Tempero, MA; Zetterman, RK | 1 |
| Amberger, H | 1 |
| Suzuki, H; Umehara, N | 1 |
| Iriyama, K; Iwata, Y; Matsumoto, K; Suzuki, H; Yamamoto, J | 1 |
| Lu, L; Orr, KB; Rogers, A; Weinerman, BH | 1 |
| Alun, ML; Duvander, A; Nylander, G; Rubio, CA; Sveander, M; Wahlin, B | 1 |
| Couch, DB; Gingerich, JD; Heddle, JA; Stuart, E | 1 |
| Bibby, MC; Double, JA | 1 |
| Saito, Y | 1 |
| Dorofeev, GI; Ivashkin, VT; Romanov, VV; Sultanov, VK; Vasil'ev, VIu | 1 |
| Roberfroid, M; Speder, A; Wilpart, M | 1 |
| Cook, HT; Phillips, RK | 1 |
| Huberman, E; Jones, CA; Oravec, CT | 1 |
| Ujihara, Y | 1 |
| Katsura, Y; Maruyama, J; Matsuda, T; Ogawa, M; Yasutomi, M | 1 |
| Koike, M; Nakazawa, S; Ozawa, T | 1 |
| Buchanan, KD; Johnston, CF; O'Hare, MM; O'Neill, AB | 1 |
| Gilbert, JM; Kark, A; Lawson, AM; Royston, JP; Setchell, KD; Worthington, J | 1 |
| Grueva, D; Hadjiolov, D | 1 |
| Colacchio, TA; Memoli, VA | 1 |
| Brasitus, TA; Brown, MD; Dahiya, R; Dudeja, PK | 1 |
| Kasahara, N; Kuwa, K; Okamoto, R; Sagara, T; Sakamoto, S; Tsukada, K | 1 |
| Wargovich, MJ | 1 |
| Shimamoto, F; Vollmer, E | 1 |
| Hickman, MS; Salinas, HC; Schwesinger, WH | 1 |
| Kauffman, P; Locniskar, M; Nauss, KM; Newberne, PM | 1 |
| Davey, PG; McGuinness, EE; Nicol, S; Wormsley, KG | 1 |
| Bland, PW; Warren, LG | 1 |
| Gabbert, H | 1 |
| Nishizumi, M | 1 |
| Aoki, N; Hamada, S; Hirayama, R; Matsumura, J; Mishima, Y; Miyanaga, T; Takagi, Y | 1 |
| Yardley, JH | 1 |
| Boffa, LC; Bolognesi, C | 1 |
| Goad, ME; Lindenschmidt, RC; Tryka, AF; Witschi, HP | 1 |
| Alun, ML; Duvander, A; Nylander, G; Rubio, CA; Sveander, M | 1 |
| Chiu, JF; Gabryelak, T; Kim, Y; Wen, BG | 1 |
| Elwyn, KE; Jones, RD; Romsdahl, MM | 1 |
| Nelson, RL; Nyhus, LM; Samelson, SL | 1 |
| Kaufmann, P; Locniskar, M; Nauss, KM; Newberne, PM | 1 |
| Hirose, M; Ikawa, E; Ito, N; Shirai, T; Thamavit, W | 1 |
| Nelson, RL; Samelson, SL | 1 |
| Koike, M; Nakazawa, S; Tanaka, M | 1 |
| Augenlicht, LH; Halsey, H; Kenna, M; Yander, G | 1 |
| Chemeris, GY; Parfenov, YD; Turusov, VS | 1 |
| Kennedy, AR; McGandy, RB; Weed, HG | 1 |
| Koga, T; Sugano, M; Watanabe, M | 1 |
| Barkla, DH; Kennedy, MF; Tutton, PJ | 2 |
| Demura, H; Demura, R; Jibiki, K; Kato, Y; Nakamura, S; Oda, S; Odagiri, E | 1 |
| Elwyn, KE; Jones, RD; Karlin, DA; McBath, M; Romsdahl, MM | 1 |
| Ahnen, DJ | 1 |
| Dufek, V; Kolár, Z; Král, V; Krepela, E; Vicar, J | 1 |
| Abe, O; Ishimura, Y; Kodaira, S; Okuda, K; Sadahiro, S; Takahashi, T; Takami, H | 1 |
| Delapierre, F; Halkin, E; Laumonier, R; Roussel, F | 1 |
| Hawks, A; Hicks, RM; Holsman, JW; Magee, PN | 1 |
21 review(s) available for dimethylhydrazines and Colonic Neoplasms
| Article | Year |
|---|---|
Techniques to Improve Photodynamic Therapy.
Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Eye Diseases; Humans; Mice, Hairless; Mice, Inbred BALB C; Photochemotherapy; Rats; Rats, Wistar; Retina; Urinary Bladder Neoplasms | 2020 |
Recent advances in dietary fiber and colorectal diseases.
Topics: 1,2-Dimethylhydrazine; Animals; Cellulose; Colitis; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Crohn Disease; Dietary Fats; Dietary Fiber; Dimethylhydrazines; Disease Models, Animal; Diverticulum, Colon; Humans; Rectal Diseases | 1981 |
Dietary and endogenous cholesterol and human cancer.
Topics: Adult; Age Factors; Aged; Animals; Anticholesteremic Agents; Breast Neoplasms; Cholesterol; Cholesterol, Dietary; Clinical Trials as Topic; Colonic Neoplasms; Diet; Dimethylhydrazines; Epidemiologic Methods; Feces; Female; Humans; Male; Mice; Middle Aged; Neoplasms; Neoplasms, Experimental; Precancerous Conditions; Prospective Studies; Rats; Risk; Sex Factors | 1984 |
Experimental adenomas and carcinomas of the large intestine behave as distinct entities: most carcinomas arise de novo in flat mucosa.
Topics: Adenoma; Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Neoplasm Invasiveness; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1981 |
[Experimental colorectal carcinogenesis (author's transl)].
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Neoplasms, Experimental | 1982 |
Role of aberrant crypt foci in understanding the pathogenesis of colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Genes, ras; Humans; Intestinal Mucosa; Precancerous Conditions | 1995 |
Biology of large bowel cancer. Present status and research frontiers.
Topics: Adenoma; Adult; Animals; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Epithelial Cells; Epithelium; Female; Humans; Male; Multiple Endocrine Neoplasia; Neoplasms, Experimental; Rectal Neoplasms | 1975 |
Dietary effects on chemical carcinogenesis in animal models for colon and liver tumors.
Topics: Adenocarcinoma, Mucinous; Animals; BCG Vaccine; Colonic Neoplasms; Diet; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Lipotropic Agents; Liver Neoplasms; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Rats; T-Lymphocytes; Vitamin A Deficiency | 1975 |
Experimental colon cancer.
Topics: Adenocarcinoma, Mucinous; Animals; Antigens, Neoplasm; Bacteria; Bile Acids and Salts; Carcinogens; Colonic Neoplasms; Cricetinae; Dietary Fats; Dietary Fiber; Dimethylhydrazines; Humans; Immunity; Intestinal Polyps; Intestines; Methylhydrazines; Mice; Neoplasms, Experimental; Rats | 1978 |
Multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. Histologic correlation.
Topics: Animals; Antibodies, Neoplasm; Colonic Neoplasms; Dimethylhydrazines; Gastrointestinal Neoplasms; Immunization, Passive; Immunotherapy; Levamisole; Lymphocytes; Neoplasms, Experimental; Propionibacterium acnes; Rats; Rats, Inbred WF; Splenectomy | 1978 |
Role of bile metabolites in colon carcinogenesis. Animal models.
Topics: Animals; Bile Acids and Salts; Colon; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Female; Neoplasms, Experimental | 1975 |
Dietary fiber-mediated mechanisms in carcinogenesis.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Colon; Colonic Neoplasms; Denmark; Dietary Fiber; Dimethylhydrazines; Fatty Acids, Volatile; Feces; Fermentation; Finland; Growth Substances; Humans; Ornithine Decarboxylase; Rats; Rectal Neoplasms | 1992 |
Gastrointestinal tumours after stapler vs vicryl anastomoses in carcinogen-treated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Neoplasm Recurrence, Local; Nickel; Polyglactin 910; Rats; Surgical Staplers; Suture Techniques; Sutures | 1990 |
Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.
Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Benzo(a)pyrene; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Dietary Proteins; Dimethylhydrazines; Disease Models, Animal; Drug Synergism; Epidemiologic Methods; Humans; Lung Neoplasms; Male; Methylnitronitrosoguanidine; Models, Biological; Prostatic Neoplasms; Vitamin A | 1986 |
Animal models of carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal | 1988 |
Cholesterol conundrums: the relationship between dietary and serum cholesterol in colon cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Animals; Azoxymethane; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Cocarcinogenesis; Colonic Neoplasms; Diagnosis-Related Groups; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Epidemiologic Methods; Humans; Methylnitronitrosoguanidine; Methylnitrosourea | 1986 |
Colorectal cancer in animal models--a review.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Rats; Rectal Neoplasms | 1987 |
Dietary fat and colon cancer: variable results in animal models.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Energy Intake; Gastrointestinal Neoplasms; Meat | 1986 |
The metabolism of the intestinal microflora and its relationship to dietary fat, colon and breast cancer.
Topics: 1,2-Dimethylhydrazine; Amino Acids; Animals; Biotransformation; Breast Neoplasms; Carcinogens; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Enterohepatic Circulation; Hormones; Humans; Intestines; Mutagens; NADH, NADPH Oxidoreductases; Neoplasms, Experimental; Nitroreductases; Nitrosamines | 1986 |
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Colonic Neoplasms; Cytochrome P-450 Enzyme System; Diet; Dietary Proteins; Dimethylhydrazines; Enzyme Induction; Epilepsy; Glutathione; Humans; Liver; Liver Neoplasms; Phenobarbital | 1986 |
Mechanisms of tumor invasion: evidence from in vivo observations.
Topics: 1,2-Dimethylhydrazine; Animals; Atrophy; Basement Membrane; Cell Differentiation; Cell Division; Cell Movement; Cells, Cultured; Colon; Colonic Neoplasms; Dimethylhydrazines; Edema; Extracellular Matrix; Humans; Intercellular Junctions; Muscle, Smooth; Neoplasm Invasiveness; Neoplasm Proteins; Oxygen; Peptide Hydrolases; Rats | 1985 |
3 trial(s) available for dimethylhydrazines and Colonic Neoplasms
| Article | Year |
|---|---|
Chemopreventive and metabolic effects of inulin on colon cancer development.
Topics: Animals; Bacterial Proteins; Colon; Colonic Neoplasms; Colony Count, Microbial; Cyclooxygenase 2; Cytokines; Diet; Dietary Supplements; Dimethylhydrazines; Enterobacteriaceae; Fatty Acids, Volatile; Female; Gene Expression Regulation; Inulin; Lactobacillaceae; Male; NF-kappa B; Prebiotics; Rats; Rats, Sprague-Dawley | 2013 |
Dietary and endogenous cholesterol and human cancer.
Topics: Adult; Age Factors; Aged; Animals; Anticholesteremic Agents; Breast Neoplasms; Cholesterol; Cholesterol, Dietary; Clinical Trials as Topic; Colonic Neoplasms; Diet; Dimethylhydrazines; Epidemiologic Methods; Feces; Female; Humans; Male; Mice; Middle Aged; Neoplasms; Neoplasms, Experimental; Precancerous Conditions; Prospective Studies; Rats; Risk; Sex Factors | 1984 |
Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Aged; Animals; Carcinogens; Colitis, Ulcerative; Colonic Neoplasms; Dimethylhydrazines; Drug Evaluation; Drug Screening Assays, Antitumor; Feasibility Studies; Female; Humans; Injections, Intralesional; Liver Neoplasms; Male; Middle Aged; Rats; Rats, Inbred Strains; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1992 |
721 other study(ies) available for dimethylhydrazines and Colonic Neoplasms
| Article | Year |
|---|---|
5-fluorouracil and curcumin with pectin coating as a treatment regimen for titanium dioxide with dimethylhydrazine-induced colon cancer model.
Topics: Animals; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Curcumin; Dimethylhydrazines; Fluorouracil; Pectins; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Titanium | 2022 |
Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Colonic Neoplasms; Dimethylhydrazines; Ficus; Inflammation; Latex; Plant Extracts; Rats; Rats, Wistar; Xenobiotics | 2022 |
Anticancer potential of human intestinal defensin 5 against 1, 2-dimethylhydrazine dihydrochloride induced colon cancer: A therapeutic approach.
Topics: alpha-Defensins; Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley | 2020 |
Probing the chemoprevention potential of the antidepressant fluoxetine combined with epigallocatechin gallate or kaempferol in rats with induced early stage colon carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Apoptosis; Catechin; Cell Proliferation; Chemoprevention; Colon; Colonic Neoplasms; Dimethylhydrazines; Fluoxetine; Kaempferols; Male; Phytotherapy; Rats, Sprague-Dawley | 2021 |
Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model.
Topics: Animals; Anticarcinogenic Agents; Cell Proliferation; Colon; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Glutamates; Janus Kinase 2; Ki-67 Antigen; Male; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Theobromine; TOR Serine-Threonine Kinases | 2021 |
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Comet Assay; Dimethylhydrazines; DNA Damage; Male; Oxidative Stress; Plant Extracts; Plant Stems; Protective Agents; Rats; Rats, Wistar; Styrax | 2021 |
Protective Effect of Lactobacillus casei on DMH-Induced Colon Carcinogenesis in Mice.
Topics: Animals; Carcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Humans; Lacticaseibacillus casei; Mice; Polyamines; Probiotics | 2017 |
Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma.
Topics: Animals; Apoptosis; Carcinoma; Cell Proliferation; Colonic Neoplasms; Dimethylhydrazines; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Oxidative Stress; Pyrazinamide; Rats; Stress, Physiological | 2017 |
Galantamine attenuates N,N-dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission.
Topics: Acetylcholinesterase; Animals; Biomarkers; Body Weight; Cholinesterase Inhibitors; Colonic Neoplasms; Dimethylhydrazines; Galantamine; Hydrogen-Ion Concentration; Oxidative Stress; Rats, Wistar; Receptors, Nicotinic; Synaptic Transmission | 2018 |
Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Caco-2 Cells; Cadherins; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Comet Assay; Dimethylhydrazines; Disease Progression; Gene Expression Profiling; Hemin; Humans; Indoles; Lipid Peroxidation; Male; Neoplasm Invasiveness; Nerve Tissue Proteins; Proto-Oncogene Proteins c-raf; Rats, Wistar; Real-Time Polymerase Chain Reaction; Red Meat; Reverse Transcriptase Polymerase Chain Reaction; Synbiotics; Tumor Necrosis Factor-alpha | 2018 |
Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway.
Topics: Animals; Apoptosis; Body Weight; Carcinogenesis; Cell Line; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Dimethylhydrazines; Endoplasmic Reticulum Stress; Mice, Inbred C57BL; Mitochondria; Signal Transduction; Starch; Tumor Cells, Cultured | 2018 |
Impact of dihydropyrrol derivative on the normal colonic mucosa of DMH-induced colon cancer rats compared with 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Fluorouracil; Intestinal Mucosa; Male; Pyrroles; Pyrrolidinones; Rats; Rats, Wistar | 2013 |
Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon.
Topics: Aberrant Crypt Foci; Animals; Bifidobacterium; Carcinogens; Colonic Neoplasms; Combined Modality Therapy; Dimethylhydrazines; Lactobacillus delbrueckii; Male; Mice; Precancerous Conditions; Probiotics; Reproducibility of Results; Saccharomyces; Time Factors | 2013 |
Partial lipectomy reduces dimethylhydrazine-induced carcinogenic initiation in the colon of rats.
Topics: Animals; Apoptosis; Carcinogens; Cell Proliferation; Colonic Neoplasms; Diet, High-Fat; Dimethylhydrazines; Female; Inflammation; Intestinal Mucosa; Intra-Abdominal Fat; Lipectomy; Male; Mutation; Precancerous Conditions; Random Allocation; Rats; Rats, Wistar | 2014 |
Oral 5-fluorouracil colon-specific delivery through in vivo pellet coating for colon cancer and aberrant crypt foci treatment.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Adenoma; Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Cellulose; Chemistry, Pharmaceutical; Colonic Neoplasms; Dimethylhydrazines; Drug Delivery Systems; Feasibility Studies; Female; Fluorouracil; Pectins; Powders; Rats, Sprague-Dawley; Solubility; Tablets, Enteric-Coated; Technology, Pharmaceutical; Tumor Burden | 2014 |
Alterations in lipid mediated signaling and Wnt/ β -catenin signaling in DMH induced colon cancer on supplementation of fish oil.
Topics: Animals; beta Catenin; Ceramides; Colonic Neoplasms; Cyclooxygenase 2; Dimethylhydrazines; Fish Oils; Gene Expression Regulation, Neoplastic; Humans; PPAR gamma; Rats; Wnt Signaling Pathway | 2014 |
Luteolin supplementation adjacent to aspirin treatment reduced dimethylhydrazine-induced experimental colon carcinogenesis in rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Aspirin; Carcinoembryonic Antigen; Carcinogenesis; Colonic Neoplasms; Cyclooxygenase 2; Dimethylhydrazines; Humans; Lipid Peroxidation; Luteolin; Neoplasms, Experimental; Oxidative Stress; Rats; Rats, Wistar | 2015 |
Genistein regulates tumor microenvironment and exhibits anticancer effect in dimethyl hydrazine-induced experimental colon carcinogenesis.
Topics: Aberrant Crypt Foci; AC133 Antigen; Animals; Antineoplastic Agents; Antioxidants; beta Catenin; Carcinogenesis; Cell Proliferation; Colon; Colonic Neoplasms; Dimethylhydrazines; Drug Screening Assays, Antitumor; Fibrillar Collagens; Genistein; Heme Oxygenase-1; Hyaluronan Receptors; Male; Mucins; NF-E2-Related Factor 2; Proliferating Cell Nuclear Antigen; Rats, Wistar; Tumor Microenvironment | 2016 |
Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention.
Topics: Animals; Apoptosis; beta Catenin; Blotting, Western; Carcinogens; Cell Division; Colonic Neoplasms; Connexin 43; Diet; Dimethylhydrazines; Down-Regulation; Female; Gene Expression Regulation; Genes, bcl-2; Immunohistochemistry; Intestinal Mucosa; Mice; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingomyelins | 2009 |
[Effect of jinfu kang to experimental precancerous colon lesions and urinary metabolites in rat].
Topics: Animals; Colonic Neoplasms; Colonic Polyps; Dimethylhydrazines; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Male; Rats; Rats, Wistar | 2008 |
High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver.
Topics: Animals; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Glutathione Peroxidase; Liver; Mutation; Rats; Sodium Selenite; Transcription Factors | 2009 |
Effect of processing on folic acid fortified Baladi bread and its possible effect on the prevention of colon cancer.
Topics: Animals; Body Weight; Bread; Carcinogens; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cooking; Diet; Dimethylhydrazines; Drug Stability; Eating; Flour; Folic Acid; Food, Fortified; Glycine max; Humidity; Intestinal Mucosa; Rats; Triticum | 2009 |
Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression.
Topics: Animals; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Dimethylhydrazines; Diterpenes; Epoxy Compounds; Humans; Interleukin-6; Janus Kinases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Neoplasm Transplantation; Phenanthrenes; rac1 GTP-Binding Protein; Signal Transduction; STAT3 Transcription Factor; Tumor Burden | 2009 |
Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Catechin; Colon; Colonic Neoplasms; Coloring Agents; Curcumin; Dimethylhydrazines; DNA Fragmentation; Drug Synergism; In Situ Nick-End Labeling; Indicators and Reagents; Male; Rats; Rats, Wistar; Rectum; Tea | 2010 |
Role of zinc in modulating histo-architectural and biochemical alterations during dimethylhydrazine (DMH)-induced rat colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Catalase; Colon; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Glutathione; Glutathione Reductase; Glutathione Transferase; Lipid Peroxidation; Male; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Zinc | 2009 |
Suppression of colonic aberrant crypt foci by soy isoflavones is dose-independent in dimethylhydrazine-treated rats.
Topics: Animals; Colonic Neoplasms; Cyclooxygenase 2; Dimethylhydrazines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression; Glycine max; Humans; Isoflavones; Male; Plant Extracts; Rats; Rats, Sprague-Dawley | 2010 |
[Effects of Coptis chinensis and Evodia rutaecarpa water extract on DMH-induced precancerous lesion of colon].
Topics: Animals; Apoptosis; Cell Proliferation; Colonic Neoplasms; Coptis; Dimethylhydrazines; Disease Models, Animal; Evodia; Humans; Male; Plant Extracts; Random Allocation; Rats; Rats, Wistar | 2010 |
Chemopreventive effect of different ratios of fish oil and corn oil in experimental colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Corn Oil; Dimethylhydrazines; Fish Oils; Male; Rats; Rats, Wistar; Reactive Oxygen Species | 2010 |
The effect of apple feeding on markers of colon carcinogenesis.
Topics: Aberrant Crypt Foci; Alanine Transaminase; Animals; Biomarkers, Tumor; Carcinogens; Chemoprevention; Colonic Neoplasms; Comet Assay; Diet; Dimethylhydrazines; Disease Models, Animal; DNA Damage; Liver; Male; Malus; Precancerous Conditions; Rats; Rats, Inbred F344 | 2011 |
Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis.
Topics: Acyclic Monoterpenes; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Drug Screening Assays, Antitumor; Intestinal Mucosa; Male; Norisoprenoids; Rats; Rats, Wistar; Terpenes | 2011 |
Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.
Topics: Animals; Atorvastatin; Colonic Neoplasms; Dimethylhydrazines; Female; Heptanoic Acids; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung Neoplasms; Mice; Nitrosamines; Pyrroles; RNA, Messenger; Urethane; Vorinostat | 2012 |
EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine.
Topics: Aging; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers, Tumor; Carcinogens; Cetuximab; Colon; Colonic Neoplasms; Dimethylhydrazines; ErbB Receptors; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Male; MicroRNAs; Neoplastic Stem Cells; Rats | 2012 |
Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; beta Catenin; Caspase 3; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dextran Sulfate; Dimethylhydrazines; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression; Genes, Reporter; HCT116 Cells; Humans; Luciferases, Firefly; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2012 |
Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis.
Topics: Animals; Colon; Colonic Neoplasms; Corn Oil; Dimethylhydrazines; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fish Oils; Flow Cytometry; Fluorescent Antibody Technique; Male; Mitogen-Activated Protein Kinase 3; ras Proteins; Rats; Rats, Wistar; Signal Transduction | 2012 |
PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Dimethylhydrazines; Drug Therapy, Combination; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Membrane Potential, Mitochondrial; Phosphatidylinositol 3-Kinase; Phycocyanin; Piroxicam; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2012 |
Dietary folate suppresses DMH-induced colon carcinogenesis in a rat model and affects DMH-induced expression of four DNA repair enzymes.
Topics: Animals; Colon; Colonic Neoplasms; Diet; Dietary Supplements; Dimethylhydrazines; DNA Damage; DNA Repair; DNA Repair Enzymes; Folic Acid; Male; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2012 |
Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Colonic Neoplasms; Curcumin; Cyclooxygenase 1; Cyclooxygenase 2; Dimethylhydrazines; Fluorouracil; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Male; Membrane Proteins; Rats; Rats, Wistar | 2012 |
Frequency of proliferation, apoptosis, and their ratio during rat colon carcinogenesis and their characteristic pattern in the dimethylhydrazine-induced colon adenoma and carcinoma.
Topics: Adenoma; Animals; Apoptosis; Carcinogens; Carcinoma; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Humans; Male; Rats; Rats, Wistar | 2002 |
Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis.
Topics: Animals; Antimetabolites; Biomarkers, Tumor; Bromodeoxyuridine; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Rats; Rats, Wistar | 2002 |
Inhibition of tumor progression and neoangiogenesis using cyclic RGD-peptides in a chemically induced colon carcinoma in rats.
Topics: Animals; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Disease Progression; Male; Neovascularization, Pathologic; Oligopeptides; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Effects of Bowman-Birk inhibitor on rat colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Colonic Neoplasms; Dimethylhydrazines; Incidence; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Trypsin Inhibitor, Bowman-Birk Soybean | 2002 |
Relationship between formation of aberrant crypts and acute responses of colonic epithelial cells to genotoxic treatment among inbred rat strains.
Topics: Animals; Apoptosis; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; DNA Damage; Epithelial Cells; Gamma Rays; Neoplasms, Radiation-Induced; Precancerous Conditions; Rats; Rats, Inbred Strains | 2003 |
Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Fatty Acids; Female; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Safflower Oil | 2003 |
Modifying effect of propolis on dimethylhydrazine-induced DNA damage but not colonic aberrant crypt foci in rats.
