Page last updated: 2024-10-18

dimethylglycine and Chronic Kidney Failure

dimethylglycine has been researched along with Chronic Kidney Failure in 3 studies

dimethylglycine: metabolic product of calcium pangamate; mutagen when mixed with nitrite; RN given refers to parent cpd
N,N-dimethylglycine : An N-methylglycine that is glycine carrying two N-methyl substituents.

Research Excerpts

ExcerptRelevanceReference
"Fasting and post-methionine load hyperhomocysteinemia are independent risk factors for vascular disease that are common in chronic renal failure."9.10Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2002)
"Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown."7.71Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2001)
"Fasting and post-methionine load hyperhomocysteinemia are independent risk factors for vascular disease that are common in chronic renal failure."5.10Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2002)
"Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown."3.71Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. ( Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA, 2001)
"Seven pre-dialysis chronic renal failure patients consumed 400 mg of dimethylglycine or placebo daily for 28 days."2.71Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients. ( Chambers, ST; George, PM; Lee, MB; Lever, M; McGregor, DO; Slow, S, 2004)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Slow, S1
McGregor, DO3
Lever, M3
Lee, MB1
George, PM3
Chambers, ST3
Dellow, WJ2
Robson, RA2

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria[NCT00283387]Phase 215 participants (Actual)Interventional2007-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Urinary Oxalate Excretion

"The patients were randomly assigned oral betaine or placebo for 2 months, followed by a 2 month washout. Each patient then received the alternate study medication for 2 months.~Urinary Oxalate Excretion was measured by oxalate oxidase. Two 24 hour urine collections were obtained at baseline, and during the eighth week of each study period." (NCT00283387)
Timeframe: baseline, 2 months, 6 months

Interventionumol/mg (Mean)
Betaine1.43
Placebo1.04

Trials

2 trials available for dimethylglycine and Chronic Kidney Failure

ArticleYear
Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients.
    Clinical biochemistry, 2004, Volume: 37, Issue:11

    Topics: Adult; Aged; Betaine; Homocysteine; Humans; Kidney Failure, Chronic; Methionine; Middle Aged; Renal

2004
Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure.
    Kidney international, 2002, Volume: 61, Issue:3

    Topics: Aged; Betaine; Cross-Over Studies; Drug Therapy, Combination; Fasting; Female; Folic Acid; Hematinic

2002

Other Studies

1 other study available for dimethylglycine and Chronic Kidney Failure

ArticleYear
Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.
    Kidney international, 2001, Volume: 59, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Betaine; Betaine-Homocysteine S-Methyltransferase;

2001