dimethyl sulfoxide has been researched along with Multiple Myeloma in 33 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 57-year-old man with IgG multiple myeloma developed pulmonary infiltration caused by pulmonary amyloidosis, for which continuous transdermal dimethyl sulfoxide (DMSO) treatment was given." | 8.79 | A case of pulmonary amyloidosis associated with multiple myeloma successfully treated with dimethyl sulfoxide. ( Aizawa, K; Hamano, T; Iwasaki, T; Kakishita, E; Kobayashi, K, 1994) |
| " The results of this case indicate that long-term administration of IFN-alpha and DMSO with VAD is effective in treating amyloidosis with multiple myeloma." | 5.31 | Successful treatment of multiple myeloma--associated amyloidosis by interferon-alpha, dimethyl sulfoxide, and VAD (vincristine, adriamycin, and dexamethasone). ( Hatake, K; Ichida, M; Imagawa, S; Komatsu, N; Miura, Y; Ohmine, K; Ozawa, K, 2000) |
| "A 57-year-old man with IgG multiple myeloma developed pulmonary infiltration caused by pulmonary amyloidosis, for which continuous transdermal dimethyl sulfoxide (DMSO) treatment was given." | 4.79 | A case of pulmonary amyloidosis associated with multiple myeloma successfully treated with dimethyl sulfoxide. ( Aizawa, K; Hamano, T; Iwasaki, T; Kakishita, E; Kobayashi, K, 1994) |
| "Products cryopreserved with dimethyl sulfoxide (DMSO) in stem cell transplant (SCT) often cause many adverse effects during their infusion (major cardiovascular events, dyspnea … even death)." | 2.77 | An automatic wash method for dimethyl sulfoxide removal in autologous hematopoietic stem cell transplantation decreases the adverse effects related to infusion. ( Blanquer, M; Cabañas-Perianes, V; García-Hernández, A; Gómez-Espuch, J; Insausti, CL; Majado, MJ; Menchón, P; Monserrat, J; Moraleda, JM; Morales, A; Sánchez-Ibáñez, MV; Sánchez-Salinas, A, 2012) |
| "Cells from leukapheresis products from multiple myeloma patients and umbilical cord blood cells were suspended in 1, 2, 5, or 10% Me2SO for 20 min at 22 degrees C." | 1.33 | Effect of dimethyl sulfoxide on post-thaw viability assessment of CD45+ and CD34+ cells of umbilical cord blood and mobilized peripheral blood. ( Acker, JP; Akabutu, J; Liu, JZ; McGann, LE; Yang, H; Zhao, H, 2005) |
| " The results of this case indicate that long-term administration of IFN-alpha and DMSO with VAD is effective in treating amyloidosis with multiple myeloma." | 1.31 | Successful treatment of multiple myeloma--associated amyloidosis by interferon-alpha, dimethyl sulfoxide, and VAD (vincristine, adriamycin, and dexamethasone). ( Hatake, K; Ichida, M; Imagawa, S; Komatsu, N; Miura, Y; Ohmine, K; Ozawa, K, 2000) |
| " Pharmacokinetic parameters in individual patients have been related to short-term toxicity and risk of relapse after HSCT." | 1.30 | Pharmacokinetics of intravenous busulfan and evaluation of the bioavailability of the oral formulation in conditioning for haematopoietic stem cell transplantation. ( Deeg, J; Ehninger, G; Ehrsam, M; Schmidt, H; Schneider, A; Schuler, US, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 6 (18.18) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 6 (18.18) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, S | 1 |
| Chen, Y | 1 |
| Wang, X | 1 |
| Weng, S | 1 |
| Zhou, W | 1 |
| Liu, Z | 1 |
| Polymeris, AA | 1 |
