dimethyl sulfoxide has been researched along with Osteoarthritis of Knee in 16 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we use a viscous formulation of triamcinolone acetate (TCA) in hyaluronic acid to prolong the anti-allodynia effect of that steroid." | 7.83 | Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model. ( Dall, OM; Das, V; Hamilton, JL; Im, HJ; Kc, R; Kenworth, T; Kroin, JS; Li, X; Shelly, DA; van Wijnen, AJ, 2016) |
| "5% dimethyl sulfoxide (TDiclo) for the treatment of knee or hand osteoarthritis in persons aged 75 years or older." | 7.78 | Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older. ( Fuller, P; Roth, SH, 2012) |
| " In this study we use a viscous formulation of triamcinolone acetate (TCA) in hyaluronic acid to prolong the anti-allodynia effect of that steroid." | 3.83 | Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model. ( Dall, OM; Das, V; Hamilton, JL; Im, HJ; Kc, R; Kenworth, T; Kroin, JS; Li, X; Shelly, DA; van Wijnen, AJ, 2016) |
| "5% dimethyl sulfoxide (TDiclo) for the treatment of knee or hand osteoarthritis in persons aged 75 years or older." | 3.78 | Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older. ( Fuller, P; Roth, SH, 2012) |
| "125 grams 3 times daily for 12 weeks and the other received a placebo in the same dosing frequency." | 2.76 | Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. ( Agar, G; Beer, Y; Debbi, EM; Debi, R; Elbaz, A; Fichman, G; Halperin, N; Kardosh, R; Ziv, YB, 2011) |
| " The commonest adverse event associated with TDiclo was dry skin (18." | 2.74 | Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. ( Bookman, AAM; Grierson, LM; Naseer, Z; Shainhouse, ZJ; Simon, LS, 2009) |
| " A topical NSAID formulation may provide symptom relief with fewer adverse effects." | 2.71 | Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial. ( Roth, SH; Shainhouse, JZ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Toguchi, A | 1 |
| Noguchi, N | 1 |
| Kanno, T | 1 |
| Yamada, A | 1 |
| Lubis, AMT | 1 |
| Siagian, C | 1 |
| Wonggokusuma, E | 1 |
| Marsetyo, AF | 1 |
| Setyohadi, B | 1 |
| Deshmukh, V | 1 |
| Hu, H | 1 |
| Barroga, C | 1 |
| Bossard, C | 1 |
| Kc, S | 1 |
| Dellamary, L | 1 |
| Stewart, J | 1 |
| Chiu, K | 1 |
| Ibanez, M | 1 |
| Pedraza, M | 1 |
| Seo, T | 1 |
| Do, L | 1 |
| Cho, S | 1 |
| Cahiwat, J | 1 |
| Tam, B | 1 |
| Tambiah, JRS | 1 |
| Hood, J | 1 |
| Lane, NE | 1 |
| Yazici, Y | 1 |
| Notarnicola, A | 2 |
| Maccagnano, G | 1 |
| Moretti, L | 2 |
| Pesce, V | 2 |
| Tafuri, S | 2 |
| Fiore, A | 1 |
| Moretti, B | 2 |
| Alekseeva, LI | 1 |
| Sharapova, EP | 1 |
| Kashevarova, NG | 1 |
| Taskina, EA | 1 |
| Anikin, SG | 1 |
| Korotkova, TA | 1 |
| Pyanykh, SE | 1 |
| Kroin, JS | 1 |
| Kc, R | 1 |
| Li, X | 1 |
| Hamilton, JL | 1 |
| Das, V | 1 |
| van Wijnen, AJ | 1 |
| Dall, OM | 1 |
| Shelly, DA | 1 |
| Kenworth, T | 1 |
| Im, HJ | 1 |
| Simon, LS | 1 |
| Grierson, LM | 1 |
| Naseer, Z | 1 |
| Bookman, AAM | 1 |
| Shainhouse, ZJ | 1 |
| Moen, MD | 1 |
| Debbi, EM | 1 |
| Agar, G | 1 |
| Fichman, G | 1 |
| Ziv, YB | 1 |
| Kardosh, R | 1 |
| Halperin, N | 1 |
| Elbaz, A | 1 |
| Beer, Y | 1 |
| Debi, R | 1 |
| Fusaro, L | 1 |
| Roth, SH | 2 |
| Fuller, P | 1 |
| Xia, Z | 1 |
| Duan, X | 1 |
| Murray, D | 1 |
| Triffitt, JT | 1 |
| Price, AJ | 1 |
| Ezaki, J | 1 |
| Hashimoto, M | 1 |
| Hosokawa, Y | 1 |
| Ishimi, Y | 1 |
| Shainhouse, JZ | 1 |
| Kim, LS | 1 |
| Axelrod, LJ | 1 |
| Howard, P | 1 |
| Buratovich, N | 1 |
