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dimethyl sulfoxide and Invasiveness, Neoplasm

dimethyl sulfoxide has been researched along with Invasiveness, Neoplasm in 24 studies

Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.

Research Excerpts

ExcerptRelevanceReference
" We found that polar compounds and butyric acid, which are known to alter the expressions of normally silent genes, enhanced the lung-colonizing ability of cloned low-metastatic Lewis lung carcinoma cells."4.77Modification of the metastatic potential of tumor cells by drugs. ( Takenaga, K, 1986)
"Using a panel of pharmacological inhibitors (BAY 43-9006, PD98059, U0126, wortmannin, LY294002) we inhibited the MAPK and AKT signalling pathways at different levels and evaluated the effects on growth, survival and invasion of melanoma cells in monolayer and organotypic skin culture."3.74Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. ( Busch, S; Garbe, C; Herlyn, M; Kulms, D; Lasithiotakis, K; Maczey, E; Meier, F; Schittek, B, 2007)
"Overall, our study revealed a novel metastasis-promoting function of SOCS5 in HCC, acting via the PI3K/Akt/mTOR-mediated autophagy pathway."1.51SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway. ( Chua, MS; Han, B; Li, H; Liu, S; Luo, D; Sun, C; Wang, S; Zhang, M; Zhang, S, 2019)
"A major challenge in the management of prostate cancer (PC) is to limit tumor growth and metastases."1.48Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells. ( Domińska, K; Habrowska-Górczyńska, DE; Kowalska, K; Piastowska-Ciesielska, AW; Urbanek, KA, 2018)
"CAY10591 treatment dose- and time-dependently increased SIRT1 level and activity."1.46CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells. ( Mikami, Y; Murofushi, T; Suzuki, N; Tsuda, H; Yamaguchi, Y, 2017)
"Melanoma is a highly metastatic and lethal form of skin cancer."1.40BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling. ( Cook, M; Girotti, MR; Gore, M; Hayes, A; Larkin, J; Lorigan, P; Marais, R; Niculescu-Duvaz, D; Pedersen, M; Sanchez-Laorden, B; Saturno, G; Springer, C; Turajlic, S; Viros, A; Zambon, A, 2014)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.33)18.7374
1990's4 (16.67)18.2507
2000's12 (50.00)29.6817
2010's6 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, M1
Liu, S1
Chua, MS1
Li, H1
Luo, D1
Wang, S1
Zhang, S1
Han, B1
Sun, C1
Murofushi, T1
Tsuda, H1
Mikami, Y1
Yamaguchi, Y1
Suzuki, N1
Kowalska, K1
Habrowska-Górczyńska, DE1
Domińska, K1
Urbanek, KA1
Piastowska-Ciesielska, AW1
Sanchez-Laorden, B1
Viros, A1
Girotti, MR1
Pedersen, M1
Saturno, G1
Zambon, A1
Niculescu-Duvaz, D1
Turajlic, S1
Hayes, A1
Gore, M1
Larkin, J1
Lorigan, P1
Cook, M1
Springer, C1
Marais, R1
Valls-Mateus, M1
Román, LS1
Macho, J1
Nadal, A1
Bernal-Sprekelsen, M1
Vilaseca, I1
Horiguchi, A1
Asano, T2
Ito, K1
Sumitomo, M1
Hayakawa, M1
Wang, W1
Zhang, N1
Wang, J1
Bu, XM1
Zhao, CH1
Bergamo, A6
Gava, B3
Alessio, E4
Mestroni, G2
Serli, B2
Cocchietto, M5
Zorzet, S5
Sava, G7
Turrin, C1
Vita, F1
Soranzo, M1
Zabucchi, G1
DiGiovine, S1
Pezzoni, G1
Sartor, L1
Garbisa, S1
Stocco, G1
Casarsa, C1
Schwarzer, R1
Tondera, D1
Arnold, W1
Giese, K1
Klippel, A1
Kaufmann, J1
Spessotto, P1
Jeong, YI1
Kim, SH1
Jung, TY1
Kim, IY1
Kang, SS1
Jin, YH1
Ryu, HH1
Sun, HS1
Jin, S1
Kim, KK1
Ahn, KY1
Jung, S1
Meier, F1
Busch, S1
Lasithiotakis, K1
Kulms, D1
Garbe, C1
Maczey, E1
Herlyn, M1
Schittek, B1
Griffith, D1
Cecco, S1
Zangrando, E1
Marmion, CJ1
Maehara, M1
Yagita, M1
Isobe, Y1
Hoshino, T1
Nakagawara, G1
Popowicz, P1
Engel, G1
Marshall, H1
Linder, S1
Nakae, T1
Horai, T1
Imamura, F1
Akedo, H1
Higashino, K1
Vajkoczy, P1
Menger, MD1
Goldbrunner, R1
Ge, S1
Fong, TA1
Vollmar, B1
Schilling, L1
Ullrich, A1
Hirth, KP1
Tonn, JC1
Schmiedek, P1
Rempel, SA1
Sorc, A1
Iengo, E1
Bentel, JM1
Rhodes, GC1
Markus, I1
Smith, GJ1
Takenaga, K1
Ossowski, L1

Reviews

2 reviews available for dimethyl sulfoxide and Invasiveness, Neoplasm

ArticleYear
Ruthenium anticancer drugs.
    Metal ions in biological systems, 2004, Volume: 42

    Topics: Antineoplastic Agents; Cell Cycle; Dimethyl Sulfoxide; Humans; Mitogen-Activated Protein Kinases; Ne

2004
Modification of the metastatic potential of tumor cells by drugs.
    Cancer metastasis reviews, 1986, Volume: 5, Issue:2