Topics: Animals; Antimutagenic Agents; Colon; Colonic Neoplasms; Comet Assay; Dimethylhydrazines; DNA Damage; Male; Mutagenicity Tests; Precancerous Conditions; Propolis; Rats; Rats, Wistar | 2005 |
DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Bixaceae; Carcinogens; Carotenoids; Colonic Neoplasms; Comet Assay; Dimethylhydrazines; DNA Damage; Male; Plant Extracts; Rats; Rats, Wistar; Seeds | 2005 |
A proteomics approach to identify changes in protein profiles in pre-cancerous colon.
Topics: Animals; Carcinogens; Chromatography, Liquid; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Homeostasis; Male; Neoplasm Proteins; Precancerous Conditions; Proteomics; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Weight Gain | 2005 |
Simple mucin-type cancer associated antigens are pre-cancerous biomarkers during 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: Animals; Antigens, Tumor-Associated, Carbohydrate; Biomarkers, Tumor; Colon; Colonic Neoplasms; Diagnosis, Differential; Dimethylhydrazines; Female; Glycoproteins; Immunohistochemistry; Mucins; Precancerous Conditions; Rats; Rats, Wistar | 2005 |
Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats.
Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Killer Cells, Natural; Male; Phytic Acid; Rats; Rats, Wistar | 2005 |
Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis.
Topics: Animals; Carcinogens; Carrier Proteins; Colonic Neoplasms; Dimethylhydrazines; Female; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Poly(ADP-ribose) Polymerases; RNA-Binding Proteins; Urethane; Vault Ribonucleoprotein Particles | 2005 |
Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Carcinogens; Colon; Colonic Neoplasms; Dextran Sulfate; Dimethylhydrazines; Humans; Male; Mutation; Neoplasm Metastasis; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred F344 | 2006 |
Adherence and anticarcinogenic effects of Bacillus polyfermenticus SCD in the large intestine.
Topics: Animals; Anticarcinogenic Agents; Bacillus; Bacterial Adhesion; Caco-2 Cells; Cell Proliferation; Colon; Colonic Neoplasms; Dietary Supplements; Dimethylhydrazines; Humans; Intestinal Mucosa; Male; Probiotics; Rats; Rats, Inbred F344 | 2007 |
Effect of chronic dietary ethanol consumption on colonic cancer in rats induced by 1,1-dimethylhydrazine.
Topics: Alcoholism; Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Colon; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Dimethylhydrazines; Ethanol; Intestinal Mucosa; Liver; Rats; Rats, Wistar | 2007 |
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; Blotting, Western; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Doxorubicin; Epithelial Cells; Flow Cytometry; HCT116 Cells; Humans; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Mice; Mice, Transgenic; Myeloid Cell Leukemia Sequence 1 Protein; Pregnane X Receptor; Proto-Oncogene Proteins c-bcl-2; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; Ubiquitin-Protein Ligases | 2008 |
Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats.
Topics: Animals; Apoptosis; Biomarkers; Brassicaceae; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Gene Expression Regulation; Male; Mucins; Rats; Rats, Wistar; Vegetables | 2008 |
Intrinsic denervation of the colon is associated with a decrease of some colonic preneoplastic markers in rats treated with a chemical carcinogen.
Topics: Animals; Benzalkonium Compounds; beta Catenin; Biomarkers, Tumor; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Denervation; Dimethylhydrazines; Male; Precancerous Conditions; Rats; Rats, Wistar; Time Factors | 2008 |
Exercise reduces inflammation and cell proliferation in rat colon carcinogenesis.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Dimethylhydrazines; Inflammation; Interleukin-6; Intestinal Mucosa; Male; Physical Conditioning, Animal; Rats; Rats, Wistar; Risk Factors | 2008 |
Fructooligosaccharide and soy isoflavone suppress colonic aberrant crypt foci and cyclooxygenase-2 expression in dimethylhydrazine-treated rats.
Topics: Animals; Anticarcinogenic Agents; Bile Acids and Salts; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dimethylhydrazines; Feces; Glycine max; Intestinal Mucosa; Isoflavones; Oligosaccharides; Rats; Rats, Sprague-Dawley | 2008 |
Effect of Metamucil on tumour formation by 1,2-dimethylhydrazine dihydrochloride in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Drug Synergism; Female; Intussusception; Male; Mice; Neoplasms, Experimental; Psyllium; Sex Factors | 1984 |
Enhancement of 1,2-dimethylhydrazine-induced large bowel tumorigenesis in Balb/c mice by corn, soybean, and wheat brans.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Glycine max; Male; Mice; Mice, Inbred BALB C; Triticum; Zea mays | 1984 |
[Neuropharmacologic regulation of the carcinogenic action of 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Adrenergic alpha-Antagonists; Animals; Atropine; Autonomic Nervous System; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Dioxanes; Guanethidine; Male; Methylhydrazines; Neoplasms, Experimental; Norepinephrine; Rats | 1981 |
Effects of glucocorticoid hormones on cell proliferation in dimethylhydrazine-induced tumours in rat colon.
Topics: Adenocarcinoma; Adrenalectomy; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Glucocorticoids; Male; Rats | 1981 |
The influence of androgens, anti-androgens, and castration on cell proliferation in the jejunal and colonic crypt epithelia, and in dimethylhydrazine-induced adenocarcinoma of rat colon.
Topics: Adenocarcinoma; Anilides; Animals; Castration; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Flutamide; Intestinal Mucosa; Jejunum; Male; Rats; Testosterone | 1982 |
Ultracytochemistry of the cell surface and microfilaments in dimethylhydrazine-induced colonic tumor cells.
Topics: 1,2-Dimethylhydrazine; Actins; Adenosine Triphosphatases; Animals; Cell Membrane; Colonic Neoplasms; Cytoskeleton; Dimethylhydrazines; Female; Histocytochemistry; Mice; Myosin Subfragments | 1984 |
Antigenic changes in nuclear chromatin in 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Chromatin; Colonic Neoplasms; Dimethylhydrazines; Epitopes; Male; Methylhydrazines; Neoplasms, Experimental; Precancerous Conditions; Rats; Time Factors | 1980 |
Effect of dioctyl sodium sulfosuccinate feeding on rat colorectal 1,2-dimethylhydrazine carcinogenesis.
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Dioctyl Sulfosuccinic Acid; Dose-Response Relationship, Drug; Drug Synergism; Duodenal Neoplasms; Gastrointestinal Neoplasms; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred F344; Rectal Neoplasms; Succinates; Time Factors | 1980 |
Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon.
Topics: Animals; Cell Division; Colon; Colonic Neoplasms; Colostomy; Dimethylhydrazines; DNA; Male; Methylhydrazines; Proteins; Rats; RNA | 1981 |
Enhancing effect of dextran sulfate sodium on colorectal carcinogenesis by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Animals; Cocarcinogenesis; Colonic Neoplasms; Dextran Sulfate; Dextrans; Dimethylhydrazines; Male; Methylhydrazines; Molecular Weight; Rats; Rats, Inbred ACI; Rectal Neoplasms | 1983 |
Pharmacokinetic studies of 5-fluorouracil and 5'-deoxy-5-fluorouridine in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dimethylhydrazines; Female; Floxuridine; Fluorouracil; Kidney; Kinetics; Neoplasm Transplantation; Protein Binding; Rats; Rats, Inbred F344; Time Factors | 1983 |
Hematoporphyrin derivative: quantitative uptake in dimethylhydrazine-induced murine colorectal carcinoma.
Topics: Animals; Biopsy; Colonic Neoplasms; Dimethylhydrazines; Hematoporphyrin Derivative; Hematoporphyrins; Mice; Mice, Inbred ICR; Rectal Neoplasms; Spectrometry, Fluorescence | 1983 |
Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone.
Topics: Animals; Body Weight; Cell Cycle; Colonic Neoplasms; Dehydroepiandrosterone; Dimethylhydrazines; DNA; Feeding Behavior; Female; Methylation; Methylhydrazines; Mice | 1984 |
The effect of 1,2-dimethylhydrazine (DMH) carcinogenesis on peripheral T cell subsets in the Wistar Furth rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Monoclonal; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Methylhydrazines; Neoplasms, Experimental; Phenotype; Rats; Rats, Inbred WF; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 1984 |
[Contribution of experimental carcinogenesis to the pathogenesis of colorectal cancer in man].
Topics: Adenocarcinoma; Adenoma; Animals; Cholecystectomy; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Humans; Mice; Rats | 1984 |
Effects of diet on chemically induced bowel cancer.
Topics: Animals; Body Weight; Cellulose; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Dimethylhydrazines; Feces; Intestine, Large; Intestine, Small; Neoplasms, Experimental; Organ Size; Rats; Vitamin A | 1980 |
Intracellular adenosine and guanosine 3',5'-cyclic monophosphate concentrations in rat small and large bowel following single and multiple exposures to 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Dimethylhydrazines; Injections, Subcutaneous; Intestinal Neoplasms; Kinetics; Male; Precancerous Conditions; Rats | 1980 |
A double-blind study on the effects of differing purified cellulose and pectin fiber diets on 1,2-dimethylhydrazine-induced rat colonic neoplasia.
Topics: Adenocarcinoma; Animals; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Male; Neoplasms, Experimental; Pectins; Rats | 1980 |
Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine.
Topics: Adenocarcinoma; Animals; Bile Acids and Salts; Carcinoma; Cellulose; Cocarcinogenesis; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Duodenal Neoplasms; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1980 |
Genesis of 1,2-dimethylhydrazine-induced colon cancer. A light and electron microscopic study.
Topics: Adenocarcinoma, Mucinous; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Male; Microscopy, Electron; Neoplasms, Experimental; Precancerous Conditions; Rats | 1981 |
Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat.
Topics: Adenocarcinoma; Animals; Bacteria; Body Weight; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Feces; Glucuronidase; Male; Methylhydrazines; Pectins; Rats | 1981 |
Enhancement of 1,2-dimethylhydrazine-induced colon carcinogenesis in mice by dietary agar.
Topics: 1,2-Dimethylhydrazine; Agar; Animals; Carcinogens; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Dimethylhydrazines; Feces; Male; Methylhydrazines; Mice | 1981 |
Carcinogen binding to various types of dietary fiber.
Topics: Cellulose; Chemical Phenomena; Chemistry; Citrus; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Edible Grain; Humans; Hydrogen-Ion Concentration; Medicago sativa; Methylhydrazines; Pectins | 1981 |
Adenosine 3',5'-cyclic monophosphate dependent and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Cyclic AMP; Dimethylhydrazines; Hydrogen-Ion Concentration; Kinetics; Male; Neoplasm Proteins; Neoplasms, Experimental; Protein Kinases; Rats; Time Factors | 1982 |
Pathogenesis of 1,2-dimethylhydrazine-induced carcinomas in rat intestine. I. The induction of mucin producing carcinomas in rat intestine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Cecal Neoplasms; Colonic Neoplasms; Dimethylhydrazines; Intestinal Neoplasms; Intestine, Large; Intestine, Small; Male; Methylhydrazines; Mucins; Rats; Rats, Inbred Strains | 1982 |
Increased incidence of experimental colon cancer associated with long-term metronidazole therapy.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Metronidazole; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Different dose-response relationships in the induction of different types of colonic tumors in Wistar rats by 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1983 |
Enhancement of rat colon carcinogenesis by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Drug Synergism; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Triticum | 1983 |
Effects of wheat, rice, corn, and soybean bran on 1,2-dimethylhydrazine-induced large bowel tumorigenesis in F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Glycine max; Male; Methylhydrazines; Oryza; Rats; Rats, Inbred F344; Triticum; Zea mays | 1983 |
Influence of high dietary cellulose on fecal glycosidases in experimental rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Feces; Glycoside Hydrolases; Male; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Factors influencing the mutagenic activity of the colon carcinogen 1,2-dimethylhydrazine in Salmonella typhimurium strain TA 1535 in vitro.
Topics: 1,2-Dimethylhydrazine; Animals; Biotransformation; Colonic Neoplasms; Dimethylhydrazines; Female; Methylhydrazines; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1984 |
Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carboxy-Lyases; Carcinogens; Cell Survival; Colonic Neoplasms; Dimethylhydrazines; DNA; Eflornithine; Humans; Methylhydrazines; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
The intestinal monoxygenase enzyme system in DMH-induced rat colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Methylhydrazines; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxygenases; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucose Dehydrogenase | 1984 |
An investigation into the mechanism of co-carcinogenesis of dietary cholesterol during the induction of colon cancer in rats by 1,2 dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogens; Cholesterol, Dietary; Colonic Neoplasms; Dimethylhydrazines; Female; Methylhydrazines; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Experimental colon neoplasia enhanced by extract of sperm (protamine).
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Colonic Polyps; Dimethylhydrazines; Female; Fluorouracil; Heparin; Male; Protamines; Rats; Rats, Inbred Strains; Spermatozoa | 1984 |
Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colonic Neoplasms; Dimethylhydrazines; Indomethacin; Intestinal Neoplasms; Neoplasm Transplantation; Rats; Rats, Inbred Strains | 1984 |
[An experimental model of cancer of the large intestine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Cholestyramine Resin; Colonic Neoplasms; Dimethylhydrazines; Female; Mice; Neoplasms, Experimental; Rectal Neoplasms | 1984 |
The role of histamine antagonists on the development of experimental cancer in the rat.
Topics: Animals; Cimetidine; Colonic Neoplasms; Dimethylhydrazines; Diphenhydramine; Neoplasm Staging; Rats; Rats, Inbred Strains | 1984 |
Mast cell accumulation in 1,2-dimethylhydrazine induced colon tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Mast Cells; Rats | 1984 |
[Chemoinduced early precancerous colonic lesions in rats].
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Methylhydrazines; Neoplasms, Experimental; Precancerous Conditions; Rats; Time Factors | 1984 |
[Thymidine kinase isozyme in DMH-induced colon tumor in rats].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Isoenzymes; Male; Rats; Rats, Inbred Strains; Thymidine Kinase | 1984 |
The effect of promoters on 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Female; Hyperplasia; Intestinal Mucosa; Male; Metaphase; Methylhydrazines; Mice; Mice, Inbred C57BL; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Vincristine | 1984 |
The relationship of colonic carcinogenesis and hepatic vascular tumors induced by subcutaneously injected-1,2-dimethylhydrazine dihydrochloride in specific pathogen free mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Germ-Free Life; Hemangioendothelioma; Hemangiosarcoma; Liver Neoplasms; Mice; Mice, Inbred BALB C | 1984 |
High-fat diet promotes and causes distal shift of experimental rat colonic cancer--beer and alcohol do not.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Alcohol Drinking; Animals; Beer; Carcinogens; Colonic Neoplasms; Diet; Dietary Fats; Dimethylhydrazines; Ethanol; Male; Rats; Rats, Inbred Strains | 1984 |
Differential susceptibility of AKR, C57BL/6J, and CF1 mice to 1,2-dimethylhydrazine-induced colonic tumor formation predicted by proliferative characteristics of colonic epithelial cells.
Topics: Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Disease Susceptibility; Female; Intestinal Mucosa; Methylhydrazines; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Inbred Strains; Time Factors | 1983 |
Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/Ha mice given 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disease Susceptibility; DNA; Guanine; Intestine, Large; Methylation; Methylhydrazines; Mice; Precancerous Conditions; Species Specificity; Time Factors | 1983 |
Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride.
Topics: 1,2-Dimethylhydrazine; Anal Gland Neoplasms; Animals; Cecal Neoplasms; Colonic Neoplasms; Diet; Dimethylhydrazines; Drug Synergism; Duodenal Neoplasms; Female; Intestinal Neoplasms; Kidney Neoplasms; Male; Methylhydrazines; Mice; Neoplasms, Vascular Tissue; Rectal Neoplasms; Vitamin E | 1983 |
Early histopathologic events to evolution of colon cancer in C57BL/6 and CF1 mice treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Histocytochemistry; Kinetics; Methylhydrazines; Mice; Mice, Inbred Strains; Mitotic Index; Mucins; Neoplasms, Experimental; Time Factors | 1983 |
Effect of 13 cis retinoic acid on early precancerous antigenic goblet-cell modifications and induction of cancer during 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Neoplasms; Isotretinoin; Methylhydrazines; Neoplasm Metastasis; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains; Tretinoin | 1983 |
BALB/c mice fed milk or beef protein: differences in response to 1,2-dimethylhydrazine carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cattle; Cocarcinogenesis; Colonic Neoplasms; Cytotoxicity, Immunologic; Diet; Dimethylhydrazines; Killer Cells, Natural; Male; Meat; Methylhydrazines; Mice; Mice, Inbred BALB C; Milk Proteins; Organ Size | 1983 |
Comparative study of the morphologic, histochemical, and proliferative changes induced in the large intestine of ICR/Ha and C57BL/Ha mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Female; Histocytochemistry; Intestine, Large; Male; Methylhydrazines; Mice; Mice, Inbred Strains; Mucins; Precancerous Conditions; Rectal Neoplasms; Sialomucins | 1983 |
Early precancerous modifications in the mucus of human and rat distal colon: a comparative immunohistologic study.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Humans; Intestinal Mucosa; Precancerous Conditions; Rats; Rats, Inbred Strains | 1983 |
Effects of specific active immunization on tumor recurrence following primary tumor resection in WF rats with 1,2-dimethylhydrazine-induced bowel cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Immunotherapy; Male; Neoplasm Recurrence, Local; Neoplasm Transplantation; Rats; Rats, Inbred Strains | 1984 |
Morphology and distribution of 1,2-dimethylhydrazine dihydrochloride-induced colon tumors and their relationship to gut-associated lymphoid tissue in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Aggregation; Colon; Colonic Neoplasms; Dimethylhydrazines; Lymphocytes; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1984 |
Cell proliferation in gastrointestinal carcinogenesis.
Topics: Animals; Autoradiography; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Dimethylhydrazines; Gastric Mucosa; Gastrointestinal Neoplasms; Humans; Hyperplasia; Intestinal Mucosa; Mice; Rats; Thymidine; Time Factors; Tritium | 1984 |
The relationship between intestinal hyperplasia and carcinogenesis.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Cell Division; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; Hyperplasia; Intestinal Mucosa; Intestine, Small; Male; Postoperative Complications; Rats; Rats, Inbred Strains; Rectal Neoplasms; Rectum | 1984 |
Modification of a transplantable colon tumor and immune responses in mice fed different sources of protein, fat and carbohydrate.
Topics: Adenocarcinoma; Animals; Antibody-Dependent Cell Cytotoxicity; Colonic Neoplasms; Dextrins; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Dimethylhydrazines; Immunity, Cellular; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Milk Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Phytohemagglutinins; Spleen; Sucrose; T-Lymphocytes | 1983 |
The immune status of the rat with carcinoma of the bowel.
Topics: 1,2-Dimethylhydrazine; Animals; B-Lymphocytes; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Immunocompetence; Leukocytes; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Time Factors | 1983 |
The influence of surgical transection and anastomosis on the rate of cell proliferation in the colonic epithelium of normal and DMH-treated rats.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelial Cells; Intestinal Fistula; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1983 |
Identification of carcinogens by measurement of cell-mediated immunity. IV. Antitumor immunity following perinatal exposure to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Cytotoxicity, Immunologic; Dimethylhydrazines; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Female; Fetus; Immunity, Cellular; Lymphocytes; Maternal-Fetal Exchange; Methylhydrazines; Pregnancy; Rats; Rats, Inbred F344 | 1983 |
[Tumors induced by 1,2-dimethylhydrazine in hybrid mice with the pituitary gland transplanted in the kidney].
Topics: 1,2-Dimethylhydrazine; Animals; Anus Neoplasms; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Hybridization, Genetic; Kidney; Liver Neoplasms; Mammary Neoplasms, Experimental; Methylhydrazines; Mice; Neoplasms, Experimental; Ovarian Neoplasms; Pituitary Gland; Pituitary Neoplasms; Prolactin; Uterine Neoplasms | 1983 |
Combination chemotherapy with 5-fluorouracil (5FU) and 1,3-bis(2-chloro-ethyl)-1-nitrosourea (BCNU) prolongs survival of rats with dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Carmustine; Colonic Neoplasms; Dimethylhydrazines; Female; Fluorouracil; Rats | 1983 |
Experimental cancer of the bowel in the Nb rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Female; Intestinal Polyps; Neoplasms, Experimental; Rats | 1983 |
Induction of colon mucosal beta-glucuronidase production as a mechanism for 1,2-dimethylhydrazine colon carcinogenesis.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Glucuronidase; Intestinal Mucosa; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1983 |
Changes in the intestinal microflora in association with colon tumorigenesis in rats treated with 1,2-dimethylhydrazine hydrochloride.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Enterobacteriaceae; Feces; Intestines; Male; Methylhydrazines; Methylnitronitrosoguanidine; Rats; Rats, Inbred Strains | 1983 |
[Strain differences in susceptibility of rat colon to 1,2-dimethyl-hydrazine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Methylhydrazines; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Effect of feeding fermented milk on the incidence of chemically induced colon tumors in rats.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Fermentation; Lactobacillus; Milk; Rats; Rats, Inbred F344; Streptococcus; Yogurt | 1983 |
[Production of experimental colonic cancer in dog. A comparative study of administrative methods of carcinogen].
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Dogs; Female; Lymphatic Metastasis; Male; Methylhydrazines; Methylnitronitrosoguanidine; Suppositories | 1983 |
Lectin histochemistry of 1,2-dimethylhydrazine-induced rat colon neoplasia.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Lectins; Male; Neoplasms, Experimental; Peanut Agglutinin; Plant Lectins; Rats; Rats, Inbred Strains; Wheat Germ Agglutinins | 1983 |
Effects of choledochojejunostomy with Roux-en-Y exclusion on dimethylhydrazine induced neoplasms in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Bile; Colonic Neoplasms; Common Bile Duct; Dimethylhydrazines; Female; Intestinal Neoplasms; Jejunum; Methods; Methylhydrazines; Rats; Rats, Inbred Strains | 1984 |
The effects of ascorbic acid and butylated hydroxyanisole in the chemoprevention of 1,2-dimethylhydrazine-induced large bowel neoplasms.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Administration, Oral; Animals; Anisoles; Ascorbic Acid; Butylated Hydroxyanisole; Colonic Neoplasms; Diet; Dimethylhydrazines; Female; Mice | 1984 |
Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats.
Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Female; Indomethacin; Methylhydrazines; Neoplasm Metastasis; Rats; Rats, Inbred F344 | 1984 |
Faecal mutagens and intestinal tumours in the dimethylhydrazine-injected rat.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Duodenal Neoplasms; Feces; Intestinal Neoplasms; Male; Methylhydrazines; Mutagenicity Tests; Mutagens; Rats | 1984 |
Morphological studies on the long-term organ culture of colonic mucosa from normal and dimethylhydrazine treated rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Methylhydrazines; Organ Culture Techniques; Precancerous Conditions; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Nuclear DNA content in dimethylhydrazine-induced colonic carcinoma and mucosal dysplasia in rats.
Topics: Animals; Carcinoma; Cell Nucleus; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Female; Intestinal Mucosa; Methylhydrazines; Rats | 1984 |
Selective inhibition of replicative and repair DNA synthesis in mouse colon following administration of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Caffeine; Colonic Neoplasms; Digestive System; Dimethylhydrazines; DNA; DNA Repair; DNA Replication; Drug Interactions; Female; Gastrointestinal Neoplasms; Injections, Intraperitoneal; Methylhydrazines; Mice | 1984 |
Differential effects of surgical suture materials in 1,2-dimethylhydrazine-induced rat intestinal neoplasia.
Topics: Animals; Cecal Neoplasms; Cecum; Chromium; Colon; Colonic Neoplasms; Dimethylhydrazines; Feces; Glucuronidase; Iron; Male; Polymers; Rats; Rats, Inbred Strains; Sutures | 1984 |
Effect of long-term metronidazole (MTZ) therapy on experimental colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; Drug Evaluation, Preclinical; Male; Metronidazole; Rats; Rats, Inbred Strains; Time Factors | 1984 |
The effect of cholecystectomy on the induction of colorectal tumors in mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma; Cholecystectomy; Colonic Neoplasms; Dimethylhydrazines; Female; Methylhydrazines; Mice; Rectal Neoplasms | 1984 |
Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Drinking; Eating; Indomethacin; Liver Neoplasms; Lymphatic Metastasis; Male; Meclofenamic Acid; Peritoneal Neoplasms; Prostaglandin Antagonists; Rats; Rats, Inbred Strains | 1984 |
Inhibition of experimental colorectal cancer by razoxane (ICRF-159).
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Administration Schedule; Female; Piperazines; Random Allocation; Rats; Rats, Inbred Strains; Razoxane; Rectal Neoplasms | 1984 |
Aldrin epoxidase and dimethylhydrazine demethylase activities in tumorous and non-tumorous tissue of the human colon and rectum.
Topics: Adenocarcinoma; Aldrin; Biotransformation; Colonic Neoplasms; Dimethylhydrazines; Epoxide Hydrolases; Female; Humans; Intestinal Mucosa; Liver; Male; Oxidoreductases, N-Demethylating; Rectal Neoplasms | 1984 |
Is the changing pattern of colorectal cancer caused by selenium deficiency?
