dimethylglycine has been researched along with Homocystinuria in 4 studies
dimethylglycine: metabolic product of calcium pangamate; mutagen when mixed with nitrite; RN given refers to parent cpd
N,N-dimethylglycine : An N-methylglycine that is glycine carrying two N-methyl substituents.
Homocystinuria: Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We studied the pharmacokinetics of betaine and its metabolite dimethylglycine (DMG) in healthy subjects and in three patients with homocystinuria." | 9.10 | Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria. ( Balkenhol, N; Hafner, D; Hohlfeld, T; Laryea, MD; Schwahn, BC; Wendel, U, 2003) |
| " We studied the pharmacokinetics of betaine and its metabolite dimethylglycine (DMG) in healthy subjects and in three patients with homocystinuria." | 5.10 | Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria. ( Balkenhol, N; Hafner, D; Hohlfeld, T; Laryea, MD; Schwahn, BC; Wendel, U, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwahn, BC | 1 |
| Hafner, D | 1 |
| Hohlfeld, T | 1 |
| Balkenhol, N | 1 |
| Laryea, MD | 2 |
| Wendel, U | 2 |
| Burns, SP | 1 |
| Iles, RA | 1 |
| Ryalls, M | 1 |
| Leonard, JV | 1 |
| Zass, R | 1 |
| Ritgen, J | 1 |
| Tjørnelund, J | 1 |
| Hansen, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria[NCT00283387] | Phase 2 | 15 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The patients were randomly assigned oral betaine or placebo for 2 months, followed by a 2 month washout. Each patient then received the alternate study medication for 2 months.~Urinary Oxalate Excretion was measured by oxalate oxidase. Two 24 hour urine collections were obtained at baseline, and during the eighth week of each study period." (NCT00283387)
Timeframe: baseline, 2 months, 6 months
| Intervention | umol/mg (Mean) |
|---|---|
| Betaine | 1.43 |
| Placebo | 1.04 |
1 trial available for dimethylglycine and Homocystinuria
| Article | Year |
|---|---|
Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria.
Topics: Administration, Oral; Adult; Betaine; Female; Homocystinuria; Humans; Male; Sarcosine | 2003 |
3 other studies available for dimethylglycine and Homocystinuria
| Article | Year |
|---|---|
Methylgenesis from betaine in cystathionine-beta-synthase deficiency.
Topics: Adolescent; Adult; Betaine; Child; Child, Preschool; Cystathionine gamma-Lyase; Homocystinuria; Huma | 1993 |
Simultaneous determination of betaine and N,N-dimethylglycine in urine.
Topics: Betaine; Child, Preschool; Chromatography, High Pressure Liquid; Homocystinuria; Humans; Reproducibi | 1994 |
Gas chromatographic assay for N,N-dimethylglycine in urine.
Topics: Betaine; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Homocystinuria; Humans; Hypergly | 1990 |