dimethyl sulfoxide has been researched along with Parkinson Disease in 10 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dimethyl sulfoxide (DMSO) is a highly utilized small molecule that serves many purposes in scientific research." | 1.72 | Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein. ( Baun, A; Gram, H; Haikal, C; Jensen, PH; Kovacs, G; Li, JY; Nielsen, J; Otzen, DE; Reimer, L; Ruesink, H; Theologidis, V, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reimer, L | 1 |
| Haikal, C | 1 |
| Gram, H | 1 |
| Theologidis, V | 1 |
| Kovacs, G | 1 |
| Ruesink, H | 1 |
| Baun, A | 1 |
| Nielsen, J | 1 |
| Otzen, DE | 1 |
| Li, JY | 1 |
| Jensen, PH | 1 |
| Darbinyan, L | 1 |
| Simonyan, K | 1 |
| Manukyan, L | 1 |
| Hambardzumyan, L | 1 |
| Kaplan Algin, A | 1 |
| Tomruk, C | 1 |
| Gözde Aslan, Ç | 1 |
| Şaban Akkurt, S | 1 |
| Mehtap Çinar, G | 1 |
| Ulukaya, S | 1 |
| Uyanikgil, Y | 1 |
| Akçay, Y | 1 |
| von Stockum, S | 1 |
| Sanchez-Martinez, A | 1 |
| Corrà, S | 1 |
| Chakraborty, J | 1 |
| Marchesan, E | 1 |
| Locatello, L | 1 |
| Da Rè, C | 1 |
| Cusumano, P | 1 |
| Caicci, F | 1 |
| Ferrari, V | 1 |
| Costa, R | 1 |
| Bubacco, L | 1 |
| Rasotto, MB | 1 |
| Szabo, I | 1 |
| Whitworth, AJ | 1 |
| Scorrano, L | 1 |
| Ziviani, E | 1 |
| Li, S | 1 |
| Shen, C | 1 |
| Guo, W | 1 |
| Zhang, X | 1 |
| Liu, S | 1 |
| Liang, F | 1 |
| Xu, Z | 1 |
| Pei, Z | 1 |
| Song, H | 1 |
| Qiu, L | 1 |
| Lin, Y | 1 |
| Pang, J | 1 |
| Angelova, PR | 1 |
| Agrawalla, BK | 1 |
| Elustondo, PA | 1 |
| Gordon, J | 1 |
| Shiba, T | 1 |
| Abramov, AY | 1 |
| Chang, YT | 1 |
| Pavlov, EV | 1 |
| Matsuda, N | 1 |
| Sato, S | 1 |
| Shiba, K | 1 |
| Okatsu, K | 1 |
| Saisho, K | 1 |
| Gautier, CA | 1 |
| Sou, YS | 1 |
| Saiki, S | 1 |
| Kawajiri, S | 1 |
| Sato, F | 1 |
| Kimura, M | 1 |
| Komatsu, M | 1 |
| Hattori, N | 1 |
| Tanaka, K | 1 |
| Högen, T | 1 |
| Levin, J | 1 |
| Schmidt, F | 1 |
| Caruana, M | 1 |
| Vassallo, N | 1 |
| Kretzschmar, H | 1 |
| Bötzel, K | 1 |
| Kamp, F | 1 |
| Giese, A | 1 |
| Butterfield, PG | 1 |
| Valanis, BG | 1 |
| Spencer, PS | 1 |
| Lindeman, CA | 1 |
| Nutt, JG | 1 |
| McLean, PJ | 1 |
| Kawamata, H | 1 |
| Hyman, BT | 1 |
10 other studies available for dimethyl sulfoxide and Parkinson Disease
| Article | Year |
|---|---|
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein.
Topics: alpha-Synuclein; Animals; Dimethyl Sulfoxide; Mice; Mice, Inbred C57BL; Mice, Transgenic; Parkinson | 2022 |
EFFECTS OF DIMETHYL SULFOXIDE ON HIPPOCAMPAL ACTIVITY IN A ROTENONE-INDUCED RAT MODEL OF PARKINSON'S DISEASE.
Topics: Dimethyl Sulfoxide; Hippocampus; Humans; Neurodegenerative Diseases; Parkinson Disease; Rotenone | 2023 |
Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Dimethyl Sulfoxide; Disease Models, Animal; Humans; Parkinson Disease; Rat | 2023 |
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.
Topics: Animals; Cell Line; Dimethyl Sulfoxide; Dopamine; Dopaminergic Neurons; Down-Regulation; Drosophila; | 2019 |
Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models.
Topics: Animals; Caenorhabditis elegans; Cell Survival; Dimethyl Sulfoxide; Disease Models, Animal; Mice; Mi | 2013 |
In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8.
Topics: Animals; Astrocytes; Benzimidazoles; Brain; Cells, Cultured; Dimethyl Sulfoxide; Disease Models, Ani | 2014 |
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
Topics: Animals; Biomarkers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dimethyl Sulfoxide; Fibroblasts; Flu | 2010 |
Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state.
Topics: alpha-Synuclein; Cell Membrane; Dimethyl Sulfoxide; Fluorescence Resonance Energy Transfer; Parkinso | 2012 |
Environmental antecedents of young-onset Parkinson's disease.
Topics: Adult; Age Factors; Case-Control Studies; Dimethyl Sulfoxide; Environmental Exposure; Family; Female | 1993 |
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.
Topics: alpha-Synuclein; Animals; Brain; Carrier Proteins; Cerebral Cortex; Cryoprotective Agents; Cysteine | 2001 |