| Stehle, GT | 1 |
| Medinger, M | 1 |
| De Marchis, GM | 1 |
| Reich-Slotky, R | 1 |
| Makhani, SS | 1 |
| Vasovic, LV | 1 |
| Pearse, RN | 1 |
| Rossi, A | 1 |
| Philips, A | 1 |
| Cushing, MM | 1 |
| Singh, AD | 1 |
| van Besien, K | 1 |
| Hoskote, SS | 1 |
| Reddy, DR | 1 |
| Onigkeit, JA | 1 |
| Akkök, CA | 2 |
| Holte, MR | 1 |
| Tangen, JM | 1 |
| Ostenstad, B | 1 |
| Bruserud, O | 3 |
| Abdelkefi, A | 1 |
| Lakhal, A | 1 |
| Moojat, N | 1 |
| Hamed, LB | 1 |
| Fekih, J | 1 |
| Ladeb, S | 1 |
| Torjman, L | 1 |
| Othman, TB | 1 |
| Liseth, K | 2 |
| Ersvær, E | 1 |
| Abrahamsen, JF | 3 |
| Nesthus, I | 2 |
| Ryningen, A | 1 |
| Bruserud, Ø | 1 |
| Veeraputhiran, M | 1 |
| Theus, JW | 1 |
| Pesek, G | 1 |
| Barlogie, B | 1 |
| Cottler-Fox, M | 1 |
| Elie, R | 1 |
| Sánchez-Salinas, A | 1 |
| Cabañas-Perianes, V | 1 |
| Blanquer, M | 1 |
| Majado, MJ | 1 |
| Insausti, CL | 1 |
| Monserrat, J | 1 |
| Sánchez-Ibáñez, MV | 1 |
| Menchón, P | 1 |
| García-Hernández, A | 1 |
| Gómez-Espuch, J | 1 |
| Morales, A | 1 |
| Moraleda, JM | 1 |
| Windrum, P | 1 |
| Morris, TC | 1 |
| Bakken, AM | 1 |
| Yang, H | 1 |
| Zhao, H | 1 |
| Acker, JP | 1 |
| Liu, JZ | 1 |
| Akabutu, J | 1 |
| McGann, LE | 1 |
| Løkeland, T | 1 |
| Tefre, K | 1 |
| Adolf, GR | 1 |
| Haas, OA | 1 |
| Fischer, P | 1 |
| Swetly, P | 1 |
| Kisilevsky, R | 1 |
| Kodama, F | 1 |
| Motomura, S | 1 |
| Itoh, A | 1 |
| Fukushima, K | 1 |
| Ono, Y | 1 |
| Shimoyama, K | 1 |
| Shimizu, S | 1 |
| Shiozawa, S | 1 |
| Shiozawa, K | 1 |
| Arita, C | 1 |
| Isobe, T | 1 |
| Fujita, T | 1 |
| Urano, Y | 1 |
| Misra, DN | 1 |
| Noeman, SA | 1 |
| Kunz, HW | 1 |
| Gill, TJ | 1 |
| Glenner, GG | 1 |
| Galmés, A | 1 |
| Besalduch, J | 1 |
| Bargay, J | 1 |
| Matamoros, N | 1 |
| Morey, M | 1 |
| Novo, A | 1 |
| Sampol, A | 1 |
| Iwasaki, T | 1 |
| Hamano, T | 1 |
| Aizawa, K | 1 |
| Kobayashi, K | 1 |
| Kakishita, E | 1 |
| Comas, D | 1 |
| Mateu, J | 1 |
| Schuler, US | 1 |
| Ehrsam, M | 1 |
| Schneider, A | 1 |
| Schmidt, H | 1 |
| Deeg, J | 1 |
| Ehninger, G | 1 |
| Loubat, A | 1 |
| Rochet, N | 1 |
| Turchi, L | 1 |
| Rezzonico, R | 1 |
| Far, DF | 1 |
| Auberger, P | 1 |
| Rossi, B | 1 |
| Ponzio, G | 1 |
| Ichida, M | 1 |
| Imagawa, S | 1 |
| Ohmine, K | 1 |
| Komatsu, N | 1 |
| Hatake, K | 1 |
| Ozawa, K | 1 |
| Miura, Y | 1 |
| Hachmann, HJ | 1 |
| Lezius, AG | 1 |
| Mizuno, M | 2 |
| Kawashima, S | 2 |
| Rodi, CP | 1 |
| Sauerbier, W | 1 |
| Kojima, K | 1 |
| Hasegawa, H | 1 |
| Fujishiro, T | 1 |
| Yanai, T | 1 |
| Murai, S | 1 |
| Funahashi, N | 1 |
| Ogawa, T | 1 |
| Ohkusa, T | 1 |
| Kishida, K | 1 |
| Nagano, Y | 1 |
| Ishii, K | 1 |
| Nakahara, Y | 2 |
| Tomita, M | 1 |
| Ushida, S | 1 |
| Kadoya, M | 1 |
| Matsuyama, E | 1 |
| Leder, P | 1 |
| Ross, J | 1 |
| Gielen, J | 1 |
| Packman, S | 1 |
| Ikawa, Y | 1 |
| Aviv, H | 1 |
| Swan, D | 1 |
| Lezius, A | 1 |
| Müller-Lornsen, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Proliferative Potential of Human Peripheral Blood Stem Cells Based on Demographic Factors and Cryopreservation Time[NCT05573412] | 100 participants (Anticipated) | Observational | 2022-08-16 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dimethyl sulfoxide and Multiple Myeloma
| Article | Year |
|---|---|
Amyloidosis: a familiar problem in the light of current pathogenetic developments.