Topics: Animals; Colonic Neoplasms; Diet; Dimethylhydrazines; Fluorides; Humans; Mice; New Zealand; Rats; Rectal Neoplasms; Risk; Selenium; United Kingdom; United States; Zinc | 1984 |
Carcinogenesis at colonic anastomotic sites. An animal study.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Neoplasm Recurrence, Local; Rats; Rats, Inbred Strains; Sutures | 1984 |
Studies on experimental colon tumorigenesis in rats. 1. Strain differences in incidence, location and tumor types of 1, 2-dimethylhydrazine-induced tumors.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Female; Incidence; Male; Methylhydrazines; Neoplasm Metastasis; Rats; Rats, Inbred Strains; Species Specificity | 1981 |
Identification of carcinogens by measurement of cell-mediated immunity. I. Immunity induced by rat pancreas and colon carcinogens.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cells, Cultured; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Dimethylhydrazines; Dose-Response Relationship, Drug; Immunity, Cellular; Methylhydrazines; Neoplasms, Radiation-Induced; Pancreatic Neoplasms; Rats | 1980 |
Antibody-dependent cell cytotoxicity in chemical-induced rat pancreas and colon cancer.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Antibody-Dependent Cell Cytotoxicity; Colonic Neoplasms; Dimethylhydrazines; Male; Neoplasms, Experimental; Pancreatic Neoplasms; Rats; Rats, Inbred F344 | 1981 |
Interference with dimethylhydrazine induction of colon tumors in mice by epsilon-aminocaproic acid.
Topics: Adenocarcinoma; Aminocaproates; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Methylhydrazines; Mice; Neoplasms, Experimental; Plasminogen; Plasminogen Activators; Plasminogen Inactivators; Protein Binding | 1982 |
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitrosamine; Fluorouracil; Male; Methylhydrazines; Neoplasms, Experimental; Nitrosourea Compounds; Phenylurea Compounds; Rats; Rats, Inbred Strains; Tegafur | 1982 |
[Anticancer effect of levamisole and tegafur on 1,2-dimethylhydrazine (DMH)-induced colonic cancers in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Fluorouracil; Levamisole; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tegafur | 1982 |
Metabolic activation of DMH by colonic microsomes: a process influenced by type of dietary fat.
Topics: 1,2-Dimethylhydrazine; Animals; Bacillus subtilis; Biotransformation; Colon; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Fats, Unsaturated; Male; Methylhydrazines; Microsomes; Mucous Membrane; Mutagens; Rats; Rats, Inbred Strains | 1982 |
Effects of small bowel transection, resection, or bypass in 1,2-dimethylhydrazine-induced rat intestinal neoplasia.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Feces; Gastrointestinal Motility; Glucuronidase; Intestinal Neoplasms; Intestine, Small; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Development and cell kinetics of colonic tumors induced in mice by dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Autoradiography; Carcinoma; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1983 |
A scanning electron microscopy study of changes in the colonic mucus layer during chemical carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains | 1983 |
Selenium inhibition of 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Erythrocyte Count; Hematocrit; Leukocyte Count; Male; Methylhydrazines; Rats; Rats, Inbred Strains; Selenium | 1983 |
Polyamines in colorectal cancer--a clinical and experimental approach.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Humans; Male; Neoplasms, Experimental; Polyamines; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1983 |
Effect of Konjac mannan on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in Fischer 344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Intestinal Neoplasms; Intestine, Small; Male; Mannans; Methylhydrazines; Neoplasms, Experimental; Polysaccharides; Rats; Rats, Inbred F344 | 1983 |
[Induced intestinal tumor development in mice following truncal vagotomy].
Topics: Animals; Cholecystectomy; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Female; Methylhydrazines; Mice; Neoplasms, Experimental; Time Factors; Vagotomy | 1983 |
Chemotherapy of chemically-induced colorectal tumours.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Female; Fluorouracil; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1983 |
Metabolism of the carcinogen 1,2-dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Biotransformation; Carcinogens; Cells, Cultured; Colon, Sigmoid; Colonic Neoplasms; Dimethylhydrazines; Female; Humans; Hydrocortisone; Intestinal Mucosa; Male; Methylhydrazines; Middle Aged; Mixed Function Oxygenases; Phenobarbital | 1983 |
Effect of alterations in the quality and quantity of dietary fat on 1,2-dimethylhydrazine-induced colon tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diet; Dietary Fats; Dimethylhydrazines; Energy Intake; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1983 |
Modification of the carcinogenic process in colorectal cancer by endogenous and exogenous factors: effect of colestipol hydrochloride on tumors induced by dimethylhydrazine.
Topics: Animals; Carcinogens; Cocarcinogenesis; Colestipol; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Mice; Polyamines; Rectal Neoplasms | 1983 |
Morphometric study of the rat duodenal epithelium during the initial six months of 1,2-dimethylhydrazine carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Duodenum; Epithelial Cells; Epithelium; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1983 |
Effect of a protein-bound polysaccharide preparation, PS-K, on dimethyl hydrazine induction of intestinal tumors in rats.
Topics: Animals; Antibiotics, Antineoplastic; Colonic Neoplasms; Dimethylhydrazines; Intestinal Neoplasms; Male; Methylhydrazines; Neoplasms, Experimental; Proteoglycans; Rats; Rats, Inbred Strains | 1983 |
Gut-associated lymphoid tissue and dimethylhydrazine-induced colorectal carcinoma in the Wistar/Furth rat.
Topics: Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Intestines; Lymphoid Tissue; Male; Methylhydrazines; Neoplasm Invasiveness; Rats; Rats, Inbred WF; Rectal Neoplasms; Time Factors | 1983 |
Experimental colon cancer in the absence of intestinal contents in Sprague-Dawley rats.
Topics: Adenocarcinoma; Animals; Bile Acids and Salts; Colon; Colonic Neoplasms; Dimethylhydrazines; Neoplasms, Experimental; Rats | 1980 |
Carcinogenic effects of combined treatment of inbred mice with 3-methylcholanthrene and 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Interactions; Leukemia, Experimental; Lung Neoplasms; Methylcholanthrene; Methylhydrazines; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1980 |
Superoxide dismutase activity in 1,2-dimethylhydrazine-induced rat colon adenocarcinoma.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Male; Neoplasms, Experimental; Nitroblue Tetrazolium; Rats; Superoxide Dismutase | 1980 |
Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Administration Schedule; Female; Hyperplasia; Intestinal Mucosa; Methylhydrazines; Mice; Neoplasms, Experimental; Precancerous Conditions; Time Factors | 1981 |
Effect of antibiotics on incidence of rat intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride.
Topics: Animals; Anti-Bacterial Agents; Biotransformation; Colonic Neoplasms; Dimethylhydrazines; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1981 |
The immune response to carcinoma of the colon in a rat model: a temporal study.
Topics: Animals; Carcinoma; Cell Migration Inhibition; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Dimethylhydrazines; Disease Models, Animal; Leukocytes; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1981 |
Surgical resection of the rat colon: effects on carcinogenesis by 1,2-dimethylhydrazine.
Topics: Animals; Colectomy; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1982 |
Kinetic properties of thymidine kinase from the cytosol of a rat colon adenocarcinoma.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Cytosol; Dimethylhydrazines; Female; Kinetics; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred F344; Thymidine Kinase | 1982 |
Modulation of immunological competence in 1,2-dimethylhydrazine-sensitive SWR/J mice during colorectal carcinogenesis.
Topics: Adenocarcinoma; Animals; B-Lymphocytes; Colonic Neoplasms; Dimethylhydrazines; Hyperplasia; Immunocompetence; Male; Methylhydrazines; Mice; Neoplasm Invasiveness; Rectal Neoplasms; T-Lymphocytes; Time Factors | 1980 |
Enhanced growth of colon carcinoma isografts in rats concurrently receiving organ allografts.
Topics: Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Heart Transplantation; Neoplasm Transplantation; Rats; Rats, Inbred BN; Time Factors; Transplantation Immunology | 1981 |
Effects of sublethal irradiation on changes in crypts of the mouse colon during treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Autoradiography; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Methylhydrazines; Mice; Neoplasms, Experimental; Precancerous Conditions; Time Factors; Whole-Body Irradiation | 1982 |
Cloning and screening of sequences expressed in a mouse colon tumor.
Topics: Animals; Cell Transformation, Neoplastic; Clone Cells; Colonic Neoplasms; Dimethylhydrazines; Gene Expression Regulation; Hybrid Cells; Kidney; Kinetics; Liver; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Plasmids | 1982 |
Dimethylhydrazine-induced colonic neoplasia: dissociation from endogenous gastrin levels.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Gastric Fundus; Gastrins; Male; Neoplasms, Experimental; Pyloric Antrum; Rats | 1982 |
Ultrastructural alterations in the colonic mucus layer during carcinogenesis : a scanning electron microscopy study.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Humans; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1982 |
Dietary cholesterol deprivation improves survival and reduces incidence of metastatic colon cancer in dimethylhydrazine-pretreated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cholesterol, Dietary; Colonic Neoplasms; Dimethylhydrazines; Female; Neoplasms, Experimental; Rats | 1982 |
Effect of bile acids on 1,2-dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Feces; Female; Ileum; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1982 |
Studies on experimental colon tumorigenesis in rats. 2. Cell kinetics of the colon epithelium and its relation to histogenesis of colon tumors.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Female; Kinetics; Male; Methylhydrazines; Mitotic Index; Neoplasms, Experimental; Rats; Rats, Inbred WF | 1982 |
The assessment of response of murine transplantable colon tumors to combination chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carmustine; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Drug Therapy, Combination; Fluorouracil; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Semustine | 1982 |
Morphogenesis of colonic adenomas in mice treated with N,N'-dimethylhydrazine dihydrochloride.
Topics: Adenoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Intestinal Mucosa; Mice; Mice, Inbred ICR; Neoplasms, Experimental | 1982 |
Significance of the labeling index and labeling distribution as kinetic parameters in colorectal mucosa of cancer patients and DMH treated animals.
Topics: Adenoma; Animals; Carcinoma; Colon; Colonic Neoplasms; Dimethylhydrazines; Humans; Intestinal Mucosa; Kinetics; Mice; Mitotic Index; Neoplasms, Experimental; Rats; Rectal Neoplasms | 1982 |
Strain differences in susceptibility of female mice to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Anal Gland Neoplasms; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Methylhydrazines; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Ovarian Neoplasms; Species Specificity; Uterine Neoplasms | 1982 |
Region-specific patterns of mucin reaction demonstrated by paradoxical concanavalin A-staining in normal colonic epithelium and in colorectal cancers induced in rats by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Concanavalin A; Dimethylhydrazines; Epithelium; Histocytochemistry; Intestinal Mucosa; Male; Mucins; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1982 |
Experimental colitis as a promoter in large-bowel tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Acetates; Adenocarcinoma; Adenoma; Animals; Colitis; Colonic Neoplasms; Dimethylhydrazines; Disease Susceptibility; Enema; Intestinal Mucosa; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Effects of fecal stream on experimental colorectal carcinogenesis. Morphologic and histochemical changes.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Feces; Female; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1982 |
Effect of dietary sodium ascorbate on 1,2-dimethylhydrazine- or methylnitrosourea-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Colonic Neoplasms; Diet; Dimethylhydrazines; Female; Methylhydrazines; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1982 |
[Morphogenesis of experimental cancer of the large intestine (according to the results of scanning electron and light microscopy)].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Hybridization, Genetic; Hyperplasia; Intestinal Polyps; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microscopy, Electron, Scanning; Rats | 1982 |
[Experimental colonic cancer induced by 1,2-dimethylhydrazine (DMH). Especially, emphasis on sequential observations by endoscopy and X-ray].
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Colonoscopy; Dimethylhydrazines; Male; Methylhydrazines; Neoplasms, Experimental; Radiography; Rats; Rats, Inbred Strains | 1982 |
Subtotal colectomy in the dimethylhydrazine-treated rat. A surgical model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colectomy; Colonic Neoplasms; Dimethylhydrazines; Female; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1982 |
[Pathological studies on rat colonic tumors induced by 1,2-dimethylhydrazine and N-Methyl-N'-Nitro-N-Nitrosoguanidine, with special reference to aging factors of animals, different carcinogen administration, and histogenesis of developed tumors].
Topics: Aging; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Methylhydrazines; Neoplasms, Experimental; Nitrosoguanidines; Rats; Rats, Inbred Strains | 1982 |
Colon carcinogenesis and the role of dehydrogenase enzyme activity: inhibition of tumorigenesis by pyrazole.
Topics: Animals; Biotransformation; Colonic Neoplasms; Dimethylhydrazines; Intestinal Neoplasms; Methylazoxymethanol Acetate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neoplasms, Experimental; Organ Specificity; Pyrazoles; Rats | 1980 |
Potentiation of dimethylhydrazine bowel carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; FANFT; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Urinary Bladder Neoplasms; Urinary Diversion | 1981 |
Induction of colon tumors by a single oral dose of 1,2-dimethylhydrazine.
Topics: Administration, Oral; Animals; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1980 |
Evidence for a defective mitochondrial membrane in 1,2-dimethylhydrazine-induced colon adenocarcinoma in rat: enhanced lipid peroxidation potential in vitro.
Topics: Adenocarcinoma; Animals; Cell Membrane; Colonic Neoplasms; Dimethylhydrazines; Lipid Peroxides; Male; Mitochondria; Rats | 1980 |
Metachronous carcinomas of the large and small bowel.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Diet; Dimethylhydrazines; Humans; Neoplasms, Experimental; Rats | 1980 |
Relationship of colonic mucosal background to neoplastic proliferative activity in dimethylhydrazine-treated mice.
Topics: 1,2-Dimethylhydrazine; Animals; Bacterial Vaccines; Cell Division; Citrobacter; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Male; Methylhydrazines; Mice; Mitotic Index; Thymidine | 1981 |
Effects of 1,2-symmetrical dimethylhydrazine on jejunocolic transposition in Sprague-Dawley rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Hyperplasia; Injections, Subcutaneous; Intestinal Mucosa; Jejunal Neoplasms; Male; Methylhydrazines; Microscopy, Electron; Rats | 1981 |
Changes in tumor-specific nuclear antigen activity in carcinogen-treated colon by tumor promoter and carcinogen inhibitors.
Topics: Animals; Antigens, Neoplasm; Barbiturates; Butylated Hydroxytoluene; Cell Nucleus; Chromatin; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Male; Methylhydrazines; Precancerous Conditions; Rats | 1981 |
Effects of dietary fat on incidence of spontaneous and induced cancer in mice.
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Energy Intake; Fatty Acids, Unsaturated; Female; Liver Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H | 1981 |
Dietary fat, immunological response, and cancer in rats.
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Susceptibility; Immunocompetence; Lipid Metabolism; Lipids; Lymphocytes; Male; Neoplasms, Experimental; Rats; Sterols | 1981 |
Further studies on the carcinogenesis of the colon of the rat with special reference to the absence of intestinal contents.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Neoplasms, Experimental; Rats | 1981 |
The effects of cholic acid and bile salt binding agents on 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat.
Topics: 1,2-Dimethylhydrazine; Aluminum Hydroxide; Animals; Bile Acids and Salts; Body Weight; Cholestyramine Resin; Cholic Acids; Colonic Neoplasms; Dimethylhydrazines; Methylhydrazines; Neoplasm Metastasis; Neoplasms, Experimental; Rats | 1981 |
Experimental evidence against the bile salt theory of colon carcinogenesis.
Topics: Aluminum Hydroxide; Animals; Bile Acids and Salts; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Female; Rats; Rats, Inbred Strains | 1981 |
Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Cell Count; Blood Proteins; Colonic Neoplasms; Diet; Dimethylhydrazines; Glutathione Peroxidase; Liver; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Selenium; Time Factors | 1981 |
Effect of inhibitors of tumorigenesis on the formation of O6-methylguanine in the colon of 1,2-dimethylhydrazine-treated rats.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; DNA; Guanine; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1981 |
Effect of retinoids on the induction of colon cancer in F344 rats by N-methyl-N-nitrosourea or by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Interactions; Endoscopy; Male; Methylhydrazines; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Time Factors; Vitamin A | 1981 |
Experimental colon carcinogenesis is facilitated by endogenous factors in the intestinal contents.
Topics: Adenoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Feces; Female; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Rectum | 1981 |
Effects of colonic ligation on the carcinogenesis by 1,2-dimethylhydrazine dihydrochloride in Balb/C mice.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Ligation; Methylhydrazines; Mice; Mice, Inbred BALB C; Neoplasms, Experimental | 1981 |
Glucose increases experimentally induced colorectal cancer: a preliminary report.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Glucose; Male; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1981 |
Preneoplastic changes in epithelium and mesenchyme in colon of rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Basement Membrane; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Female; Methylhydrazines; Microscopy, Electron; Precancerous Conditions; Rats; Rats, Inbred Strains | 1981 |
Androgen receptors in chemically-induced colon carcinogenesis.
Topics: Animals; Castration; Colonic Neoplasms; Dihydrotestosterone; Dimethylhydrazines; Female; Male; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Ovary; Rats; Receptors, Androgen; Receptors, Steroid; Testis | 1980 |
Neural control of colonic cell proliferation.
Topics: Animals; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Histamine; Male; Mitosis; Neoplasms, Experimental; Rats; Serotonin; Sympathetic Nervous System; Sympatholytics; Sympathomimetics | 1980 |
Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice.
Topics: Animals; Colonic Neoplasms; Diet; Dimethylhydrazines; Male; Methylhydrazines; Mice; Neoplasms, Experimental; Rectal Neoplasms; Vitamin E | 1980 |
1-2 Dimethylhydrazine induced colonic tumours in rats.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Polyps; Methylhydrazines; Neoplasms, Experimental; Precancerous Conditions; Rats | 1980 |
Differences in colonic nuclear proteins of two mouse strains with different susceptibilities to 1, 2-dimethylhydrazine-induced carcinogenesis.
Topics: Animals; Cell Nucleus; Chromosomal Proteins, Non-Histone; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Isoelectric Point; Mice; Mice, Inbred Strains; Molecular Weight; Neoplasms, Experimental | 1980 |
A comparison of [3H]galactose and [3H]fucose uptake with the morphological and histochemical changes observed in mucous secretion in chemically induced rat colonic carcinoma.
Topics: Animals; Carcinoma in Situ; Colonic Neoplasms; Dimethylhydrazines; Female; Fucose; Galactose; Intestinal Mucosa; Mucus; Neoplasms, Experimental; Rats | 1980 |
Differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Susceptibility; Injections, Subcutaneous; Methylhydrazines; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Rectal Neoplasms | 1980 |
Colonic tumorigenesis in rats with 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma, Squamous Cell; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Duodenal Neoplasms; Ear Neoplasms; Injections, Subcutaneous; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1980 |
[Experimental contribution to the etiology of colorectal carcinomas in the rat. Surgical technique and chronic administration of 1,2-dimethylhydrazine (author's transl)].
Topics: Animals; Colectomy; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rectal Neoplasms | 1980 |
Colon tumor specific nuclear antigen with potential as a pre-tumor diagnostic probe.
Topics: Animals; Antigens, Neoplasm; Cell Nucleus; Colon; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Male; Neoplasms, Experimental; Precancerous Conditions; Rats | 1980 |
A study of the effect of colotomy and mucosal field changes in experimental colon cancer.
Topics: Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Intestinal Mucosa; Male; Methods; Neoplasms, Experimental; Rats | 1980 |
Carcinogenicity of 1,2-dimethylhydrazine dihydrochloride in mice.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Hemangioma; Male; Methylhydrazines; Mice; Mice, Inbred BALB C; Neoplasms, Experimental | 1980 |
Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
Topics: Animals; Cell Cycle; Colonic Neoplasms; Dimethylhydrazines; Female; Mitosis; Mitotic Index; Neoplasms, Experimental; Rats; Time Factors | 1980 |
Modification of early dimethylhydrazine carcinogenesis by colonic mucosal hyperplasia.
Topics: Animals; Citrobacter; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Enterobacteriaceae Infections; Hyperplasia; Intestinal Mucosa; Methylhydrazines; Mice; Neoplasms, Experimental | 1980 |
Cholecystectomy has no influence on frequency of chemically induced colonic cancer in mice.
Topics: Animals; Cholecystectomy; Colonic Neoplasms; Dimethylhydrazines; Female; Mice | 1980 |
Confirmation of the two-step nature of chemical carcinogenesis in the rat colon adenocarcinoma model.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Male; Models, Biological; Neoplasms, Experimental; Rats; Time Factors | 1981 |
Assessment of the nucleolar organizer regions by automated image analysis in benign and malignant colonic tumours and adjacent tissues in rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Colonic Polyps; Dimethylhydrazines; Image Processing, Computer-Assisted; Nucleolus Organizer Region; Rats; Rats, Sprague-Dawley; Silver Staining | 1995 |
[Interference of selenium germanium and calcium in carcinogenesis of colon cancer].
Topics: Animals; Antineoplastic Agents; Calcium; Carcinogens; Carcinoma, Papillary; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Germanium; Male; Organometallic Compounds; Propionates; Rats; Rats, Wistar; Selenium | 1995 |
Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice.
Topics: 1,2-Dimethylhydrazine; Alleles; Amino Acid Sequence; Animals; Base Sequence; Chromosome Deletion; Colonic Neoplasms; Dimethylhydrazines; Genes, p53; Humans; Hybridization, Genetic; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation | 1995 |
Induction of aberrant crypts in murine colon with varying sensitivity to colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Mice; Mice, Inbred Strains; Predictive Value of Tests; Sensitivity and Specificity; Species Specificity | 1995 |
[Inhibitive effects of spirulina on aberrant crypts in colon induced by dimethylhydrazine].
Topics: Animals; Antineoplastic Agents, Phytogenic; beta Carotene; Carotenoids; Colonic Neoplasms; Dimethylhydrazines; Eukaryota; Male; Mice; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Vitamin E | 1995 |
Sarcomatous lesions in CBA female mice treated with 1,2-dimethylhydrazine: independent primaries or metastases?
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Estradiol; Female; Incidence; Mice; Mice, Inbred CBA; Mutagens; Sarcoma; Stomach Neoplasms; Uterine Neoplasms | 1995 |
Influence of different diets on development of DMH-induced aberrant crypt foci and colon tumor incidence in Wistar rats.
Topics: Animals; Colon; Colonic Neoplasms; Dextrins; Diet; Dietary Carbohydrates; Dietary Fiber; Dimethylhydrazines; Male; Precancerous Conditions; Rats; Sucrose | 1995 |
[A model for sensitivity determination of anticancer agents against chemical-induced colon cancer in rats].
Topics: Animals; Camptothecin; Cell Division; Cisplatin; Colonic Neoplasms; Dimethylhydrazines; Drug Screening Assays, Antitumor; Irinotecan; Male; Rats; Rats, Sprague-Dawley | 1995 |
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; CDX2 Transcription Factor; Colon; Colonic Neoplasms; Dimethylhydrazines; Homeodomain Proteins; Humans; Immunohistochemistry; Intestinal Mucosa; Male; Neoplasm Invasiveness; Rats; Rats, Sprague-Dawley; Rectal Neoplasms; Reference Values; Trans-Activators | 1995 |
Ulex europeus agglutinin I binding pattern during chemical carcinogenesis in the rat gastrointestinal tract.
Topics: Animals; Biomarkers, Tumor; Colon; Colonic Neoplasms; Dimethylhydrazines; Duodenum; Fluoresceins; Indoles; Intestinal Mucosa; Lectins; Male; Plant Lectins; Precancerous Conditions; Rats; Rats, Wistar; Staining and Labeling | 1993 |
Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Mucins; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1995 |
Difference in histology and size in colonic tumors of rats receiving two different carcinogens.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Glutamic Acid; Male; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1994 |
Cruciferous vegetables and glutathione: their effects on colon mucosal glutathione level and colon tumor development in rats induced by DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Brassica; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Glutathione; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Solanum tuberosum; Vegetables | 1995 |
Non-promoting effects of lean beef in the rat colon carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adipose Tissue; Animals; Carcinogens; Cattle; Colonic Neoplasms; Cooking; Diet; Dietary Fats; Dietary Proteins; Dimethylhydrazines; Female; Humans; Male; Meat; Random Allocation; Rats; Rats, Sprague-Dawley; Risk Factors | 1995 |
Genetic analysis of colon cancer susceptibility in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazines; Disease Models, Animal; Disease Progression; Genetic Markers; Genetic Predisposition to Disease; Humans; Lod Score; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Molecular Sequence Data; Polymerase Chain Reaction; Sequence Homology, Nucleic Acid; Species Specificity | 1994 |
Induction of colon adenocarcinomas in rats fed trypsin and tamoxifen diets by parenteral and intragastric 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diet; Dimethylhydrazines; Gastric Lavage; Infusions, Parenteral; Male; Rats; Rats, Sprague-Dawley; Survival Rate; Tamoxifen; Trypsin | 1994 |
[Inhibitory effects of OK-432 administered orally on colon carcinoma induced by DMH in rats].