    Topics: Animals; Azacitidine; Butyrates; Butyric Acid; Carcinoma; Cell Division; Cell Line; Cells, Cultured;

1986

Other Studies

22 other studies available for dimethyl sulfoxide and Invasiveness, Neoplasm

ArticleYear
SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway.
    Cell death & disease, 2019, 08-13, Volume: 10, Issue:8

    Topics: Animals; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Dimethyl Sulfoxide;

2019
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
    Journal of oral science, 2017, Volume: 59, Issue:3

    Topics: Cell Division; Cell Line, Tumor; Cyclopentanes; Dimethyl Sulfoxide; Gingival Neoplasms; Humans; Neop

2017
Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells.
    Environmental toxicology and pharmacology, 2018, Volume: 64

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movem

2018
BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.
    Science signaling, 2014, Mar-25, Volume: 7, Issue:318

    Topics: Animals; Blotting, Western; Cell Shape; Dimethyl Sulfoxide; Drug Resistance, Neoplasm; Enzyme-Linked

2014
Transoral ultrasonic surgery of pharyngolaryngeal giant hemangioma after ethylene-vinyl alcohol copolymer (Onyx) embolization.
    Head & neck, 2017, Volume: 39, Issue:6

    Topics: Aged; Combined Modality Therapy; Dimethyl Sulfoxide; Embolization, Therapeutic; Follow-Up Studies; H

2017
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
    The Journal of urology, 2008, Volume: 180, Issue:2

    Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Cell Count; Cell

2008
Inhibition of proliferation, viability, migration and invasion of gastric cancer cells by Aurora-A deletion.
    Asian Pacific journal of cancer prevention : APJCP, 2011, Volume: 12, Issue:10

    Topics: Aurora Kinases; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dimethyl Sulfoxi

2011
Ruthenium-based NAMI-A type complexes with in vivo selective metastasis reduction and in vitro invasion inhibition unrelated to cell cytotoxicity.
    International journal of oncology, 2002, Volume: 21, Issue:6

    Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Dimethyl Sulfoxide; G2 Phase; Humans; Lung Ne

2002
Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:5

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Adhesion; Cell Division;

2003
Reduction of in vivo lung metastases by dinuclear ruthenium complexes is coupled to inhibition of in vitro tumour invasion.
    International journal of oncology, 2004, Volume: 24, Issue:2

    Topics: Animals; Cell Line, Tumor; Collagen; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Comb

2004
REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.
    Oncogene, 2005, Feb-10, Volume: 24, Issue:7

    Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Chromones; Cobalt; Dimethyl Sulfoxide; Gene Expression; H

2005
Inhibition of B16 melanoma metastases with the ruthenium complex imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate and down-regulation of tumor cell invasion.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Adhesion Molecules; Cell Cycle; Cell Line, Tumor; Dimethyl Sulf

2006
Polyion complex micelles composed of all-trans retinoic acid and poly (ethylene glycol)-grafted-chitosan.
    Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:11

    Topics: Adsorption; Antineoplastic Agents; Brain Neoplasms; Carbohydrate Sequence; Cell Line, Tumor; Cell Su

2006
Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment.
    The British journal of dermatology, 2007, Volume: 156, Issue:6

    Topics: Androstadienes; Apoptosis; Benzenesulfonates; Blotting, Western; Cell Line, Tumor; Cell Proliferatio

2007
Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2008, Volume: 13, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dimethyl Sulfox

2008
Dimethyl sulfoxide (DMSO) increases expression of sialyl Lewis x antigen and enhances adhesion of human gastric carcinoma (NUGC4) cells to activated endothelial cells.
    International journal of cancer, 1993, May-08, Volume: 54, Issue:2

    Topics: Antibodies, Monoclonal; Antigens, Tumor-Associated, Carbohydrate; Carcinoma; Cell Adhesion; Cell Adh

1993
Repression of stromelysin metalloprotease expression in rat fibrosarcoma cells by dimethylsulfoxide.
    Clinical & experimental metastasis, 1993, Volume: 11, Issue:1

    Topics: Animals; Blotting, Northern; Cell Adhesion; Cell Division; Cell Line, Transformed; Cell Movement; Di

1993
Expression of cathepsin B in small cell lung carcinoma cells in relation to in vitro invasiveness.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1998, Volume: 19, Issue:2

    Topics: Carcinoma, Small Cell; Cathepsin B; Cell Aggregation; Cell Division; Cell Line; Cells, Cultured; Dim

1998
Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC.
    International journal of cancer, 2000, Jul-15, Volume: 87, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Cell Division; Cell Movement; Dimethyl Sulfoxid

2000
Lack of In vitro cytotoxicity, associated to increased G(2)-M cell fraction and inhibition of matrigel invasion, may predict In vivo-selective antimetastasis activity of ruthenium complexes.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: Animals; Antineoplastic Agents; Collagen; Dimethyl Sulfoxide; Drug Combinations; G2 Phase; Humans; L

2000
Enhanced invasiveness and metastatic potential of epithelial cell lines cultured in the presence of dimethyl sulphoxide.
    International journal of cancer, 1990, Aug-15, Volume: 46, Issue:2

    Topics: Animals; Cell Line; Clone Cells; Dimethyl Sulfoxide; Epithelium; Immune Tolerance; Mice; Mice, Inbre

1990
Plasminogen activator dependent pathways in the dissemination of human tumor cells in the chick embryo.
    Cell, 1988, Feb-12, Volume: 52, Issue:3

    Topics: Allantois; Animals; Catalysis; Chick Embryo; Chorion; Dimethyl Sulfoxide; Humans; Immunoglobulin G;

1988