Topics: Amino Acid Sequence; Amyloid; Amyloidosis; Animals; Blood Coagulation Disorders; Blood Physiological | 1983 |
Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).
Topics: Adrenal Cortex Hormones; Aged; Amyloid; Amyloidosis; Antineoplastic Agents; Bence Jones Protein; Bio | 1980 |
A case of pulmonary amyloidosis associated with multiple myeloma successfully treated with dimethyl sulfoxide.
Topics: Administration, Cutaneous; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Dimethyl Sul | 1994 |
4 trials available for dimethyl sulfoxide and Multiple Myeloma
| Article | Year |
|---|---|
Hematopoietic engraftment of dimethyl sulfoxide-depleted autologous peripheral blood progenitor cells.
Topics: Adult; Amyloidosis; Blood Preservation; Cryoprotective Agents; Dimethyl Sulfoxide; Female; Graft Sur | 2009 |
Long-term cryopreservation of autologous stem cell grafts: a clinical and experimental study of hematopoietic and immunocompetent cells.
Topics: Cryopreservation; Cryoprotective Agents; Dimethyl Sulfoxide; Female; Flow Cytometry; Hematopoietic S | 2009 |
An automatic wash method for dimethyl sulfoxide removal in autologous hematopoietic stem cell transplantation decreases the adverse effects related to infusion.
Topics: Adult; Aged; Blood Component Removal; Blood Preservation; Blood Transfusion, Autologous; Cell Surviv | 2012 |
A simplified method for cryopreservation of hematopoietic stem cells with -80 degrees C mechanical freezer with dimethyl sulfoxide as the sole cryoprotectant.
Topics: Adult; Blood Preservation; Breast Neoplasms; Cryopreservation; Dimethyl Sulfoxide; Female; Freezing; | 1995 |
26 other studies available for dimethyl sulfoxide and Multiple Myeloma
| Article | Year |
|---|---|
Effect of EPA on Hsp90 and GRα protein expression in multiple myeloma drug-resistant cells.
Topics: Apoptosis; Cell Culture Techniques; Cell Proliferation; Cryoprotective Agents; Dexamethasone; Dimeth | 2021 |
Transient focal neurologic deficits upon hematopoietic stem cell transplantation: just a coincidence?
Topics: Aged; Cerebrovascular Disorders; Cryopreservation; Cryoprotective Agents; Dimethyl Sulfoxide; Hemato | 2019 |
Comparison of time to engraftment between autologous patients receiving washed versus non-washed cryopreserved peripheral blood stem cell products.
Topics: Aged; Blood Platelets; Cell Survival; Cryopreservation; Cryoprotective Agents; Dimethyl Sulfoxide; F | 2018 |
Precipitation of ventricular bigeminy by DMSO during autologous haematopoietic stem cell transplantation.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Atrioventricular Block; Bortezomib; Cryoprotec | 2015 |
Severe neurotoxicity associated with dimethyl sulphoxide following PBSCT.
Topics: Cryoprotective Agents; Dimethyl Sulfoxide; Female; Hematopoietic Stem Cell Transplantation; Hematopo | 2009 |
Viability and engraftment of hematopoietic progenitor cells after long-term cryopreservation: effect of diagnosis and percentage dimethyl sulfoxide concentration.
Topics: Antigens, CD34; Blood Platelets; Cell Count; Cell Survival; Cryopreservation; Dimethyl Sulfoxide; Gr | 2010 |
Dimethyl sulphoxide does not contribute to renal failure in patients undergoing stem cell transplant for multiple myeloma and primary amyloidosis.
Topics: Amyloidosis; Dimethyl Sulfoxide; Female; Humans; Kidney Function Tests; Male; Multiple Myeloma; Rena | 2012 |
Severe neurotoxicity because of dimethyl sulphoxide following peripheral blood stem cell transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cryopreservation; Cryopro | 2003 |
No differences in colony formation of peripheral blood stem cells frozen with 5% or 10% dimethyl sulfoxide.