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Colonic Neoplasms; Cytotoxicity, Immunologic; Dimethylhydrazines; Killer Cells, Natural; Male; Picibanil; Rats; Rats, Sprague-Dawley | 1994 |
Effect of iron deficiency on DMH-induced gastrointestinal tract tumors and occurrence of hepatocyte abnormalities in Fischer rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Duodenal Neoplasms; Incidence; Iron Deficiencies; Liver; Male; Rats; Rats, Inbred F344 | 1994 |
Effects of 2.45-GHz microwave radiation and phorbol ester 12-O-tetradecanoylphorbol-13-acetate on dimethylhydrazine-induced colon cancer in mice.
Topics: Adenomatous Polyps; Animals; Carcinoma; Cocarcinogenesis; Colonic Neoplasms; Colonic Polyps; Dimethylhydrazines; Female; Male; Mice; Mice, Inbred BALB C; Microwaves; Neoplasms, Radiation-Induced; Radiation Dosage; Tetradecanoylphorbol Acetate | 1994 |
Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Cholesterol; Colonic Neoplasms; Dimethylhydrazines; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Mice, Inbred ICR; Pravastatin; Simvastatin | 1994 |
Early stages of 1,2-dimethylhydrazine-induced colon carcinogenesis suppress immune-regulated ion transport of mouse distal colon.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Antigens, Helminth; Child; Colon; Colonic Neoplasms; Dimethylhydrazines; Dinoprostone; DNA Damage; Humans; Ion Transport; Jejunum; Methylation; Mice; Serotonin; Trichinella spiralis; Trichinellosis | 1994 |
Bombesin enhances experimental carcinogenesis induced in rat colon by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Bombesin; Carcinogens; Cell Division; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Intestinal Mucosa; Male; Rats; Rats, Inbred F344; Stimulation, Chemical | 1994 |
Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cell Cycle; Cell Division; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Hyperplasia; Immunohistochemistry; Lymphoid Tissue; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha | 1994 |
Scanning electron microscopy of aberrant crypt foci in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Evaluation Studies as Topic; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Precancerous Conditions; Rats; Rats, Inbred F344 | 1994 |
Aspirin reduces the incidence of colonic carcinoma in the dimethylhydrazine rat animal model.
Topics: Animals; Aspirin; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar | 1994 |
Flat adenoma-adenocarcinoma sequence in the colon of rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley | 1994 |
Promoting and synergistic effects of chrysazin on 1,2-dimethylhydrazine-induced carcinogenesis in male ICR/CD-1 mice.
Topics: 1,2-Dimethylhydrazine; Animals; Anthraquinones; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred ICR; Mutagens; Ornithine Decarboxylase | 1994 |
Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Choristoma; Colonic Neoplasms; Dimethylhydrazines; Intestinal Diseases; Intestine, Large; Lymphoid Tissue; Male; Mice; Rats | 1994 |
Colonoscopic colostomy model in rats for colon tumorigenesis studies.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Colonoscopy; Colostomy; Dimethylhydrazines; Disease Models, Animal; Male; Methylazoxymethanol Acetate; Rats; Rats, Inbred F344 | 1994 |
Influence of a dietary fiber on development of dimethylhydrazine-induced aberrant crypt foci and colon tumor incidence in Wistar rats.
Topics: Animals; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Intestinal Mucosa; Male; Rats; Rats, Wistar | 1994 |
Estrogen modification of 1,2-dimethylhydrazine carcinogenesis in C3HA mice.
Topics: 1,2-Dimethylhydrazine; Animals; Cholangiocarcinoma; Colonic Neoplasms; Dimethylhydrazines; Estradiol; Female; Liver Neoplasms; Mice; Mice, Inbred C3H; Ovarian Neoplasms; Sarcoma, Experimental; Skin Neoplasms; Uterine Neoplasms | 1994 |
The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Neoplasm; Carcinogens; Cell Division; Chi-Square Distribution; Cimetidine; Colonic Neoplasms; Dimethylhydrazines; Female; Immunoenzyme Techniques; Neoplasm Invasiveness; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley | 1993 |
The effect of misoprostol on colon cancer.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Humans; Mice; Mice, Nude; Misoprostol; Neoplasm Invasiveness; Random Allocation; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous; Tumor Cells, Cultured | 1994 |
Effect of aspirin on incidence and growth of aberrant crypt foci induced in the rat colon by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Aspirin; Body Weight; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Drug Interactions; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Effects of high corn oil diet on preneoplastic murine colons: prostanoid production and lipid composition.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Corn Oil; Dimethylhydrazines; Dinoprostone; Epoprostenol; Female; Intestinal Mucosa; Lipid Metabolism; Lipids; Mice; Mice, Inbred Strains; Precancerous Conditions; Prostaglandins; Thromboxane A2 | 1994 |
[A histogenetic study on the carcinogenesis of colonic mucous membrane glands induced by 1,2-dimethylhydrazine in rats].
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Hyperplasia; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1993 |
Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Administration, Oral; Animals; Carcinogens; Cell Division; Choristoma; Colonic Neoplasms; Dimethylhydrazines; Female; Mice; Sphingomyelins; Weight Gain | 1994 |
Failure of tripeptide colon mitosis inhibitor to suppress the cell proliferation of dimethylhydrazine-induced colonic cancers in rats.
Topics: Adenocarcinoma; Adenoma; Amino Acid Sequence; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Growth Inhibitors; Hyperplasia; Intestinal Mucosa; Male; Molecular Sequence Data; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 1993 |
Action of estrogen and adrenocorticoids on adenocarcinoma induction by 1,2-dimethylhydrazine in male rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Cortisone; Desoxycorticosterone; Dimethylhydrazines; Estradiol; Injections, Subcutaneous; Intestinal Neoplasms; Male; Peanut Oil; Plant Oils; Rats; Rats, Sprague-Dawley | 1993 |
Selenium and difluoromethylornithine additively inhibit DMH-induced distal colon tumor formation in rats fed a fiber-free diet.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Dimethylhydrazines; Drug Interactions; Eflornithine; Liver; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Sprague-Dawley; Reference Values; S-Adenosylmethionine; Selenium; Spermidine; Spermine | 1993 |
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Butylated Hydroxytoluene; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Gastrointestinal Neoplasms; Hydroquinones; Hyperplasia; Kidney; Kidney Neoplasms; Male; Methylnitronitrosoguanidine; Neoplasms, Experimental; Nitrosamines; Organ Size; Precancerous Conditions; Propyl Gallate; Rats; Rats, Inbred F344; Vitamin E | 1993 |
[Establishment of a transplantable rat colon cancer and a model of metastasis].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Liver Neoplasms; Lung Neoplasms; Neoplasm Transplantation; Peritoneal Neoplasms; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 1993 |
Pilot study on alcohol-induced chemonecrosis of hepatic metastases from colonic cancer. A new approach for percutaneous localized dynamic destruction of the hepatic spread.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Aged; Animals; Carcinogens; Colectomy; Colon; Colonic Neoplasms; Combined Modality Therapy; Dimethylhydrazines; Dose-Response Relationship, Drug; Ethanol; Female; Humans; Injections, Intralesional; Liver; Liver Neoplasms; Male; Middle Aged; Pilot Projects; Rats; Rats, Sprague-Dawley | 1993 |
[Influence of sodium butyrate intake on murine colonic carcinogenesis].
Topics: Animals; Butyrates; Butyric Acid; Colectomy; Colonic Neoplasms; Dimethylhydrazines; Feces; Male; Rats; Rats, Wistar; Sodium Chloride | 1993 |
Preventive effect of magnesium hydroxide on carcinogen-induced large bowel carcinogenesis in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Colon; Colonic Neoplasms; Dimethylhydrazines; Magnesium Hydroxide; Male; Methylazoxymethanol Acetate; Mitotic Index; Rats; Rats, Inbred F344 | 1993 |
The growth of preneoplastic lesions by 1,2-dimethylhydrazine in rat colon is inhibited by dietary starch.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Diet; Dietary Carbohydrates; Dimethylhydrazines; Female; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Starch; Sucrose | 1993 |
No allelic loss at the p53 locus in 1,2-dimethylhydrazine-induced mouse colon tumours: PCR-SSCP analysis with sequence-tagged microsatellite site primers.
Topics: 1,2-Dimethylhydrazine; Alleles; Animals; Base Sequence; Carcinogens; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazines; DNA, Satellite; Gene Deletion; Genes, p53; Mice; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Genetic; Sequence Tagged Sites | 1993 |
[Role in mucosal ornithine decarboxylase activity during dimethylhydrazine-induced colonic carcinogenesis in the rat].
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Ornithine Decarboxylase; Rats; Rats, Wistar | 1993 |
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Catechin; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Intestinal Neoplasms; Intestine, Small; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Models, Biological; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1993 |
The effect of the fiber components cellulose and lignin on experimental colon neoplasia.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cellulose; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Feces; Lignin; Rats; Rats, Sprague-Dawley | 1993 |
Butyrate production from dietary fibre and protection against large bowel cancer in a rat model.
Topics: Animals; Butyrates; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Disease Models, Animal; Edible Grain; Fermentation; Galactans; Male; Mannans; Plant Gums; Rats; Triticum | 1993 |
Effect of dietary vitamin D3 (cholecalciferol) on colon carcinogenesis induced by 1,2-dimethylhydrazine in male Fischer 344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Autoradiography; Bone Density; Calcifediol; Cholecalciferol; Colonic Neoplasms; Diet; Dimethylhydrazines; Male; Rats; Rats, Inbred F344 | 1993 |
Tumors produced in rats with a single dosage of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Injections, Subcutaneous; Kidney Neoplasms; Male; Pilot Projects; Rats; Rats, Sprague-Dawley; Wilms Tumor | 1993 |
Effects of high-fiber diets on pathological changes in DMH-induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Male; Rats; Rats, Sprague-Dawley | 1993 |
Influence of dietary calcium and vitamin D on colon epithelial cell proliferation and 1,2-dimethylhydrazine-induced colon carcinogenesis in rats fed high fat diets.
Topics: 1,2-Dimethylhydrazine; Animals; Autoradiography; Body Weight; Calcifediol; Calcium, Dietary; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Epithelial Cells; Epithelium; Male; Phosphorus; Rats; Rats, Inbred F344; Vitamin D | 1993 |
Effect of heat processing and of vegetables and fruit in human diets on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diet; Dimethylhydrazines; Fruit; Hot Temperature; Intestinal Neoplasms; Male; Rats; Rats, Wistar; Vegetables | 1993 |
Sulphated bile acid per se inhibits colonic carcinogenesis in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Administration, Oral; Administration, Rectal; Animals; Bile Acids and Salts; Carcinogens; Carcinoma, Squamous Cell; Cholic Acids; Colon; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Feces; Female; Germ-Free Life; Injections, Subcutaneous; Lithocholic Acid; Methylnitrosourea; Mice; Mice, Inbred ICR | 1993 |
The permissive role of oxygen-derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Free Radicals; Male; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 1993 |
Photo detection of carcinoma of the colon in a rat model: a pilot study.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma in Situ; Colonic Neoplasms; Dihematoporphyrin Ether; Dimethylhydrazines; Fluorescence; Photography; Pilot Projects; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Effects of kampo (Japanese herbal) medicine "sho-saiko-to" on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced colonic carcinomas in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Dimethylhydrazines; DNA; Drugs, Chinese Herbal; Male; Rats; Thymidine Kinase; Thymidylate Synthase | 1993 |
Effects of menadione on 1,2-dimethylhydrazine-induced mouse colon adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Female; Intestinal Mucosa; Mice; Mice, Inbred ICR; Superoxide Dismutase; Vitamin K; Vitamin K 3 | 1993 |
Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Docosahexaenoic Acids; Male; Rats; Rats, Inbred F344 | 1993 |
Tissue and cell-specific patterns of expression of rat liver and intestinal fatty acid binding protein during development and in experimental colonic and small intestinal adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carrier Proteins; Colon; Colonic Neoplasms; Dimethylhydrazines; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Humans; Intestinal Neoplasms; Intestine, Small; Male; Neoplasm Proteins; Nerve Tissue Proteins; Phenotype; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Neoplasm; Tumor Suppressor Proteins | 1993 |
Non-homogeneous marking of distal colonic mucosa using Dolichos biflorus lectin.
Topics: 1,2-Dimethylhydrazine; Animals; Binding Sites; Biomarkers, Tumor; Carcinogens; Chimera; Colonic Neoplasms; Dimethylhydrazines; Endothelium, Vascular; Epithelium; Genetic Predisposition to Disease; Intestinal Mucosa; Lectins; Male; Mice; Mice, Inbred AKR; Mice, Inbred DBA; Mice, Inbred Strains; Phenotype; Plant Lectins; Polymorphism, Genetic; Precancerous Conditions; Receptors, Mitogen | 1995 |
Comparison of resistant starch with cellulose diet on 1,2-dimethylhydrazine-induced colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cecum; Cellulose; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Fatty Acids, Volatile; Feces; Male; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Starch | 1996 |
Effects of dietary fibre on dimethylhydrazine-induced changes in prostanoid concentrations in rat colonic mucosa.
Topics: 1,2-Dimethylhydrazine; 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Dinoprostone; Galactans; Injections, Subcutaneous; Intestinal Mucosa; Male; Mannans; Plant Gums; Prostaglandin D2; Prostaglandins; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 1995 |
Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromosome Mapping; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazines; Disease Susceptibility; Female; Genes, Tumor Suppressor; Genetic Linkage; Genetic Markers; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Recombination, Genetic | 1996 |
Effect of dairy products on initiation of precursor lesions of colon cancer in rats.
Topics: Animals; Bifidobacterium; Carcinogens; Cecum; Colonic Neoplasms; Dairy Products; Dimethylhydrazines; Glucuronidase; Hydrogen-Ion Concentration; Male; Microsomes, Liver; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1995 |
Unexpected antagonistic action of 3,2'-dimethyl-4-aminobiphenyl on aberrant crypt induction by 1,2-dimethylhydrazine or azoxymethane in rat colon.
Topics: 1,2-Dimethylhydrazine; Aminobiphenyl Compounds; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Inbred Lew | 1995 |
Primary monoclonal and secondary polyclonal growth of colon neoplastic lesions in C3H/HeN<-->BALB/c chimeric mice treated with 1,2-dimethylhydrazine immunohistochemical detection of C3H strain-specific antigen and simple sequence length polymorphism analy
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Carrier Proteins; Chimera; Colonic Neoplasms; Dimethylhydrazines; DNA; Female; HSP70 Heat-Shock Proteins; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred ICR; Molecular Sequence Data | 1996 |
Distribution of lymphoid nodules, aberrant crypt foci and tumours in the colon of carcinogen-treated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Lymphoid Tissue; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1996 |
Promotion of colon carcinogenesis through increasing lipid peroxidation induced in rats by a high cholesterol diet.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cholesterol; Cholesterol, Dietary; Cholic Acid; Cholic Acids; Cocarcinogenesis; Colon; Colonic Neoplasms; Depression, Chemical; Dimethylhydrazines; Glutathione Peroxidase; Hypercholesterolemia; Lipid Peroxidation; Lipids; Male; Peroxides; Rats; Rats, Sprague-Dawley | 1996 |
Different genetic susceptibility to aberrant crypts and colon adenomas in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazines; Disease Progression; Disease Susceptibility; Female; Genes, APC; Genes, ras; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Precancerous Conditions | 1996 |
Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes.
Topics: Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Cyclophosphamide; Cytosine Deaminase; Dimethylhydrazines; Disease Progression; Female; Fibrosarcoma; Gene Transfer Techniques; Genetic Vectors; Immunocompromised Host; Immunosuppressive Agents; Interleukin-6; Lung Neoplasms; Methylcholanthrene; Mice; Mice, Inbred C57BL; Nucleoside Deaminases; Tumor Cells, Cultured; Vaccines, Synthetic | 1996 |
Endogenous antioxidant status in neoplastic and adjacent tissues in 1,2-dimethylhydrazine-induced colon cancer in rats: effects of olsalazine.
Topics: 1,2-Dimethylhydrazine; Aminosalicylic Acids; Animals; Antioxidants; Colonic Neoplasms; Dimethylhydrazines; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase | 1996 |
Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Colonic Neoplasms; Deoxyguanosine; Dimethylhydrazines; Lipid Peroxidation; Male; Phosphatidylcholines; Plant Extracts; Rats; Rats, Sprague-Dawley; Tea | 1996 |
[Inhibition of colorectal carcinoma induced by 1, 2-dimethylhydrazine in mice with tea polyphenols].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Flavonoids; Free Radical Scavengers; Male; Mice; Mice, Inbred ICR; Phenols; Polymers; Polyphenols; Tea | 1995 |
The effect of Lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in the rat.
Topics: Animals; Body Weight; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Feces; Intestinal Neoplasms; Lacticaseibacillus casei; Male; Rats; Rats, Inbred F344 | 1996 |
The relationship between megacolon and carcinoma of the colon: an experimental approach.
Topics: 1,2-Dimethylhydrazine; Animals; Benzalkonium Compounds; Carcinogens; Chagas Disease; Colonic Neoplasms; Dimethylhydrazines; Male; Megacolon; Rats; Rats, Wistar | 1996 |
Epithelial cell proliferation during colonic chemical carcinogenesis in the rat.
Topics: Animals; Cell Division; Cells, Cultured; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Immunohistochemistry; Intestinal Mucosa; Male; Mitotic Index; Rats; Rats, Sprague-Dawley | 1996 |
Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Mice; Precancerous Conditions; Sphingomyelins | 1996 |
Lactobacillus- and bifidobacterium-mediated antigenotoxicity in the colon of rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Bifidobacterium; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA Damage; Immunohistochemistry; Lactobacillus; Lactobacillus acidophilus; Male; Methylnitronitrosoguanidine; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley | 1996 |
[Effect of melatonin on 1,2-dimethylhydrazine-induced intestinal tumors in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Neoplasms; Melatonin; Rats; Rats, Inbred Strains | 1996 |
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cathepsin B; Colonic Neoplasms; Dimethylhydrazines; Esters; Gabexate; Guanidines; Leupeptins; Male; Protease Inhibitors; Rats | 1996 |
Cyclosporin A enhances locoregional metastasis of the CC531 rat colon tumour.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Carcinogens; Colonic Neoplasms; Cyclosporine; Dimethylhydrazines; Doxorubicin; Drug Resistance, Neoplasm; Immunosuppressive Agents; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms | 1997 |
Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats.
Topics: Analysis of Variance; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Drug Administration Schedule; Folic Acid; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Dissimilar activation patterns of the carcinogen dimethylhydrazine (DMH) on intracellular polyamine metabolism in various organs.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Enzyme Activation; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Tissue Distribution | 1996 |
Suppression of preneoplastic changes in the intestine of rats fed low levels of polyamines.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Movement; Colon; Colonic Neoplasms; Dimethylhydrazines; Ileum; Intestinal Mucosa; Male; Polyamines; Precancerous Conditions; Putrescine; Rats; Rats, Wistar; Spermidine | 1997 |
Specific species of intestinal bacteria influence the induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteroides; Bifidobacterium; Carcinogens; Clostridium; Colonic Diseases; Colonic Neoplasms; Dimethylhydrazines; Enterococcus faecalis; Escherichia coli; Female; Germ-Free Life; Intestines; Male; Mutagens; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Administration of anti-asialo GM1 serum increases aberrant crypt foci induced by 1,2-dimethylhydrazine in the large bowel of rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; G(M1) Ganglioside; Immune Sera; Killer Cells, Natural; Precancerous Conditions; Rats; Rats, Wistar | 1996 |
Zinc deprivation promotes progression of 1,2-dimethylhydrazine-induced colon tumors but reduces malignant invasion in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Carcinoma in Situ; Collagenases; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Immunohistochemistry; Liver; Male; Matrix Metalloproteinase 9; Mice; Neoplasm Invasiveness; Organ Size; Zinc | 1997 |
Dietary sucrose and starch affect dysplastic characteristics in carcinogen-induced aberrant crypt foci in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dietary Sucrose; Dimethylhydrazines; Female; Intestinal Mucosa; Mucins; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Starch | 1997 |
Interaction of fiber and energy registration in experimental colon carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Energy Intake; Male; Rats; Rats, Inbred F344 | 1997 |
Chemopreventive efficacy of low dose of pravastatin, an HMG-CoA reductase inhibitor, on 1,2-dimethylhydrazine-induced colon carcinogenesis in ICR mice.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred ICR; Pravastatin; Water Supply | 1996 |
Lack of promotion of colon carcinogenesis by high-oleic safflower oil.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Eating; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phospholipids; Safflower Oil; Weight Gain | 1997 |
Monoclonal and polyclonal development of digestive tract tumors in chimeric mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carrier Proteins; Chimera; Colonic Neoplasms; Diethylnitrosamine; Digestive System Neoplasms; Dimethylhydrazines; HSP70 Heat-Shock Proteins; Immunohistochemistry; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Proteins; Precancerous Conditions; Stomach Neoplasms | 1997 |
Role of redchilli (Capsaicin) in the formation of colonic carcinoma.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Colonic Diseases; Colonic Neoplasms; Dimethylhydrazines; Male; Rats; Rats, Sprague-Dawley; Spices | 1997 |
Aspirin, but not sodium salicylate, indomethacin, or nabumetone, reversibly suppresses 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats.
Topics: 1,2-Dimethylhydrazine; 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; Dimethylhydrazines; Indomethacin; Male; Nabumetone; Rats; Rats, Sprague-Dawley; Sodium Salicylate | 1997 |
Murraya koenigii and Brassica juncea--alterations on lipid profile in 1-2 dimethyl hydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Brassica; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Lipid Metabolism; Male; Mustard Plant; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Spices | 1996 |
Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Diet; Dimethylhydrazines; Female; Mice; Milk; Precancerous Conditions; Sphingolipids; Sphingomyelins; Weight Gain | 1997 |
Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dimethylhydrazines; Genes, p53; Genes, ras; Male; Mutagens; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344 | 1997 |
Influence of diets containing high and low risk factors for colon cancer on early stages of carcinogenesis in human flora-associated (HFA) rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Biomarkers; Body Weight; Colon; Colonic Diseases; Colonic Neoplasms; Diet; Dimethylhydrazines; Disease Models, Animal; DNA; Female; Food, Formulated; Germ-Free Life; Humans; Intestinal Mucosa; Male; Mitotic Index; Precancerous Conditions; Rats; Rats, Inbred F344; Risk Factors | 1997 |
Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Intestinal Neoplasms; Melatonin; Rats | 1997 |
Development of oxygen insensitivity of the quantitative histochemical assay of G6PDH activity during colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Colon; Colonic Neoplasms; Colonic Polyps; Crohn Disease; Dimethylhydrazines; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Hyperplasia; Intestinal Mucosa; Mice; Mice, Mutant Strains; Oxygen; Precancerous Conditions; Predictive Value of Tests | 1997 |
The incidence of aberrant crypt foci and colonic carcinoma in dimethylhydrazine-treated rats varies in a site-specific manner and depends on tumor histology.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma; Cecal Neoplasms; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Rats; Rats, Wistar | 1997 |
Inhibition of dimethylhydrazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of the glucosinolate sinigrin.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Colonic Neoplasms; Dimethylhydrazines; Glucosinolates; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Precancerous Conditions; Rats; Rats, Wistar; Time Factors | 1998 |
A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Docosahexaenoic Acids; Eicosapentaenoic Acid; Male; Rats; Rats, Inbred F344 | 1998 |
A diet containing chickpeas and wheat offers less protection against colon tumors than a casein and wheat diet in dimethylhydrazine-treated rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carcinogens; Caseins; Cholesterol; Cohort Studies; Colonic Neoplasms; Dimethylhydrazines; Fabaceae; Fatty Acids, Volatile; Feces; Male; Nitrogen; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Triticum | 1998 |
Calcium inhibits colon carcinogenesis in an experimental model in the rat.
Topics: Animals; Body Weight; Calcium, Dietary; Colonic Neoplasms; Dimethylhydrazines; Edetic Acid; Female; Male; Neoplasm Transplantation; Rats; Rats, Sprague-Dawley | 1998 |
The protective effect of estrogen against chemically induced murine colon carcinogenesis is associated with decreased CpG island methylation and increased mRNA and protein expression of the colonic vitamin D receptor.
Topics: Animals; Carcinogens; Colonic Neoplasms; CpG Islands; Dimethylhydrazines; DNA Methylation; Estradiol; Estrogens; Female; Organ Size; Ovariectomy; Parathyroid Hormone; Rats; Receptors, Calcitriol; RNA, Messenger; Uterus | 1999 |
Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Calcium, Dietary; Carcinogens; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Disease Models, Animal; Folic Acid; Male; Random Allocation; Rats; Rats, Inbred F344 | 1999 |
The effect of red beet (Beta vulgaris var. rubra) fiber on alimentary hypercholesterolemia and chemically induced colon carcinogenesis in rats.