| Waters, RF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of PENNSAID® for Pain Management in the Emergency Department[NCT01350622] | 0 participants (Actual) | Interventional | 2011-12-31 | Withdrawn (stopped due to Study never initiated) | |||
| [NCT01188213] | 0 participants | Interventional | Completed | ||||
| Double-blind Randomized Clinical Study on Topical Diclofenac Efficacy in Symptomatic Relief of Temporomandibular Degenerative Joint Disease in Women.[NCT00471393] | 28 participants (Actual) | Interventional | 2006-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 trials available for dimethyl sulfoxide and Osteoarthritis of Knee
| Article | Year |
|---|---|
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Dimethyl Sulfoxide; Double-Blind Method; Humans; Knee Joint; Osteoarthritis, Knee; Pain; Quality of | 2023 |
Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
Topics: Anti-Inflammatory Agents; Chondroitin Sulfates; Dietary Supplements; Dimethyl Sulfoxide; Double-Blin | 2017 |
Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial.
Topics: Adult; Aged; Dimethyl Sulfoxide; Female; Glucosamine; Humans; Male; Middle Aged; Osteoarthritis, Kne | 2016 |
[Use of ARTRA MSM FORTE in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug].
Topics: Aged; Anti-Inflammatory Agents; Chondroitin Sulfates; Dimethyl Sulfoxide; Drug Combinations; Female; | 2015 |
Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis.
Topics: Activities of Daily Living; Administration, Oral; Administration, Topical; Aged; Anti-Inflammatory A | 2009 |
Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents; | 2011 |
The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.
Topics: Aged; Anti-Inflammatory Agents; Dietary Supplements; Dimethyl Sulfoxide; Double-Blind Method; Drug T | 2011 |
Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Di | 2004 |
Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Di | 2004 |
Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Di | 2004 |
Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Di | 2004 |
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
Topics: Adult; Aged; Analgesics; Dietary Supplements; Dimethyl Sulfoxide; Double-Blind Method; Drug Administ | 2006 |
7 other studies available for dimethyl sulfoxide and Osteoarthritis of Knee
| Article | Year |
|---|---|
A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Cell Differentiation; Cells, Cultured; Chon | 2018 |
Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model.
Topics: Animals; Biomechanical Phenomena; Delayed-Action Preparations; Dimethyl Sulfoxide; Disease Models, A | 2016 |
Topical diclofenac solution.
Topics: Activities of Daily Living; Administration, Cutaneous; Administration, Oral; Anti-Inflammatory Agent | 2009 |
Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older.
Topics: Administration, Topical; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, No | 2012 |
A method of isolating viable chondrocytes with proliferative capacity from cryopreserved human articular cartilage.
Topics: Aged; Aged, 80 and over; Cartilage, Articular; Cell Proliferation; Cell Separation; Cell Survival; C | 2013 |
Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model.
Topics: Animals; Anti-Inflammatory Agents; Cartilage; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Respo | 2013 |
Supplement may ease pain of knee osteoarthritis.
Topics: Analgesics; Arthralgia; Dimethyl Sulfoxide; Humans; Osteoarthritis, Knee; Sulfones | 2006 |