Topics: Bone Neoplasms; Cell Division; Colony-Forming Units Assay; Cryoprotective Agents; Dimethyl Sulfoxide | 2003 |
Effect of dimethyl sulfoxide on post-thaw viability assessment of CD45+ and CD34+ cells of umbilical cord blood and mobilized peripheral blood.
Topics: Antigens, CD34; Cell Survival; Cryopreservation; Cryoprotective Agents; Data Interpretation, Statist | 2005 |
Autologous peripheral blood progenitor cells cryopreserved with 5 and 10 percent dimethyl sulfoxide alone give comparable hematopoietic reconstitution after transplantation.
Topics: Adolescent; Adult; Antigens, CD34; Blood Preservation; Blood Transfusion; Cryopreservation; Cryoprot | 2008 |
Spontaneous production of alpha- and beta-interferon in human lymphoblastoid and lymphoma cell lines.
Topics: Bromodeoxyuridine; Cell Line; Dexamethasone; Dimethyl Sulfoxide; Hematopoiesis; Humans; Interferons; | 1982 |
Trials of intravenous dimethyl sulfoxide therapy and scanning for soft-tissue amyloid to a patient with amyloidosis associated with multiple myeloma: a case report.
Topics: Amyloidosis; Dimethyl Sulfoxide; Diphosphonates; Female; Humans; Middle Aged; Multiple Myeloma; Radi | 1981 |
[Effect of dimethylsulfoxide-ointment in carpal tunnel syndrome with amyloidosis and Bence Jones kappa-type multiple myeloma].
Topics: Administration, Topical; Amyloidosis; Carpal Tunnel Syndrome; Dimethyl Sulfoxide; Female; Humans; Mi | 1984 |
Production of monoclonal antibodies to rat MHC antigens using different myelomas.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Antigen-Antibody Reactions; Dimethyl Sulfoxide; | 1981 |
Treatment of extravasation of both doxorubicin and vincristine administration in a Y-site infusion.
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protoc | 1996 |
Pharmacokinetics of intravenous busulfan and evaluation of the bioavailability of the oral formulation in conditioning for haematopoietic stem cell transplantation.
Topics: Administration, Oral; Adult; Animals; Biological Availability; Busulfan; Dimethyl Sulfoxide; Dogs; H | 1998 |
Evidence for a p23 caspase-cleaved form of p27[KIP1] involved in G1 growth arrest.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase | 1999 |
Successful treatment of multiple myeloma--associated amyloidosis by interferon-alpha, dimethyl sulfoxide, and VAD (vincristine, adriamycin, and dexamethasone).
Topics: Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Dimethyl Sulfoxide; Doxo | 2000 |
High-molecular-weight DNA polymerases from mouse myeloma. Purification and properties of three enzymes.
Topics: Animals; Cardiolipins; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatogra | 1975 |
[Plasma exchange therapy of myeloma].
Topics: Acute Kidney Injury; Aged; Blood Viscosity; Dimethyl Sulfoxide; Female; Hemofiltration; Humans; Male | 1992 |
Structure of transcriptionally active chromatin: radiological evidence for requirement of torsionally constrained DNA.
Topics: Animals; Cell Line; Chromatin; Dimethyl Sulfoxide; DNA; DNA-Directed RNA Polymerases; DNA, Single-St | 1989 |
[Successful treatments of plasma exchange, hemodialysis, immunosuppressive agents and dimethylsulfoxide in a case of myeloma kidney].
Topics: Bence Jones Protein; Combined Modality Therapy; Dimethyl Sulfoxide; Humans; Immunosuppressive Agents | 1987 |
[A case of multiple myeloma with diffuse parenchimatous alveoloseptal amyloidosis].
Topics: Amyloidosis; Dimethyl Sulfoxide; Humans; Lung Diseases; Male; Melphalan; Middle Aged; Multiple Myelo | 1986 |
Regulated expression of mammalian genes: globin and immunoglobulin as model systems.
Topics: Animals; Antibody Formation; Carcinoma, Krebs 2; Cell Line; Dactinomycin; Dimethyl Sulfoxide; DNA, N | 1974 |
Effects of phospholipids and dimethylsulfoxide on the activity of RNA polymerase A from mouse myeloma cells.
Topics: Adenine Nucleotides; Animals; Cardiolipins; Cattle; Cell-Free System; Centrifugation, Density Gradie | 1972 |