Page last updated: 2024-10-18

dimethyl sulfoxide and Parkinson Disease

dimethyl sulfoxide has been researched along with Parkinson Disease in 10 studies

Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.

Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Research Excerpts

ExcerptRelevanceReference
"Dimethyl sulfoxide (DMSO) is a highly utilized small molecule that serves many purposes in scientific research."1.72Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein. ( Baun, A; Gram, H; Haikal, C; Jensen, PH; Kovacs, G; Li, JY; Nielsen, J; Otzen, DE; Reimer, L; Ruesink, H; Theologidis, V, 2022)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's5 (50.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Reimer, L1
Haikal, C1
Gram, H1
Theologidis, V1
Kovacs, G1
Ruesink, H1
Baun, A1
Nielsen, J1
Otzen, DE1
Li, JY1
Jensen, PH1
Darbinyan, L1
Simonyan, K1
Manukyan, L1
Hambardzumyan, L1
Kaplan Algin, A1
Tomruk, C1
Gözde Aslan, Ç1
Şaban Akkurt, S1
Mehtap Çinar, G1
Ulukaya, S1
Uyanikgil, Y1
Akçay, Y1
von Stockum, S1
Sanchez-Martinez, A1
Corrà, S1
Chakraborty, J1
Marchesan, E1
Locatello, L1
Da Rè, C1
Cusumano, P1
Caicci, F1
Ferrari, V1
Costa, R1
Bubacco, L1
Rasotto, MB1
Szabo, I1
Whitworth, AJ1
Scorrano, L1
Ziviani, E1
Li, S1
Shen, C1
Guo, W1
Zhang, X1
Liu, S1
Liang, F1
Xu, Z1
Pei, Z1
Song, H1
Qiu, L1
Lin, Y1
Pang, J1
Angelova, PR1
Agrawalla, BK1
Elustondo, PA1
Gordon, J1
Shiba, T1
Abramov, AY1
Chang, YT1
Pavlov, EV1
Matsuda, N1
Sato, S1
Shiba, K1
Okatsu, K1
Saisho, K1
Gautier, CA1
Sou, YS1
Saiki, S1
Kawajiri, S1
Sato, F1
Kimura, M1
Komatsu, M1
Hattori, N1
Tanaka, K1
Högen, T1
Levin, J1
Schmidt, F1
Caruana, M1
Vassallo, N1
Kretzschmar, H1
Bötzel, K1
Kamp, F1
Giese, A1
Butterfield, PG1
Valanis, BG1
Spencer, PS1
Lindeman, CA1
Nutt, JG1
McLean, PJ1
Kawamata, H1
Hyman, BT1

Other Studies

10 other studies available for dimethyl sulfoxide and Parkinson Disease

ArticleYear
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein.
    Scientific reports, 2022, 03-08, Volume: 12, Issue:1

    Topics: alpha-Synuclein; Animals; Dimethyl Sulfoxide; Mice; Mice, Inbred C57BL; Mice, Transgenic; Parkinson

2022
EFFECTS OF DIMETHYL SULFOXIDE ON HIPPOCAMPAL ACTIVITY IN A ROTENONE-INDUCED RAT MODEL OF PARKINSON'S DISEASE.
    Georgian medical news, 2023, Issue:339

    Topics: Dimethyl Sulfoxide; Hippocampus; Humans; Neurodegenerative Diseases; Parkinson Disease; Rotenone

2023
Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease.
    Neuroscience letters, 2023, 09-25, Volume: 814

    Topics: alpha-Synuclein; Animals; Dimethyl Sulfoxide; Disease Models, Animal; Humans; Parkinson Disease; Rat

2023
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.
    Life science alliance, 2019, Volume: 2, Issue:2

    Topics: Animals; Cell Line; Dimethyl Sulfoxide; Dopamine; Dopaminergic Neurons; Down-Regulation; Drosophila;

2019
Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models.
    Marine drugs, 2013, Dec-18, Volume: 11, Issue:12

    Topics: Animals; Caenorhabditis elegans; Cell Survival; Dimethyl Sulfoxide; Disease Models, Animal; Mice; Mi

2013
In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8.
    ACS chemical biology, 2014, Sep-19, Volume: 9, Issue:9

    Topics: Animals; Astrocytes; Benzimidazoles; Brain; Cells, Cultured; Dimethyl Sulfoxide; Disease Models, Ani

2014
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
    The Journal of cell biology, 2010, Apr-19, Volume: 189, Issue:2

    Topics: Animals; Biomarkers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dimethyl Sulfoxide; Fibroblasts; Flu

2010
Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state.
    Biophysical journal, 2012, Apr-04, Volume: 102, Issue:7

    Topics: alpha-Synuclein; Cell Membrane; Dimethyl Sulfoxide; Fluorescence Resonance Energy Transfer; Parkinso

2012
Environmental antecedents of young-onset Parkinson's disease.
    Neurology, 1993, Volume: 43, Issue:6

    Topics: Adult; Age Factors; Case-Control Studies; Dimethyl Sulfoxide; Environmental Exposure; Family; Female

1993
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.
    Neuroscience, 2001, Volume: 104, Issue:3

    Topics: alpha-Synuclein; Animals; Brain; Carrier Proteins; Cerebral Cortex; Cryoprotective Agents; Cysteine

2001