dimethylglycine and Pregnancy studies

dimethylglycine: metabolic product of calcium pangamate; mutagen when mixed with nitrite; RN given refers to parent cpd
N,N-dimethylglycine : An N-methylglycine that is glycine carrying two N-methyl substituents.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
"We aimed to compare serum betaine concentrations between South Asian and European pregnant women, and to determine the relation between betaine and tHcy concentrations in early pregnancy."	7.91	Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity. ( Lamers, Y; Mujica-Coopman, MF; Schroder, TH; Sinclair, G; Tan, A; Vallance, HD, 2019)
"The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy."	7.79	Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. ( Ballesteros, M; Berrocal-Zaragoza, MI; Cavallé-Busquets, P; Fernandez-Ballart, JD; Fernàndez-Roig, S; Murphy, MM; Salat-Batlle, J; Ueland, PM, 2013)
"Choline needs are increased in pregnancy."	7.79	Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013)
"Choline plays an essential role in the integrity of cell membranes, methylation reactions, and memory development."	5.39	Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. ( Blom, HJ; den Heijer, M; Hogeveen, M; Semmekrot, BA; Sporken, JM; Ueland, PM, 2013)
"We sought to quantify the effects of pregnancy and maternal choline intake on maternal and fetal indicators of choline metabolism."	5.16	Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. ( Allen, RH; Caudill, MA; Devapatla, S; Jiang, X; Malysheva, OV; Perry, CA; Pressman, E; Stabler, SP; Vermeylen, F; West, AA; Yan, J, 2012)
"We aimed to compare serum betaine concentrations between South Asian and European pregnant women, and to determine the relation between betaine and tHcy concentrations in early pregnancy."	3.91	Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity. ( Lamers, Y; Mujica-Coopman, MF; Schroder, TH; Sinclair, G; Tan, A; Vallance, HD, 2019)
"Choline deficiency during pregnancy can lead to adverse birth outcomes, including impaired neurodevelopment and birth defects."	3.81	Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. ( Berger, H; Caudill, MA; Croxford, R; El-Sohemy, A; Kim, YI; Lausman, AY; Ly, A; Malysheva, O; Masih, S; Nielsen, DE; O'Connor, DL; Plumptre, L; Sohn, KJ; Visentin, CE, 2015)
" Women who differed in prenatal alcohol use were recruited during pregnancy and assigned to a group (No study-provided supplements, multivitamin/mineral supplement, or multivitamin/mineral supplement plus choline supplement)."	3.81	The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. ( Chambers, CD; Coles, CD; Jones, KL; Kable, JA; Keen, CL; Kulikovsky, Y; Pedersen, TL; Uriu-Adams, JY; Wertelecki, W; Yevtushok, L, 2015)
"The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy."	3.79	Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. ( Ballesteros, M; Berrocal-Zaragoza, MI; Cavallé-Busquets, P; Fernandez-Ballart, JD; Fernàndez-Roig, S; Murphy, MM; Salat-Batlle, J; Ueland, PM, 2013)
"Choline needs are increased in pregnancy."	3.79	Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. ( Dyer, RA; Innis, SM; King, DJ; Mulder, KA; Wu, BT, 2013)
"Little is known about the interactions between choline and folate and homocysteine metabolism during pregnancy despite the facts that pregnancy places considerable stress on maternal folate and choline stores and that choline is a critical nutrient for the fetus."	3.73	Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. ( Brody, LC; Conley, M; Cox, C; Daly, SF; Kirke, PN; Mills, JL; Molloy, AM; Scott, JM; Ueland, PM, 2005)
"Choline plays an essential role in the integrity of cell membranes, methylation reactions, and memory development."	1.39	Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. ( Blom, HJ; den Heijer, M; Hogeveen, M; Semmekrot, BA; Sporken, JM; Ueland, PM, 2013)
"Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system."	1.39	Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. ( Bonham, MP; Davidson, PW; Henderson, J; Kobrosly, RW; McAfee, AJ; McSorley, EM; Mulhern, MS; Myers, GJ; Shamlaye, CF; Strain, JJ; Thurston, SW; Ueland, PM; van Wijngaarden, E; Wallace, JM; Watson, GE, 2013)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (11.76)	29.6817
2010's	14 (82.35)	24.3611
2020's	1 (5.88)	2.80