Topics: Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diet; Dietary Fiber; Dimethylhydrazines; Erythrocytes; Hypercholesterolemia; Lipid Metabolism; Lipids; Lipoproteins; Male; Rats; Rats, Wistar; Vegetables | 2000 |
Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats.
Topics: Animals; Carcinogens; Colon; Colonic Neoplasms; Copper; Diet; Dimethylhydrazines; Gene Expression; Isoenzymes; Liver; Male; Protein Kinase C; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2001 |
Predominant mutation of codon 41 of the beta-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol.
Topics: Animals; beta Catenin; Carcinogens; Codon; Colonic Neoplasms; Cytoskeletal Proteins; Dimethylhydrazines; DNA Primers; Genes, ras; Male; Mutation; Phosphorylation; Polymerase Chain Reaction; Proto-Oncogene Mas; Rats; Rats, Wistar; Trans-Activators | 2001 |
Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats.
Topics: Adenocarcinoma; Animals; Biological Assay; Biomarkers, Tumor; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Male; Precancerous Conditions; Rats; Rats, Wistar | 2002 |
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Chromosome Mapping; Colonic Neoplasms; Dimethylhydrazines; Gene Deletion; Gene Silencing; Genetic Markers; Humans; Loss of Heterozygosity; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Nuclear Proteins; Phosphoproteins; Polymorphism, Genetic; Protein Tyrosine Phosphatases; Quantitative Trait, Heritable; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 2002 |
Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Ammonia; Animals; Blood Urea Nitrogen; Caseins; Cecum; Cholesterol; Colon; Colonic Neoplasms; Dietary Proteins; Dimethylhydrazines; Ear Neoplasms; Female; Hydrazines; Hydrogen-Ion Concentration; Intestinal Neoplasms; Intestine, Small; Neoplasms; Nitrogen; Papilloma; Rats; Urea; Urease | 1976 |
Gamma glutamyl transpeptidase in colon cancer induced by 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Age Factors; Animals; Animals, Newborn; Colon; Colonic Neoplasms; Dimethylhydrazines; gamma-Glutamyltransferase; Histocytochemistry; Hydrazines; Intestine, Small; Male; Rats | 1977 |
The multiple forms and kinetic properties of the N-acetyl-beta-D-hexosaminidases from colonic tumours and mucosa of rats treated with 1,2-dimethylhydrazine.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Hexosaminidases; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Neoplasms, Experimental; Rats | 1979 |
Cell population kinetics of 1,2-dimethylhydrazine-induced colonic neoplasms and their adjacent colonic mucosa in the mouse.
Topics: Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Kinetics; Mice | 1979 |
Protective effect of dietary fibre against chemically induced bowel tumours in rats.
Topics: Animal Feed; Animals; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Male; Neoplasms, Experimental; Rats | 1978 |
Failure of bran to protect against experimental colon cancer in rats.
Topics: Adenocarcinoma; Animals; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Evaluation Studies as Topic; Female; Neoplasms, Experimental; Rats | 1978 |
Bran and experimental colon cancer.
Topics: Animal Feed; Animals; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Disease Models, Animal; Humans; Injections, Subcutaneous; Rats | 1979 |
Immunogenicity of chemically induced murine colon cancers.
Topics: Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Colonic Neoplasms; Dimethylhydrazines; Epitopes; Female; Immunotherapy; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Isogeneic | 1979 |
Cell proliferation in dimethylhydrazine-induced colonic adenocarcinomata following cytotoxic drug treatment.
Topics: 5,7-Dihydroxytryptamine; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cimetidine; Colonic Neoplasms; Dimethylhydrazines; Fluorouracil; Male; Rats; Time Factors | 1978 |
Pathological features of the colonic tumours induced in rats by the administration of 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma; Cell Differentiation; Colonic Neoplasms; Dimethylhydrazines; Female; Rats | 1978 |
Production of intestinal and other tumours by 1,2-dimethylhydrazine dihydrochloride in mice. II. Scanning electron microscopic and cytochemical study of colonic neoplasms.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Glycosaminoglycans; Histocytochemistry; Mice; Microscopy, Electron, Scanning | 1976 |
Early X-ray detection of colonic and rectal tumours in European hamsters.
Topics: Animals; Colonic Neoplasms; Cricetinae; Dimethylhydrazines; Female; Male; Neoplasms, Experimental; Radiography; Rectal Neoplasms; Time Factors | 1976 |
Cholecystectomy and carcinoma of the colon. An experimental study.
Topics: Animals; Cholecystectomy; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Female; Mice; Neoplasms, Experimental | 1977 |
Carcinogenicity of 1,2-dimethylhydrazine dihydrochloride in BALB/c mice. Influence of the route of administration and dosage.
Topics: Administration, Oral; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Injections, Subcutaneous; Intubation, Gastrointestinal; Liver Neoplasms; Male; Methylhydrazines; Mice; Mice, Inbred BALB C; Neoplasms, Vascular Tissue; Soft Tissue Neoplasms | 1979 |
Immunologic aspects of 1, 2-dimethylhydrazine-induced colon tumors in rats.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Antibody Formation; Antigens, Neoplasm; Carcinoembryonic Antigen; Colon; Colonic Neoplasms; Cross Reactions; Dimethylhydrazines; Fetus; Intubation, Gastrointestinal; Male; Neoplasms, Experimental; Rats | 1975 |
Effect of BCG on dimethylhydrazine induction of colon tumors in rats.
Topics: Adenocarcinoma, Mucinous; Animals; BCG Vaccine; Colonic Diseases; Colonic Neoplasms; Dimethylhydrazines; Granuloma; Hydrazines; Immunotherapy; Male; Mycobacterium bovis; Neoplasm Metastasis; Neoplasms, Experimental; Rats | 1975 |
Intestinal carcinogenesis in rats using 1,2-dimethylhydrazine with or without degraded carrageenan.
Topics: Animals; Body Weight; Carrageenan; Cell Nucleolus; Cell Nucleus; Colon; Colonic Neoplasms; Dimethylhydrazines; Duodenal Neoplasms; Duodenum; Female; Hydrazines; Hyperplasia; Ileum; Intestinal Mucosa; Intestinal Neoplasms; Lung Neoplasms; Male; Mitosis; Neoplasms, Glandular and Epithelial; Precancerous Conditions; Rats; Rectal Neoplasms | 1975 |
Colon carcinoma antigens in the rat.
Topics: Animals; Antigens, Neoplasm; Colonic Neoplasms; Dimethylhydrazines; Kidney; Lymphocytes; Methylnitronitrosoguanidine; Neoplasms, Experimental; Polyomavirus; Rats; Sarcoma | 1975 |
Transplantable colon tumors as chemotherapy screening models.
Topics: Adenocarcinoma, Mucinous; Animals; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Homologous | 1975 |
Histogenesis and growth pattern of 1,2-dimethylhydrazine-induced rat colon adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Epithelium; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Time Factors | 1976 |
Inhibition of macromolecular synthesis in tumors by L-1-tosylamido-2-phenylethyl chloromethyl ketone.
Topics: Amino Acid Chloromethyl Ketones; Animals; Carcinoma, Hepatocellular; Colonic Neoplasms; Dimethylhydrazines; DNA Replication; Female; Kinetics; Liver; Liver Neoplasms; Liver Regeneration; Neoplasms, Experimental; Protein Biosynthesis; Rats; Tosylphenylalanyl Chloromethyl Ketone | 1977 |
Inhibits of of colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disulfides; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Female; Maneb; Mice; Thiocarbamates | 1977 |
Cyclic nucleotide concentrations in 1,2-dimethylhydrazine induced rat colon adenocarcinoma.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Dimethylhydrazines; Female; Rats | 1978 |
[Studies on carcinogenesis and extension of 1,2-dimethylhydrazine induced large-bowel cancer in rats (author's transl)].
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1978 |
Lysosomal enzymes in macrophages of colonic tumors induced in rats by 1,2-dimethylhydrazine dihydrochloride.
Topics: Acid Phosphatase; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Glucuronidase; Lysosomes; Macrophages; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1978 |
Strain differences in susceptibility of rat colon to 1,2-dimethylhydrazine carcinogenesis.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Species Specificity | 1978 |
Adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate phosphodiesterase activities in 1,2-dimethylhydrazine induced colon adenocarcinoma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1979 |
Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay.
Topics: Aminoacetonitrile; Animals; Azo Compounds; Azoxymethane; Carbon Disulfide; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Ditiocarb; Drug Evaluation, Preclinical; Male; Maneb; Methylhydrazines; Mice; Mutagens; Neoplasms, Experimental; Pyrazoles | 1979 |
Intestinal transit time as an important factor in the pathogenesis of dimethyl-hydrazine-induced rat colon cancer.
Topics: Animals; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Gastrointestinal Transit; Male; Rats; Rats, Inbred F344 | 1978 |
Studies on the kinetics of glycosidases from chemically-induced rat colonic tumours and normal rat colon.
Topics: Acetylgalactosamine; Acetylglucosamine; alpha-L-Fucosidase; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Fetus; Fucose; Galactose; Galactosidases; Gestational Age; Glycoside Hydrolases; Hexosaminidases; Hydrogen-Ion Concentration; Intestinal Mucosa; Kinetics; Lactones; Nitrophenols; Rats; Stereoisomerism | 1975 |
Induction of colon tumors in 1,2-dimethylhydrazine-resistant Lobund Wistar rats by methylazoxymethanol acetate.
Topics: Adenocarcinoma; Animals; Azo Compounds; Biotransformation; Colon; Colonic Neoplasms; Dimethylhydrazines; Drug Resistance; Female; Intestinal Neoplasms; Male; Methylazoxymethanol Acetate; Methylhydrazines; Neoplasms, Experimental; Rats; Species Specificity | 1978 |
Ultrastructure of 1,2-dimethylhydrazine-induced adenocarcinomas in rat colon.
Topics: Adenocarcinoma; Animals; Cell Cycle; Cell Differentiation; Cell Membrane; Cell Nucleus; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Male; Methylhydrazines; Microscopy, Electron; Necrosis; Neoplasms, Experimental; Rats; Thymidine | 1978 |
DNA repair as regulatory factor in the organotropy of alkylating carcinogens.
Topics: Alkylation; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; DNA Repair; Guanine; Kidney Neoplasms; Neoplasms; Nervous System Diseases; Nitrosourea Compounds; Organ Specificity; Time Factors; Triazenes | 1979 |
Polyunsaturated fat, cholesterol and large bowel tumorigenesis.
Topics: Animals; Cholesterol; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Fats, Unsaturated; Lipidoses; Lymphocyte Activation; Male; Rats; T-Lymphocytes | 1977 |
Immunologic surveillance against chemically induced primary colon carcinoma in rats.
Topics: Animals; Antigens, Neoplasm; Antilymphocyte Serum; Colonic Neoplasms; Dimethylhydrazines; Female; Immunity; Male; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred WF; T-Lymphocytes | 1978 |
Demonstration of effective antitumor immunity in an autochthonous host bearing primary colon tumors induced by 1,2-dimethylhydrazine dihydrochloride.
Topics: Animals; Antilymphocyte Serum; Colon; Colonic Neoplasms; Cytotoxicity, Immunologic; Dimethylhydrazines; Female; Gastrointestinal Neoplasms; Immunity; Intestinal Mucosa; Lymphocytes; Neoplasm Metastasis; Neoplasms, Experimental; Rats; Rats, Inbred WF; T-Lymphocytes; Time Factors | 1979 |
Detection of antibodies to embryonic antigens in sera of multiparous or colon tumor-bearing rats by a new indirect immunofluorescence assay.
Topics: Animals; Antibodies; Antibodies, Neoplasm; Antibody Specificity; Carcinoembryonic Antigen; Colonic Neoplasms; Dimethylhydrazines; Female; Fluorescent Antibody Technique; Methods; Neoplasms, Experimental; Pregnancy; Rats | 1977 |
Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol colon carcinogenesis: correlative studies on selenium effects on the mutagenicity and sister chromatid exchange rates of selected carcinogens.
Topics: Animals; Carcinogens; Cells, Cultured; Chromosomes, Human; Colonic Neoplasms; Dimethylhydrazines; Humans; Lymphocytes; Male; Methylazoxymethanol Acetate; Mutagens; Rats; Recombination, Genetic; Salmonella typhimurium; Selenium | 1977 |
Detection of mutagenicity of the colon carcinogen 1,2-dimethylhydrazine by the host-mediated assay and its correlation to carcinogenicity.
Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Evaluation, Preclinical; Female; Male; Methylhydrazines; Mice; Mice, Inbred C57BL; Mutagens; Neoplasms, Experimental; Salmonella typhimurium; Sex Factors; Species Specificity | 1978 |
Protective effect of oral Salmonella enteritidis 11RX infection against colon tumor induction by 1,2-dimethylhydrazine in mice.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Salmonella enteritidis; Salmonella Infections | 1979 |
Organ and tumor specificity of colon mucoprotein antigen in a rat model.
Topics: Amino Acids; Animals; Antigens; Antigens, Neoplasm; Carbohydrates; Colon; Colonic Neoplasms; Dimethylhydrazines; Fluorescent Antibody Technique; Humans; Intestinal Mucosa; Mucins; Mucoproteins; Neoplasm Transplantation; Neoplasms, Experimental; Organ Specificity; Rabbits; Radioimmunoassay; Rats; Rats, Inbred F344 | 1979 |
Alterations in fecal microflora enzymes related to diet, age, lactobacillus supplements, and dimethylhydrazine.
Topics: Aging; Animals; Azo Compounds; Colonic Neoplasms; Diet; Dimethylhydrazines; Feces; Glucuronidase; Lactobacillus acidophilus; Male; Methylhydrazines; Nitro Compounds; Oxidoreductases; Rats | 1977 |
Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Butylated Hydroxytoluene; Colonic Neoplasms; Cresols; Dimethylhydrazines; Duodenal Neoplasms; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1979 |
[Chenodeoxycholic acid therapy and colorectal carcinoma--an experimental approach (author's transl)].
Topics: Animals; Carcinoma; Chenodeoxycholic Acid; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Male; Neoplasms, Experimental; Rats; Rectal Neoplasms; Time Factors | 1979 |
Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis.
Topics: Animals; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Hyperplasia; Ileum; Intestinal Mucosa; Male; Methylhydrazines; Neoplasms, Experimental; Rats; RNA | 1979 |
[Effect of age, castration and pregnancy on carcinogenesis, induced by 1,2-dimethylhydrazine, in CBA mice].
Topics: Adenoma; Age Factors; Aging; Animals; Castration; Colonic Neoplasms; Dimethylhydrazines; Female; Hemangioma; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Ovarian Neoplasms; Pregnancy; Pregnancy, Animal; Sarcoma, Experimental; Uterine Neoplasms | 1979 |
[Effect of BCG immunotherapy on kinetic parameters and growth curves of 5 transplantable lines of colon carcinoma chemically induced in rat (author's transl)].
Topics: Adenocarcinoma; Animals; BCG Vaccine; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Neoplasm Transplantation; Neoplasms, Experimental; Rats | 1979 |
Effects of methylazoxymethanol acetate on inbred mice: influence of genetic factors on tumor induction.
Topics: Animals; Azo Compounds; Colonic Neoplasms; Dimethylhydrazines; Drug Resistance; Methylazoxymethanol Acetate; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Inbred Strains; Neoplasms, Experimental; Rectal Neoplasms; Species Specificity | 1979 |
Dietary fibre and colonic neoplasia.
Topics: Animals; Bile Acids and Salts; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Eukaryota; Humans; Lignin; Pectins; Polymers; Polysaccharides; Rats | 1979 |
Effect of dietary fiber on the induction of colorectal tumors and fecal beta-glucuronidase activity in the rat.
Topics: Animals; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Feces; Glucuronidase; Male; Neoplasms, Experimental; Rats; Rectal Neoplasms | 1979 |
Selective protective effect of butylated hydroxytoluene against 1,2-dimethylhydrazine carcinogenesis in BALB/c mice.
Topics: Adenocarcinoma; Adenoma; Animals; Butylated Hydroxytoluene; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Methylhydrazines; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Sex Factors | 1979 |
Relationship between dose, time, and tumor yield in mouse dimethylhydrazine-induced colon tumorigenesis.
Topics: Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Methylhydrazines; Neoplasms, Experimental; Rectal Neoplasms; Time Factors | 1979 |
Cytotoxicity of p-chloroamphetamine in dimethylhydrazine-induced carcinomata of rat colon.
Topics: Amphetamines; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Male; Neoplasms, Experimental; p-Chloroamphetamine; Rats; Time Factors | 1979 |
Decrease in colon absorptive capacity preceding development of tumors in a DMH tumor model.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Absorption; Intestinal Mucosa; Male; Methylhydrazines; Precancerous Conditions; Rats; Risk | 1979 |
Distal colonic hyperplasia after colostomy closure: a promoter of chemical carcinogenesis.
Topics: Animals; Colon; Colonic Neoplasms; Colostomy; Dimethylhydrazines; DNA; Hyperplasia; Male; Neoplasms, Experimental; Proteins; Rats; RNA | 1979 |
Occult blood testing using the guaiac method (haemoccult-test) for detection of tumorous lesions induced with 1,2-dimethyl-hydrazine and acetoxymethyl-methyl-nitrosamine in rats.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitrosamine; Guaiac; Male; Occult Blood; Rats | 1979 |
Effect of mitomycin-C on McCall rat colon adenocarcinoma.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Injections, Intraperitoneal; Male; Mitomycins; Neoplasms, Experimental; Rats; Time Factors | 1978 |
Cellular binding proteins for vitamin A in colorectal adenocarcinoma of rat.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Neoplasm Proteins; Neoplasms, Experimental; Rats; Rectal Neoplasms; Retinol-Binding Proteins; Retinol-Binding Proteins, Cellular | 1978 |
Colonic neoplasms in mice produced with six injections of 1,2-dimethylhydrazine.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Injections, Subcutaneous; Methylhydrazines; Mice; Neoplasms, Experimental | 1977 |
Cytotoxicity of cyproheptadine and methysergide to chemically induced carcinomas of rat colon.
Topics: Animals; Colonic Neoplasms; Cyproheptadine; Dimethylhydrazines; Male; Methysergide; Microscopy, Electron; Rats | 1977 |
Increased invasiveness of colonic carcinomas induced by dimethylhydrazine in rats with partial small-bowel resection.
Topics: Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Intestine, Small; Male; Methylhydrazines; Neoplasm Invasiveness; Neoplasms, Experimental; Rats | 1977 |
Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats.
Topics: Animals; Bacterial Vaccines; Colonic Neoplasms; Dimethylhydrazines; Female; Neoplasm Metastasis; Neoplasms, Experimental; Propionibacterium acnes; Rats | 1978 |
Histogenesis of symmetrical 1,2-dimethylhydrazine-induced neoplasms of the colon in the mouse.
Topics: Adenocarcinoma; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Female; Hyperplasia; Intestinal Mucosa; Methylhydrazines; Mice; Neoplasms, Experimental; Precancerous Conditions; Time Factors | 1978 |
The effect of bran on dimethylhydrazine-induced colon carcinogenesis in the rat.
Topics: Animals; Body Weight; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Duodenal Neoplasms; Energy Intake; Feces; Intestines; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Time Factors | 1978 |
[3H]thymidine-labeled colonic epithelial cells and mucosa in mice and man.
Topics: Adolescent; Adult; Aged; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Epithelium; Female; Humans; Male; Mice; Middle Aged; Polyps; Precancerous Conditions; Risk | 1978 |
[Stages of carcinogenesis of experimental colonic tumors induced with 1-2 dimethylhydrazine].
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Intestinal Polyps; Methylhydrazines; Neoplasms, Experimental; Rats | 1978 |
Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata.
Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colon; Colonic Neoplasms; Dimethylhydrazines; Histamine; Intestinal Mucosa; Male; Metiamide; Pyrilamine; Rats; Receptors, Histamine; Receptors, Histamine H2; Stimulation, Chemical; Thiourea | 1978 |
A double-blind study on the effect of purified cellulose dietary fiber on 1,2-dimethylhydrazine-induced rat colonic neoplasia.
Topics: Adenocarcinoma; Animals; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Double-Blind Method; Male; Methylhydrazines; Neoplasms, Experimental; Rats; Time Factors | 1978 |
DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: Animals; Biotransformation; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Ileum; Kidney; Liver; Male; Methylation; Methylhydrazines; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neoplasms, Experimental; Purines; Species Specificity | 1978 |
Effects of diet on colon carcinogenesis and the immune system in rats treated with 1,2-dimethylhydrazine.
Topics: Animals; Cholesterol; Colonic Neoplasms; Diet; Dietary Carbohydrates; Dietary Fats; Dimethylhydrazines; Immunity; Immunoglobulin G; Leukocyte Count; Liver; Lymphocytes; Male; Methylhydrazines; Neoplasm Metastasis; Neoplasms, Experimental; Nutritional Physiological Phenomena; Rats; Rats, Inbred WF; Receptors, Antigen, B-Cell; Triglycerides | 1978 |
Glycoprotein metabolism in normal proximal and distal rat colon and changes associated with 1,2-dimethylhydrazine-induced colonic neoplasia.
Topics: Animals; Carbohydrate Metabolism; Colon; Colonic Neoplasms; Dimethylhydrazines; Galactosyltransferases; Glycoproteins; Glycoside Hydrolases; Intestinal Mucosa; Male; Methylhydrazines; Neoplasm Proteins; Neoplasms, Experimental; Rats; Sialyltransferases | 1978 |
Effect of bile acids and dietary fat on large bowel carcinogenesis in animal models.
Topics: Animals; Bile Acids and Salts; Colonic Neoplasms; Colostomy; Dietary Fats; Dietary Proteins; Dimethylhydrazines; Feces; Female; Male; Methylnitronitrosoguanidine; Neoplasms, Experimental; Rats | 1978 |
Experimental colonic tumours in the rat. II. Double contrast examination and microscopy.
Topics: Adenocarcinoma; Adenoma; Animals; Colon; Colonic Neoplasms; Contrast Media; Dimethylhydrazines; Female; Intestinal Mucosa; Intestinal Polyps; Male; Methylnitronitrosoguanidine; Neoplasms, Experimental; Radiography; Rats | 1978 |
Colonic protection from dimethylhydrazine by a high fiber diet.
Topics: Adenoma; Animals; Carcinoma in Situ; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Female; Methylhydrazines; Mice; Neoplasms, Experimental | 1978 |
Experimental colonic tumours in the rat. III. Induction time, distribution and appearance of induced tumours.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Hyperplasia; Injections; Injections, Intravenous; Injections, Subcutaneous; Intestinal Mucosa; Male; Methylnitronitrosoguanidine; Neoplasm Metastasis; Neoplasms, Experimental; Radiography; Rats; Rectum; Time Factors | 1978 |
[Neomycin sulfate and colonic carcinoma. Experimental study].
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Male; Neomycin; Rats | 1978 |
Induction of colonic adenocarcinomas by 1,2-dimethylhydrazine intrarectally administered in rats.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Hyperplasia; Injections; Intestinal Mucosa; Methylhydrazines; Neoplasms, Experimental; Rats; Rectum | 1978 |
[Carcinogenesis of the colon in Wistar rats induced by 1,2-dimethylhydrazine (author's transl)].
Topics: Adenoma; Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Methylhydrazines; Neoplasms, Experimental; Rats | 1978 |
[Action mechanism of the carcinogen 1,2-dimethylhydrazine].
Topics: Alkylation; Animals; Biotransformation; Colon; Colonic Neoplasms; Dimethylhydrazines; Ileum; Kidney; Liver; Methylhydrazines; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Rats; Species Specificity | 1978 |
[Ultrastructure study of the preneoplastic colon (carcinogenesis with 1,2-dimethylhydrazine)].
Topics: Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Dimethylhydrazines; Microscopy, Electron; Neoplasms, Experimental; Precancerous Conditions; Rats; Time Factors | 1978 |
Cell proliferation in the descending colon of dimethylhydrazine treated rats and in dimethylhydrazine induced adenocarcinomata.
Topics: Adenocarcinoma; Animals; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Hydrazines; Male; Mitosis; Rats; Time Factors; Vinblastine | 1976 |
A comparison of cell proliferation in normal and neoplastic intestinal epithelia following either biogenic amine depletion or monoamine oxidase inhibition.
Topics: Adenocarcinoma; Animals; Biogenic Amines; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Jejunum; Male; Monoamine Oxidase Inhibitors; Nialamide; Rats; Reserpine | 1976 |
Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine.
