Page last updated: 2024-10-18

dimethyl sulfoxide and Kidney Papillary Necrosis

dimethyl sulfoxide has been researched along with Kidney Papillary Necrosis in 2 studies

Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.

Kidney Papillary Necrosis: A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.

Research Excerpts

ExcerptRelevanceReference
"When diphenylamine in DMSO was administered orally to male Syrian hamsters (400, 600 or 800 mg/kg body weight/day for up to 9 days), the incidence of renal papillary necrosis was almost zero."1.28Decreased incidence of diphenylamine-induced renal papillary necrosis in Syrian hamsters given dimethylsulphoxide. ( Carlton, WW; Lenz, SD, 1991)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wolf, DC1
Carlton, WW2
Turek, JJ1
Lenz, SD1

Other Studies

2 other studies available for dimethyl sulfoxide and Kidney Papillary Necrosis

ArticleYear
Experimental renal papillary necrosis in the Mongolian gerbil (Meriones unguiculatus).
    Toxicologic pathology, 1992, Volume: 20, Issue:3 Pt 1

    Topics: Animals; Dimethyl Sulfoxide; Diuresis; Ethylamines; Female; Gerbillinae; Kidney Medulla; Kidney Papi

1992
Decreased incidence of diphenylamine-induced renal papillary necrosis in Syrian hamsters given dimethylsulphoxide.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1991, Volume: 29, Issue:6

    Topics: Administration, Oral; Animals; Cricetinae; Dimethyl Sulfoxide; Diphenylamine; Dose-Response Relation

1991