Trial	Enrollment	Study Type	Start Date	Status
Phase 1 Study of the Effect of Maternal Nutritional Status on Placental Vascular Function, Fetal Growth and Intrauterine Growth Retardation.[NCT01778205]	831 participants (Actual)	Observational	2005-01-31	Completed
Supply of Term and Preterm Neonates With Choline, Lipids and Vitamines[NCT02027584]	414 participants (Actual)	Observational	2008-11-30	Completed
Nahrungsergänzung Mit Cholin- Und Docosahexaensäure Bei Sehr Unreifen Frühgeborenen[NCT02509728]	24 participants (Actual)	Interventional	2015-07-31	Completed
[NCT02244684]	368 participants (Actual)	Observational	2010-09-30	Completed
Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia[NCT04694235]	653 participants (Anticipated)	Interventional	2021-02-12	Recruiting
Vitamin D Status and Metabolism in Pregnant and Nonpregnant Control Women Consuming Controlled and Equivalent Intakes of Vitamin D[NCT03051867]	47 participants (Actual)	Observational	2009-01-15	Completed
Effect of Maternal Choline Intake on Maternal/Fetal Biomarkers of Choline Status[NCT01127022]	82 participants (Actual)	Interventional	2009-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Effects of dimethylglycine sodium salt supplementation on growth performance, hepatic antioxidant capacity, and mitochondria-related gene expression in weanling piglets born with low birth weight1. Journal of animal science, 2018, Sep-07, Volume: 96, Issue:9 Topics: Alanine Transaminase; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, New	2018
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. The American journal of clinical nutrition, 2012, Volume: 95, Issue:5 Topics: Adult; Betaine; Biomarkers; Choline; Female; Fetal Blood; Fetus; Humans; Methionine; Pregnancy; Sarc	2012

Article	Year
Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity. The Journal of nutrition, 2019, 12-01, Volume: 149, Issue:12 Topics: Adult; Betaine; Canada; Ethnicity; Europe; Female; Homocysteine; Humans; India; Pregnancy; Retrospec	2019
Comprehensive metabolomic analysis of first-trimester serum identifies biomarkers of early-onset hypertensive disorder of pregnancy. Scientific reports, 2020, 08-17, Volume: 10, Issue:1 Topics: Biomarkers; Cysteine; Early Diagnosis; Electrophoresis, Capillary; Female; Humans; Hypertension, Pre	2020
Association between one-carbon metabolism indices and DNA methylation status in maternal and cord blood. Scientific reports, 2018, 11-15, Volume: 8, Issue:1 Topics: Adult; Carbon; CpG Islands; DNA Methylation; Female; Fetal Blood; Humans; Metabolome; Pregnancy; Sar	2018
Maternal betaine status, but not that of choline or methionine, is inversely associated with infant birth weight. The British journal of nutrition, 2019, Volume: 121, Issue:11 Topics: Adult; Betaine; Birth Weight; Choline; Female; Homocysteine; Humans; Infant, Newborn; Infant, Small	2019
Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. Pediatric research, 2013, Volume: 73, Issue:6 Topics: Betaine; Birth Weight; Choline; Female; Humans; Infant, Newborn; Male; Pregnancy; Sarcosine; Umbilic	2013
Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. The American journal of clinical nutrition, 2013, Volume: 97, Issue:6 Topics: Adult; Betaine; Choline; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Lon	2013
Methylation metabolites in amniotic fluid depend on gestational age. Prenatal diagnosis, 2013, Volume: 33, Issue:9 Topics: Adult; Amniotic Fluid; Betaine; Choline; Female; Gestational Age; Humans; Methionine; Methylation; M	2013
Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. The American journal of clinical nutrition, 2013, Volume: 98, Issue:5 Topics: Adult; Betaine; British Columbia; Child Development; Choline; Dietary Supplements; Female; Folic Aci	2013
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma. European journal of nutrition, 2015, Volume: 54, Issue:5 Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;	2015
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma. European journal of nutrition, 2015, Volume: 54, Issue:5 Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;	2015
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma. European journal of nutrition, 2015, Volume: 54, Issue:5 Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;	2015
Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma. European journal of nutrition, 2015, Volume: 54, Issue:5 Topics: Adolescent; Adult; Betaine; Choline; Chromatography, Liquid; Enteral Nutrition; Female; Fetal Blood;	2015
Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. The Journal of nutrition, 2015, Volume: 145, Issue:7 Topics: Adolescent; Adult; Betaine; Canada; Choline; Female; Fetal Blood; Fetus; Genotype; Healthy Volunteer	2015
The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. Alcohol (Fayetteville, N.Y.), 2015, Volume: 49, Issue:7 Topics: Adult; Central Nervous System Depressants; Choline; Dietary Supplements; Ethanol; Female; Fetal Alco	2015
Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. The British journal of nutrition, 2013, Jul-28, Volume: 110, Issue:2 Topics: Betaine; Child Development; Child, Preschool; Choline; Cognition; Female; Homocysteine; Humans; Lang	2013
Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. The American journal of clinical nutrition, 2005, Volume: 82, Issue:4 Topics: Betaine; Choline; Chromatography, Liquid; Creatinine; Cross-Sectional Studies; Female; Fetal Blood;	2005
Relationship of dimethylglycine, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants. The Journal of nutrition, 2007, Volume: 137, Issue:12 Topics: Adolescent; Adult; Betaine; Choline; Choline Dehydrogenase; Female; Gene Expression Regulation, Enzy	2007