Topics: Animals; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazines; Female; Genes, Dominant; Genetic Linkage; Hydrazines; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neoplasms, Experimental; Species Specificity | 1977 |
Surface changes in the descending colon of rats treated with dimethylhydrazine.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelial Cells; Epithelium; Hydrazines; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Neoplasms, Experimental; Precancerous Conditions; Rats; Time Factors | 1977 |
Dimethylhydrazine-induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Dimethylhydrazines; Dose-Response Relationship, Drug; Hydrazines; Male; Oils; Rats; Triticum | 1977 |
Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors.
Topics: Adenocarcinoma; Animals; Azo Compounds; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Hydrazines; Male; Methylazoxymethanol Acetate; Neoplasms, Experimental; Rats; Selenium | 1977 |
Cytotoxicity of 5,6-dihydroxytryptamine in dimethylhydrazine-induced carcinomas of rat colon.
Topics: 5,6-Dihydroxytryptamine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Hydrazines; Male; Neoplasms, Experimental; Rats; Tryptamines | 1977 |
Effect of type and amount of dietary fat and 1,2-dimethylhydrazine on biliary bile acids, fecal bile acids, and neutral sterols in rats.
Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Cholic Acids; Colonic Neoplasms; Deoxycholic Acid; Dietary Fats; Dimethylhydrazines; Feces; Female; Hydrazines; Liver; Male; Neoplasms, Experimental; Oils; Rats; Rats, Inbred F344; Sterols; Zea mays | 1977 |
[Cholecystectomy and experimental coloncarcinoma (author's transl)].
Topics: Adenocarcinoma; Animals; Cholecystectomy; Colonic Neoplasms; Dimethylhydrazines; Female; Mice | 1977 |
[Malignant degeneration of experimental ulcerative colitis of the rat following s.c. injection of 1,2-dimethylhydrazine (author's transl)].
Topics: Adenocarcinoma; Animals; Colitis, Ulcerative; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Male; Rats | 1977 |
Early changes in the dynamics of crypt cell populations in mouse colon following administration of 1,2-dimethylhydrazine.
Topics: Animals; Cell Division; Cell Movement; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Hydrazines; Mice; Neoplasms, Experimental; Precancerous Conditions; Time Factors | 1977 |
Effect of hepatotoxic or nephrotoxic agents on the induction of colon cancers in rats by 1,2-dimethylhydrazine.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzhydryl Compounds; Chemical and Drug Induced Liver Injury; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Drug Interactions; Hydrazines; Kidney; Kidney Diseases; Kidney Function Tests; Liver; Liver Function Tests; Rats; Succinimides | 1977 |
Morphological studies of chemically induced colon tumors in hamsters.
Topics: Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Cricetinae; Dimethylhydrazines; Kidney Cortex; Liver; Liver Neoplasms; Male; Neoplasm Metastasis | 1977 |
Effects of disulfiram and related compounds on the metabolism in vivo of the colon carcinogen, 1,2-dimethylhydrazine.
Topics: Animals; Azo Compounds; Breath Tests; Carbon Dioxide; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Drug Interactions; Male; Methylhydrazines; Oxidation-Reduction; Rats; Rats, Inbred F344; Time Factors; Tissue Distribution | 1977 |
Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea.
Topics: Adenocarcinoma; Adenoma; Animals; Azo Compounds; Cattle; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Male; Meat; Methylazoxymethanol Acetate; Methylhydrazines; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344 | 1977 |
The large bowel carcinogenic effects of hydrazines and related compounds occurring in nature and in the environment.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens, Environmental; Colonic Neoplasms; Cricetinae; Dimethylhydrazines; Female; Hydrazines; Liver Neoplasms; Male; Methylhydrazines; Mice; Rats; Splenic Neoplasms | 1977 |
Influence of gonadal hormones and age on 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: Adenocarcinoma; Aging; Animals; Castration; Colonic Neoplasms; Dihydrotestosterone; Dimethylhydrazines; Female; Gonadal Steroid Hormones; Male; Methylhydrazines; Rats; Sex Factors | 1977 |
Preventive role of vitamin A in colon carcinogenesis in rats.
Topics: Aflatoxins; Animals; Colonic Neoplasms; Diet; Dimethylhydrazines; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Vitamin A | 1977 |
Changes in chromosomal proteins in colon cancer: the complexity and DNA-binding properties of tumor-associated proteins and evidence for their association with the malignant state in human colonic epithelium.
Topics: Adenocarcinoma; Animals; Chromatography, Affinity; Chromosomal Proteins, Non-Histone; Colonic Neoplasms; Dimethylhydrazines; DNA; Electrophoresis, Polyacrylamide Gel; Humans; Male; Neoplasm Proteins; Rats | 1977 |
Selective inhibition with sodium cyanate of protein synthesis in colon cancer cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Colon; Colonic Neoplasms; Cyanates; Dimethylhydrazines; Fibroblasts; HeLa Cells; Humans; Male; Neoplasm Proteins; Protein Biosynthesis; Rats | 1977 |
Morphogenesis of early 1, 2-dimethylhydrazine-induced lesions and latent period reduction of colon carcinogenesis in mice by a variant of Citrobacter freundii.
Topics: Animals; Citrobacter; Colon; Colonic Neoplasms; Dimethylhydrazines; Enterobacteriaceae Infections; Female; Hyperplasia; Intestinal Mucosa; Male; Methylhydrazines; Mice; Neoplasms, Experimental; Precancerous Conditions; Time Factors | 1977 |
Experimental carcinoma of the colon induced by 1,2-dimethylhydrazine-diHCl: value as a model of human disease.
Topics: Adenocarcinoma; Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Female; Humans; Intestinal Polyps; Lymphatic Metastasis; Male; Neoplasm Metastasis; Neoplasm Transplantation; Rats | 1976 |
Effect of a diet with high levels of protein and fat on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine.
Topics: Animals; Body Weight; Colonic Neoplasms; Dietary Fats; Dietary Proteins; Dimethylhydrazines; Female; Glycine max; Hydrazines; Meat; Oils; Rats; Rats, Inbred F344; Zea mays | 1976 |
Detection and estimation of azomethane in expired air of 1,2-dimethylhydrazine-treated rats.
Topics: Animals; Azo Compounds; Carbon Dioxide; Colonic Neoplasms; Dimethylhydrazines; Hydrazines; Male; Methane; Rats; Rats, Inbred F344; Respiration; Time Factors | 1976 |
Species variation in response to dimethylhydrazine.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Dogs; Guinea Pigs; Hydrazines; Male; Rats; Species Specificity; Swine | 1976 |
Chronic hepatotoxicity and intestinal bleeding in 1,2-dimethylhydrazine carcinogenesis in rats and mice.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Gastrointestinal Hemorrhage; Hydrazines; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Time Factors | 1975 |
The significance of nonspecific injury for colon carcinogenesis in rats.
Topics: Animals; Cecal Neoplasms; Cecum; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Foreign-Body Reaction; Male; Neoplasms, Experimental; Rats; Sutures; Thymidine | 1975 |
Sequential studies of serum blocking activity in rats bearing chemically induced primary bowel tumors.
Topics: Adenocarcinoma; Aminobiphenyl Compounds; Animals; Antigen-Antibody Complex; Carcinogens; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Dimethylhydrazines; Intestinal Neoplasms; Lymph Nodes; Lymphocytes; Neoplasms, Experimental; Nitrosoguanidines; Radiography; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1975 |
The mechanism of carcinogenic action of 1,2-dimethylhydrazine (SDMH) in rats.
Topics: Alkylation; Brain; Colonic Neoplasms; Dimethylhydrazines; DNA; Glucuronates; Hepatectomy; Hydrazines; Intestinal Mucosa; Kidney; Liver; Proteins; RNA; Spleen; Thymus Gland; Time Factors | 1975 |
[Induction of colonic carcinoma in mice using 1,2-dimethylhydrazine hydrochloride].
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Hydrazines; Mice; Neoplasms, Experimental; Precancerous Conditions; Time Factors; Tritium | 1975 |
Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma; Chemical Phenomena; Chemistry; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
Proceedings: Transplantable adenocarcinomata of the colon in mice as possible models for chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Mice; Neoplasms, Experimental | 1975 |
Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study.
Topics: Animals; Carcinoma in Situ; Cecum; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Hyperplasia; Intestinal Mucosa; Mucins; Mucus; Neoplasms, Experimental; Rats; Time Factors | 1975 |
Tumor-associated and embryonic antigens in soluble fractions of a chemically-induced rat colon carcinoma.
Topics: Adenocarcinoma; Animals; Antigen-Antibody Reactions; Antigens, Neoplasm; Carcinoembryonic Antigen; Cells, Cultured; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Dimethylhydrazines; Lymph Nodes; Lymphocytes; Methylnitronitrosoguanidine; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred BUF; Rats, Inbred WF; Transplantation, Homologous | 1975 |
Animal models for the study of dietary factors and cancer of the large bowel.
Topics: Animals; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Guinea Pigs; Intestines; Lithocholic Acid; Methylnitrosourea; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Rats; Taurocholic Acid; Vitamin A Deficiency | 1975 |
Selective synthesis and accumulation of nuclear non-histone proteins during carcinogenesis of the colon induced by 1, 2-dimethylhydrazine.
Topics: Amino Acids; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Epithelium; Hydrazines; Leucine; Male; Neoplasm Proteins; Neoplasms, Experimental; Nucleoproteins; Rats | 1975 |
In vivo repair of rat intestinal DNA damage by alkylating agents.
Topics: Alkylating Agents; Animals; Centrifugation, Density Gradient; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA Repair; DNA, Neoplasm; Intestinal Mucosa; Jejunum; Male; Methylazoxymethanol Acetate; Mitomycins; Neoplasms, Experimental; Nitrogen Mustard Compounds; Rats | 1975 |
Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine.
Topics: Animals; Azo Compounds; Azoxymethane; Chromatography, Gel; Chromatography, Thin Layer; Colonic Neoplasms; Dimethylhydrazines; Hydrazines; Methane; Methylazoxymethanol Acetate; Neoplasms, Experimental | 1975 |
A colon tumor model for anticancer agent evaluation.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
Significance of precancerous lesions in the colon and rectum.
Topics: Animals; Basement Membrane; Colitis, Ulcerative; Colonic Neoplasms; Dimethylhydrazines; Epithelial Cells; Epithelium; Humans; Intestinal Mucosa; Intestinal Neoplasms; Intestinal Polyps; Mitosis; Precancerous Conditions; Rats; Rectal Neoplasms | 1975 |
[Proliferative activity of the epithelium of the rat large intestine during carcinogenesis].
Topics: Adenocarcinoma; Animals; Carcinoma in Situ; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Mitosis; Rats | 1976 |
Effect of quality and quantity of dietary fat and dimethylhydrazine in colon carcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Carcinoma; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Ear Canal; Ear Neoplasms; Female; Hydrazines; Intestinal Neoplasms; Kidney Neoplasms; Neoplasms, Experimental; Rats | 1976 |
Changes in nuclear non-histone protein composition during normal differentiation and carcinogenesis of intestinal epithelial cells.
Topics: Animals; Cell Differentiation; Cell Fractionation; Cell Nucleus; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; DNA; Histones; Intestinal Mucosa; Male; Neoplasms, Experimental; Nucleoproteins; Rats; RNA | 1976 |
Colon carcinogenesis in germ-free rats with intrarectal 1,2-dimethylhydrazine and subcutaneous azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; Dimethylhydrazines; Female; Germ-Free Life; Hydrazines; Injections, Subcutaneous; Intestines; Rats | 1976 |
Effects of aspirin on 1,2-dimethylhydrazine-induced colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Colonic Neoplasms; Cyclic AMP; Dimethylhydrazines; Dinoprostone; DNA; Male; Rats; Rats, Inbred Strains | 1992 |
Dietary supplementation with pectin and guar gum on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Energy Intake; Galactans; Male; Mannans; Pectins; Plant Gums; Rats; Rats, Inbred Strains | 1992 |
A protective role of 1,25-dihydroxyvitamin D3 in chemically induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Calcitriol; Calcium; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Ornithine Decarboxylase; Rats; Receptors, Calcitriol; Receptors, Steroid | 1992 |
Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Neoplasm; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Nuclear Proteins; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Reference Values; Tissue Distribution | 1992 |
The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model.
Topics: Adenocarcinoma; Aminosalicylic Acids; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Incidence; Inflammatory Bowel Diseases; Male; Mesalamine; Metronidazole; Neoplasm Invasiveness; Rats; Rats, Wistar; Sulfasalazine | 1992 |
Histological reactivity of a monoclonal antibody against rat colon cancer cells on human and rat normal gut and colonic tumours.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies, Monoclonal; Blood Group Antigens; Carbohydrate Conformation; Carbohydrate Sequence; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Epitopes; Female; Fluorescein-5-isothiocyanate; Gastric Mucosa; Humans; Immunoenzyme Techniques; Intestinal Mucosa; Male; Molecular Sequence Data; Oligosaccharides; Organ Specificity; Rats; Rats, Inbred Strains | 1992 |
Inhibitory effect of cryptoporic acid E, a product from fungus Cryptoporus volvatus, on colon carcinogenesis induced with N-methyl-N-nitrosourea in rats and with 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Colon; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Enzyme Induction; Feeding Behavior; Female; Intestinal Mucosa; Methylnitrosourea; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Polyporaceae; Rats; Rats, Inbred F344; Sesquiterpenes; Weight Gain | 1992 |
Morphological, histochemical and immunohistochemical differences between tumorous and adjacent tissues in chemically induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Glycosaminoglycans; Histocytochemistry; Immunohistochemistry; Male; Methylnitronitrosoguanidine; Rats; Rats, Sprague-Dawley; Time Factors | 1992 |
Induction of aberrant crypts in the colons of rats by alkylating agents.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Wistar | 1992 |
Individual variability of pathological parameters in chemically induced rat colon tumors.
Topics: 1,2-Dimethylhydrazine; Animals; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Histocytochemistry; Immunohistochemistry; Male; Methylnitronitrosoguanidine; Mitotic Index; Ornithine Decarboxylase; Peptides; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Tissue Polypeptide Antigen | 1992 |
Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats.
Topics: Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Folic Acid Deficiency; Male; Rats; Rats, Inbred Strains | 1992 |
Effects of low copper intake on dimethylhydrazine-induced colon cancer in rats.
Topics: Analysis of Variance; Anemia; Animals; Body Weight; Ceruloplasmin; Colonic Neoplasms; Copper; Dimethylhydrazines; Hypertrophy; Male; Myocardium; Rats; Rats, Inbred Strains; Superoxide Dismutase | 1992 |
Removing oxygen-derived free radicals delays hepatic metastases and prolongs survival in colonic cancer. A study in the rat.
Topics: 1,2-Dimethylhydrazine; Allopurinol; Animals; Carcinogens; Colonic Neoplasms; Dimethyl Sulfoxide; Dimethylhydrazines; Free Radicals; Liver Neoplasms, Experimental; Male; Oxygen; Rats; Rats, Inbred Strains; Survival Analysis | 1992 |
Calcium, vitamin D, and colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Calcium; Calcium, Dietary; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Humans; Mice; Rats; Vitamin D | 1992 |
Appearance of ear tumors in Sprague-Dawley rats treated with 1,2-dimethylhydrazine when used as a model for colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma, Squamous Cell; Colonic Neoplasms; Dimethylhydrazines; Ear; Ear Neoplasms; Ear, External; Hyperplasia; Papilloma; Rats; Rats, Inbred Strains | 1992 |
Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Isoenzymes; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Strains | 1992 |
[Animal experiment studies of carcinogen-induced tumor development in colotomies in relation to suture materials].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Dimethylhydrazines; Nickel; Polyglactin 910; Rats; Risk Factors; Surgical Staplers; Sutures | 1992 |
Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Administration, Oral; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Hydralazine; Injections, Subcutaneous; Isoniazid; Male; Phenelzine; Rats; Rats, Inbred Strains | 1992 |
Tumor induction in monkeys after administration of dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Macaca fascicularis; Male; Myoma; Neoplasms, Experimental; Uterine Neoplasms | 1992 |
Inhibition of the Na+,K(+)-ATPase pump during induction of experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Barium; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Kinetics; Mice; Models, Biological; Ouabain; Precancerous Conditions; Sodium-Potassium-Exchanging ATPase | 1991 |
The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.
Topics: 1,2-Dimethylhydrazine; Animals; Biomarkers, Tumor; Carcinogenicity Tests; Colonic Neoplasms; Dimethylhydrazines; DNA Probes; Female; Genetic Predisposition to Disease; Isoantigens; Male; Mice; Mice, Inbred BALB C; Polymorphism, Restriction Fragment Length; Recombination, Genetic; Sex Characteristics | 1991 |
Uncoupling of sodium chloride transport in premalignant mouse colon.
Topics: 1,2-Dimethylhydrazine; Action Potentials; Animals; Bicarbonates; Carcinogens; Chlorides; Colonic Neoplasms; Dimethylhydrazines; Electric Conductivity; Female; Intestinal Mucosa; Ion Channels; Isotonic Solutions; Mice; Precancerous Conditions; Rats; Rats, Inbred Strains; Ringer's Solution; Sodium Channels | 1990 |
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mitomycin; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1992 |
Reduction of aberrant crypt formation in the colon of CF1 mice by potential chemopreventive agents.
Topics: 1,2-Dimethylhydrazine; Animals; Butylated Hydroxyanisole; Cecum; Colonic Neoplasms; Colorectal Neoplasms; Dimethylhydrazines; Female; Methylene Blue; Mice; Mice, Inbred Strains; Precancerous Conditions; Thiophenes | 1991 |
[Effects of fecal bile acids on experimental colon carcinogenesis].
Topics: Adenocarcinoma; Animals; Bile Acids and Salts; Colonic Neoplasms; Dimethylhydrazines; Feces; Gastrointestinal Transit; Ileum; Jejunum; Male; Rats; Rats, Inbred Strains | 1991 |
Evaluation of dietary dehydroepiandrosterone for chemoprotection against tumorigenesis in premalignant colonic epithelium of male F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dehydroepiandrosterone; Diet; Dimethylhydrazines; Epithelium; Male; Muscle, Smooth; Precancerous Conditions; Rats; Rats, Inbred F344; Reference Values | 1991 |
[Increased polyamine levels of normal-appearing mucosa and cancers in DMH induced cancer-bearing colon in rats].
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Intestinal Mucosa; Male; Polyamines; Rats; Rats, Inbred Strains | 1991 |
Fluorescence localization of early colonic cancer in the rat by hematoporphyrin derivative.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; False Positive Reactions; Female; Fluorescence; Hematoporphyrins; Lasers; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1991 |
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Calcium, Dietary; Codon; Colonic Neoplasms; Dimethylhydrazines; Genes, ras; Male; Molecular Sequence Data; Mutagenesis; Oligonucleotide Probes; Polymerase Chain Reaction; Rats; Rats, Inbred Strains; Vitamin D Deficiency | 1991 |
Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Female; Precancerous Conditions; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Dietary calcium and vitamin D modulate 1,2-dimethylhydrazine-induced colonic carcinogenesis in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Calcium, Dietary; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Polyamines; Rats; Vitamin D | 1991 |
[Effect of gastrin and enprostil, a PGE2 analog, on colonic cancerous cell growth].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Combinations; Enprostil; Gastrins; Proglumide; Rats; Stimulation, Chemical; Tumor Cells, Cultured | 1991 |
[Mucosubstance and lectin histochemistry of DMH induced colonic tumor in rats].
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Histocytochemistry; Intestinal Mucosa; Lectins; Male; Mucus; Rats; Rats, Inbred Strains | 1991 |
Sulindac inhibits the rate of growth and appearance of colon tumors in the rat.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Male; Random Allocation; Rats; Rats, Inbred Strains; Remission Induction; Sulindac | 1991 |
Demonstration of the need for end point validation of putative biomarkers: failure of aberrant crypt foci to predict colon cancer incidence.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Colon; Colonic Neoplasms; Corn Oil; Diet; Dimethylhydrazines; Male; Pectins; Prognosis; Rats; Rats, Inbred Strains; Regression Analysis | 1991 |
Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon.
Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Precancerous Conditions; Rats; Rats, Inbred Strains | 1991 |
Role of iron in cell proliferation and tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Humans; Iron; Male; Mice; Mice, Inbred Strains; Rectal Neoplasms | 1991 |
Quantification of acid mucins in the descending colon of rats having simultaneously growing colonic tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alcian Blue; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Mucins; Rats; Rats, Inbred Strains; Reference Values | 1991 |
[Primary localization of 1,2-dimethylhydrazine-induced cancer in lymphoid patches of the large intestine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma, Mucinous; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Lymphatic System; Male; Rats | 1990 |
The effect of endotoxin on 1,2-dimethylhydrazine-induced colonic tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; Endotoxins; Escherichia coli; gamma-Glutamyltransferase; Glutathione; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Mucosa; Male; Methylhydrazines; Random Allocation; Rats; Rats, Inbred Strains | 1990 |
A quantitative study of epithelial alterations during the early stages of experimental colonic tumorigenesis in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Bromodeoxyuridine; Cell Count; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Female; Histocytochemistry; Kinetics; Male; Mice; Mice, Inbred ICR; Mucus; S Phase | 1990 |
Development of lung metastases after curative intraperitoneal chemotherapy in a rat colon cancer model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dimethylhydrazines; Injections, Intraperitoneal; Lung Neoplasms; Rats; Rats, Inbred F344 | 1991 |
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Cell Transformation, Neoplastic; Codon; Colonic Neoplasms; Dimethylhydrazines; DNA; Genes, ras; Intestinal Mucosa; Male; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Polymerase Chain Reaction; Precancerous Conditions; Rats | 1991 |
Isolation and characterization of normal and neoplastic colonic epithelial cell populations.
Topics: Animals; Cells, Cultured; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; In Vitro Techniques; Intestinal Mucosa; Rats; Swine; Thymidine; Tumor Cells, Cultured | 1991 |
Effect of dietary calcium on colon carcinogenesis induced by a single injection of 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Autoradiography; Body Weight; Bone Density; Calcium, Dietary; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Rats; Rats, Inbred F344 | 1991 |
Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Membrane; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosol; Diglycerides; Dimethylhydrazines; Down-Regulation; Intestinal Mucosa; Protein Kinase C; Rats | 1991 |
Heterogenicity of ornithine decarboxylase during mouse colon carcinogenesis and in human colon tumors.
Topics: Alkaline Phosphatase; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Humans; Isoenzymes; Mice; Ornithine Decarboxylase | 1991 |
[Raised polyamines in erythrocytes of DMH administrated rats with colonic cancers and those relationship to tumor volume].
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Erythrocytes; Male; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1991 |
Local eradication of rat colon cancer with photodynamic therapy: correlation of distribution of photosensitiser with biological effects in normal and tumour tissue.
Topics: Aluminum; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Indoles; Intestinal Mucosa; Male; Organometallic Compounds; Photochemotherapy; Rats; Rats, Inbred Strains | 1991 |
Effect of disulfiram on 1,2-dimethylhydrazine- and azoxymethane-induced aberrant crypt foci.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Female; Intestinal Mucosa; Mice; Precancerous Conditions | 1991 |
Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line.
Topics: Animals; Base Sequence; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Carcinogens; Cell Line; Colon; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylhydrazines; Enzyme Induction; Humans; Isoenzymes; Male; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Polymerase Chain Reaction; Rats; RNA, Messenger | 1991 |
Effect of dietary carbohydrates on the growth of dysplastic crypt foci in the colon of rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Calcium, Dietary; Carcinogens; Cellulose; Colon; Colonic Neoplasms; Dietary Carbohydrates; Dimethylhydrazines; Female; Precancerous Conditions; Rats; Rats, Inbred Strains; Starch; Sucrose | 1991 |
Alterations in lectin binding in the proximal and distal colon of Sprague-Dawley rats with 1,2 dimethylhydrazine administration.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Lectins; Male; Microscopy, Fluorescence; Mucins; Plant Lectins; Rats; Rats, Inbred Strains | 1991 |
The effect of sulindac on colonic tumour formation in dimethylhydrazine-treated mice.
