dimethylglyoxime and Dermatitis--Contact

To determine the release of nickel from 1- and 2-euro coins and the ability to produce allergic contact dermatitis from the application of coins to the palmar skin of nickel-sensitized individuals.. Three experiments were conducted. Experiments 1 and 2 checked the release of nickel from 1- and 2-euro coins by using the dimethylglyoxime test. In experiment 3, the elicitation of positive reactions was checked by applying coins to the palmar skin for 48 h under occlusion in nickel-sensitized and non-sensitized individuals.. The dimethylglyoxime test for release of nickel was positive in all cases. Positive patch test reactions to euro coins applied to the palmar skin of nickel-sensitized individuals were observed at 48 and 96 h.. The results show that positive patch test reactions to euro coins can be obtained from nickel-sensitized individuals after 48 h of application to the palmar skin under occlusion. These results do not contradict other experiments in which repeated handling of coins was unable to provoke fingertip allergic contact dermatitis. A dose-response relationship is a credible explanation to support such potential discrepancies.

Topics: Belgium; Dermatitis, Contact; European Union; Female; Hand Dermatoses; Humans; Male; Nickel; Numismatics; Oximes; Patch Tests; Reference Values; Risk Assessment; Sampling Studies; Sensitivity and Specificity

Topics: Dermatitis, Contact; Ear, External; Humans; Nickel; Oximes; Punctures; Stainless Steel

Topics: Denmark; Dermatitis, Contact; Female; Humans; Male; Nickel; Oximes

Topics: Dermatitis, Contact; Humans; Nickel; Oximes

In 22 nickel-sensitive subjects, 57 metal clothing objects were said to be not tolerated (37) or tolerated (20). They were analysed by X-ray energy dispersion in electron microscopy, and by the dimethylglyoxime spot test. The correlation between the analytical results and the statements of patients is discussed. Patch tests to nickel-plated metal samples with various thicknesses of chromium (0.25 mu to 1 mu) or gold/copper/cadmium (0.5 mu) were performed in human subjects or in guinea pigs sensitive to nickel. Surface-plating and anticorrosive techniques, as well as the results in nickel-sensitive subjects, are described and discussed. Good tolerance will not be obtained under experimental conditions if nickel in any form is a component of the object. It is to be hoped that appropriate regulations will prohibit the use of nickel in the manufacture of clothing objects.

Topics: Adolescent; Adult; Animals; Clothing; Corrosion; Dermatitis, Contact; Electron Probe Microanalysis; Electroplating; Female; Guinea Pigs; Humans; Male; Middle Aged; Nickel; Oximes; Patch Tests