dimethylglycine and Pregnancy

Research Excerpts

Research

Studies (17)

Authors

Clinical Trials (7)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Mujica-Coopman, MF	1
Tan, A	1
Schroder, TH	1
Sinclair, G	1
Vallance, HD	1
Lamers, Y	1
Kyozuka, H	1
Fukuda, T	1
Murata, T	1
Endo, Y	1
Kanno, A	1
Yasuda, S	1
Yamaguchi, A	1
Ono, M	1
Sato, A	1
Hashimoto, K	1
Fujimori, K	1
Feng, C	1
Bai, K	1
Wang, A	1
Ge, X	1
Zhao, Y	1
Zhang, L	1
Wang, T	1
Knight, AK	1
Park, HJ	1
Hausman, DB	1
Fleming, JM	1
Bland, VL	1
Rosa, G	1
Kennedy, EM	1
Caudill, MA	3
Malysheva, O	2
Kauwell, GPA	1
Sokolow, A	1
Fisher, S	1
Smith, AK	1
Bailey, LB	1
Du, YF	1
Wei, Y	1
Yang, J	1
Cheng, ZY	1
Zuo, XF	1
Wu, TC	1
Shi, HF	1
Wang, XL	1
Hogeveen, M	1
den Heijer, M	1
Semmekrot, BA	1
Sporken, JM	1
Ueland, PM	4
Blom, HJ	2
Fernàndez-Roig, S	1
Cavallé-Busquets, P	2
Fernandez-Ballart, JD	2
Ballesteros, M	1
Berrocal-Zaragoza, MI	1
Salat-Batlle, J	1
Murphy, MM	2
Imbard, A	1
Schlemmer, D	1
Barto, R	1
Czerkiewicz, I	1
Rigal, O	1
Muller, F	1
Benoist, JF	1
Wu, BT	1
Innis, SM	2
Mulder, KA	1
Dyer, RA	1
King, DJ	1
Bernhard, W	1
Raith, M	1
Kunze, R	1
Koch, V	1
Heni, M	1
Maas, C	1
Abele, H	1
Poets, CF	1
Franz, AR	1
Visentin, CE	1
Masih, S	1
Plumptre, L	1
Nielsen, DE	1
Sohn, KJ	1
Ly, A	1
Lausman, AY	1
Berger, H	1
Croxford, R	1
El-Sohemy, A	1
O'Connor, DL	1
Kim, YI	1
Kable, JA	1
Coles, CD	1
Keen, CL	1
Uriu-Adams, JY	1
Jones, KL	1
Yevtushok, L	1
Kulikovsky, Y	1
Wertelecki, W	1
Pedersen, TL	1
Chambers, CD	1
Solé-Navais, P	1
Yan, J	1
Jiang, X	1
West, AA	1
Perry, CA	1
Malysheva, OV	1
Devapatla, S	1
Pressman, E	1
Vermeylen, F	1
Stabler, SP	1
Allen, RH	1
Strain, JJ	1
McSorley, EM	1
van Wijngaarden, E	1
Kobrosly, RW	1
Bonham, MP	1
Mulhern, MS	1
McAfee, AJ	1
Davidson, PW	1
Shamlaye, CF	1
Henderson, J	1
Watson, GE	1
Thurston, SW	1
Wallace, JM	1
Myers, GJ	1
Molloy, AM	1
Mills, JL	1
Cox, C	1
Daly, SF	1
Conley, M	1
Brody, LC	1
Kirke, PN	1
Scott, JM	1
Friesen, RW	1
Novak, EM	1
Hasman, D	1