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dimethyl sulfoxide and Nerve Degeneration

dimethyl sulfoxide has been researched along with Nerve Degeneration in 9 studies

Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
"The safety and tolerability of a free radical scavenger with Na+ channel blocking activity (dimethyl sulfoxide (DMSO)) combined with a glycolytic intermediate and high energy substrate (fructose 1,6-disphosphate (FDP)) were assessed in a mostly elderly patient group presenting with acute and subacute ischemic stroke."5.10Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial. ( de la Torre, JC; Demir, S; Karaça, M; Kiliç, E; Yazici, B, 2002)
"Dimethyl sulfoxide (DMSO) is a solvent that is routinely used as a cryopreservative in allogous bone marrow and organ transplantation."1.35Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. ( Farber, NB; Hanslick, JL; Lau, K; Mennerick, S; Noguchi, KK; Olney, JW; Zorumski, CF, 2009)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's2 (22.22)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Di Giorgio, AM1
Hou, Y1
Zhao, X1
Zhang, B1
Lyeth, BG1
Russell, MJ1
Hanslick, JL1
Lau, K1
Noguchi, KK1
Olney, JW1
Zorumski, CF1
Mennerick, S1
Farber, NB1
Henschen, A1
Olson, L1
de la Torre, JC2
Fukuchi, K1
Sopher, B1
Furlong, CE1
Smith, AC1
Dang, N1
Martin, GM1
Hiraide, T1
Katsura, K1
Muramatsu, H1
Asano, G1
Katayama, Y1
Karaça, M1
Kiliç, E1
Yazici, B1
Demir, S1
Blakemore, WF1
Cavanagh, JB1
Knott, LW1
Katz, J1
Rubinstein, LJ1

Trials

1 trial available for dimethyl sulfoxide and Nerve Degeneration

ArticleYear
Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial.
    Neurological research, 2002, Volume: 24, Issue:1

    Topics: Adult; Aged; Aging; Brain; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Drug Combin

2002

Other Studies

8 other studies available for dimethyl sulfoxide and Nerve Degeneration

ArticleYear
Dimethyl sulfoxide provides neuroprotection in a traumatic brain injury model.
    Restorative neurology and neuroscience, 2008, Volume: 26, Issue:6

    Topics: alpha-Tocopherol; Analysis of Variance; Animals; Brain; Brain Injuries; Dimethyl Sulfoxide; Disease

2008
Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system.
    Neurobiology of disease, 2009, Volume: 34, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; Cells, Cultured; Dimethyl Sulfoxide;

2009
Hexachlorophene-induced degeneration of adrenergic nerves: application of quantitative image analysis to Falck-Hillarp fluorescence histochemistry.
    Acta neuropathologica, 1983, Volume: 59, Issue:2

    Topics: Animals; Axons; Computers; Dimethyl Sulfoxide; Female; Hexachlorophene; Histocytochemistry; Iris; Ma

1983
Treatment of head injury in mice, using a fructose 1,6-diphosphate and dimethyl sulfoxide combination.
    Neurosurgery, 1995, Volume: 37, Issue:2

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Brain; Cerebral Cortex; Dimethyl Sulfoxi

1995
Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid precursor protein.
    Neuroscience letters, 1993, May-14, Volume: 154, Issue:1-2

    Topics: Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Su

1993
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil.
    Brain research, 2001, Aug-10, Volume: 910, Issue:1-2

    Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Isch

2001
"Neuroaxonal dystrophy" occurring in an experimental "dying back" process in the rat.
    Brain : a journal of neurology, 1969, Volume: 92, Issue:4

    Topics: Animals; Axons; Dimethyl Sulfoxide; Male; Microscopy, Electron; Mitosis; Nerve Degeneration; Nerve F

1969
Separate and combined effects of phenol, hyaluronidase, and dimethyl sulfoxide on the sciatic nerve of the rat. II. Chronic studies.
    Neurology, 1969, Volume: 19, Issue:10

    Topics: Animals; Axons; Dimethyl Sulfoxide; Drug Synergism; Follow-Up Studies; Hyaluronoglucosaminidase; Ner

1969