Topics: Adenoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Mice; Mice, Inbred BALB C; Reference Values; Sulindac | 1990 |
Influence of caloric restriction and exercise on tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Colonic Neoplasms; Diet, Reducing; Dietary Fats; Dimethylhydrazines; Female; Male; Mammary Neoplasms, Experimental; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1990 |
Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenofibroma; Adenoma; alpha-Linolenic Acid; Animals; Body Weight; Carcinogens; Carcinoma, Papillary; Carcinoma, Squamous Cell; Colonic Neoplasms; Dietary Fats, Unsaturated; Dimethylhydrazines; Ear Neoplasms; Female; Linoleic Acids; Mammary Neoplasms, Animal; Methylhydrazines; Papilloma; Plant Oils; Rats; Rats, Inbred Strains; Safflower Oil; Sebaceous Gland Neoplasms; Soybean Oil | 1990 |
[Effects of hyperthermochemotherapy on activities of DNA-synthesizing enzymes in 1, 2-dimethylhydrazine (DMH)-induced colon carcinomas in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Dimethylhydrazines; Hyperthermia, Induced; Isoenzymes; Rats; Rats, Inbred Strains; Tegafur; Thymidine Kinase; Thymidylate Synthase; Uracil | 1990 |
1,2-Dimethylhydrazine-induced alterations in protein kinase C activity in the rat preneoplastic colon.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Diglycerides; Dimethylhydrazines; Inositol Phosphates; Intestinal Mucosa; Male; Methylhydrazines; Phosphatidylinositols; Precancerous Conditions; Protein Kinase C; Rats; Rats, Inbred Strains; Time Factors | 1990 |
[Growth rate of experimental colonic cancer in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Barium Sulfate; Colonic Neoplasms; Dimethylhydrazines; Enema; Male; Radiography; Rats; Rats, Inbred Strains | 1990 |
[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Kidney Neoplasms; Lactation; Liver Neoplasms; Mesenchymoma; Neoplasms, Experimental; Parity; Pregnancy; Pseudopregnancy; Rats | 1990 |
Lipid absorption and intestinal tumour incidence in rats fed on varying levels of calcium and butterfat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Butter; Calcium, Dietary; Carcinogens; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Feces; Intestinal Absorption; Lipid Metabolism; Lipids; Male; Rats; Rats, Inbred Strains | 1990 |
1,2-Dimethylhydrazine-induced alterations in lipid peroxidation in preneoplastic and neoplastic colonic tissues.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Fatty Acids; Intestinal Mucosa; Lipid Peroxidation; Lipofuscin; Male; Malondialdehyde; Microsomes; Precancerous Conditions; Rats | 1990 |
Effect of small bowel resection on fecal bile acid excretion and on experimental colon tumour in rats.
Topics: 1,2-Dimethylhydrazine; Anastomosis, Surgical; Animals; Bile Acids and Salts; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Feces; Ileum; Intestine, Small; Jejunum; Rats; Rats, Inbred Strains | 1990 |
Endoscopic and radiographic evaluation of the murine colon.
Topics: 1,2-Dimethylhydrazine; Animals; Barium Sulfate; Carcinogens; Colon; Colonic Neoplasms; Colonoscopes; Colonoscopy; Dimethylhydrazines; Enema; Male; Radiography; Rats; Rats, Inbred Strains | 1990 |
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenocarcinoma; Animals; Base Sequence; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Genes, ras; Male; Molecular Sequence Data; Neoplasms, Experimental; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polymerase Chain Reaction; Putrescine; Rats; Rats, Inbred Strains | 1990 |
An assessment of the risk of neoplasia in long-term ileal reservoirs using the DMH rodent model.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Ileal Neoplasms; Ileostomy; Ileum; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains; Time Factors | 1990 |
Changes in intestinal function of rats initiated with DMH and fed varying levels of butterfat, calcium, and magnesium.
Topics: 1,2-Dimethylhydrazine; Animals; Bone Density; Calcium, Dietary; Carcinogens; Cecum; Colon; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Feces; Glucuronidase; In Vitro Techniques; Intestinal Absorption; Magnesium; Male; Nitroreductases; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1990 |
Effect of DL-buthionine-S,R-sulfoximine on 1,2-dimethyl-hydrazine-induced colonic tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Buthionine Sulfoximine; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Glutathione; Intestinal Mucosa; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1990 |
Microvascular architecture of experimental colon tumors in the rat.
Topics: Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Microcirculation; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Selective necrosis in dimethylhydrazine-induced rat colon tumors using phthalocyanine photodynamic therapy.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Fluorescence; Indoles; Injections, Intravenous; Isoindoles; Laser Therapy; Male; Methylhydrazines; Necrosis; Photochemistry; Photochemotherapy; Pigments, Biological; Rats; Rats, Inbred Strains | 1990 |
Dietary milk proteins inhibit the development of dimethylhydrazine-induced malignancy.
Topics: Adenocarcinoma; Animals; Body Weight; Caseins; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Female; Methylhydrazines; Mice; Milk Proteins | 1990 |
The influence of dietary levels of vitamin A and fat on colon cancer.
Topics: Animals; Body Weight; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Eating; Food, Formulated; Male; Rats; Rats, Inbred Strains; Vitamin A; Vitamin A Deficiency | 1990 |
Protease inhibitor suppression of colon and anal gland carcinogenesis induced by dimethylhydrazine.
Topics: Animals; Anus Neoplasms; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Humans; Male; Mice; Oligopeptides; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors | 1990 |
Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Body Weight; Carcinogens; Colonic Neoplasms; Cysteine; Dimethylhydrazines; Disulfides; Female; Mice; Mice, Inbred C57BL; Structure-Activity Relationship; Sulfides | 1990 |
Vanadate supplements and 1,2-dimethylhydrazine induced colon cancer in mice: increased thymidine incorporation without enhanced carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; DNA; Drug Interactions; Male; Mice; Mice, Inbred Strains; RNA; Thymidine; Vanadium | 1986 |
Serial observations of colonic carcinogenesis in the rat. Premalignant mucosa binds Ulex europeus agglutinin.
Topics: Animals; Binding Sites; Biopsy; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Lectins; Male; Mucins; Plant Lectins; Precancerous Conditions; Rats; Staining and Labeling | 1987 |
[Lectin histochemistry of 1,2-dimethylhydrazine-induced rat colonic neoplasia and human colorectal neoplasia].
Topics: 1,2-Dimethylhydrazine; Animals; Binding Sites; Carbohydrates; Colonic Neoplasms; Dimethylhydrazines; Histocytochemistry; Humans; Lectins; Male; Methylhydrazines; Rats; Rats, Inbred Strains; Staining and Labeling | 1988 |
1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels in rat distal colonic mucosa: effects of 2-difluoromethylornithine.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Intestinal Mucosa; Male; Methylhydrazines; Ornithine Decarboxylase; Polyamines; Rats; Spermidine | 1989 |
Chemoprevention of mouse colon tumors with difluoromethylornithine during and after carcinogen treatment.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Erythrocytes; Male; Mice; Polyamines; Reference Values | 1989 |
Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Colonic Neoplasms; Dimethylhydrazines; Ear Neoplasms; Female; Leukemia, Experimental; Linoleic Acids; Lipid Peroxides; Mammary Neoplasms, Experimental; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1989 |
Effect of dietary cellulose on cell proliferation and progression of 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Cell Division; Cellulose; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Energy Intake; Methylhydrazines; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1989 |
[Endoscopic study on the effect of dietary fiber against 1,2-dimethylhydrazine-induced colonic carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Colonoscopy; Dietary Fiber; Dimethylhydrazines; Male; Rats; Rats, Inbred Strains | 1989 |
Early colonic dysplasia: comparison of differential mucin staining and tritiated thymidine labeling.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Intestinal Mucosa; Male; Mitosis; Mucins; Rats; Sialomucins; Staining and Labeling; Thymidine; Tritium | 1985 |
[The influence of theophylline on polyamine metabolism and colonic carcinogenesis induced by 1.2-dimethylhydrazine in mice].
Topics: Animals; Biogenic Polyamines; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Theophylline | 1989 |
Tumor induction in mice administered neonatally with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Animals, Newborn; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphoma; Male; Methylhydrazines; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Survival Rate | 1989 |
Lectin-binding sites in neoplastic and non-neoplastic colonic mucosa of 1,2-dimethylhydrazine-treated rats.
Topics: Animals; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Dimethylhydrazines; Fluorescent Antibody Technique; Glycoconjugates; Intestinal Mucosa; Lectins; Methylhydrazines; Rats; Rats, Inbred Strains | 1989 |
Influence of dietary cis and trans fats on DMH-induced colon tumors, steroid excretion, and eicosanoid production in rats prone to colon cancer.
Topics: Animals; Aorta; Bile Acids and Salts; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Eicosanoic Acids; Feces; Female; Lipids; Liver; Male; Methylhydrazines; Rats; Rats, Inbred WF; Steroids | 1989 |
Colonic cancer induced by 1,2-dimethylhydrazine: promotion by experimental colitis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colitis; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Mice | 1989 |
Comparison of the significance of three histopathological thresholds of malignancy in experimental colorectal tumours.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma in Situ; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Neoplasm Invasiveness; Rats; Rectal Neoplasms | 1989 |
The electrical and sodium transport characteristics of sutured premalignant mouse colon.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Catgut; Cell Membrane; Colon; Colonic Neoplasms; Dimethylhydrazines; Electric Conductivity; Female; Insect Proteins; Membrane Potentials; Mice; Mice, Inbred Strains; Precancerous Conditions; Proteins; Silk; Sodium; Sutures | 1989 |
Urinary excretion of N1-acetylspermidine and other acetylated and free polyamines in the 1,2-dimethylhydrazine model of experimental rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Acetylation; Animals; Biogenic Polyamines; Biomarkers, Tumor; Colonic Neoplasms; Dimethylhydrazines; Male; Predictive Value of Tests; Putrescine; Rats; Spermidine; Spermine | 1989 |
Genetic factors controlling inheritance of susceptibility to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Female; Genetic Predisposition to Disease; Male; Methylazoxymethanol Acetate; Methylhydrazines; Mice; Mice, Inbred Strains; Sex Factors | 1989 |
Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Diet; Dimethylhydrazines; Dose-Response Relationship, Drug; Male; Methylhydrazines; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Effect of change of fecal bile acid excretion achieved by operative procedures on 1,2-dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Feces; Intestines; Male; Rats; Rats, Inbred Strains | 1989 |
Effect of indomethacin in autotransplanted colonic tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Indomethacin; Kidney; Kidney Neoplasms; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains | 1989 |
[The role of bile in the development of colon cancer induced by 1,2-dimethyl hydrazine in rats].
Topics: Animals; Bile; Cholecystectomy; Colonic Neoplasms; Dimethylhydrazines; Humans; Neoplasms, Experimental; Postoperative Complications; Rats | 1989 |
1,2-Dimethylhydrazine-induced carcinogenesis influenced by different colonic anastomoses in rats.
Topics: 1,2-Dimethylhydrazine; Anastomosis, Surgical; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Feces; Male; Methylhydrazines; Rats; Rats, Inbred F344 | 1989 |
Recognition of a high molecular weight glycoprotein (HMW-GP) associated with rat colon cancer cells by rat monoclonal antibodies.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Membrane Glycoproteins; Mice; Rats; Rats, Inbred BN; Rats, Inbred WF | 1989 |
Reduction of DMH-induced colon tumors in rats fed psyllium husk or cellulose.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Feces; Male; Methylhydrazines; Psyllium; Rats; Rats, Inbred Strains | 1987 |
Reduction of colonic carcinogenesis by wheat bran independent of fecal bile acid concentration.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Body Weight; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Eating; Feces; Gastrointestinal Motility; Male; Methylhydrazines; Rats; Rats, Inbred F344 | 1987 |
Absence of large bowel tumors in rats injected with 1,2-dimethylhydrazine and fed high dietary cellulose.
Topics: 1,2-Dimethylhydrazine; Animals; Cellulose; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1987 |
Enzyme histochemical studies on DMH-induced colonic adenocarcinoma in mice.
Topics: Acetylcholinesterase; Adenocarcinoma; Animals; Cathepsin B; Colonic Neoplasms; Dimethylhydrazines; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Glucuronidase; Histocytochemistry; Mice; Mice, Inbred ICR; Oxidoreductases; Phosphoric Monoester Hydrolases | 1987 |
Indole and cholic acid effects on some biochemical changes during dimethylhydrazine carcinogenesis in mice large intestine.
Topics: Animals; Cholic Acids; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Female; Free Radicals; Indoles; Intestine, Large; Mice; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Rectal Neoplasms; Superoxides | 1987 |
[Colonic cancer induced by 1,2-dimethylhydrazine (DMH) in rats after partial colectomy].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Colectomy; Colonic Neoplasms; Dimethylhydrazines; Male; Rats; Rats, Inbred Strains | 1987 |
The influence of diet and dimethylhydrazine on the small and large intestine of vervet monkeys.
Topics: Animals; Chlorocebus aethiops; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Dimethylhydrazines; Diverticulum, Colon; Female; gamma-Glutamyltransferase; Intestinal Mucosa; Intestine, Large; Intestine, Small; Methylhydrazines; Mucins; Mucus; Organ Size; Sialomucins | 1986 |
Sequential histochemical and morphometric studies on preneoplastic and neoplastic lesions induced in rat colon by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Acid Phosphatase; Animals; Colonic Neoplasms; Dimethylhydrazines; gamma-Glutamyltransferase; Gluconeogenesis; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycogen Synthase; Glycolysis; Histocytochemistry; Male; Methylhydrazines; Pentose Phosphate Pathway; Phosphorylases; Precancerous Conditions; Rats; Rats, Inbred Strains | 1987 |
Gamma glutamyl transferase activity in rat colon during experimental colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; gamma-Glutamyltransferase; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Rat or murine colonic carcinomas? M.A.L. Maley et al. versus C.D. Gerharz.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Methylhydrazines; Mice; Muridae; Rats; Species Specificity; Terminology as Topic | 1988 |
Experimental liver metastasis. Implications of clonal proclivity and organ specificity.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cecal Neoplasms; Colonic Neoplasms; Dimethylhydrazines; Liver; Liver Neoplasms, Experimental; Lung; Lung Neoplasms; Male; Neoplasm Transplantation; Organ Specificity; Rats; Rats, Inbred BN; Rats, Inbred WF | 1989 |
Apparent synergism between radiation and the carcinogen 1,2-dimethylhydrazine in the induction of colonic tumors in rats.
Topics: Adenoma; Animals; Cocarcinogenesis; Colonic Neoplasms; Colonic Polyps; Dimethylhydrazines; Male; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Rats; Rats, Inbred F344 | 1989 |
Premalignant alterations in rat colonic N1-acetylspermidine levels induced by 1,2-dimethylhydrazine: effects of a high corn oil dietary regimen.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Biogenic Polyamines; Colonic Neoplasms; Corn Oil; Dimethylhydrazines; Intestinal Mucosa; Male; Methylhydrazines; Plant Oils; Precancerous Conditions; Rats; Rats, Inbred Strains; Spermidine | 1989 |
Detection of the cancer-prone colon, using transepithelial impedance analysis.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Disease Susceptibility; Electric Conductivity; Electrodiagnosis; Epithelium; Female; Intestinal Mucosa; Mice; Mice, Inbred DBA; Mice, Inbred Strains | 1989 |
N-acetylneuraminic acid and N-glycolylneuraminic acid in glycopeptides of colonic tumor and mucosa in rats treated with carrageenan and 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carrageenan; Colonic Neoplasms; Dimethylhydrazines; Glycopeptides; Intestinal Mucosa; Methylhydrazines; N-Acetylneuraminic Acid; Neuraminic Acids; Rats; Sialic Acids | 1989 |
[Gnotobiotic studies on SPF mice in relation to a study of tumor development in the colon after cholecystectomy].
Topics: Animals; Bacteria; Cholecystectomy; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Intestines; Mice; Specific Pathogen-Free Organisms | 1985 |
Changes in the tissue-specific antimitotic effect of mice serum during 1,2-dimethylhydrazine induced cancerogenesis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Chick Embryo; Colonic Neoplasms; Dimethylhydrazines; Epithelial Cells; Female; Intestines; Mice; Mice, Inbred ICR; Mitosis; Mitotic Index | 1986 |
The changes of Con A binding affinity to mice colon during DMH-induced carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Concanavalin A; Dimethylhydrazines; Female; Glucose; Mannose; Mice | 1986 |
Natural killer cell activity and autologous mixed lymphocyte response of splenic, mesenteric lymph node, and colonic lymphocytes during DMH-induced colon carcinogenesis in the rat.
Topics: Animals; Colon; Colonic Neoplasms; Cytotoxicity, Immunologic; Dimethylhydrazines; Killer Cells, Natural; Lymph Nodes; Lymphocyte Culture Test, Mixed; Lymphocytes; Mesentery; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Spleen | 1987 |
Stromal reaction associated with the DMH-induced mice colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Granulocytes; Lymphocytes; Mice; Mice, Inbred ICR | 1987 |
Mast cells in experimental and human cancerogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cervix Uteri; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Germ-Free Life; Humans; Mast Cells; Mice; Mice, Inbred ICR; Uterine Cervical Neoplasms | 1987 |
Rodent models for carcinoma of the colon.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alkylation; Animals; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Dietary Proteins; Dimethylhydrazines; Disease Models, Animal; Female; Male; Mice; Mice, Inbred Strains; Minerals; Rats; Rats, Inbred F344; Vitamins | 1985 |
[Effects of dietary factors and fecal bile acids on DMH induced colon cancer in rat].
Topics: Animals; Bile Acids and Salts; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Dimethylhydrazines; Feces; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1985 |
Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Cellulose; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Feces; Galactans; Hydrogen-Ion Concentration; Male; Mannans; Pectins; Plant Gums; Rats; Rats, Inbred Strains | 1986 |
Effects of differing purified cellulose, pectin, and hemicellulose fiber diets on fecal enzymes in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: Animals; beta-Glucosidase; Cellulose; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Feces; Glucosidases; Glucuronidase; Male; Pectins; Rats | 1986 |
The role of sphingomyelin synthetase and sphingomyelinase in 1,2-dimethylhydrazine-induced lipid alterations of rat colonic plasma membranes.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Membrane Fluidity; Methylhydrazines; Microvilli; Phosphoric Diester Hydrolases; Phosphotransferases; Rats; Sphingomyelin Phosphodiesterase; Sphingomyelins; Transferases (Other Substituted Phosphate Groups) | 1986 |
The interaction of retrovirus and chemical carcinogen in experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Neoplasms; Male; Methylhydrazines; Models, Biological; Oncogenes; Rats; Rats, Inbred Strains; Retroviridae Infections | 1987 |
Intestinal carcinogenesis and dietary fibers: the influence of cellulose or Fybogel chronically given after exposure to DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Bicarbonates; Body Weight; Cellulose; Citrates; Citric Acid; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Dimethylhydrazines; Drug Combinations; Feces; Intestinal Neoplasms; Male; Plant Extracts; Rats; Rats, Inbred Strains; Sodium Bicarbonate | 1987 |
Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Rats; Tegafur; Thymidine Kinase; Thymidylate Synthase; Uracil | 1986 |
Plasminogen activators in experimental colorectal neoplasia: a role in the adenoma-carcinoma sequence?
Topics: Animals; Colon; Colonic Neoplasms; Colonic Polyps; Culture Techniques; Dimethylhydrazines; Female; Rats; Rats, Inbred Strains; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 1987 |
[The effect of UFT on thymidine kinase and thymidylate synthetase activities and autoradiograph in DMH-induced colon cancer in rat].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Autoradiography; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Male; Rats; Tegafur; Thymidine; Thymidine Kinase; Thymidylate Synthase; Uracil | 1987 |
[Effects of SSM (purified polysaccharides from human tubercle bacillus, maruyama vaccine) and UFT (a combination of tegafur and uracil) on DNA-synthesizing enzyme activities in 1,2-dimethylhydrazine (DMH)-induced rat colon carcinomas].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biological Products; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Lipids; Mannans; Rats; Tegafur; Thymidine Kinase; Thymidylate Synthase; Uracil | 1987 |
Activated K-ras in tumorigenic and non-tumorigenic cell variants from a rat colon adenocarcinoma, induced by dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Base Sequence; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Killer Cells, Natural; Proto-Oncogenes; Rats; Trypsin; Tumor Cells, Cultured | 1988 |
Changes in the lectin-binding pattern of PNA-agglutinin and UEA1 during the DMH-induced carcinogenesis in the normal appearing colonic mucosa of the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescence; Intestinal Mucosa; Lectins; Mucins; Peanut Agglutinin; Plant Lectins; Rats; Rats, Inbred Strains; Thiocyanates | 1988 |
Xanthine oxidase activity in intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Male; Rats; Xanthine Dehydrogenase; Xanthine Oxidase | 1988 |
1,2-Dimethylhydrazine carcinogenesis in neonatally androgenized CBA mice.
Topics: 1,2-Dimethylhydrazine; Animals; Animals, Newborn; Colonic Neoplasms; Dimethylhydrazines; Estrus; Female; Male; Methylhydrazines; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Sexual Maturation; Testosterone; Uterine Neoplasms | 1988 |
Pigmentation of kidneys and lymph nodes of mesocolon in rats fed diets containing the laxative danthron.
Topics: 1,2-Dimethylhydrazine; Animals; Anthraquinones; Carcinogens; Cathartics; Colonic Neoplasms; Diet; Dimethylhydrazines; Kidney; Lymph Nodes; Male; Mesocolon; Microscopy, Electron; Pigments, Biological; Rats; Rats, Inbred Strains | 1988 |
Effect of activity-stress on experimental rat colon carcinogenesis: early histopathologic changes and colon tumor induction.
Topics: Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethylhydrazines; Male; Rats; Rats, Inbred Strains; Stress, Psychological | 1988 |
Relationship of dietary cholesterol and cellulose in the prevention of colon cancer.
Topics: Animals; Bile Acids and Salts; Cellulose; Cholesterol, Dietary; Colonic Neoplasms; Dimethylhydrazines; Feces; Male; Rats; Rats, Inbred Strains; Sterols | 1988 |
A protective effect of sulindac against chemically-induced primary colonic tumours in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Indenes; Mice; Mice, Inbred BALB C; Sulindac | 1988 |
Superoxide dismutase activity during dimethylhydrazine colon carcinogenesis and the effects of cholic acid and indole.
Topics: Adenocarcinoma; Animals; Cholic Acid; Cholic Acids; Colonic Neoplasms; Dimethylhydrazines; Indoles; Mice; Superoxide Dismutase; Time Factors | 1988 |
Promoter function of carrageenan on development of colonic tumors induced by 1,2-dimethylhydrazine in rats.
Topics: Animals; Bile Acids and Salts; Carrageenan; Chromatography, Liquid; Colonic Neoplasms; Diet; Dimethylhydrazines; Drug Synergism; Feces; Male; Methylhydrazines; Rats; Rats, Inbred F344 | 1988 |
[Cocarcinogenic and promoting effects of choleretic cholagogues on large bowel carcinogenesis evoked by 1,2-dimethylhydrazine in Wistar rats].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cholagogues and Choleretics; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Female; Methylhydrazines; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1988 |
Rat colonic carcinogenesis after ureterosigmoidostomy: pathogenesis and immunohistological study.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Antigens, Neoplasm; Colon, Sigmoid; Colonic Neoplasms; Dimethylhydrazines; Female; Immunoenzyme Techniques; Mucins; Rats; Rats, Inbred Strains; Urinary Diversion | 1988 |
Distribution of laminin and collagen type IV in rat colon tumors induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Basement Membrane; Carcinoma in Situ; Collagen; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Fluorescent Antibody Technique; Intestinal Mucosa; Laminin; Methylhydrazines; Neoplasm Invasiveness; Rats | 1987 |
Expression of cell-surface antigens on rat colonic cancer cells.
Topics: Adenocarcinoma; Adenoma; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Colonic Neoplasms; Dimethylhydrazines; Enzyme-Linked Immunosorbent Assay; Immunoassay; Immunohistochemistry; Male; Microvilli; Molecular Weight; Rats; Rats, Inbred F344 | 1988 |
Susceptibility to 1,2-dimethylhydrazine-induced colonic tumors and epithelial cell proliferation characteristics of F1, F2, and reciprocal backcrosses derived from SWR/J and AKR/J parental mouse strains.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazines; Injections, Subcutaneous; Methylhydrazines; Mice; Neoplasms, Experimental | 1988 |
Low power interstitial Nd YAG laser photocoagulation in normal and neoplastic rat colon.
Topics: Animals; Colon; Colonic Diseases; Colonic Neoplasms; Dimethylhydrazines; Intestinal Perforation; Light Coagulation; Necrosis; Pressure; Rats; Rats, Inbred Strains | 1988 |
Induction of beta-glucuronidase activity during dimethylhydrazine carcinogenesis and additive effects of cholic acid and indole.
Topics: Adenocarcinoma; Animals; Cholic Acids; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Enzyme Activation; Female; Glucuronidase; Hyperplasia; Indoles; Intestinal Mucosa; Intestine, Large; Methylhydrazines; Mice | 1988 |
Splenectomy and the induction of murine colon cancer.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma in Situ; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Humans; Male; Rats; Rats, Inbred Strains; Splenectomy | 1988 |
The relationship between faecal bile acids and the development of experimental colon cancer.
Topics: Animals; Bile Acids and Salts; Colonic Neoplasms; Dimethylhydrazines; Feces; Female; Rats; Rats, Inbred Strains | 1988 |
Carcinogenicity of deuterium-labeled 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Biotransformation; Carcinogens; Colonic Neoplasms; Deuterium; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Kidney Neoplasms; Liver Neoplasms, Experimental; Male; Methylhydrazines; Mice; Mice, Inbred CBA; Neoplasms, Experimental; Sex Factors | 1988 |
Stimulating effect of pentagastrin on cancer cell proliferation kinetics in chemically induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; DNA Replication; Kinetics; Male; Pentagastrin; Rats; Rats, Inbred Strains | 1988 |
Cellular proliferation in proximal and distal rat colon during 1,2-dimethylhydrazine-induced carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Autoradiography; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Rats; Rats, Inbred Strains; Thymidine; Time Factors; Tritium | 1988 |
Target tissue DNA damage in inbred mouse strains with different susceptibility to the colon carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA Damage; Methylhydrazines; Mice; Mice, Inbred Strains; Species Specificity | 1988 |
Dietary whey protein inhibits the development of dimethylhydrazine induced malignancy.
Topics: 1,2-Dimethylhydrazine; Amino Acids; Animals; Carcinogens; Colonic Neoplasms; Dietary Proteins; Dimethylhydrazines; Female; Mice; Mice, Inbred A; Milk Proteins; Minerals; Vitamins; Whey Proteins | 1988 |
Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethyl Sulfoxide; Dimethylhydrazines; Formamides; Gastrointestinal Neoplasms; Male; Methylhydrazines; Rats; Rats, Inbred Strains; Solvents; Sulfones; Time Factors | 1988 |
Dietary iron enhances the tumor rate in dimethylhydrazine-induced colon carcinogenesis in mice.
Topics: Alcohol Dehydrogenase; Animals; Cocarcinogenesis; Colonic Neoplasms; Deferoxamine; Diet; Dimethylhydrazines; Female; Iron; Mice | 1988 |
The role of the liver in the protection by elemental diets against experimental colon cancer.
Topics: Animals; Cholesterol, Dietary; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Female; Food Additives; Food, Formulated; Liver; Organic Chemicals; Phospholipids; Rats; Rats, Inbred Strains | 1988 |
1,2-Dimethylhydrazine-induced premalignant alterations in the S-adenosylmethionine/S-adenosylhomocysteine ratio and membrane lipid lateral diffusion of the rat distal colon.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Decanoic Acids; Diffusion; Dimethylhydrazines; Homocysteine; Membrane Lipids; Methionine Adenosyltransferase; Methylhydrazines; Precancerous Conditions; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1988 |
Multigenic control of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Genes; Mice; Mice, Inbred Strains; Species Specificity | 1988 |
[Localization of Ulex europaeus agglutinin-1 (UEA1) binding sites in normal and 1,2-dimethylhydrazine (DMH) treated rat bowel].
Topics: 1,2-Dimethylhydrazine; Animals; Binding Sites; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestine, Small; Lectins; Male; Methylhydrazines; Plant Lectins; Rats; Rats, Inbred F344; Risk | 1987 |
Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: role of dietary vitamin E.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Colitis; Colonic Neoplasms; Diet; Dimethylhydrazines; Free Radicals; Male; Mice; Mice, Inbred Strains; Vitamin E | 1986 |
Increase by deoxycholic acid of the colonic nuclear damage induced by known carcinogens in C57BL/6J mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Nucleus; Cocarcinogenesis; Colon; Colonic Neoplasms; Deoxycholic Acid; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Mitotic Index; Time Factors | 1986 |
Interactions of selenium deficiency, vitamin E, polyunsaturated fat, and saturated fat on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Fatty Acids, Unsaturated; Intestinal Neoplasms; Male; Rats; Rats, Inbred F344; Selenium; Vitamin E | 1986 |
Expression of developmentally regulated crypt cell antigens in human and rat intestinal tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies, Monoclonal; Antigens; Carcinoembryonic Antigen; Colonic Neoplasms; Dimethylhydrazines; Female; Humans; Intestinal Mucosa; Intestinal Neoplasms; Male; Mice; Pregnancy; Rats; Rats, Inbred Strains | 1986 |
Effect of different levels of dietary corn oil and lard during the initiation phase of colon carcinogenesis in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; Bile Acids and Salts; Body Weight; Colon; Colonic Neoplasms; Corn Oil; Dietary Fats; Dimethylhydrazines; Eating; Male; Oils; Ornithine Decarboxylase; Rats; Rats, Inbred F344 | 1986 |
Protective effect of beta-carotene against colon tumors in mice.
Topics: Animals; Body Weight; Carotenoids; Colonic Neoplasms; Diet; Dimethylhydrazines; Hyperplasia; Mice; Mice, Inbred ICR | 1987 |
1,2-Dimethylhydrazine-induced nuclear aberrations in A/J and C57BL/6J mouse colonic crypts.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Nucleus; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Methylhydrazines; Mice; Mice, Inbred Strains; Mitosis; Species Specificity | 1987 |
Selenium and cabbage and colon carcinogenesis in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Body Weight; Brassica; Colonic Neoplasms; Dimethylhydrazines; Eating; Female; Mice; Mice, Inbred ICR; Selenium | 1987 |
Qualitative and quantitative changes in sialomucins during 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Ethanol; Mucins; Rats; Rats, Inbred Strains; Rectal Neoplasms; Sialic Acids; Sialomucins | 1987 |
Effect of 13-cis-retinoic acid on tumor prevention, tumor growth, and metastasis in experimental colon cancer.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Isotretinoin; Lung Neoplasms; Male; Rats; Tretinoin | 1987 |
T-cell mitogenesis and natural killer cell activity in colonic tumor-bearing and nontumor-bearing rats fed diets high in lipid with and without cholesterol.
Topics: 1,2-Dimethylhydrazine; Animals; Cholesterol, Dietary; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Killer Cells, Natural; Lymphocyte Activation; Male; Membrane Fluidity; Rats; Rats, Inbred Strains; T-Lymphocytes | 1987 |
Growth factor-induced proliferative responses of human and DMH-induced rat colorectal tumour cell lines.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Epidermal Growth Factor; Humans; Male; Rats; Rats, Inbred Strains; Rectal Neoplasms; Species Specificity; Tumor Stem Cell Assay | 1986 |
Expression of Ha-ras oncogene product in rat gastrointestinal carcinomas induced by chemical carcinogens.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Methylnitronitrosoguanidine; Oncogene Protein p21(ras); Oncogene Proteins, Viral; Proto-Oncogenes; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1987 |
Transplantable colonic adenocarcinomas in rats.
Topics: Adenocarcinoma; Animals; Ascites; Colonic Neoplasms; Cytoskeletal Proteins; Desmoplakins; Desmosomes; Dimethylhydrazines; Dose-Response Relationship, Drug; Epithelium; Fluorescent Antibody Technique; Membrane Proteins; Microscopy, Electron; Neoplasm Metastasis; Neoplasm Transplantation; Rats; Rats, Inbred F344 | 1987 |
Enhancing effect of carrageenan on the induction of rat colonic tumors by 1,2-dimethylhydrazine and its relation to beta-glucuronidase activities in feces and other tissues.
Topics: 1,2-Dimethylhydrazine; Animals; Carrageenan; Colonic Neoplasms; Diet; Dimethylhydrazines; Drug Synergism; Feces; Glucuronidase; Intestinal Mucosa; Liver; Methylhydrazines; Rats; Rats, Inbred F344 | 1986 |
Experimental colorectal cancer as a model of human disease.
Topics: Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Humans; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1987 |
The histogenesis of DMH-induced colonic carcinoma in rats.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1987 |
[Inhibition of chemically induced tumors in mice by concanavalin A: reaction and detection of changes in the composition of intestinal glycoconjugates using lectins].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Concanavalin A; Dimethylhydrazines; Female; Glycoproteins; Lectins; Mice; Mice, Inbred ICR | 1987 |
Treatment with endotoxins of peritoneal carcinomatosis induced by colon tumor cells in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Endotoxins; Female; Male; Neoplasm Transplantation; Peritoneal Neoplasms; Rats | 1987 |
Effect of beef fat on DMH-induced colon tumorigenesis: influence of rat strain and nutrient composition.
Topics: Adenocarcinoma; Animals; Body Weight; Cattle; Cocarcinogenesis; Colonic Neoplasms; Diet; Dietary Fats; Dimethylhydrazines; Energy Intake; Liver Neoplasms; Lung Neoplasms; Male; Meat; Rats; Rats, Inbred F344; Statistics as Topic | 1987 |
Effect of dietary copper on colonic tumor production and aortic integrity in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Aorta, Abdominal; Colonic Neoplasms; Copper; Dimethylhydrazines; Male; Rats; Rats, Inbred Strains | 1987 |
Increased erythrocyte stearic acid desaturation in rats with chemically induced colorectal carcinomas.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Erythrocyte Membrane; Male; Membrane Fluidity; Oleic Acid; Oleic Acids; Rats; Rats, Inbred Strains; Rectal Neoplasms; Stearic Acids | 1987 |
Co-carcinogenic effect of carbon black ingestion with dietary fat on the development of colon tumors in rats.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Body Weight; Carbon; Carcinogens; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Drug Synergism; Female; Rats; Rats, Inbred Strains | 1987 |
Sodium transport in a mouse model of colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Amiloride; Animals; Biological Transport; Chlorides; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Methylazoxymethanol Acetate; Mice; Mice, Inbred Strains; Sodium | 1987 |
Proliferative characteristics of chronic crypt cells in C57BL/6J and A/J mice as predictors of subsequent tumor formation.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cell Division; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Species Specificity | 1987 |
In vivo ethane production in vitamin E-deficient rats with DMH-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Ethane; Fatty Acids, Unsaturated; Lipid Peroxides; Male; Rats; Rats, Inbred Strains; Vitamin E Deficiency | 1987 |
Effect of high fat and nutrient depleted diets on colon tumor formation in mice.
Topics: Adenocarcinoma; Adenoma; Animal Nutritional Physiological Phenomena; Animals; Cocarcinogenesis; Colonic Neoplasms; Diet; Dietary Fats; Dimethylhydrazines; Female; Mice | 1987 |
Autotransplantation of colonic tumors into the colonic wall of the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Biopsy; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Neoplasm Seeding; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Transplantation, Autologous | 1987 |
Changes in serum lipids related to the presence of experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenoma; Alanine Transaminase; Alkaline Phosphatase; Animals; Carcinoma; Cholesterol; Colonic Neoplasms; Dimethylhydrazines; Female; Lipids; Phospholipids; Rats; Rats, Inbred Strains; Triglycerides | 1987 |
Three new rat colon tumour cell lines from 1,2-dimethylhydrazine induced adenocarcinomas: morphology, karyotype and clonogenicity.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Growth Substances; Karyotyping; Male; Neoplastic Stem Cells; Rats; Rats, Inbred Strains | 1987 |
The effect of dietary milk and calcium on experimental colorectal carcinogenesis.
Topics: Adenocarcinoma; Animals; Calcium, Dietary; Colonic Neoplasms; Dimethylhydrazines; Intestinal Obstruction; Male; Milk; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1987 |
Effects of sodium cholate on experimental carcinogenesis and cell proliferation in an excluded colonic segment.
Topics: Animals; Autoradiography; Carcinogens; Cell Division; Cholic Acids; Colonic Neoplasms; Colostomy; Dimethylhydrazines; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1987 |
Different autochthonous models of colorectal cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitrosamine; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rectal Neoplasms | 1986 |
Effect of colon tumor development and dietary fat on the immune system of rats treated with DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Cytotoxicity, Immunologic; Dietary Fats; Dimethylhydrazines; Immune System; Killer Cells, Natural; Lymphocyte Activation; Male; Methylhydrazines; Organ Size; Rats; Rats, Inbred Strains; Spleen; Weaning | 1986 |
Early mucosal changes in dimethylhydrazine-induced colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cytophotometry; Dimethylhydrazines; DNA, Neoplasm; Epithelium; Intestinal Mucosa; Precancerous Conditions; Rats | 1986 |
Effects of immunostimulation with OK432, coenzyme Q10, or levamisole on dimethylhydrazine-induced colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Biological Products; Cell Transformation, Neoplastic; Coenzymes; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Intestinal Mucosa; Levamisole; Picibanil; Rats; Ubiquinone | 1986 |
Low-dose (diagnostic-like) x-ray as a cocarcinogen in mouse colon carcinoma.
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Female; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Radiation-Induced; Radiation Dosage; Radiography; Risk; X-Rays | 1986 |
Monitoring the histogenesis of colonic tumors in the Sprague-Dawley rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Intestinal Mucosa; Lymphoid Tissue; Male; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Induction of sister chromatid exchanges in murine colonic tissue.
Topics: 1,2-Dimethylhydrazine; Animals; Bromodeoxyuridine; Chromosome Aberrations; Colon; Colonic Neoplasms; Dimethylhydrazines; Dose-Response Relationship, Drug; Epithelium; Female; Metaphase; Mice; Mice, Inbred C57BL; Sister Chromatid Exchange; Time Factors | 1986 |
Effects of differing concentrations of sodium butyrate on 1,2-dimethylhydrazine-induced rat intestinal neoplasia.
Topics: Animals; Butyrates; Butyric Acid; Colonic Neoplasms; Dimethylhydrazines; Intestinal Neoplasms; Intestine, Small; Male; Rats; Rats, Inbred Strains | 1986 |
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alanine; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Dipeptides; Glycine; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Nitrosourea Compounds | 1986 |
[Serial endoscopic examinations of 1,2-dimethylhydrazine induced colon tumors in rat and effects of fecal stream].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Colonoscopy; Dimethylhydrazines; Feces; Male; Rats | 1986 |
[Protein kinase activity and phosphorylation of endogenous proteins in the rat colonic mucosa during chemical carcinogenesis].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mucosa; Male; Phosphoproteins; Phosphorylation; Protein Kinases; Proteins; Rats | 1986 |
Anti-initiation activity of N-acetylcysteine in experimental colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Acetylcysteine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Intestinal Neoplasms; Male; Methylhydrazines; Rats; Rats, Inbred Strains | 1986 |
Effect of steel wire sutures on the incidence of chemically induced rodent colonic tumours.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cicatrix; Colitis; Colonic Neoplasms; Dimethylhydrazines; Female; Insect Proteins; Postoperative Complications; Proteins; Rats; Silk; Stainless Steel; Sutures | 1986 |
Activation of the colon carcinogen 1,2-dimethylhydrazine in a rat colon cell-mediated mutagenesis assay.
Topics: 1,2-Dimethylhydrazine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Colon; Colonic Neoplasms; Dimethylhydrazines; Liver Neoplasms; Male; Methylhydrazines; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains | 1986 |
[The effects of gastrectomy on experimentally induced colonic cancer in rats].
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Gastrectomy; Rats | 1986 |
[Experimental carcinogenesis on the rat intestine induced by combination of 1, 2-dimethylhydrazine and n-methyl-n'-nitro-n-nitrosoguanidine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Methylnitronitrosoguanidine; Rats; Rats, Inbred Strains | 1986 |
[Investigation of endogenous prostaglandins in 1,2-dimethyl-hydrazine induced colonic cancer in rats--inhibition of proliferation in colonic cancer with indomethacin treatment].
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Indomethacin; Methylhydrazines; Prostaglandins E; Rats | 1986 |
The mode of growth and compartmentalization of neoplastic glands during experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Cycle; Colonic Neoplasms; Dimethylhydrazines; Female; Growth; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1986 |
A scanning electron microscopy study of changes in rat colonic mucosa during carcinogenesis.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Methylhydrazines; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Neuroendocrine cells within colorectal tumours induced by dimethylhydrazine. An immunocytochemical study.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Gastrointestinal Hormones; Immunoassay; Male; Neuropeptides; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1986 |
Detailed faecal bile acid profile: a diagnostic test for colorectal cancer?
Topics: Animals; Bile Acids and Salts; Chromatography, Gas; Colonic Neoplasms; Dimethylhydrazines; Feces; Female; Gas Chromatography-Mass Spectrometry; Rats; Rats, Inbred Strains; Rectal Neoplasms; Statistics as Topic | 1986 |
Effect of combined tigason and selenium treatment on colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dimethylhydrazines; Etretinate; Male; Methylnitrosourea; Rats; Selenium | 1986 |
Chemoprevention of colorectal neoplasms. Ascorbic acid and beta-carotene.
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; beta Carotene; Body Weight; Carotenoids; Colonic Neoplasms; Diet; Dimethylhydrazines; Male; Rats; Rectal Neoplasms | 1986 |
1,2-Dimethylhydrazine-induced alterations in colonic plasma membrane fluidity: restriction to the luminal region.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Membrane; Colon; Colonic Neoplasms; Dimethylhydrazines; Drug Resistance; Immunity, Innate; Male; Membrane Fluidity; Membrane Lipids; Methylation; Methylhydrazines; Microvilli; Phospholipids; Rats; Rats, Inbred Strains | 1987 |
Premalignant alterations in the glycosphingolipid composition of colonic epithelial cells of rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Fatty Acids; Glycosphingolipids; Male; Methylhydrazines; Precancerous Conditions; Rats | 1987 |
Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Isoenzymes; Kinetics; Male; Rats; Rats, Inbred Strains; Thymidine Kinase; Thymidylate Synthase | 1987 |
Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Allyl Compounds; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Garlic; Methylhydrazines; Mice; Mice, Inbred C57BL; Plants, Medicinal; Sulfides | 1987 |
Changes in intestinal mucosa above lymph follicles during carcinogenesis in rats. A light and electron microscopic study.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Cecum; Colonic Neoplasms; Dimethylhydrazines; Duodenum; Female; Intestinal Mucosa; Intestinal Neoplasms; Jejunum; Lymphatic System; Male; Microscopy, Electron; Rats; Rats, Inbred Strains | 1987 |
Does cholecystectomy affect colonic tumorigenesis?
Topics: Animals; Carcinoma in Situ; Cholecystectomy; Cocarcinogenesis; Colonic Neoplasms; Colonic Polyps; Dimethylhydrazines; Female; Mice | 1987 |
Changes in cell proliferation and morphology in the large intestine of normal and DMH-treated rats following colostomy.
Topics: Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Colostomy; Dimethylhydrazines; Hyperplasia; Intestine, Large; Male; Mitotic Index; Neoplasm Recurrence, Local; Rats; Rats, Inbred Strains | 1987 |
Comparison of immune status and 1,2-dimethylhydrazine induced tumorigenesis in brown--Norway and Fischer rats. Emphasis on splenic and colonic lymphocyte function.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Dimethylhydrazines; Dose-Response Relationship, Drug; Killer Cells, Natural; Male; Methylhydrazines; Rats; Rats, Inbred F344; Rats, Inbred Strains; Spleen; T-Lymphocytes; Time Factors | 1985 |
Experimental colitis and colonic cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Immunohistologic analysis of the T-cell and macrophage infiltrate in 1,2-dimethylhydrazine-induced colon tumors in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Histocompatibility Antigens Class II; Macrophages; Major Histocompatibility Complex; Male; Rats; Rats, Inbred Strains; T-Lymphocytes | 1985 |
Effect of PCBs on DMH-induced colon tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1985 |
Longer survival and fewer metastases by levamisole and tegafur in 1, 2-dimethylhydrazine-induced murine colonic cancers.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Levamisole; Male; Neoplasm Metastasis; Rats; Tegafur | 1985 |
Comments on comparative pathology of colonic neoplasia in cotton-top marmoset (Saguinus oedipus oedipus).
Topics: 1,2-Dimethylhydrazine; Animal Diseases; Animals; Azoxymethane; Callitrichinae; Colitis, Ulcerative; Colonic Neoplasms; Dimethylhydrazines; Histocytochemistry; Humans; Intestinal Mucosa; Rats; Saguinus | 1985 |
Correlation between incidence of 1,2-dimethylhydrazine-induced colon carcinomas and DNA damage in six genetically different mouse strains.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Disease Susceptibility; DNA, Neoplasm; Kidney; Liver; Methylhydrazines; Mice; Mice, Inbred Strains; Species Specificity | 1986 |
The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Colonic Neoplasms; Diet; Dimethylhydrazines; Female; Gastrointestinal Neoplasms; Liver Neoplasms; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Multiple Primary; Time Factors | 1986 |
Minimal invasive carcinoma of the colon in rats.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Lymphoid Tissue; Male; Neoplasm Invasiveness; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Colon adenocarcinoma-associated nuclear antigens.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Cell Nucleus; Chromatin; Colonic Neoplasms; Dimethylhydrazines; Female; Kidney; Liver; Molecular Weight; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1985 |
Inhibitory effects of secretin on gastrin-stimulated rat colon neoplasms.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; DNA; Gastric Mucosa; Gastrins; Injections, Subcutaneous; Intestinal Mucosa; Male; Pyloric Antrum; Rats; Secretin | 1985 |
Protective role of faecal pH in experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Diet; Dimethylhydrazines; Feces; Hydrogen-Ion Concentration; Lactulose; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Risk; Sulfates | 1985 |
Interaction of dietary fat and route of carcinogen administration on 1,2-dimethylhydrazine-induced colon tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Male; Methylhydrazines; Rats | 1985 |
Modification by five antioxidants of 1,2-dimethylhydrazine-initiated colon carcinogenesis in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Ethoxyquin; Male; Propyl Gallate; Rats; Rats, Inbred F344 | 1985 |
Neither dietary ethanol nor beer augments experimental colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Beer; Cocarcinogenesis; Colonic Neoplasms; Diet; Dimethylhydrazines; Ethanol; Male; Rats; Rats, Inbred Strains | 1985 |
The effect of carbon black ingestion on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats and mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carbon; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Female; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains | 1985 |
[Investigation of endogenous prostaglandins in DMH induced colonic cancer in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Male; Methylhydrazines; Prostaglandins; Rats | 1985 |
Amplification and elevated expression of c-myc in a chemically induced mouse colon tumor.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Gene Amplification; Male; Mice; Mice, Inbred BALB C; Oncogenes; Poly A; RNA, Messenger; RNA, Neoplasm | 1985 |
Effect of dietary selenium deficiency on incidence and size of 1,2-dimethylhydrazine-induced colon tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Diet; Dimethylhydrazines; Male; Rats; Selenium | 1985 |
Modulation of symmetrical 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis by isoproterenol (IPR).
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Isoproterenol; Methylhydrazines; Mice; Mice, Inbred Strains | 1985 |
Pararenal angiosarcoma induced in male mice by 1,2-dimethylhydrazine--a model for studying the role of androgens in chemical carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Androgens; Animals; Carcinogens; Castration; Colonic Neoplasms; Dimethylhydrazines; Female; Hemangiosarcoma; Kidney Neoplasms; Liver Neoplasms, Experimental; Male; Methylhydrazines; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Species Specificity; Testosterone | 1985 |
Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor.
Topics: Adenoma; Animals; Colonic Neoplasms; Diet; Dimethylhydrazines; Glycine max; Male; Mice; Mice, Inbred Strains; Plant Extracts; Protease Inhibitors | 1985 |
Influence of dietary cis- and trans-fat on 1,2-dimethylhydrazine-induced colon tumors and fecal steroid excretion in Fischer 344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Cholesterol; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Fatty Acids; Feces; Lipids; Liver; Male; Rats; Rats, Inbred F344; Steroids; Vitamin A; Vitamin E | 1985 |
Adrenergic factors regulating cell division in the colonic crypt epithelium during carcinogenesis and in colonic adenoma and adenocarcinoma.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; Mice; Sympathectomy, Chemical; Sympatholytics; Sympathomimetics | 1985 |
Steroid receptors in dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Rats; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Rectum | 1985 |
Comparison of the circadian variation in cell proliferation in normal and neoplastic colonic epithelial cells.
Topics: Animals; Cell Division; Circadian Rhythm; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; Male; Mice; Sympathectomy, Chemical | 1985 |
Hypergastrinemia and colorectal carcinogenesis in the rat.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Gastrins; Male; Neoplasm Proteins; Radioimmunoassay; Rats; Rats, Inbred Strains; Rectal Neoplasms; RNA, Neoplasm; Time Factors | 1985 |
Are animal models of colon cancer relevant to human disease.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Colonoscopy; Dimethylhydrazines; Disease Models, Animal; Humans; Neoplasm Metastasis; Precancerous Conditions; Rats | 1985 |
Changes in tissue and serum activity of cathepsin B-like cysteine proteinase during colorectal carcinogenesis by 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Cathepsin B; Cathepsins; Colonic Neoplasms; Dimethylhydrazines; Female; Methylhydrazines; Mice; Ovariectomy; Rectal Neoplasms; Time Factors | 1985 |
[Development of 1,2-dimethylhydrazine-induced colonic neoplasia in rats and changes in cellular proteins of colonic mucosa].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Electrophoresis, Polyacrylamide Gel; Intestinal Mucosa; Male; Methylhydrazines; Neoplasm Proteins; Rats; Rats, Inbred Strains | 1985 |
[Experimental colonic cancers].
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Methylhydrazines; Rats | 1985 |
Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Endoplasmic Reticulum; Hydrazines; Kidney Neoplasms; Lethal Dose 50; Leucine; Liver; Male; Mice; Mitochondria; Monomethylhydrazine; Neoplasms; Neoplasms, Experimental; Rats; Ribosomes | 1974 |